We are absolutely convinced that Alzheimer’s and other brain diseases are generally treatable and reversible. Early translational evidence supports this belief. The Evolving Past Alzheimer’s podcast brings you the highest caliber information about what you can do to identify, prevent, and treat Alzheimer’s disease. The show’s secondary goal is to use Alzheimer’s and cognition as a platform to explore consciousness and the human experience in it’s “second half of life.” Topics include emerging technologies, transhumanism, traditional medicinal approaches, spiritual conversations, and stories of people living with – and through – Alzheimer’s. This show brings you conversations with experts around the world that are leading the charge in treatment and prevention of Alzheimer’s and other brain disease.
Why I'm excited about Aducanumab (Aduhelm)!
11:58Dr. Nate Bergman quickly summarizes the story up the FDA's recent "accelerated approval" of Biogen's - Aducanumab (brand named, Aduhelm). He ends off with surprise about why he is excited about the approval...and it's probably not what you think! A quick, but useful listen. In this episode we talk about… The terms of the approval of the drug What Aducanumab was able to accomplish in Alzheimer's patients The circumstances that led to Aducanumab being approved Some of the problems that arise with Aducanumab Why I am excited about Aducanumab
Living well with Alzheimer's - Lisa's story of getting back to herself.
1:06:07In this episode, we talk with Lisa, a woman in her early 70s living with Alzheimer's. Lisa is a patient of Dr. Bergman at Kemper Cognitive Wellness. Lisa is joined in this conversation by her daughters, Stacy and Natalie. We discuss the successes and challenges they have had as a family living with Alzheimer's disease. Lisa shares her thoughts about being diagnosed as well as the hope and results they have had since starting on a journey of living well with Alzheimer's. This episode is an important listen for anyone with doubts, reservations, or skepticism around a precision, functional medicine approach to the treatment of Alzheimer's disease. Note: names/identities were changed to preserve anonymity. 1:50 - what it was like to get diagnosed with Alzheimer’s and how the family responded 12:13 - living with Alzheimer’s during the events of 2020 14:33 - beginning treatment at Kempler Cognitive Wellness 19:05 - how patients can navigate the healthcare system to find the best treatment plan for their diagnosis 24:58 - implementing your treatment plan and navigating the necessary lifestyle changes 36:34 - results that this family has seen from this treatment plan 45:33 - maintaining motivation in a world where we don’t see a lot of people who are living their lives with Alzheimer’s 53:48 - processing the permanent lifestyle changes that are involved with Alzheimer’s treatment plans 55:44 - what “success” looks like with Alzheimer’s treatment
Does the new Alzheimer's drug Aducanumab mean the end of Alzheimer's? with Marwan Sabbagh, MD.
42:22In this episode, we hear the argument in favor of the new Alzheimer's drug, Aducanumab (Aduhelm). Dr. Marwan Sabbagh is a clinical and research leader at the Cleveland Clinic's Lou Ruvo Center for Brain Health. He was a doctor that saw patients in one of the trials that led to the FDA's Accelerated (provisional) Approval. Note: Dr. Sabbagh notes his disclosure as an advisor to Biogen, the maker of Aducanumab. We discuss what Dr. Sabbagh noted in his own patients involved in the recent Phase 3 clinical trial of Aducanumab. Controversy over the FDA's decision and why Dr. Sabbagh's 25+ years of diagnosing and treating Alzheimer's makes him optimistic about this drug. Dr. Sabbagh talks through who he thinks might be a good candidate for Aducanumab, the drug's known practical side effects, and how people might get access to the medication in the near future. Ultimately, Dr. Sabbagh sees people in the near future living with Alzheimer's like a chronic disease much like HIV or diabetes, or even cancer. This episode presents a slightly different perspective than many of our listeners are used to. We hope you find it useful. 2:33 - what is this new drug and how does it actually treat Alzheimer's 5:28 - Why Dr. Sabbagh is optimistic about this new drug 11:43 - Reasons for some of the skepticism around the study 14:11 - Dr. Sabbagh’s observations of the people who have taken the drug 21:10 - What are the risks of taking the drug? 27:08 - Responding to the criticism of the drug 32:30 - Other promising drugs that may be available in the future for Alzheimer's patients 37:18 - How do people get access to this new drug?
People Getting Better- More Trial Results with Drs Ann Hathaway & Deborah Gordon
1:17:32This week we will do almost a Part 2 from the last episode with Drs Dale Bredesen and Kat Toups. In that episode, we featured recently released results data on MedArchive from a clinical trial in which 84% of 25 patients with early Alzheimer's Disease and Mild Cognitive Impairment improved with a Precision Medicine approach. With that in mind, we want to get another perspective from the other 2 physicians who led this ground-breaking clinical trial. This week we are joined by Doctors Ann Hathaway and Deborah Gordon. We dive deeper into the details of testing, treatment, and people involved in this trial. The study results (not yet available in a peer-reviewed journal) were released here https://www.medrxiv.org/content/10.1101/2021.05.10.21256982v1.full.pdf Precision Medicine Approach to Alzheimer’s Disease: Successful Proof-of-Concept Trial 5:07 - how the care for the patients in the study is different from the normal protocol 8:40 - getting the study group to work with the technology required for the study 19:07 - some of the reasons patients were not able to be successful 25:23 - how they helped their patients create sustainable lifestyle improvement 34:48 - viral infections that contribute to Alzheimer's and how they approached treating that 44:52 - why is hormone replacement so important for cognitive recovery? 51:15 - bacterial infections that can lead to cognitive decline 1:11:15 - criticisms they will apply to future studies
New Study Results with Drs Kat Toups & Dale Bredesen
1:03:40Our guests today are Drs Kat Toups & Dale Bredesen. Link to the study results just released online: https://www.medrxiv.org/content/10.1101/2021.05.10.21256982v1.full.pdf Important to note, this has not yet been peer-reviewed yet. 25 participants in this group, underwent a 9-month trial. 21 people improved, 1 person no real changes and 3 people got worse to some degree. 2:32 - what is MedArchive and have these study results been peer-reviewed yet? 5:05 - the results of the study and what they learned about cognitive impairment 10:23 - how they determined the cutoff for the participants in the study 17:15 - lessons Dale brought into the study from his previous trial 23:53 - how they proved that environmental factors were leading to cognitive decline 31:03 - key attributes to people who are successful in improving during the study 35:07 - main factors that lead to exposure to toxicity 44:34 - the decision to study genetic factors of Alzheimer's and cognitive decline 50:26 - responding to criticisms of the trial 58:58 - plans for a follow-up trial
Being Patient - The Evolution of Data in Alzheimer's & Dementia with Deborah Kan
42:59Deborah Kan is a former executive producer with the Wall Street Journal. In 2017 she founded the website BeingPatient.com, a comprehensive website dedicated to Alzheimer's news, stories, and support. This interview covers how Deborah sees the current world of Alzheimer's research and trends in brain health and wellness. 5:42 - Being Patient and how it serves people who are taking care of loved ones with Alzheimer’s 8:35 - Early signs of Alzheimer’s that are often overlooked 17:17 - How the dementia space is evolving with the rise in early diagnosis 20:25 - Why there are more women diagnosed with Alzheimer’s than men 26:09 - The importance of prevention over curing 31:04 - Functional medicine in Alzheimer’s treatment for the people who can’t wait for the science 37:10 - Education and prevention for Alzheimer’s that everyone needs
Pushing Back Against Dementia - Chrissy's Journey
1:20:05This is a really unique and important episode. We are witnessing a sea change in dementia. More people are being diagnosed, earlier and younger. And people are figuring out how to actually fight back against the disease and taking ownership of their condition. My guest this week on the Evolving Past Alzheimer's podcast, Chrissy Thelker, was diagnosed with Vascular dementia at age 57 and nearly 5 years later is still living on her own, driving, and living a life of incredible purpose... her story inspires, but she also gives useful information for anyone out there working through the early stages of the disease. This is one you're crazy not to listen to....an amazing episode! 2:00 - What it was like to receive a dementia diagnosis 6:22 - Why a dementia specialist refused to take Chrissy on as a patient 9:44 - How Chrissy followed the Bredesen protocol to slow her dementia symptoms and almost completely prevent herself from getting worse 14:56 - What it’s like to live with dementia 19:22 - How to balance fighting against the dementia with tending to your new needs living with the disease 21:22 - “You have to monitor yourself, and if we all learned from a younger age that it’s ok to rest, we would all be doing better in our health.” 23:37 - What does it mean to live with purpose after a dementia diagnosis? 29:45 - What it feels like to hear “you don’t look like you have dementia” 37:31 - How Chrissy thinks about the future 43:54 - Some major conversations happening in the DAI community and people living with dementia - the connection between sleep and brain health 48:33 - “Dementia is like a spider web. We need treatments to help manage the different aspects and symptoms rather than a cure.” 52:40 - Why organizations working towards treatments and cures need more people suffering from the disease at the table 1:00:00 - “Have those conversations early in receiving your diagnosis about your driving and other aspects of your independence.” 1:06:16 - How has COVID impacted her function as someone living with dementia Resources Mentioned Chrissy's Book - For This I'm Grateful Chrissy's Blog Dementia Alliance International
A Patient Story: The Heart-Brain Connection & Energy
34:53Some listeners have requested more personal stories of people improving and how they are doing it. In this episode, we want to introduce you to an amazing couple, Betsy and George Muller. George suffered a major brain injury as a result of his heart stopping about 4 years ago. Fortunately, he has successfully recovered from the brain injury and this is the story of how the Mullers did it! If you're interested in more details of the Muller's journey, check out Betsy's book - The Comeback - An Energy Makeover Love Story (available on Amazon and Audible). 9:24 - What George and Betsy have learned about brain health and brain resilience from their experience 14:41 - How meditation can help anyone who is suffering from a cognitive issue or their caregiver 17:33 - Tapping into the power of routine to help someone recover cognitive function 18:44 - The connection between heart health and brain health 21:43 - How to deal with some of the challenges of navigating a loved one who needs a caregiver 26:59 - How to keep your brain as healthy as possible Several Resources were mentioned that are relevant to folks with Alzheimer's and other dementias. Among them: AlzU.org - comprehensive website for evidence-based, Alzheimer's education led by previous guest Richard Isaacson MD. Lumosity Brain Training Donna Eden Energy Medicine - Betsy recommends do this with your partner of someone with dementia you are caregiving for. It takes only about 6-7 minutes.
Taking Hormones After Menopause - New Data with Felice Gersh MD
57:10We get many questions from listeners and people seeking Alzheimer’s prevention and early intervention about the risks and benefits of hormone therapies, such as estrogen and progesterone. Our guest this episode, Felice Gersh MD and co-authors recently published an article entitled: Postmenopausal hormone therapy for cardiovascular health: the evolving data In this episode we talk about: Hormone Therapy in this episode is referring to Estrogen (ie estradiol) and Progesterone. 4:29 We talk about the ideal forms to take 10:28 We discuss doses and the best way to monitor for safety and effectiveness according to the recent journal article. 15:55 - Hormone Therapy’s potential benefits to heart and brain of Estrogen. 21:15 - How estrogen might help the natural process of inflammation that occurs in women’s bodies after menopause. 40:28 - Why it might make more sense to start estrogen therapy earlier rather than later. 48:50 - Considerations for starting estrogen after age 60 or more than 10 years after menopause and how long it may take to see results.
Live Well With Dementia
36:56In this episode, you'll meet the co-founders of Kemper House and Kemper Cognitive Wellness. Betty and Kristin Kemper talk about the ideas that inspired them to start: 1) Kemper House - a dedicated assisted living environment pushing the boundaries of what people thought was possible for Alzheimer's and dementia care 2) Kemper Cognitive Wellness - one of the nation’s leading companies for Alzheimer's and dementia prevention, support, and services. We treat everything from brain fog and ADHD all the way through dementia You'll also hear from Cheryl Freed, Vice President of Learning & Education at Kemper and family dementia coach at Kemper Cognitive Wellness on the principles that shape living well even with a diagnosis of Alzheimer's or dementia. Finally, we'll tell you about our latest project that we are so proud of - a course for Caregivers of someone with Alzheimer's or other dementia - called, Live Well with Dementia. Learn more at: Livewellwithdementia.com Learn more about the work at Kemper: Kemperwellness.com kemperhouse.com 7:48 - What they learned when Kristen’s father and Betty’s husband ended up in the care of their organization 10:49 - The mission of Kemper Cognitive Wellness to catch cognitive decline early 13:13 - What it is like to work in the innovative environment of Kemper vs a traditional assisted living model 15:25 - What can you do when you recieve a diagnosis? 20:03 - What does success look like when someone is moving through the later stages of Dementia? 23:50 - What does success look like when a loved one is at the end of their life?