#341 The Science of Stress: How to Train the Brain for Calm, Focus, and Performance
Stress, anxiety, trauma, poor sleep, burnout. These aren’t edge cases anymore. They’re the operating system most people are running on.
In this episode, I sit down with Jim Poole, CEO of NuCalm, for one of the most illuminating conversations I’ve had about the brain, stress, and performance. Jim has spent the last 17 years pioneering a field most people have never heard of but desperately need to understand: applied neuropsychobiology, or how the brain actually regulates stress, fear, sleep, and focus.
Jim shares his personal background, from growing up with two psychotherapist parents and moving 14 times before graduating high school, to working in private equity and mental health institutions, to ultimately finding his life’s work through NuCalm. He explains why stress is responsible for 95–99% of disease, why our nervous systems are stuck in survival mode, and why most people don’t fail because of mindset, but because of physiology.
This conversation breaks down complex neuroscience in a way that finally makes sense. We talk about the amygdala, oxygen, brainwave frequency, sleep architecture, trauma, and why mindfulness works when it works—and why it often doesn’t.
If you’ve ever felt like you’re doing “all the right things” but still living in stress, exhaustion, or fight-or-flight, this episode will change how you understand your brain and what’s actually within your control.
What We Talked About:
Bullets:
- Why chronic stress is at an all-time high and how the nervous system is wired for survival, not modern life
- The role of the amygdala, oxygen-rich blood, and brainwave frequency in stress, anxiety, focus, and sleep
- Why mindfulness works physiologically, not philosophically, and why most people struggle to practice it
- How trauma and prolonged stress trap the brain in high-frequency survival states
- The science behind NuCalm and how it guides the brain into specific states like deep sleep, focus, creativity, and recovery
- Why sleep is non-negotiable for health, performance, and longevity
- How entrepreneurs and high performers can self-regulate without burnout
3️⃣ ⏱ Timestamps
These come after the bullets.
Timestamps:
- 00:00 Introduction to Jim Poole and NuCalm
- 04:49 Jim Poole's Background and Early Influences
- 08:14 The Journey to NuCalm and Its Impact
- 11:38 Dr. Blake Holloway's Story and Motivation
- 15:08 The Entrepreneurial Partnership Between Jim and Blake
- 20:41 Understanding Stress, Trauma, and the Nervous System
- 27:58 Understanding Our Shared Human Experience
- 30:20 The Battle for Brain Resources
- 32:11 The Importance of Mindfulness and Oxygen
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