‘The Next Big Idea Daily’: Human History on Drugs

For years, cardiologist Eric Topol hunted for the rarest people in America: those over 80 who had never been sick. When he finally found 1,400 of them, he made a shocking discovery. It wasn't their genes. These "super agers" were often the last ones standing in families where everyone else died decades earlier. So what separates people who live into their 80s or 90s feeling great from those who battle chronic disease? In his new book, Super Agers, Eric reveals what the science actually shows, shares practical advice you can use at any age, and takes on the bro scientists selling false promises along the way. This is part one of our interview with Eric. Part two will be available right here next week. If you can't until then, you can listen now on the Next Big Idea app: https://nextbigideaclub.com/app/

📱 Follow The Next Big Idea Daily on ⁠Apple Podcasts⁠, ⁠Spotify⁠, or ⁠wherever you listen⁠ When we talk about the forces that shape history, we usually hear about wars, revolutions, inventions, maybe the occasional love affair. But there’s one powerful force that’s rarely acknowledged because, well, it makes people uncomfortable. That force is drugs. In his new book Human History on Drugs, writer and historian Sam Kelly uncovers the surprising, often scandalous ways that everything from opium to cocaine has shaped leaders, inspired art, fueled some bad decisions — and some good ones. It’s a provocative and oddly humanizing look at the past, and it just might change the way you think about both history and substance use. 📩 Want more bite-sized insights from the best new nonfiction delivered straight to your inbox? Sign up for our Book of the Day newsletter

Sign up for our Substack! Arthur Schopenhauer said, “Talent hits a target no one else can hit. Genius hits a target no one else can see.” Thomas Edison famously claimed, “Genius is 1% inspiration and 99% perspiration.” Helen Lewis has a different take entirely. To her, the term genius licenses noxious eccentricities, exasperating ego trips, and downright bad behavior. Sure, plenty of things qualify as acts of genius — Shakespeare’s sonnets, penicillin — but when we pin the genius badge on a person instead of an achievement, we grant them membership in a supposedly superior class. That, Helen says, is the genius myth. She wants to demolish it and, in its place, tell the real story of how breakthroughs happen and who deserves credit.

Life changes can sneak up on all of us, and sometimes they hit pretty hard. Cassidy Krug spent 20 years training to be one of the best divers in the world. She made it to the Olympics. And then, in a single moment, her lifelong dream ended—with no medal, no encore, just the quiet shock of “What now?” Cassidy’s new book, ⁠Resurface⁠, is a guide for anyone navigating life’s big transitions—grief, identity shifts, career changes, reinventions. In the book, she gathers wisdom from Olympians, veterans, new parents, and more. Below, she shares what she’s learned about letting go, asking for help, and redefining success. 📱 Follow The Next Big Idea Daily on Apple Podcasts, Spotify, or wherever you listen 📩 Want more bite-sized insights from the best new nonfiction delivered straight to your inbox? Sign up for our Book of the Day newsletter

Sign up for our daily Substack here! Kevin Kelly has made a career out of looking to the future. He helped pioneer online social networking all the way back in the 1980s, and he co-founded Wired, the magazine devoted to digital technology, when the internet was still an infant. But in his new book, Excellent Advice for Living, he looks backward. It’s a collection of 450 bits of wisdom he wishes he’d known when he was young. Things like “Being enthusiastic is worth 25 IQ points” and “That thing that made you weird as a kid could make you great as an adult—if you don’t lose it.” Today on the show he shares his best advice for building careers, nurturing relationships, solving problems, and finding satisfaction. He also explains why he’s more optimistic than ever about technology (yes, even AI).

Let’s talk about revenge. Not the juicy, action-movie kind with flaming cars and dramatic showdowns, but the kind that quietly simmers in your brain long after someone cuts you off in traffic or sends a snarky email. According to Yale psychiatry lecturer and lawyer James Kimmel, revenge isn’t just an emotion. It’s an addiction. A hit of dopamine here, a rumination there, and suddenly we’re hooked on the fantasy of payback. But what if we could quit cold turkey? In his new book, ⁠The Science of Revenge⁠, James explains how to rewire our minds, embrace forgiveness, and break free from the cycles of grievance that keep us stuck. 📱 Follow The Next Big Idea Daily on Apple Podcasts, Spotify, or wherever you listen 📩 Want more bite-sized insights from the best new nonfiction delivered straight to your inbox? Sign up for our Book of the Day newsletter

AI, according to Andy Sack and Adam Brotman, co-founders of Forum3 and co-authors of the new book AI First, isn't just a neat new tool. It's "a tsunami of technology and capabilities." And if you don't start learning how to use it properly, they say, "you are absolutely gonna be left behind." The problem? Most people are using AI wrong. They're treating it like Google search when it should be treated like "an alien synthetic intelligence that can really reason and think and help you." In this episode, Andy and Adam share the mindset shifts and practical techniques that can help you harness AI to supercharge your productivity, creativity, and capability.

Science journalist Melinda Wenner Moyer, shares research-backed strategies for parenting with compassion, curiosity, and resilience from her new book, Hello, Cruel World!: Science-Based Strategies for Raising Terrific Kids in Terrifying Times. 📱 Follow The Next Big Idea Daily on Apple Podcasts, Spotify, or wherever you listen 📩 Want more bite-sized insights from the best new nonfiction delivered straight to your inbox? Sign up for our Book of the Day newsletter

This is one of our favorite conversations from the last year. On the surface, it's an interview we did with Michael Lewis to coincide with the paperback release of Going Infinite, his book about Sam Bankman-Fried and the collapse of FTX. Michael, who spent months hovering over Sam's shoulder, believes he wasn't some malevolent grifter: he was an awkward kid undone by a “pathological ability to foist risk upon other people without asking their permission." But what we love about this episode is that it's not only about the rise and fall of Sam Bankman-Fried. It's also about Michael's approach to writing — and living. He opens up about losing his daughter, shares what draws him to a story, and explains how taking pleasure in the world produces his best work. 🏛️ Check out Michael's latest book, Who Is Government?: The Untold Story of Public Service 🎁 Get 25% off a Next Big Idea Club subscription when you use the code PODCAST at https://nextbigideaclub.com/

Today, Travis Bradberry, author of ⁠The New Emotional Intelligence⁠, argues that understanding and managing your emotions — and the emotions of others — is even more important than IQ when it comes to success at work and in life. 📱 Follow The Next Big Idea Daily on ⁠Apple Podcasts⁠, ⁠Spotify⁠, or ⁠wherever you listen⁠ 📩 Want more bite-sized insights from the best new nonfiction delivered straight to your inbox? ⁠Sign up for our Book of the Day newsletter⁠