Dr Darshan Shah: The Early Death Metric: This Blood Test Can Predict Cancer & Heart Disease

When a top surgeon faces his own health collapse, he’s forced to question everything he’s ever believed about medicine. In this gripping conversation, Dr. Darshan Shah reveals how hitting rock bottom led him to uncover the true keys to longevity — from biomarker mastery and advanced testing to the future of AI-driven health and gene therapy. This episode will make you rethink what it means to live — and how long you can do it.Join the most comprehensive female-specific community for health and longevity optimization. After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.https://kayla-barnes-lentz.circle.so/checkout/become-a-memberKayla's social + website:Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter: https://x.com/femalelongevityWebsite: https://www.kaylabarnes.com YouTube: www.youtube.com/@KaylaBarnesLentzApple: https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227Follow Her Female Protocol: https://www.protocol.kaylabarnes.comDr. Shah social + website:https://www.drshah.com/Instagram: https://www.instagram.com/darshanshahmd/YouTube: https://www.youtube.com/darshanshahmdX: https://x.com/DarshanShah_MDLinkedIn: https://www.linkedin.com/in/darshanshahmd/Facebook: https://www.facebook.com/healthhackerMD

Most people think heart disease is just about cholesterol. But what if the real issue is in your genes, your environment, and even your daily stress?In this episode, I’m joined by Dr. Christopher Davis, a triple board-certified interventional cardiologist who’s redefining what it means to take care of your heart. After years of performing stent procedures, he realized the conventional system was only treating symptoms, not causes. So he made a bold shift from reactive cardiology to a root-cause approach that blends advanced testing, functional medicine, detoxification, and even ancient healing wisdom. We discuss how genetics determine whether saturated fats help or harm you, why cholesterol itself isn’t the enemy, and how inflammation and oxidative stress are the real threats to your arteries. If you’ve ever wondered why someone with perfect cholesterol can still have a heart attack, or why your stress levels matter just as much as your diet, this conversation will change how you think about cardiovascular health forever.Guest’s website + socials:Website: https://revealvitality.com/christopher-davis/Instagram: @cjdavismdKayla's social + website:Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter: https://x.com/femalelongevity Website: https://www.kaylabarnes.com/Follow Her Female Protocol: https://www.protocol.kaylabarnes.com/Become a Member of Kayla's Female Longevity Membership: https://kayla-barnes-lentz.circle.so/checkout/become-a-member

Brain coach Jim Kwik went from being called “the boy with the broken brain” to teaching millions how to unlock their limitless potential. In this episode, he reveals the simple shifts that supercharge focus, memory, and learning speed—helping you read faster, think clearer, and retain more.Discover why mindset, motivation, and method are the three keys to peak mental performance, and how to apply them in everyday life. Whether you’re an entrepreneur or lifelong learner, this conversation will change the way you use your brain.Join the most comprehensive female-specific community for health and longevity optimization. After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.https://kayla-barnes-lentz.circle.so/checkout/become-a-memberChapters:00:00 Intro 01:30 Jim Kwik’s story: from “broken brain” to brain coach 07:15 The moment that changed everything 09:20 The Limitless Model: Mindset, Motivation, Methods 19:30 Memory and focus hacks 33:55 Becoming a limitless learner 48:31 Speed reading & overcoming common obstacles 01:00:40 Using AI to enhance, not replace, your brain 01:10:30 10 keys to a limitless brain 01:18:58 Closing challenge & wrap-upKayla's social + website:Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter: https://x.com/femalelongevityWebsite: https://www.kaylabarnes.comYouTube: http://www.youtube.com/@KaylaBarnesLentzApple: https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227Follow Her Female Protocol: https://www.protocol.kaylabarnes.comJim's social + website:Facebook: https://www.facebook.com/jimkwikofficial/Instagram: https://www.instagram.com/jimkwik/TikTok: https://www.tiktok.com/@jimkwik?lang=enX: https://x.com/jimkwikFree Brain Tips: https://go.kwikbrain.com/30-tips-yt

A lot of women are tired, busy, and trying to stay healthy. But what if you didn’t need to do everything perfectly to feel good? In this episode, we talk about the key parts of health that matter most. You’ll learn how much sleep your body actually needs, what kind of movement helps you stay strong, how to eat for steady energy, and why your relationships can change your health.We also talk about real numbers and real habits that work. All you have to do is to learn what truly helps your body stay balanced, strong, and full of energy.See Kayla's full protocol here: https://www.protocol.kaylabarnes.comTech items mentioned: Pulsetto:  https://pulsetto.sjv.io/raOKYy (use code Kayla10 to save!) Chapters00:00:44: Introduction of health pillars and minimum effective dosage.00:01:44: Benefits of sleep and women's unique sleep needs.00:05:34: Kayla's personal sleep routine and wind-down practices.00:08:17: Optimal sleep duration and key sleep hygiene tips.00:13:30: Analysis of sleep metrics like deep and REM sleep.00:22:14: Hormonal benefits of sleep, specifically cortisol and melatonin.00:24:22: Introduction to exercise and Kayla's detailed protocol.00:30:26: Minimum effective dose for exercise, focusing on Zone 2.00:34:00: Importance of strength training and general fitness goals.00:38:07: Understanding body composition, fat mass, and bone density.00:47:37: Nutrition personalization and metabolic health goals.00:56:18: Social connection as a pillar of longevity.Guest’s socials + websiteInstagram: @saragottfriedmdWebsite: https://saraszalmd.com/Kayla's social + website:Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter: https://x.com/femalelongevity Website: https://www.kaylabarnes.com/Follow Her Female Protocol: https://www.protocol.kaylabarnes.com/Become a Member of Kayla's Female Longevity Membership: https://kayla-barnes-lentz.circle.so/checkout/become-a-member

Dr. Brad Schoenfeld, PhD is one of the world’s leading researchers on muscle hypertrophy (muscle growth). He is a Professor of Exercise Science at Lehman College in New York, where he directs the Human Performance Laboratory. Over his career, he has published more than 300 peer-reviewed articles, book chapters, and textbooks on resistance training, body composition, and nutrition.He is the author of Science and Development of Muscle Hypertrophy and The Max Muscle Plan, and has received prestigious honors such as the NSCA Young Investigator of the Year and the Dwight D. Eisenhower Fitness Award. Beyond academia, he has been a personal trainer and natural bodybuilding competitor, which allows him to uniquely bridge cutting-edge science with practical application.Here's what he knows: the fitness industry has been selling you the wrong story. Not maliciously, but confidently. And most people are paying the price without even realizing it.In this episode, Brad reveals why so many people are working harder than they need to while missing the basics that matter most. We discuss the beliefs keeping women from reaching their potential, the risks that sneak up when you avoid certain types of training, and what actually determines whether you stay strong and independent decades from now. He also tackles the myths around supplements, workout structure, and whether you're doing enough or too much.If you're ready to stop spinning your wheels and start training smarter, this conversation will show you exactly where to begin.Chapters:00:00 - Meet Dr. Schoenfeld & why strength training is vital for health07:00 - Metabolic health, bone density & preventing osteoporosis15:00 - Training for strength, hypertrophy & power (and busting myths)25:00 - Practical routines: how much volume, soreness, and recovery time34:00 - Glute growth, exercise variety & women’s training differences45:00 - Protein, fueling & the truth about creatineDr. Schoenfeld’s Social + WebsiteWebsite: https://www.lookgreatnaked.com/Instagram: https://www.instagram.com/bradschoenfeldphd/Kayla's Social + WebsiteInstagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter: https://x.com/femalelongevityWebsite: https://www.kaylabarnes.comFollow Her Female Protocol: https://www.protocol.kaylabarnes.com

For years, women have been told that birth control or IVF are the only solutions to reproductive issues. Dr. Naomi Whitaker knows that’s not the full story. Through Restorative Reproductive Medicine, she helps women identify the deeper health imbalances that fuel infertility, endometriosis, PCOS, and hormones, and shows how healing the body’s natural rhythms can change everything. In this episode, Dr. Whitaker reveals why standard lab ranges are often misleading, how cycle charting can act like a “health report card,” and why bioidentical hormone support is a game changer for energy, mood, and long-term vitality. She also shares her perspective on endometriosis surgery, PCOS subtypes, and the future of reproductive care. If you are tired of one size fits all advice and want science based, patient focused solutions that aim to fix root causes, this conversation gives straightforward clarity and practical next steps.Chapters:00:05:22 - Introduction to Restorative Reproductive Medicine00:08:14 - The evolution of medicine and limitations of traditional research00:17:24 - Core principles of Restorative Reproductive Medicine (RRM)00:19:36 - Challenging the concept of "incessant ovulation" as a cancer risk00:25:27 - Importance of thorough patient intake and cycle charting in RRM00:33:19 - Practical tips for Creighton Model cycle charting00:45:27 - The role and importance of bioidentical progesterone in women's health00:59:05 - Reversing high FSH with DHEA for ovarian longevity01:10:27 - Comprehensive insulin resistance testing and management strategies01:43:22 - Surgical options and novel treatments for PCOS01:55:53 - Adhesion prevention and delicate surgical techniques in pelvic reconstruction02:19:57 - Understanding endometriosis in DetailGuest’s socials + websiteInstagram: @napro_fertility_surgeonWebsite: https://bio.site/napro_fertility_surgeon Kayla's social + website:Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter: https://x.com/femalelongevity Website: https://www.kaylabarnes.com/Follow Her Female Protocol: https://www.protocol.kaylabarnes.com/Become a Member of Kayla's Female Longevity Membership: https://kayla-barnes-lentz.circle.so/checkout/become-a-member

Today I’m joined by Dr. Lara Briden, a naturopathic doctor, best-selling author, and internationally recognized expert in women’s hormones for a wide-ranging conversation on cycle health and why ovulation is a vital sign of wellbeing.We talked about how monthly ovulation creates hormones that support bones, metabolism, and brain function, and what happens when that rhythm is disrupted by stress, restrictive eating, or birth control. Dr. Briden explains why natural estradiol and progesterone are so protective, how they differ from synthetic hormones, and what that means for both younger women and women approaching perimenopause.She also shares her perspective on missing periods, hypothalamic amenorrhea, and the four functional types of PCOS, along with the growing role of insulin resistance in hormone imbalance. We talk about how to track ovulation, what lab markers to look for, and why restoring cycles is one of the most powerful steps for long-term health.Chapters00:49 - Ovulation as a vital sign of female health02:57 - Impact of hormonal birth control on ovulation and hormones07:51 - Benefits of natural estrogen and progesterone09:47 - Perimenopause and importance of hormones in young women11:49 - Benefits of estradiol and progesterone17:37 - Dysregulated or missing periods19:50 - Anovulatory cycles and tracking ovulation22:50 - Lag time for menstrual cycle disruption and recovery26:50 - Differentiating between hypothalamic amenorrhea and PCOS31:18 - Four different types of PCOS36:25 - Lab markers for insulin resistance58:53 - Recommendations for managing insulin-resistant PCOSDr. Briden socials + websiteWebsite: ⁠https://www.larabriden.com/about/⁠ Instagram: ⁠@larabriden⁠Kayla's social + website:Instagram: ⁠https://www.instagram.com/kaylabarnes/⁠TikTok: ⁠https://www.tiktok.com/@femalelongevity⁠Twitter: ⁠https://x.com/femalelongevity⁠ Website: ⁠https://www.kaylabarnes.com/⁠Follow Her Female Protocol: ⁠https://www.protocol.kaylabarnes.com/⁠Become a Member of Kayla's Female Longevity Membership: ⁠https://kayla-barnes-lentz.circle.so/checkout/become-a-member⁠

Join us in this insightful episode as we sit down with Dr. Ja-Nae Duane, a behavioral scientist, futurist, and bestselling author. We delve into the intersection of exponential technology, human systems, and the future of health. Discover how Dr. Duane's journey from opera singer to futurist informs her mission to improve life for a billion people.Chapters:Introduction to Dr. Janaye Duane (0:00 - 2:30)Overview of Dr. Duane's background and mission.From Opera Singer to Futurist (2:31 - 10:00)Dr. Duane shares her career journey and the transition to futurism.The Impact of COVID-19 (10:01 - 18:00)Discussion on how the pandemic has shifted scenario planning and work dynamics.Biohacking and Longevity (18:01 - 30:00)Exploring future trends in biohacking and longevity medicine.Ethical Considerations in AI (30:01 - 40:00)Delving into the ethical implications of AI in healthcare.Practical Tools for Growth (40:01 - 50:00)Exercises and tools for personal and professional development.Conclusion and Future Outlook (50:01 - End)Final thoughts and the importance of ongoing conversations about health and technology.

Brigid Titgemeier, a functional medicine dietitian and founder of Being Brigid Nutrition, has seen countless women walk into her clinic exhausted, bloated, and frustrated despite eating all the right foods. She knows that feeling firsthand, too. Instead of blaming willpower or cutting out everything you love, Brigid discovered how simple, personalized nutrition changes could completely shift energy, hormones, and mood.In this episode, she shares why common advice like “just eat clean” or “go low-carb” often backfires, and what really moves the needle when it comes to gut health, hormone balance, and long-term vitality. We also talked about the hype around weight-loss drugs, overlooked biomarkers that reveal hidden stress in the body, and why your microbiome might hold the biggest key to feeling better.If you’ve ever wondered why eating healthy doesn’t always feel healthy, this conversation will give you the clarity and hope you’ve been missing.Chapters00:00 Introduction00:02:59 - Introduction of Brigid Tegemeier00:05:08 - The three biggest nutrition myths.00:05:56 - Myth 1: Just eating a variety of whole foods is enough for improving overall health.00:07:04 - Myth 2: A low carb lifestyle works well for every single person.00:07:32 - Myth 3: The obsession with protein is always beneficial.00:08:24 - Why individuals might not see results even if they're doing everything for their health.00:15:09 - How long it should take to see results 00:18:15 - GLP1 medications for weight loss.00:22:59 - Establishing a good baseline for diet, focusing on fiber diversity and prebiotic sources.00:29:36 - Recommendations for protein intake for women.00:30:35 - Carbohydrate intake and its impact on female hormones and stress response.01:09:54 - Seed oils and the balance of Omega 6s to Omega 3s.Guest’s socials + websiteLinkedIn: https://www.linkedin.com/in/brigid-titgemeier-b437574b Website: https://beingbrigid.com/ Instagram: @beingbrigidKayla's social + website:Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter: https://x.com/femalelongevity Website: https://www.kaylabarnes.com/Follow Her Female Protocol: https://www.protocol.kaylabarnes.com/Become a Member of Kayla's Female Longevity Membership: https://kayla-barnes-lentz.circle.so/checkout/become-a-member

Brigid Titgemeier, a functional medicine dietitian and founder of Being Brigid Nutrition, has seen countless women walk into her clinic exhausted, bloated, and frustrated despite eating all the right foods. She knows that feeling firsthand, too. Instead of blaming willpower or cutting out everything you love, Brigid discovered how simple, personalized nutrition changes could completely shift energy, hormones, and mood.In this episode, she shares why common advice like “just eat clean” or “go low-carb” often backfires, and what really moves the needle when it comes to gut health, hormone balance, and long-term vitality. We also talked about the hype around weight-loss drugs, overlooked biomarkers that reveal hidden stress in the body, and why your microbiome might hold the biggest key to feeling better.If you’ve ever wondered why eating healthy doesn’t always feel healthy, this conversation will give you the clarity and hope you’ve been missing.Chapters00:00 Introduction00:02:59 - Introduction of Brigid Tegemeier00:05:08 - The three biggest nutrition myths.00:05:56 - Myth 1: Just eating a variety of whole foods is enough for improving overall health.00:07:04 - Myth 2: A low carb lifestyle works well for every single person.00:07:32 - Myth 3: The obsession with protein is always beneficial.00:08:24 - Why individuals might not see results even if they're doing everything for their health.00:15:09 - How long it should take to see results 00:18:15 - GLP1 medications for weight loss.00:22:59 - Establishing a good baseline for diet, focusing on fiber diversity and prebiotic sources.00:29:36 - Recommendations for protein intake for women.00:30:35 - Carbohydrate intake and its impact on female hormones and stress response.01:09:54 - Seed oils and the balance of Omega 6s to Omega 3s.Guest’s socials + websiteLinkedIn: https://www.linkedin.com/in/brigid-titgemeier-b437574b Website: https://beingbrigid.com/ Instagram: @beingbrigidKayla's social + website:Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter: https://x.com/femalelongevity Website: https://www.kaylabarnes.com/Follow Her Female Protocol: https://www.protocol.kaylabarnes.com/Become a Member of Kayla's Female Longevity Membership: https://kayla-barnes-lentz.circle.so/checkout/become-a-member