Whole-brain Spatial Transcriptomics at Cellular Resolution

Learn from the experts how to refine every step of your cryo workflow, from vitrification to imaging, to preserve native structure, minimize artifacts, and reveal the hidden details that drive cellular discovery.In this podcast, you will learn how you can:• Go beyond cryo-confocal: Use spectral signatures to unlock new layers of cellular information.• Correlate across scales: Learn how to integrate cryo light and electron imaging for richer insights.• Bridge modalities: Explore how X-ray tomography connects to cryo-EM analysis.Watch the full presentation here: https://microscopyfocus.com/see-the-hidden-advancing-cryo-workflows-for-cellular-discovery/Browse all episodes of the Listen In Series here: https://listen-in.bitesizebio.com/

Discover how to automate your 3D cell culture quantification with a machine learning-based application for accurate and efficient counting of organoids, tumor spheroids, and spheroids in this episode of Listen In.In this podcast, you will:• Understand the challenges of traditional automated systems in 3D cell culture quantification• Gain insights into the benefits of non-consumable, slide-free cell counting technology• Learn how to implement user-defined parameters for customized cell counting protocols• Discover how DeNovix CellDrop Automated Cell Counter uses machine learning for accurate organoid, tumor spheroid, and spheroid countingWatch the full presentation here: https://events.bitesizebio.com/learn-to-automate-organoid-countingBrowse all episodes of the Listen In Series here: https://listen-in.bitesizebio.com/

Are you looking to elevate the performance of your immunoassays? Tune in to this Listen In episode, where experts will share valuable insights to help you optimize your assay selection, production practices, and method analysis. In this podcast, you will learn:• When to choose screening assays versus qualified or verified assays to effectively meet your research objectives• Key techniques that contribute to the reliability and consistency of immunoassays• How to leverage analytical tools to assess immunoassay results for improved experimental outcomes Watch the full presentation here: https://events.bitesizebio.com/inside-immunoassays-boost-assay Browse all episodes of the Listen In Series here: https://listen-in.bitesizebio.com/

Discover integrated solutions for precise serial sectioning and cryo-EM sample prep—supporting seamless workflows from ultramicrotomy to 3D electron microscopy.In this podcast, you will learn: • How to streamline serial sectioning for volume EM using the UC Enuity and AT module;• How to achieve in-situ targeting under cryogenic conditions for cryo-EM workflows;• How integrated imaging and AI-powered analysis enhance 3D EM data interpretation.Watch the full presentation here: https://microscopyfocus.com/integrated-solutions-for-serial-sectioning-and-cryo-em-with-uc-enuity/Browse all episodes of the Listen In Series here: https://listen-in.bitesizebio.com/

Learn how to perform a powerful new tissue-clearing method, designed for whole-brain 3D spatial RNA imaging at single cell resolution, and able to provide uniform staining while enhancing tissue transparency in whole organs across multiple species.In this webinar, you will learn:• A groundbreaking tissue-clearing technique for precise whole-brain 3D spatial RNA imaging at single-cell resolution;• How to use it for robust 3D RNA imaging of whole organs of various sizes from different species;• How to uniformly stain whole organs while enhancing tissue transparency and preserving RNA integrity. Watch the full presentation here: https://events.bitesizebio.com/whole-brain-spatial-transcriptomics Browse all episodes of the Listen In Series here: https://listen-in.bitesizebio.com/

Detecting rare antigen-specific T-cell responses requires assays that are both sensitive and scalable. Traditional methods like flow cytometry often struggle with high-throughput needs or with preserving precious sample material.In this episode of Listen In, you’ll discover how ELISpot and FluoroSpot assays overcome these challenges. These cell-based immunoassays measure cytokine and antibody secretion at the single-cell level, offering a sensitive, robust, and accessible way to capture rare immune responses.You’ll learn how ELISpot and FluoroSpot can be applied in vaccine studies, biotherapeutic evaluation, and cell and gene therapy development. The episode also explores practical guidance on assay setup and execution, the advantages of multiplex cytokine detection with FluoroSpot, and how these platforms can be qualified for use in preclinical and clinical trials.With their unique combination of sensitivity and ease of use, ELISpot and FluoroSpot provide a valuable alternative to flow cytometry, especially when high throughput and efficient data collection are priorities.Watch the full presentation here: https://events.bitesizebio.com/detecting-rare-t-cell-responses-atBrowse all episodes of the Listen In Series here: https://listen-in.bitesizebio.com/

In the life sciences, an astounding amount of unused products and materials end up in landfills instead of contributing to research progress. This issue arises across the product lifecycle, from liquidated biotech start-ups that abandon equipment to over-purchasing and pipeline deprioritization at successful firms. Even well-intentioned suppliers encounter forecasting challenges that leave perfectly good items discarded!In this episode of Listen In, explore the root causes of waste in our industry, as we draw on real-world examples of failed companies, discontinued pipelines, and canceled orders. We will examine the ripple effects this has on both operational efficiency and the broader sustainability goals of life science organizations. We will also introduce Wasteless Bio, a dedicated marketplace designed to keep high-quality, unused products in circulation—helping researchers access discounted reagents and instruments while reducing environmental impact. Whether you are a biotech executive, lab manager, or supplier, you will gain a clearer understanding of how to rescue valuable resources from the trash and reinvest them back into scientific innovation.Watch the full presentation here:Browse all episodes of the Listen In Series here: https://listen-in.bitesizebio.com/

Automated counting of certain cell types is notoriously challenging due to their irregular shapes, variable nuclei number, autofluorescence, and often high amounts of debris in samples.However, with the latest developments in cell-counting hardware and app technology, automated counting of even challenging cells is simpler than ever.In this episode, see how you can achieve reliable automated cell counts with the CellDrop Automated Cell Counter. Using hepatocytes as an example, you will learn how the machine learning technology integrated into DeNovix’s Hepatocyte app can save time, reduce human error, and provide consistent results.Watch the full presentation here: https://events.bitesizebio.com/automated-hepatocyte-counting-newBrowse all episodes of the Listen In Series here: https://listen-in.bitesizebio.com/

In this episode of Listen In, we showcase cutting-edge mass spectrometric analysis of mucins, including the characterization of mucinases, enrichment techniques, and complete mucinomic mapping of translationally relevant mucin proteins.Mucins are a diverse family of high molecular weight glycoproteins that play critical roles in protecting and lubricating epithelial surfaces, making them integral to numerous physiological processes and disease states. As a promising class of biomarkers, mucins may offer unique insights into various pathologies, such as cancer and chronic inflammatory diseases. However, their complex structures and extensive glycosylation present significant challenges in their study and application.Mucin-domain glycoproteins are densely O-glycosylated and play key roles in many biological functions. However, their dense O-glycosylation remains enigmatic both in the glycoproteomic landscape and structural dynamics, primarily due to the challenges associated with studying mucin domains.  In this episode, you will get an introduction to the (glyco)proteomic techniques used in Mucinomics and learn how proper sample preparation of mucin-containing tissues for mass spectrometry is key to discovery.MilliporeSigma is the U.S. and Canada Life Science business of Merck KGaA, Darmstadt, Germany.Watch the full presentation here: Browse all episodes of the Listen In Series here: https://listen-in.bitesizebio.com/

In this episode, learn about latest advancements in multiplex assay technology.Hear from real user experience how the advanced xMAP INTELLIFLEX® DR-SE Instrument revolutionizes assay multiplexing, enabling simultaneous rapid data acquisition for multiple sample parameters to expand the depth and breadth of your research.Watch the full presentation here: https://events.bitesizebio.com/user-experience-of-the-xmapThis compact, flow-based multiplex platform integrates xMAP® Technology with modern enhancements to streamline assay development, enhance user experience, and deliver fast, reliable results by acquiring data for two parameters per analyte simultaneously.Browse all episodes of the Listen In Series here: https://listen-in.bitesizebio.com/