What are cancer 'vaccines' and will they revolutionise treatment?

The implementation of the creamy layer doctrine for OBC reservations has been beset with complications. A Supreme Court judgement on March 11 essentially held that Union government has been doing it all wrong all these years, and that their income/wealth test was subjecting a section of OBC applicants to “hostile discrimination”. The Supreme court gave the government six months to implement its order with regard to the litigants. But the government has told the court that it will be too complicated to implement its order retrospectively. For instance, one immediate concern: what happens with the results of the 2025 civil services exams that were declared on March 6? With the court set to hear the matter again on September 17, we unpack the complex history of creamy layer implementation. How effective has it been -- in remedying the hogging of OBC reservations by a few select groups? Isn’t sub-categorisation a better approach compared to the creamy layer doctrine – when it comes to ensuring opportunities for under-represented communities within OBCs? Guest: Abhinay Lakshman from The Hindu’s bureau Host: G. Sampath Edited and produced by Sharmada Venkatasubramanian Learn more about your ad choices. Visit megaphone.fm/adchoices

This is a special bonus episode featuring the Hindu's Global Faultlines podcast where Sharmada venkatausbramanian is in conversation with Stanly Johny. Israel has fought multiple wars and military campaigns since October 7, in Gaza, Lebanon and Iran, while expanding its military and intelligence operations across the region. But military reach does not necessarily translate into strategic victory. What has Israel actually achieved, and at what cost? Has it strengthened its security and position in West Asia, or created new vulnerabilities and deeper isolation? How have these wars changed Israel’s relationship with the United States, the Gulf and India, and what do they mean for the future of the Palestinian question?  In this episode of Global Faultlines, we examine Israel’s wars, its security establishment, its evolving regional strategy and the larger question: Is Israel winning? Expert: Stanly Johny, International Affairs Editor, The Hindu  Research, Editing and Production: Sharmada Venkatasubramanian  Camera: Johan Sathyadas J Learn more about your ad choices. Visit megaphone.fm/adchoices

There’s been a lot of excitement in the cancer research field recently. Preliminary results from a trial with patients who had melanoma or skin cancer, showed that a ‘cancer vaccine’ had been successful in reducing the recurrence of melanoma tumours. This vaccine, called instamaren autogene, is based on mRNA technology – the same tech that was used to manufacture Covid vaccines during the pandemic. A number of other trials across the world are also looking into how mRNA vaccines can help prevent the recurrence of certain hard-to-treat cancers. So what are these new therapies and what cancer do they treat? Why are they called vaccines when they don’t actually prevent cancer? How does mRNA tech work and how is AI helpful in this? Will these personalised treatments be available in India any time soon and how expensive will they be? Guest: Dr. Narayana Subramaniam, Lead Consultant, Head and Neck Surgery and Oncology, Aster Hospitals, and Adjunct Faculty at the Indian Institute of Science, Bengaluru. Host: Zubeda Hamid Edited by Sharmada Venkatasubramanian Learn more about your ad choices. Visit megaphone.fm/adchoices

Much was expected from the Indian men’s hockey team after back to back bronze medals at the highest level of the sport – the Olympic Games. The core of the team that took part in the recently concluded World Cup was the same as the one that medalled at the Paris Olympics in 2024. Yet we struggled against the top teams at the recently concluded World Cup. Despite having a coach in Craig Fulton who is known for a defense-first approach, the single most disappointing aspect of the team’s performance was in defence, as it conceded 19 goals in just six games. What is the team missing, and what does this performance bode for the upcoming Asian Games where are the defending champions? We speak with Uthra Ganesan from The Hindu’s Sports Bureau. Host: G Sampath Producer: Shiksha Jural Learn more about your ad choices. Visit megaphone.fm/adchoices

Last week, jewellery brand Giva withdrew an advertisement it made for Raksha Bandhan after netizens criticised actress Kriti Sanon’s outfit as too revealing for a traditional festival. The incident is the latest in a series of brands backtracking on their advertisements following backlash that is often religiously or communally charged. Given India’s current socio-political climate, are brands overreacting to manufactured outrage? Here, we discuss the question. Guest: Mitushi Sharma and Santosh Desai Host: Sonikka Loganathan Producer: Jude Weston Learn more about your ad choices. Visit megaphone.fm/adchoices

The resilience of a nation’s economy is determined by the quality of its human capital. Other things being equal, a country with a healthy and educated population will grow much faster than one with a semi-literate and undernourished one. And yet, has historically, and consistently, under-invested in health and education – neglecting them even in years of high economic growth. There is a strong tendency to dismiss state expenditure on people’s well being a as ‘freebies’ or ‘revdi’. But are they freebies or are they basic rights that people can demand from the state? Guest: Reetika Khera, professor of economics at IIT, explores this question in her book, ‘Freebies or Rights: Understanding Social Policy in ’, which maps ’s welfare architecture and its effectiveness. Host: G Sampath Producer and editor: Jude Weston Learn more about your ad choices. Visit megaphone.fm/adchoices

As the Russia-Ukraine war enters its fifth year, the conflict shows little sign of ending. Russia and Ukraine continue to intensify drone and missile attacks, while efforts for a possible diplomatic breakthrough remain uncertain. Is Vladimir Putin under growing pressure? How has the nature of the war changed, what is driving the escalation? Guest: Stanly Johny, International Affairs Editor, The Hindu Host: Smriti Sudesh Edited and produced by Sharmada Venkatasubramanian Learn more about your ad choices. Visit megaphone.fm/adchoices

“Do you not want people to be healthy?” That was the question the Supreme Court put to the FSSAI earlier this month, while hearing a case over warning labels on the front of packaged food, for foods high in sugar, salt, and fat. The Court questioned why the regulator had delayed implementing stronger warnings, particularly when the issue directly concerns public health and children.The question becomes even more significant now, after a media investigation found that some of the world’s biggest food and beverage brands use substantially different formulations for their products in India and abroad, with Indian products containing higher levels of sugar, salt or fat, along with less prominent health warnings.So, what determines what consumers get on their shelves and how much protection do our food-safety rules really provide? To understand this, today, on In Focus, we’re joined by Hyderabad-based paediatrician Dr. Sivaranjani Santosh, whose eight-year fight over the misleading use of “ORS” label on high-sugar electrolyte drinks eventually led to FSSAI banning the use of the term by products that do not follow the prescribed formulation. Guest: Dr. Sivaranjani Santosh, Paediatrician Host: Rishita Khanna Edited by Sharmada Venkatasubramanian Learn more about your ad choices. Visit megaphone.fm/adchoices

This is a special weekend crossover episode featuring the Hindu's Rearview podcast. Did Damodar Dharmananda Kosambi solve the Riemann Hypothesis - one of mathematics's greatest puzzles? Was Kosambi, who wrote one of the most influential books on studying Indian history, ignored by both mathematicians and historians? Is he India's Alan Turing? This week we interview Prof Ram Ramaswamy, whose biography of the remarkably eclectic DD Kosambi: DD Kosambi, One Life, Many Worlds, gives a dispassionate, scholarly and insightful look into this mathematician and historian who was also a Sanskrit scholar and avowed Marxist. Ramaswamy, who's taught at JNU, IIT Delhi and is a former Vice Chancellor at University of Hyderabad, has unearthed rich archival material to investigate the motivations, frustrations and sources of inspiration that shaped one of India's greatest polymaths. Host: Jacob Koshy Producer and editor: Jude Weston Learn more about your ad choices. Visit megaphone.fm/adchoices

India has a waste management problem. Though we reportedly collect 90% of our municipal solid waste, nearly 40% does not enter formal processing. Due to this large share that is out of the formal processing system, most Indian cities have garbage mountains – open dump sites and landfills. These dump sites have been linked to groundwater contamination and other public health risks. Critically, they are massive sources of non-CO2 greenhouse gases such as Methane.How to eliminate or shrink these dump sites? How to ensure that waste segregation is followed all the way from the collection point till the end of the fresh-waste disposal chain? What are the chances India can reduce landfill methane emissions to zero?A new report, titled ‘Municipal Solid Waste Management in : Policy and Technology Pathways for Climate Action’, says that with the right reforms, can reduce waste sector methane emissions by 99% within 10–15 years. Guests: Zerin Osho, Director of the Indian Program at the Institute for Governance and Sustainable Development (IGSD), and Akshat Patni, Senior Adviser with IGSD. Host: G. Sampath Edited and produced by Sharmada Venkatasubramanian and Jude Weston Learn more about your ad choices. Visit megaphone.fm/adchoices