Immunology for the Rheumatologist: Type I Interferon & Skin Disease

In this episode, we sit down with Dr. Victoria Werth, a leading expert in dermatology and autoimmune diseases, to explore the study Understanding the Role of Type I Interferons in Cutaneous Lupus and Dermatomyositis: Toward Better Therapeutics. Dr. Werth delves into the complex immune mechanisms that drive skin manifestations in cutaneous lupus and dermatomyositis, two challenging autoimmune conditions. She explains how Type I interferons contribute to inflammation and tissue damage, and how understanding these pathways could pave the way for more targeted and effective treatment

In this episode, we explore the findings of a groundbreaking study analyzing opioid treatment trends for adults with and without systemic autoimmune and inflammatory rheumatic diseases (SARDs) from 2006 to 2019. The study, based on national data from the United States, sheds light on how individuals with conditions like rheumatoid arthritis, lupus, and ankylosing spondylitis are impacted by opioid use compared to the general population. 

As our weekend here in Washington D.C. draws to an end, we turn our spotlight on an important and timely conversation from the "Sponsoring Women in Science" session. In this episode, we sit down with Dr. Elizabeth Volkmann and Dr. Carol Feghali-Bostwick to explore the challenges women face in advancing their careers in the sciences. Our guests share insights on how to address the barriers that often impede career development for women, discuss strategies for fostering support and mentorship, and highlight the importance of growing awareness around these critical issues.

Get ready for an electrifying episode of Convergence 2024! We’re diving deep into the cutting-edge world of autoinflammatory diseases with renowned experts Drs. Grant Schulert and Arthur Kaser. Join us as they unravel the complexities of refractory and complicated systemic juvenile idiopathic arthritis (SJIA). Discover the revolutionary insights into SJIA at the single-cell level, explore the fascinating transcriptional diversity of normal and low-density granulocytes, and learn how groundbreaking approaches like UDON and SATAY-UDON are paving the way for novel disease programs. Don’t miss this chance to fuel your passion for innovation in medicine—tune in and ignite your curiosity! 

This week we're joined by two leading experts in gout remissions, Dr. Nicola Dalbeth and Dr. Dansoa Tabi-Amponsah to explore the exciting advances in gout treatment, with a particular focus on Dual-Energy CT (DECT) imaging and its role in achieving gout remission. We dive into how DECT technology is transforming our ability to visualize urate crystals in joints, its implications for patient care, and the potential it holds for long-term gout management and remission. 

In another installment in the ongoing Arthritis & Rheumatology immunology series, guest David S. Pisetsky, MD, PhD, author of Unique Interplay Between Antinuclear Antibodies and Nuclear Molecules in the Pathogenesis of Systemic Lupus Erythematosus, takes us on a deep dive into research in SLE on how the combination of ANAs and immunologically active DNA can create new structures that can promote inflammation throughout the body as well as drive organ inflammation and damage.

This week, our next guest, ACR Master Dr. Joan T. Merrill, joins us to discuss her latest study which endeavored to evaluate the efficacy and safety of upadacitinib and elsubrutinib in those with systemic lupus erythematosus (SLE). Join us for an in-depth analysis of the SLEek Study, its findings regarding the efficacy of these medications and Dr. Merrill’s conclusions. 

For those with rheumatic disease, everyday challenges can mean an increase in disease flare. However, research is increasingly pointing to the idea that psychosocial stressors could even heighten the risk of developing rheumatic diseases. Dr. Christine Parks looked deeper into this among those with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) in her latest study Life Events, Caregiving, and Risk of Autoimmune Rheumatic Diseases in the Women's Health Initiative Observational Study 

This week, we explore a groundbreaking study on the prevalence of fibromyalgia and widespread pain in patients with psoriatic arthritis with first author and ACR Master, Dr. Philip J. Mease. In his latest article, titled: Prevalence of Fibromyalgia and Widespread Pain in Psoriatic Arthritis: Association with Disease Severity Assessment in a Large US RegistryUID , Dr. Mease explains what the presence of these conditions reveals about disease severity and how they converge. 

As the dawn of the Ai revolution marches on, scientific research and clinical medicine are adopting new and more streamlined ways to investigate and serve our patients. Today, we look at how Ai-driven, large language models (LLMs) might aid our field’s researchers in analyzing data from patient interviews. Dr. Bella Mehta, corresponding author of A Novel Approach for Mixed-Methods Research Using Large Language Models: A Report Using Patients’ Perspectives on Barriers to Arthroplasty , joins us this week to give us her insights on this this quickly evolving technology and how it can be employed in both the research and clinical setting.