20VC: Anthropic Files S1 Ahead of $2TRN IPO | Instinct's Rumoured $30 Billion Fundraise | Microsoft Laysoff 27,000 While Meta Taps Equity Markets for $95 Billion Capex Spending Spree

AGENDA:  04:00 Anthropic Files S-1 Ahead of $2TRN IPO 14:50 Microsoft Offers Buyouts to 60,000 Employees 20:45 Zuckerberg Taps Equity Markets for $95 Billion AI Spending Spree 23:00 DeepSeek Raises $15 Billion as Chinese AI Faces US Backlash 34:45 OpenAI and Wiz Uncover Decade-Old Security Flaws 37:05 Instinct's Rumoured $30 Billion Valuation Divides the Panel 45:30 Invest Committee: Put 20% of the Fund Into OpenAI at $1.25 Trillion 49:40 Palmer Luckey's War Dog Startup Hits $1.5 Billion Valuation 55:00 Zuckerberg Threatens California Exit Over Billionaire Tax  

Satya Nadella is the CEO of Microsoft and one of the greatest CEOs of our time. Satya has been at the company for an astonishing 34 years. When he joined, Microsoft had a market cap of $23.5BN. 22 years later, the company was worth $300BN. At this point, Satya took the reins as CEO. Under his leadership, he has taken it from $300BN to $3.9TRN.  AGENDA:  03:08 Should We Assume Every AI Model Is Compromised? 04:13 How Do We Stop AI Agents From Causing Harm? 06:15 Can We Trust an AI Model's Chain of Thought? 07:05 Is China's Lead in Open-Source AI a Safety Risk? 08:28 Will Open or Closed Models Win the Next Two Years? 10:08 Why Should Every Company Own Its Intelligence? 12:12 Will Every Company Become AI Native? 13:22 Are We Entering an AI Implementation Economy? 15:10 Do You Need to Own the Entire AI Stack to Win? 16:49 Can the World Support $100 Billion AI Training Runs? 18:34 Can AI Radically Accelerate Global Economic Growth? 19:39 Will AI Transform Sales, Finance and Marketing Like Coding? Quickfire round  What have you changed your mind on most in the last 12 months? What looks crazy today but will be incredibly common in 5 years? What's the exercise routine given the travel schedule? Favorite cheat meal on a rest day? What are you most excited for in the next 10 years?    

AGENDA: 05:00 Will we run out of energy? 19:00 Will specialised chips threaten NVIDIA's dominance? 26:00 Can we trust AI agents more than humans? 31:00 Will data companies become commodities? 36:00 What comes after transformers? 41:00 Are software investors f****** in a world of infra and compute? 52:00 How big will the inference market be in 10 years? 53:00 Could robotics be 100x bigger than coding agents? 59:00 Why are coding agents the most overrated AI investment?  

AGENDA:  04:20 Billion-Dollar Bets or Nothing: Why VCs Are Rejecting Fast-Growing Startups 13:20 CoreWeave Sell-Off Sparks Fears of Cracks in AI Boom 18:50 Anthropic's IPO Valuation Could Fall From $2 TRN to $1.5 TRN 32:10 Modal Raises $750M at a $15.75B Valuation as Inference Booms 35:50 Town at $1B, Anduril at $90B: Have Startup Valuations Lost Touch? 42:15 Berkshire Hathaway Doubles Down on Bending Spoons 45:05 37signals' Profit Machine Challenges the Venture Capital Model 49:20 General Atlantic Eyes an IPO; Harvard's Endowment Hits $68B 54:15 Elon's Flying Roadster and $10B SpaceX Share Giveaway  

Sameer Dholakia is a Partner @ Bessemer, the first that has just raised $5.75BN across a $1.75BN seed fund and $4BN growth fund. Sameer has led investments into the likes of Anthropic, Fireworks and Legora to name a few. Prior to venture, Sameer was the CEO of SendGrid, taking it from $30M in ARR to over $200M.  AGENDA:  04:55 Why This Is a Supercycle Like Never Before 07:40 Why We Backed Anthropic to Compete With the Hyperscalers 10:05 Why Anthropic Was One of Bessemer's Most Contentious Deals 11:05 Why Open Models Don't Destroy the Market for Closed Models 16:45 Does Price Matter in AI—and Which Metric Really Determines Value? 19:45 How Much Should Consumer Businesses Be Discounted for Their Revenue Quality? 20:20 Why Today's Gross Margins Matter Less Than You Think 23:00 Competition Hasn't Changed—but the Capital Behind It Has 24:00 Why Capital Is a Moat Today 25:55 Is "Triple, Triple, Double, Double" Dead? 28:00 Can You Still Succeed With a Small Seed Fund? 29:45 Who Wins and Who Loses in the Future of Venture Capital? 32:15 Why Founders Shouldn't Hate Being an "Option Bet" 34:35 Why Signalling Risk Doesn't Worry Me 51:55 Why Companies Will Stay Private Longer—and Why the IPO Window Could Reopen by 2028 56:00 How Should Retail Investors Participate in Venture Capital? 57:25 How Fireworks Could Become a $250 Billion Business 01:02:35 Why Bessemer Is Confident It Can Deliver 5x Returns on $5.75 Billion  

Harrison Chase is the co-founder and CEO of LangChain, which helps developers build, test and deploy AI agents. Backed by Sequoia Capital, Benchmark and IVP, LangChain has announced approximately $160 million in funding with the last round at a $1.25BN valuation. The company works with 35% of the Fortune 500, has surpassed one billion open-source downloads and processes over one billion events daily through LangSmith. AGENDA: 04:10 Why Is It Still So Hard to Build AI Agents? 08:50 Will the Model Labs Eat the Agent Stack? 16:25 Is Model Routing a Real Business or a Commodity? 25:45 Why Has No One Solved AI Memory? 35:45 Why Are AI Bills Exploding as Tokens Get Cheaper? 43:25 Should Companies Be Afraid of Chinese AI Models? 46:20 Where Would Harrison Not Be Investing Today? 53:05 Should Founders Take a Discount for Benchmark and Sequoia? 57:35 OpenAI at $1.5T or Anthropic at $2T: Which Would You Buy?  

AGENDA: 04:00 Valar Atomics Sues Seed Investor Day One Ventures Over Pro Rata 17:00 Meta Returns to the AI Frontier With Muse Wonder 20:00 NVIDIA Eyes $30B Reflection Deal as Amazon Circles Decart 26:00 Jev Raises $870M at a $7.5B Valuation—Weeks After Launch 31:00 42 New Decacorns: The AI Boom Overtakes 2021's Record 36:00 Isomorphic Labs Eyes $50B Valuation in New Funding Talks 46:00 Anthropic Slashes Haiku Prices by 90% as AI Price War Intensifies 52:00 Bending Spoons Slashes Airtable's Team: What Do Founders Owe Employees? 57:00 Bumble to Go Private in $1.3B Deal: Can AI Transform Dating? 01:01:00 The SaaSpocalypse Deepens: Why $500M ARR May No Longer Be Enough 01:06:00 Flock Safety Cuts 270 Jobs Amid Privacy and Security Backlash  

Mike Cannon-Brookes is the Co-Founder and CEO of Atlassian, the company behind Jira, Confluence, Trello and Loom. Atlassian generated $6.5BN in ARR in 2026, and serves more than 350,000 customers, including over 85% of the Fortune 500. Today, Mike is leading its expansion into enterprise AI through Rovo and the Teamwork Graph, connecting company knowledge with AI agents. AGENDA:  03:00 Do AI Agents Turn Traditional Software Into Just Databases? 16:00 Will Enterprises Ever Trust Chinese AI Models? 20:00 Is Building Your Own AI Model a Losing Bet? 24:00 Can AI Startups Survive When They Finally Have to Care About Costs? 30:00 What Happens When AI Gets Cheaper Than Anyone Expects? 35:00 Is Company Context the Real Moat in Enterprise AI? 41:00 What Happens When OpenAI and Anthropic Come for Your Customers? 44:00 Why Are Young Founders Cashing Out More Than Ever? 49:00 What Does Nobody Tell You About Getting Rich?  

Max Freeman is SVP of Sales at Ramp. He joined the company as its first sales hire. By 2025, he was leading more than 300 salespeople, helping build Ramp's sales organisation from the ground up. Ramp's latest reported revenue exceeds $1.7BN, with a valuation of over $40BN.  AGENDA: 00:00 Inside Ramp's Sales Playbook 05:00 How Do You Find Exceptional Sellers—and Why Bankers Make the Best? 18:00 How Do You Build an Outbound Machine That Scales Beyond Your SDR Team? 24:00 How Do You Shorten Sales Cycles Without Slashing Your Price? 27:00 How Should You Pay Your First Reps—and Incentivise New Products? 34:00 How Do You Onboard Reps Who Can Actually Sell? 40:00 How High Should Quotas Be—and How Long Should Reps Get to Ramp? 44:00 How Do You Drive Customer Expansion and Forecast Revenue Accurately? 54:00 How Do You Grow as a Sales Leader Without Taking Over Every Important Deal?  

Joinin the trio today we have Dev Ittycheria, CEO @ MongoDB.  AGENDA:  04:00 OpenAI Nears $70B Run Rate—Anthropic's Lead Under Threat 12:00 Factory vs Cognition: Silicon Valley's Talent War Turns Ugly 23:00 Vinod Khosla Blasts His Own Portfolio Company 25:00 Reflection Launches Beam: America Strikes Back in Open-Source AI 34:00 ElevenLabs Doubles Its Valuation to $22B 37:00 Salesforce Buys Listen Labs for $2B—Sequoia Cashes In 46:00 Vercel Hits $600M ARR as Agents Drive Half Its New Business 55:00 Former Groq Engineers Sue Over Nvidia's $17B Deal 01:01:00 Meta's Muse Steals the Show as OpenAI's Dots Underwhelms 01:05:00 Oura Pulls Its IPO Despite 74% Growth—A Warning for VC