Leyla Weighs In: Fasting-Mimicking Diet for Crohn’s and Managing Antibiotic-Associated Diarrhea

Dietitian Nutritionist Leyla Muedin discusses a Stanford-led randomized controlled trial published in Nature Medicine in which a five-day, calorie-restricted fasting-mimicking diet improved symptoms and inflammatory markers in people with mild to moderate Crohn’s disease. In the three-month study of 97 patients, 65 followed monthly five-day cycles of 700–1100 calories/day with plant-based meals, while 32 continued usual diets; about two-thirds of the fasting-mimicking group reported symptom improvement, with fatigue and headaches but no serious side effects, and fecal calprotectin and other inflammatory molecules decreased. She notes bowel rest and the specific carbohydrate diet as additional approaches. The episode also explains how antibiotics can cause diarrhea by disrupting gut bacteria, lists higher-risk antibiotics, offers supportive steps (hydration, BRAT foods, avoiding irritants), recommends Saccharomyces boulardii taken away from antibiotics, and outlines warning signs requiring medical care, including possible C. difficile.

Is oatmeal healthy?I have a higher-than-normal carotid artery intima-media thickness and no appreciable plaque. Should I be concerned?Should my husband and I take the hepatitis B vaccine?

What is your protocol for 9-11 first responders for addressing toxic burden and immune support?Where do you stand on GLP-1 weight loss drugs? Help vs harm?I have a high ferritin, but cannot donate blood. Other options?

Indoor Epidemic: Prescribing Nature, Light, Air, and Movement with Dr. John La Puma, internist, chef, and regenerative farmer. His book, "Indoor Epidemic," argues that spending about 93% of life indoors undermines health through poor light timing, air quality, limited movement, and reduced nature exposure. La Puma cites data that outdoor morning light helps set circadian rhythms, while nighttime blue light can impair sleep quality and raise cardiovascular risks, referencing a large UK Biobank study. He discusses indoor pollutants and CO2 buildup affecting inflammation and cognition, recommends strategies like getting daylight early (even just a sky view), using circadian lighting, and taking brief outdoor breaks to reduce myopia risk. He describes measurable benefits of forest bathing and gardening (including immune and mood effects), notes hospital studies linking window views to shorter stays and less pain medication, and reviews his pioneering work in culinary medicine now taught widely in medical schools, emphasizing cooking and growing food as preventive and therapeutic tools.

Dr. Hoffman continues his conversation with Dr. John La Puma, internist, chef, and regenerative farmer.

New Study Links Aged Garlic Extract to Better Cognition: Holistic practitioner Jane Jansen from the Tree of Life Wellness Center in Massachusetts reveals a newly published double-blind, randomized, placebo-controlled trial at the Los Angeles Biomedical Research Institute at Harbor-UCLA involving 72 participants with pre-hypertension or hypertension. Over 12 weeks, one group took 2,400 mg/day of Kyolic Aged Garlic Extract (Reserve formula), and cognitive function was tracked using the Montreal Cognitive Assessment (MoCA). Jansen reports that 92% of the aged garlic extract group had no cognitive impairment after the trial, while the placebo group showed more cognitive decline, with benefits attributed to increased nitric oxide bioavailability, improved endothelial function, better cerebral blood flow, nerve protection/repair, and enhanced brain waste removal. She contrasts this approach with costly Alzheimer’s plaque-busting drugs and discusses prevention strategies, including diet, sleep (glymphatic system), exercise, inflammation control, and circulation-supporting nutrients such as nattokinase. 

Dr. Hoffman continues his conversation with holistic practitioner Jane Jansen from the Tree of Life Wellness Center in Massachusetts.

Pump up the volume on your exercise with HIIT to optimize disease-prevention; Natural ways to lower your LDL; Choline’s impact on the menopausal brain; How targeted supplementation can boost your nitric oxide for better health, an interview with Dr. Nathan Bryan, creator of N1O1.

When GLP-1 drugs supercharge eating disorders; Vitamin C’s brain-protective role; Can your fast-fashion clothing give you cancer? As an experiment, scientists invented a fake disease—then AI started reporting it as real; Zeaxanthin could charge cancer treatment; How long is Kyolic aged garlic extract aged?

Nutritionist Leyla Muedin discusses joint inflammation—its symptoms (swelling, pain, redness, warmth, morning stiffness, reduced range of motion) and why it is usually a sign of an underlying condition rather than a disease itself. She reviews common causes including osteoarthritis (cartilage wear and tear), rheumatoid arthritis (autoimmune synovium attack with prolonged morning stiffness and fatigue), gout (uric acid crystals, often in the big toe), psoriatic arthritis, injuries, autoimmune diseases (e.g., lupus, ankylosing spondylitis, Sjogren’s), infections such as septic arthritis requiring urgent care, and surrounding-tissue problems like tendonitis and bursitis. Lifestyle factors that worsen inflammation include excess weight, poor diet (including unaddressed food allergies; avoiding nightshades is suggested), insulin resistance contributing to gout, lack of exercise, smoking, and stress. Management strategies include rest, bracing, ice vs. heat, OTC anti-inflammatories, gentle low-impact exercise, anti-inflammatory foods, weight loss, treating root causes, and supplements such as glucosamine, chondroitin, MSM, bromelain, turmeric, Boswellia, and quercetin.