From Deus Ex Medicina: Vinod Khosla, Bob Kocher & Annie Lamont

On this episode of the Newcomer podcast, host Eric Newcomer is joined by co-host Nayeema Raza for conversations with some of the most influential voices in healthcare and venture capital. Bob Kocher, Partner at Venrock, and Annie Lamont, Founder and Managing Partner of Oak HC/FT, share their perspectives on business models in healthcare, the rise of AI applications, the promise and pitfalls of longevity drugs like GLP-1s, and the future of Medicare Advantage. Later, Vinod Khosla, Founder of Khosla Ventures, brings his trademark candor to a wide-ranging discussion about AI’s role in healthcare, regulatory challenges, global competition, and how startups can reimagine the system from the ground up

Journalist Nayeema Raza—host of Smart Girl Dumb Questions—joins Eric Newcomer to preview Deus Ex Medicina, their AI–health–longevity summit happening Tuesday, Sept 9 (San Francisco). They discuss the big themes going into the conference: how longevity went mainstream, why precision medicine and novel bio are finally feeling real, and who wins the race to own the patient. Eric and Nayeema get into the policy whiplash in D.C., HIPAA’s fraying edges in a wearables world, and whether or not AI will actually discover something novel, like a new drug or cure for Alzheimer's? Plus, what they’re most excited to ask on stage at Deus Ex Medicina.Timecodes:00:00 — The story behind the creation of Deus Ex Medicina08:39 — Longevity goes mainstream (the GLP-1 moment)12:42 — Precision medicine gets practical (targeted therapies & trials)17:11 — Bundles, frenemies, and who owns the patient22:31 — D.C. shake-ups, privacy stakes… and can AI invent a drug?

Former CIA officer and three-term Congressman Will Hurd joins Eric Newcomer, Tom Dotan, and Madeline Renbarger to break down Washington's defense tech boom and tackle the burning question: Is this all just hype? Hurd explains how Ukraine has changed the face of warfare and opened the door for new companies to break into the fold. However, it's one thing to build a prototype, but it's another to actually earn recurring revenue.We discuss how to really sell to the Pentagon, LA's role as a hub for the new defense tech wave, and Hurd's own Chaos Industries and their modular counter-drone systems.00:00 — Meet Will Hurd from CIA to Congress to Chaos06:00 — How Hurd would solve partisan redistricting13:24 — The defense-tech moment24:20 — Air superiority isn’t dead36:32— How to sell to DoD

Is the AI bubble popping—or just catching its breath? Eric Newcomer and Tom Dotan spar over Nvidia jitters, Sam Altman’s “bubble” dinner, the MIT “95% fail” headline, app-vs-model margins (Cursor, Claude Code), and Chamath’s SPAC-as-casino shtick. Then Eric sits down with Vercel founder/CEO Guillermo Rauch for a fast, idea-dense jam: assistants → agents → multi-agent teams, why GPT-5’s real story is coding, “vibe coding” and code-last workflows, who gets paid in the era of AI factory-builders, whether to study CS, why taste beats code, and Guillermo’s six-month prediction for a breakout vertical agent.00:00 Did the AI “bubble” pop? Altman dinner & sell-off vibes01:16 MIT survey “95%” headline vs reality09:04 Capitalism, incentives & Chamath’s SPAC “casino”18:17 Interview starts — Guillermo Rauch (Vercel)22:07 GPT-5 reality check & the “Einstein-in-a-box” test37:37 Future of engineering + should you study CS?48:36 6-month prediction: a breakout vertical agent; underestimating GPT-50

For this episode, we brought on Ed Zitron to make the bear case against large language models and walk us through his “Hater’s Guide To The AI Bubble.” In this fiery debate with Eric Newcomer, Tom Dotan, and Madeline Renbarger, we dig into whether generative AI is the next platform shift or a $500B mirage. From the viral TaskRabbit CAPTCHA myth to SoftBank’s high-stakes bets, we debate the hype, shaky economics, and media spin driving the AI boom.

GPT-5 has landed! Is it the leap forward OpenAI promised or just an incremental upgrade? Eric Newcomer and Tom Dotan discuss this, how AI capex might be propping up the entire economy, and what Apple’s golden gifts to Trump say about Big Tech’s political bets.

This week on the Newcomer Podcast, we're joined by a very special guest: Danny Rimer, seasoned investor and longtime partner at Index Ventures, for a timely conversation around Figma’s highly anticipated IPO.Danny takes us behind the scenes of Index’s early bet on Figma and its visionary CEO Dylan Field, sharing how the deal came together and what made the design platform stand out in a crowded startup landscape. From there, we zoom out to talk about the current venture capital climate — what’s changed, what’s stayed the same, and what the smartest investors are watching right now.We also dig into AI’s evolving role in the startup ecosystem, the tension between hype and real value, and where Danny sees the next big opportunities emerging. Whether you're a founder, investor, or just love a good origin story, this is an episode you won’t want to miss.Timecodes:00:00 Introduction to Danny Rimer02:29 How Rimer met Figma and the beginnings of design as a category16:42 Figma's failed Adobe deal and comeback25:39 How Index approaches AI deals 31:00 AI's iPhone moment and looking beyond the chatbot39:10 Shifts in the venture capital industry

Tech leaders unveiled the American AI Action Plan on Wednesday and President Trump signed 3 executive orders with big handouts to AI companies. Madeline returns fresh off of a trip to Washington DC and gives Tom and Eric the lowdown on tech's victory lap at the nation's capital. Plus, even the altruists at Anthropic feel the need to raise Middle East money.Timecodes:01:45 - The All-In podcast might as well be state-run media05:16 - The vibes at the All-In Hill and Valley event08:50 - The coming AI abundance12:29 - Woke AI and the ministry of truth15:30 - America's strategic advantage is President Trump22:36 - The AI copyright kerfuffle32:36 - Dario faces the harsh reality of capitalism

The ServiceTitan IPO has been an unexpected bright spot as 2024 comes to a close.On this year’s final episode of the Newcomer Podcast, we discuss what other startups might follow in ServiceTitan’s footsteps next year. Eric defends the controversial ratchet provision in its last funding round. And we dig into Alphabet’s big week. We focus on startups on this show, but this week was a good reminder that the big tech firms like Alphabet and Meta can still turn out impressive moonshot technology from their research labs. We’re bullish on a couple emerging venture capital firms — Laude Ventures and Dimension — who just closed big new funds. The megafunds may be sucking up the majority of LP dollars, but firms with a clear thesis and a standout team of high performers can still shine in this market. Give it a listen.Chapters:00:00 — Reflections ahead of the new year 05:02 — ServiceTitan’s IPO and Market Sentiment10:00 — Alphabet’s Wins and the AI landscape15:08 — The State of Quantum Computing19:58 — Emerging Venture Capital Trends and Final ThoughtsEpisode produced by Christopher Gates Get full access to Newcomer at www.newcomer.co/subscribe

After a brief hiatus, the Newcomer podcast is back! Madeline Renbarger has rejoined me as my co-host to help break down all of the news across venture capital and startups. This week, we’re kicking off with a massive $693 million chip deal and Google’s huge quantum computing breakthroughs, in news that feels like flashes of Silicon Valley returning to its “silicon” roots. Still, some of this tech feels a bit too early to be exciting for a venture-backable model. We also dig into the personnel shake-ups across the major multi-stage funds, including Brian Singerman’s step back from Founders Fund last week. Lightspeed also saw partners exit as part of a consumer investing reshuffle. And just this morning after recording, Lux Capital’s Bilal Zuberi announced on X that he was leaving to “embark on a new chapter.” We’re excited for you to listen. Episode produced by Christopher GatesBrought to you by BrexBrex knows runway is everything for venture-backed startups, so they built a banking solution that helps them take every dollar further. Unlike traditional banking solutions, Brex has no minimums and gives startups access to 20x the standard FDIC protection via program banks.Plus, startups can earn industry-leading yield from their first dollar — while being able to access their funds anytime. If you want to make sure your portfolio companies have a place to save, spend, and grow their capital, check out Brex here.Chapters 00:00 - Intro 01:06 - Tenstorrent’s $693 million Series D 04:44 - Google’s Quantum Computing Breakthrough06:42 - Lightspeed’s Consumer Investing Re-org09:24 - Brian Singerman Steps Back and Founders Fund’s Roster14:08 - Mega-funds in Transition and Tech’s Trump Positioning 20:19 - Conclusion and Future Discussions Get full access to Newcomer at www.newcomer.co/subscribe