We get many questions from listeners and people seeking Alzheimer’s prevention and early intervention about the risks and benefits of hormone therapies, such as estrogen and progesterone.
Our guest this episode, Felice Gersh MD and co-authors recently published an article entitled:
In this episode we talk about:
- Hormone Therapy in this episode is referring to Estrogen (ie estradiol) and Progesterone.
- 4:29 We talk about the ideal forms to take
- 10:28 We discuss doses and the best way to monitor for safety and effectiveness according to the recent journal article.
- 15:55 - Hormone Therapy’s potential benefits to heart and brain of Estrogen.
- 21:15 - How estrogen might help the natural process of inflammation that occurs in women’s bodies after menopause.
- 40:28 - Why it might make more sense to start estrogen therapy earlier rather than later.
- 48:50 - Considerations for starting estrogen after age 60 or more than 10 years after menopause and how long it may take to see results.
More episodes from "Evolving Past Alzheimer's"
Lisa's Story - Chap. 2 - Living Well with Alzheimer's
1:02:18Earlier this year, podcast episode #65 - we spoke to Lisa and her daughters Stacy and Natalie. They told us about how they were Living Well with Alzheimer's and improving using lifestyle and personalized approach. Her cognitive decline had stabilized and seen small, but significant improvements in brain function. This episode we review some of the elements that have led to their success: 1) Hiring a personal assistant for Lisa as opposed to a caregiver to force her to do things 2) Inspecting & moving out of a water damaged "moldy" home and why they did this 3) How they continue to iterate and push back against her Alzheimer's process, some tools and tricks that are working for them every day. For more information on how you can prevent or push back against Alzheimer's and other dementias visit Kemperwellness.com or call (216) 337-1400. We have support programs, virtual classes, and many other options. Consider supporting the Evolving Past Alzheimer's podcast at patreon.com/evolvingpast so we can continue to bring you the information most helpful to you. 4:44 - What has happened since we last spoke to Natalie and Stacey 7:27 - How Natalie and Stacey revolutionized typical dementia care through choosing a personal assistant over a caregiver 12:45 - What they discovered from mold tests in their mother’s home 29:15 - Navigating the process of moving their mother to a safer home 34:50 - What kept Lisa motivated to keep doing the work 41:48 - How is Lisa doing right now overall? 47:10 - The ins and outs of the system that keeps the family on track with the treatment plan
Usable Technology for Brain Aging & Dementia with Ben Hampstead PhD
53:20“We’re actually able to change the brain, even in the face of things like Alzheimer’s disease.” This was the statement made by our guest for this show, Dr. Ben Hampstead. Dr. Hampstead is a professor at the Univ of Michigan and leads a lab that is doing several studies using transcranial direct current stimulation for mild cognitive impairment, Alzheimer's, and other forms of cognitive impairment. We talk about his work and compare it to some of our own results with our patients. Exciting and thought-provoking! To learn more about the exciting work being done by Dr Hampstead https://medicine.umich.edu/dept/psychiatry/benjamin-hampstead-phd-abppcn To learn more about what we do in our clinical practice at Kemper Cognitive Wellness visit kemperwellness.com We are located in Cleveland, Ohio. Or call us at (216) 337-1400. 1:55 - How we are able to change the brain even in the face of Alzheimer's disease 9:00 - Technologies that can be used to treat cognitive decline 31:24 - Measuring the results of the non-pharmacological treatment methods 37:51 - Making medicine more personalized 47:22 - How these treatment plans can be used to prevent cognitive decline before it starts
Your Brain On Sugar
32:01Halloween is here and the other holidays are just around the corner, so we need to discuss sugar. I share about a conversation I had with Dr. Dale Bredesen about the importance of eating right when trying to prevent cognitive impairment. It has been a long time where food and wellness was not included in the treatment plan for patients with Alzheimer’s and Dementia, but it’s such a crucial part of preventing and slowing the progression of cognitive decline. Nikki Gould, a registered dietician at Kemper Cognitive Wellness is also joining us today to talk about what sugar can do to your brain and your overall health and how we can navigate the holidays with this information in mind. 6:39 - Is there a healthy amount of sugar? 11:05 - How sugar is hidden in the American diet 15:38 - Taking the first steps towards sustainable change 20:30 - Keeping sugar intake at a reasonable level during the holidays 25:04 - Supporting family members during the holidays if they are struggling with their health
Working with Trauma in Alzheimer's & Dementia
1:08:18Untreated and unresolved trauma is now considered to be a risk factor and contributor to Alzheimer's dementia. Trauma can be defined as any event that alters how we process, react to, and recall memories, by overwhelming the individual’s central nervous system. Additionally, trauma is defined as any event in which a person feels helpless and unsafe. It is not only an occurrence that happened in the past; instead, trauma is an event that leaves an imprint upon the body and the brain which persists to the present day. Our guest for this episode, Dr. Ilene Naomi Rusk completed her PhD in Neuropsychology and Psychopharmacology in the UK , and Fellowships in Neuropsychology. She has dedicated her career to studying novel treatment strategies for Alzheimer’s Disease and sees trauma as a root cause of many illnesses. She is the author of several peer reviewed articles. Dr Rusk co-founded the Brain and Behavior Clinic over 25 years ago and currently directs the Healthy Brain Program in Colorado. 4:20 - Defining trauma through reflecting on a patient story 7:26 - How trauma influences more than just the brain 16:06 - A trauma informed approach to treating neuro degeneration 21:50 - Identifying cognitive decline symptoms in patients who struggle with other mental illnesses or trauma 33:24 - Classic signs of unresolved trauma in the older generations 42:44 - How to deal with unresolved trauma in someone before it becomes cognitive decline 56:12 - How long does it take to see improvement when working with trauma-informed techniques? Strategies to improve the brain and nervous system: traditional talk therapy (eg with a psychologist) Simple deep breathing dance and movement waling Qi Gong, Tai Chi, Yoga other coregulatory exercises DisasterShock.com is a resource for people struggling with the stressors and traumas. It includes: opportunities for social connection/coregulation (including on-line) craft projects walking For more many more tools and strategies visit Ilenenaomirusk.com To learn more about the BrainFit program at Kemper Cognitive Wellness visit kemperwellness.com
Why I'm excited about Aducanumab (Aduhelm)!
11:58Dr. Nate Bergman quickly summarizes the story up the FDA's recent "accelerated approval" of Biogen's - Aducanumab (brand named, Aduhelm). He ends off with surprise about why he is excited about the approval...and it's probably not what you think! A quick, but useful listen. In this episode we talk about… The terms of the approval of the drug What Aducanumab was able to accomplish in Alzheimer's patients The circumstances that led to Aducanumab being approved Some of the problems that arise with Aducanumab Why I am excited about Aducanumab
Living well with Alzheimer's - Lisa's story of getting back to herself.
1:06:07In this episode, we talk with Lisa, a woman in her early 70s living with Alzheimer's. Lisa is a patient of Dr. Bergman at Kemper Cognitive Wellness. Lisa is joined in this conversation by her daughters, Stacy and Natalie. We discuss the successes and challenges they have had as a family living with Alzheimer's disease. Lisa shares her thoughts about being diagnosed as well as the hope and results they have had since starting on a journey of living well with Alzheimer's. This episode is an important listen for anyone with doubts, reservations, or skepticism around a precision, functional medicine approach to the treatment of Alzheimer's disease. Note: names/identities were changed to preserve anonymity. 1:50 - what it was like to get diagnosed with Alzheimer’s and how the family responded 12:13 - living with Alzheimer’s during the events of 2020 14:33 - beginning treatment at Kempler Cognitive Wellness 19:05 - how patients can navigate the healthcare system to find the best treatment plan for their diagnosis 24:58 - implementing your treatment plan and navigating the necessary lifestyle changes 36:34 - results that this family has seen from this treatment plan 45:33 - maintaining motivation in a world where we don’t see a lot of people who are living their lives with Alzheimer’s 53:48 - processing the permanent lifestyle changes that are involved with Alzheimer’s treatment plans 55:44 - what “success” looks like with Alzheimer’s treatment
Does the new Alzheimer's drug Aducanumab mean the end of Alzheimer's? with Marwan Sabbagh, MD.
42:22In this episode, we hear the argument in favor of the new Alzheimer's drug, Aducanumab (Aduhelm). Dr. Marwan Sabbagh is a clinical and research leader at the Cleveland Clinic's Lou Ruvo Center for Brain Health. He was a doctor that saw patients in one of the trials that led to the FDA's Accelerated (provisional) Approval. Note: Dr. Sabbagh notes his disclosure as an advisor to Biogen, the maker of Aducanumab. We discuss what Dr. Sabbagh noted in his own patients involved in the recent Phase 3 clinical trial of Aducanumab. Controversy over the FDA's decision and why Dr. Sabbagh's 25+ years of diagnosing and treating Alzheimer's makes him optimistic about this drug. Dr. Sabbagh talks through who he thinks might be a good candidate for Aducanumab, the drug's known practical side effects, and how people might get access to the medication in the near future. Ultimately, Dr. Sabbagh sees people in the near future living with Alzheimer's like a chronic disease much like HIV or diabetes, or even cancer. This episode presents a slightly different perspective than many of our listeners are used to. We hope you find it useful. 2:33 - what is this new drug and how does it actually treat Alzheimer's 5:28 - Why Dr. Sabbagh is optimistic about this new drug 11:43 - Reasons for some of the skepticism around the study 14:11 - Dr. Sabbagh’s observations of the people who have taken the drug 21:10 - What are the risks of taking the drug? 27:08 - Responding to the criticism of the drug 32:30 - Other promising drugs that may be available in the future for Alzheimer's patients 37:18 - How do people get access to this new drug?
People Getting Better- More Trial Results with Drs Ann Hathaway & Deborah Gordon
1:17:32This week we will do almost a Part 2 from the last episode with Drs Dale Bredesen and Kat Toups. In that episode, we featured recently released results data on MedArchive from a clinical trial in which 84% of 25 patients with early Alzheimer's Disease and Mild Cognitive Impairment improved with a Precision Medicine approach. With that in mind, we want to get another perspective from the other 2 physicians who led this ground-breaking clinical trial. This week we are joined by Doctors Ann Hathaway and Deborah Gordon. We dive deeper into the details of testing, treatment, and people involved in this trial. The study results (not yet available in a peer-reviewed journal) were released here https://www.medrxiv.org/content/10.1101/2021.05.10.21256982v1.full.pdf Precision Medicine Approach to Alzheimer’s Disease: Successful Proof-of-Concept Trial 5:07 - how the care for the patients in the study is different from the normal protocol 8:40 - getting the study group to work with the technology required for the study 19:07 - some of the reasons patients were not able to be successful 25:23 - how they helped their patients create sustainable lifestyle improvement 34:48 - viral infections that contribute to Alzheimer's and how they approached treating that 44:52 - why is hormone replacement so important for cognitive recovery? 51:15 - bacterial infections that can lead to cognitive decline 1:11:15 - criticisms they will apply to future studies
New Study Results with Drs Kat Toups & Dale Bredesen
1:03:40Our guests today are Drs Kat Toups & Dale Bredesen. Link to the study results just released online: https://www.medrxiv.org/content/10.1101/2021.05.10.21256982v1.full.pdf Important to note, this has not yet been peer-reviewed yet. 25 participants in this group, underwent a 9-month trial. 21 people improved, 1 person no real changes and 3 people got worse to some degree. 2:32 - what is MedArchive and have these study results been peer-reviewed yet? 5:05 - the results of the study and what they learned about cognitive impairment 10:23 - how they determined the cutoff for the participants in the study 17:15 - lessons Dale brought into the study from his previous trial 23:53 - how they proved that environmental factors were leading to cognitive decline 31:03 - key attributes to people who are successful in improving during the study 35:07 - main factors that lead to exposure to toxicity 44:34 - the decision to study genetic factors of Alzheimer's and cognitive decline 50:26 - responding to criticisms of the trial 58:58 - plans for a follow-up trial
Being Patient - The Evolution of Data in Alzheimer's & Dementia with Deborah Kan
42:59Deborah Kan is a former executive producer with the Wall Street Journal. In 2017 she founded the website BeingPatient.com, a comprehensive website dedicated to Alzheimer's news, stories, and support. This interview covers how Deborah sees the current world of Alzheimer's research and trends in brain health and wellness. 5:42 - Being Patient and how it serves people who are taking care of loved ones with Alzheimer’s 8:35 - Early signs of Alzheimer’s that are often overlooked 17:17 - How the dementia space is evolving with the rise in early diagnosis 20:25 - Why there are more women diagnosed with Alzheimer’s than men 26:09 - The importance of prevention over curing 31:04 - Functional medicine in Alzheimer’s treatment for the people who can’t wait for the science 37:10 - Education and prevention for Alzheimer’s that everyone needs