Parsley, Apigenin & Cancer
Dr. Ralph W. Moss and son Ben discuss the healing and preventive properties of the readily available, inexpensive and delicious, humble little parsley plant. Join us for another fascinating journey as we dive 'Beyond the Garnish' into the remarkable world of parsley and its component, Apigenin. This humble herb, often relegated to the sidelines of our plates, holds an impressive secret - the potential to significantly impact the fight against cancer. Program Notes: For more information on cancer-fighting foods and supplements, please visit our website: https://www.themossreport.com 5 Defenders Mushroom Blend https://shop.realmushrooms.com/products/organic-mushroom-blend-capsules?ref=391 “A comprehensive self-help plan for cancer includes medicinal mushrooms. They are indispensable”. – Ralph W. Moss, PhD Olive Oil From the Raw https://www.olivefromtheraw.com/?aff=2 “A study of over 1,000,000 people shows that daily consumption of 2 Tbsp of high quality, extra virgin olive oil that contain polyphenols, results in a 30-40% decrease in cancer incidents.” – Ralph W. Moss, PhD For Dr. Moss’ recommended products list, please visit https://www.themossreport.com/recommended-products/ The full scope of research on apigenin and cancer: https://pubmed.ncbi.nlm.nih.gov/?term=apigenin+cancer The Indian review article: Apigenin in cancer prevention and therapy: A systematic review and meta-analysis of animal models https://pubmed.ncbi.nlm.nih.gov/35752426/ The German clinical trial: Prospective cohort comparison of flavonoid treatment in patients with resected colorectal cancer to prevent recurrence https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703843/ Recommended parsley intake: Approximately 0.79 tablespoons or 2.37 teaspoons of chopped fresh parsley would provide 10 mg of apigenin. TAKE about one tablespoon OR THE EQUIVALENT AMT. OF DRIED PARSLEY (SEE BELOW) TWICE PER DAY. For 0.69 grams of dried parsley flakes: 0.69 grams / 0.8 grams per teaspoon ≈ 0.86 teaspoons So, approximately one teaspoon 0.86 teaspoons of dried parsley flakes would provide 10 mg of apigenin. OR TAKE THIS TWICE PER DAY. NOTE: PATIENTS IN THE GERMAN STUDY ALSO RECEIVED EGCG (GREEN TEA) AT THE SAME TIME. Based on the average amount of EGCG in one gram of Japanese Sencha green tea leaves (47.3 milligrams), and assuming that you're using one teaspoon (about 2.5 grams) of tea leaves to brew 6 ounces of tea, you can expect to get around 118.25 milligrams of EGCG in your cup of tea. A short bibliography on apigenin and cancer: Shukla S, Gupta S. Apigenin: a promising molecule for cancer prevention. Pharm Res. 2010;27(6):962-978. Salehi B, Venditti A, Sharifi-Rad M, et al. The therapeutic potential of apigenin. Int J Mol Sci. 2019;20(6):1305. Chen AY, Chen YC. A review of the dietary flavonoid, apigenin, on cancer prevention and treatment. Curr Med Chem. 2013;20(19):2570-2581. Fang J, Xia C, Cao Z, Zheng JZ, Reed E, Jiang BH. Apigenin inhibits VEGF and HIF-1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways. FASEB J. 2005;19(3):342-353. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646-674. Kim BR, Seo HS, Ku JM, et al. Apigenin inhibits cancer stem cell-like phenotypes in human glioblastoma cells via suppression of c-Met signaling. Phytother Res. 2016;30(5): 800-807. Lu L, Sun T, Chen X, et al. Apigenin inhibits epithelial-mesenchymal transition of human colon cancer cells through the AKT/GSK-3β/Snail signaling pathway. Oncol Rep. 2016;35(1):369-374. Lu Z, Xu S, ER P, et al. Apigenin inhibits the self-renewal capacity of human ovarian cancer SKOV3-derived sphere-forming cells. Mol Med Rep. 2015;11(4): 2850-2856. Wang J, Wu J, Zhang X, et al. Apigenin suppresses the growth of colorectal cancer cells by targeting Twist-mediated epithelial-mesenchymal transition. Mol Med Rep. 2018;17(5): 7305-7310. Yao J, Zhao L, Zhao Q, et al. Apigenin inhibits ovarian cancer stem cell-like properties through the modulation of the Twist1/TGF-β1/Smad3 pathway. Oncol Rep. 2016;36(1): 512-520. For Dr. Moss’ Red, Green, and Green Tea Smoothie recipes, visit The Moss Report. These smoothie recipes are just some examples of how you can incorporate natural compounds with potential health benefits into your diet.
