
How should we think about LDL and ApoB, and how much metabolic health changes the cardiovascular risk picture?
In this episode of Metabolic Mind, Dr. Bret Scher speaks with vascular surgeon Dr. Lily Johnston about cholesterol and plaque formation, along with the need to personalize cardiovascular prevention.
Dr. Johnston brings a unique perspective as both a vascular surgeon who treats advanced blood vessel disease and a physician focused on cardiometabolic prevention. She discusses why ApoB and LDL can play a role in atherosclerosis, while also emphasizing that vascular disease is shaped by many factors, including insulin resistance, diabetes, blood pressure, inflammation, smoking history, fitness, sleep, stress, social connection, and personal goals.
They cover:
- What vascular surgeons treat and why atherosclerosis affects blood vessels throughout the body
- Why prevention starts long before surgery becomes necessary
- How LDL and ApoB fit within a broader cardiovascular risk assessment
- Why metabolic health and insulin resistance deserve more attention
- How diet, medications, and imaging can help personalize risk assessment
- Why lowering ApoB may matter more for some patients than others
- What we still need to learn about lean mass hyper-responders
- Why curiosity and humility are essential in cholesterol research
- How patients can ask better questions when the conversation focuses only on LDL
This interview offers a thoughtful look at LDL, ApoB, metabolic health, and cardiovascular prevention, with a focus on better conversations between patients and clinicians.
🔎 Have questions about how to apply metabolic therapies effectively? Submit them at metabolicmind.org/questions to be featured in a future Metabolic Mailbag episode.
#LDL #ApoB #MetabolicMind #CardiovascularHealth
Expert Featured:
Dr Lily Johnston
- https://www.instagram.com/lilyjohnstonmd/
- https://www.tiktok.com/@lilyjohnstonmd
- https://www.youtube.com/channel/UCMaFSJtYbK8LQ7AyV31TrgQ
- https://x.com/lilyej
Free CME Clinician Trainings:
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Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.
Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/
About us:
Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.
Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.
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