Starting up in science: behind the scenes

Ever since scientific enquiry began, people have focused mainly on men, or if studies involve animals, on male mice, male rats or whatever it may be. And this has led to gaps in scientists’ understanding of how diseases, and responses to treatment, and many other things might vary between people of different sexes and genders.These days, mainly thanks to big funders like the NIH introducing new guidelines and mandates, a lot more scientists are thinking about sex and, where appropriate, gender. And this has led to a whole host of discoveries.But all this research is going on within a sociopolitical climate that’s becoming increasingly hostile and polarized, particularly in relation to gender identity. And in some cases, science is being weaponized to push agendas, creating confusion and fear.It is clear that sex and gender exist beyond a simple binary. This is widely accepted by scientists and it is not something we will be debating in this podcast. But this whole area is full of complexity, and there are many discussions which need to be had around funding, inclusivity or research practices.To try to lessen fear, and encourage clearer, less divisive thinking, we have asked three contributors to a special series of opinion pieces on sex and gender to come together and thrash out how exactly scientists can fill in years of neglected research – and move forward with exploring the differences between individuals in a way that is responsible, inclusive and beneficial to as many people as possible.Read the full collection: Sex and gender in science Hosted on Acast. See acast.com/privacy for more information.

In this episode:00:46 Using genomics to explain geographic differences in cancer riskThe risk of developing cancer can vary hugely depending on geographic region, but it’s not exactly clear why. To get a better idea, a team has compared the genomes of kidney cancers taken from people around the globe. They reveal a link between geographical locations and specific genetic mutations, suggesting that there are as-yet unknown environmental or chemical exposures in different locations. They hope this work will inform public health efforts to identify and reduce potential causes of cancer.Research Article: Senkin et al.News and Views: Genomics reveal unknown mutation-promoting agents at global sites07:46 Research HighlightsResearch reveals that the extinct ‘sabre-toothed salmon’ actually had tusks, and a common fungus that can clean up both heavy-metal and organic pollutants.Research Highlight: This giant extinct salmon had tusks like a warthogResearch Highlight: Garden-variety fungus is an expert at environmental clean-ups09:55 How disrupting a male mouse’s microbiome affects its offspringDisruption of the gut microbiota has been linked to issues with multiple organs. Now a team show disruption can even affect offspring. Male mice given antibiotics targeting gut microbes showed changes to their testes and sperm, which lead to their offspring having a higher probability of severe growth issues and premature death. Although it’s unknown whether a similar effect would be seen in humans, it suggests that factors other than genetics play a role in intergenerational disease susceptibility.Research article: Argaw-Denboba et al.News and Views: Dad’s gut microbes matter for pregnancy health and baby’s growth17:23 Briefing ChatAn updated atlas of the Moon that was a decade in the making, and using AI to design new gene-editing systems.Nature News: China's Moon atlas is the most detailed ever madeNature News: ‘ChatGPT for CRISPR’ creates new gene-editing toolsSubscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday. Hosted on Acast. See acast.com/privacy for more information.

Many people around the world feel lonely. Chronic loneliness is known to have far-reaching health effects and has been linked to multiple conditions and even early death. But the mechanisms through which feeling alone can lead to poor health is a puzzle. Now, researchers are looking at neurons in the hopes that they may help explain why health issues arise when social needs go unmet.This is an audio version of our Feature Why loneliness is bad for your health Hosted on Acast. See acast.com/privacy for more information.

In this episode:00:46 Optical clocks at seaOptical atomic clocks are the most precise timekeeping devices on the planet, but these devices are huge and difficult to work with, limiting their use outside of the lab. Now, researchers have developed a portable optical clock and demonstrated its robustness by sending it on a perilous sea journey. The team hope that this work will pave the way to more practical uses of optical clocks, such as on satellites where they could help improve the accuracy of GPS technologies.Research Article: Roslund et al.News and Views: Robust optical clocks promise stable timing in a portable package09:34 Research HighlightsEvidence of ritual burning of the remains of a Maya royal family, and the first solid detection of an astrophysical tau-neutrino.Research Highlight: Burnt remains of Maya royalty mark a dramatic power shiftResearch Highlight: Detectors deep in South Pole ice pin down elusive tau neutrino11:52 How marsupial gliding membranes evolvedSeveral marsupial species have evolved a membrane called a patagium that allows them to glide gracefully from tree to tree. Experiments show that mutations in areas of DNA around the gene Emx2 were key to the evolution of this ability, which has appeared independently in multiple marsupial species.Research article: Moreno et al.News and Views: Marsupial genomes reveal how a skin membrane for gliding evolved19:22 Briefing ChatHow overtraining AIs can help them discover novel solutions, and researchers manage to make one-atom thick sheets of ‘goldene’.Quanta Magazine: How Do Machines ‘Grok’ Data?Nature news: Meet ‘goldene’: this gilded cousin of graphene is also one atom thickSubscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday.Subscribe to Nature Briefing: AI and robotics Hosted on Acast. See acast.com/privacy for more information.

Humans setting up home in outer space has long been the preserve of science fiction. Now, thanks to advances in technology and the backing of billionaires, this dream could actually be realised. But is it more likely to be a nightmare?Kelly and Zach Weinersmith join us to discuss their new book A City on Mars and some of the medical, environmental and legal roadblocks that may prevent humanity from ultimately settling in space.A City on Mars: Can We Settle Space, Should We Settle Space, and Have We Really Thought This Through? Kelly and Zach Weinersmith Particular Books (2023) Hosted on Acast. See acast.com/privacy for more information.

In this episode:00:46 Mysterious methane emission from a cool brown dwarfThe James Webb Space Telescope (JWST) is revealing the makeup of brown dwarfs — strange space objects that blur the line between a planet and a star. And it appears that methane in the atmosphere of one of these objects, named W1935, is emitting infrared radiation. Where the energy comes from is a mystery however, researchers hypothesise that the glow could be caused by an aurora in the object’s atmosphere, perhaps driven by an as-yet unseen moon.Research Article: Faherty et al.10:44 Research HighlightsThe discovery that bitter taste receptors may date back 450 million years, and the first planet outside the Solar System to boast a rainbow-like phenomenon called a ‘glory’.Research Highlight: Bitter taste receptors are even older than scientists thoughtResearch Highlight: An exoplanet is wrapped in glory13:07 How working memory worksWorking memory is a fundamental process that allows us to temporarily store important information, such as the name of a person we’ve just met. However distractions can easily interrupt this process, leading to these memories vanishing. By looking at the brain activity of people doing working-memory tasks, a team have now confirmed that working memory requires two brain regions: one to hold a memory as long as you focus on it; and another to control its maintenance by helping you to not get distracted.Research article: Daume et al.News and Views: Coupled neural activity controls working memory in humans22:31 Briefing ChatThe bleaching event hitting coral around the world, and the first evidence of a nitrogen-fixing eukaryote.New York Times: The Widest-Ever Global Coral Crisis Will Hit Within Weeks, Scientists SayNature News: Scientists discover first algae that can fix nitrogen — thanks to a tiny cell structureNature video: AI and robotics demystify the workings of a fly's wingVote for us in the Webbys: https://go.nature.com/3TVYHmP Hosted on Acast. See acast.com/privacy for more information.

In this episode:00:46 Mapping ‘ghost roads’ in tropical forestsAcross the world, huge numbers of illegal roads have been cut into forests. However, due to their illicit nature, the exact numbers of these roads and their impacts on ecosystems is poorly understood. To address this, researchers have undertaken a huge mapping exercise across the tropical Asia-Pacific region. Their findings reveal over a million kilometers of roads that don’t appear on official maps, and that their construction is a key driver for deforestation.Research Article: Engert et al.10:44 Research HighlightsHow climate change fuelled a record-breaking hailstorm in Spain, and an unusual technique helps researchers detect a tiny starquake.Research Highlight: Baseball-sized hail in Spain began with a heatwave at seaResearch Highlight: Smallest known starquakes are detected with a subtle shift of colour13:02 Briefing ChatA clinical trial to test whether ‘mini livers’ can grow in a person’s lymph node, and the proteins that may determine left-handedness.Nature News: ‘Mini liver’ will grow in person’s own lymph node in bold new trialNature News: Right- or left-handed? Protein in embryo cells might help decideNature video: How would a starfish wear trousers? Science has an answerVote for us in the Webbys: https://go.nature.com/3TVYHmPSubscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday. Hosted on Acast. See acast.com/privacy for more information.

Around the world, rates of cancers that typically affect older adults are increasing in those under 50 years old. Models based on global data predict that the number of early-onset cancer cases like these will increase by around 30% between 2019 and 2030.The most likely contributors — such as rising rates of obesity and early-cancer screening — do not fully account for the increase. To try and understand the reasons behind this trend, many researchers are searching for answers buried in studies that tracked the lives and health of children born half a century ago.This is an audio version of our Feature Why are so many young people getting cancer? What the data say Hosted on Acast. See acast.com/privacy for more information.

In this episode:00:35 Pregnancy advances your ‘biological’ age — but giving birth turns it backGrowing a baby leads to changes in the distribution of certain chemical markers on a pregnant person’s DNA, but new research suggests that after giving birth, these changes can revert to an earlier state.Nature News: Pregnancy advances your ‘biological’ age — but giving birth turns it back08:07 Bird gestures to say 'after you'A Japanese tit (Parus minor) will flutter its wings to invite their mate to enter the nest first. Use of these sorts of gestures, more complex than simply pointing at an object of interest, were thought to be limited to great apes, suggesting that there are more non-vocal forms of communication to be found in the animal kingdom.Scientific American: Wild Birds Gesture ‘After You’ to Insist Their Mate Go First13:34 The carbon cost of home-grown vegResearch have estimated that the carbon footprint of home-grown food and community gardens is six-times greater than conventional, commercial farms. This finding surprised the authors — keen home-growers themselves — who emphasize that their findings can be used to help make urban efforts (which have worthwhile social benefits) more carbon-efficient.BBC Future: The complex climate truth about home-grown tomatoes20:29 A look at next week's total eclipseOn 8th April, a total eclipse of the Sun is due to trace a path across North America. We look at the experiments taking place and what scientists are hoping to learn. Hosted on Acast. See acast.com/privacy for more information.

In this episode:01:28 Inflammation’s role in memoryHow memories are stored is an ongoing question in neuroscience. Now researchers have found an inflammatory pathway that responds to DNA damage in neurons has a key role in the persistence of memories. How this pathway helps memories persist is unclear, but the researchers suggest that how the DNA damage is repaired may play a role. As inflammation in the brain is often associated with disease, the team were surprised by this finding, which they hope will help uncover ways to better preserve our memories, especially in the face of neurodegenerative disorders.Research Article: Jovasevic et al.News and Views: Innate immunity in neurons makes memories persist08:40 Research HighlightsThe effect of wind turbines on property values, and how waste wood can be used to 3D print new wooden objects.Research Highlight: A view of wind turbines drives down home values — but only brieflyResearch Highlight: Squeeze, freeze, bake: how to make 3D-printed wood that mimics the real thing11:14 How melting ice is affecting global timekeepingDue to variations in the speed of Earth’s rotation, the length of a day is rarely exactly 24 hours. By calculating the strength of the different factors affecting this, a researcher has shown that while Earth’s rotation is overall speeding up, this effect is being tempered by the melting of the polar ice caps. As global time kept by atomic clocks occasionally has to be altered to match Earth’s rotation, human-induced climate change may delay plans to add a negative leap-second to ensure the two align.Research article: AgnewNews and Views: Melting ice solves leap-second problem — for now20:04 Briefing ChatAn AI for antibody development, and the plans for the upcoming Simons observatory.Nature News: ‘A landmark moment’: scientists use AI to design antibodies from scratchNature News: ‘Best view ever’: observatory will map Big Bang’s afterglow in new detailSubscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday.Subscribe to Nature Briefing: AI and robotics Hosted on Acast. See acast.com/privacy for more information.