Episode 15— Scleroderma: Cracking the Code of a Complex Disease

🎙 Episode 17 — Autoinflammatory Diseases: Beyond AutoimmunityIn this in-depth episode of RheumRounds, Dr. Aravind Palraj unpacks the world of autoinflammatory diseases—conditions driven by the innate immune system rather than by autoantibodies or autoreactive T cells.🔑 What you’ll learn:How autoinflammation differs from autoimmunityPathophysiology of inflammasomes, IL-1, and innate cytokinesClinical features of FMF, TRAPS, CAPS, Still’s disease, and DADA2Diagnostic red flags and laboratory cluesModern treatment strategies: colchicine, IL-1 blockers, IL-6 inhibitors, and TNF agentsThe concept of the autoimmune–autoinflammatory spectrum📍 Ideal for residents, postgraduates, and clinicians who want to sharpen their understanding of these fascinating syndromes and their management.🎧 Host: Dr. Aravind Palraj🎓 Senior Resident, Clinical Immunology & Rheumatology📍 Madras Medical College, Chennai📱 Follow on X: @Rheumat_Aravind

🎙 Episode 16 — Vasculitis: When Blood Vessels Become TargetsIn this episode of RheumRounds, Dr. Aravind takes us through the fascinating and challenging world of vasculitis syndromes. What happens when the body’s own immune system launches an attack on blood vessels? How do we recognize the signs—rashes, neuropathy, organ ischemia—that point toward this diagnosis? And what are the principles of management, from glucocorticoids to biologics like rituximab?Clear, structured, and clinically grounded, this session is designed for residents and fellows who want to sharpen their reasoning skills in approaching systemic vasculitis.🔑 Key takeaways:Classification of vasculitis (large, medium, small vessel)Clinical red flags not to missDiagnostic tools: ANCA, biopsy, imagingTreatment strategies and pitfallsTune in and deepen your understanding of one of the most complex yet rewarding areas in rheumatology.🎧 Host: Dr. Aravind Palraj🎓 Senior Resident, Clinical Immunology & Rheumatology📍 Madras Medical College, Chennai📱 Follow on X: @Rheumat_Aravind

Episode 15 — Description:🩺 Scleroderma may start with cold fingers — but it’s much more than that. In this episode of RheumRounds, Dr. Aravind breaks down the types, symptoms, antibodies, and treatment strategies for this multi-system autoimmune disease. Whether you’re a medical professional or just curious, this is your guide to decoding scleroderma.🎧 Host: Dr. Aravind Palraj🎓 Senior Resident, Clinical Immunology & Rheumatology📍 Madras Medical College, Chennai📱 Follow on X: @Rheumat_Aravind

🎙️ Episode 14 – Pulmonary Hypertension in Connective Tissue Diseases: A Silent Threat“Breathlessness in systemic sclerosis isn’t always lung fibrosis — sometimes it’s the right heart struggling.”In this episode of RheumRounds, Dr. Aravind Palraj explains how to detect and manage pulmonary hypertension in connective tissue diseases before it’s too late.🧠 In just 7 minutes, you’ll learn:Which CTDs are most at riskHow to screen effectively and confirm the diagnosisCore treatment principles for better outcomes🎯 Why listen? Because spotting PH early can save lives.🎧 Host: Dr. Aravind Palraj🎓 Senior Resident, Clinical Immunology & Rheumatology📍 Madras Medical College, Chennai📱 Follow on X: @Rheumat_Aravind

🎙️ Episode 13 – Macrophage Activation Syndrome: When the Immune System Turns Deadly“In rheumatology, missing MAS by a few hours can cost a life.”In this episode of RheumRounds, Dr. Aravind Palraj breaks down the complexities of Macrophage Activation Syndrome — a hyperinflammatory crisis that can complicate systemic JIA, lupus, and other rheumatic diseases.🧠 In just 7 minutes, you’ll learn:The clinical and laboratory red flags that point toward MASHow to differentiate MAS from a flare or infection in critically ill patientsThe latest evidence-based strategies for rapid diagnosis and targeted treatment🎯 Why listen? Because in MAS, speed is everything — the earlier you act, the higher the survival rate.🎧 Host: Dr. Aravind Palraj🎓 Senior Resident, Clinical Immunology & Rheumatology📍 Madras Medical College, Chennai📱 Follow on X: @Rheumat_Aravind

🎙️ Episode 12 – Scleroderma Renal Crisis: When Blood Pressure Is the Killer“In systemic sclerosis, a sudden BP spike is never just hypertension.”In this episode of RheumRounds, Dr. Aravind Palraj explains how to recognize, prevent, and treat scleroderma renal crisis before irreversible kidney damage occurs.🧠 In just 7 minutes, you’ll learn:The high-risk patient profiles you must monitor closelyThe subtle and classic presentations of SRCWhy ACE inhibitors — not just BP control — are life-saving🎯 In systemic sclerosis, catching SRC early can mean the difference between full recovery and lifelong dialysis.🎧 Host: Dr. Aravind Palraj🎓 Senior Resident, Clinical Immunology & Rheumatology📍 Madras Medical College, Chennai📱 Follow on X: @Rheumat_Aravind

🎙️ Episode 11 – Pulmonary–Renal Syndrome: Treat First, Confirm Later“Two failing organs. One urgent decision.”In this episode of RheumRounds, Dr. Aravind Palraj explains how to recognize and act fast in Pulmonary–Renal Syndrome — one of the deadliest emergencies in rheumatology.🧠 In just 7 minutes, you’ll learn:The hallmark signs of PRS and how to spot them earlyWhy you must start treatment before confirmationThe essential workup and first-line management steps🎯 PRS is rare but deadly. Don’t let hesitation be the reason for organ loss.🎧 Host: Dr. Aravind Palraj🎓 Senior Resident, Clinical Immunology & Rheumatology📍 Madras Medical College, Chennai📱 Follow on X: @Rheumat_Aravind

🎙️ Episode 10 – Why Normal Creatinine Doesn’t Mean Normal Kidneys“The silent kidney damage you might be missing.”In this episode of RheumRounds, Dr. Aravind Palraj explains why creatinine can give a false sense of security, and how to detect early kidney involvement before it’s too late.🧠 In just 7 minutes, you’ll learn:Why creatinine is muscle-dependent, not just kidney-dependentThe importance of eGFR, urine protein, and microscopic analysisHow to catch lupus nephritis and vasculitis before irreversible damage🎯 A must-listen for anyone managing autoimmune patients — because kidney damage is easiest to treat before creatinine rises.🎧 Host: Dr. Aravind Palraj🎓 Senior Resident, Clinical Immunology & Rheumatology📍 Madras Medical College, Chennai📱 Follow on X: @Rheumat_Aravind

🎙️ Episode 9 – When to Suspect Vasculitis: Clues You Can’t Ignore“The patient’s symptoms don’t match a single system — is it vasculitis?”In this episode of RheumRounds, Dr. Aravind Palraj shares the skin signs, organ red flags, and diagnostic approach that can help you spot vasculitis before irreversible damage occurs.🧠 In just 7 minutes, you’ll learn:Why multi-system symptoms should raise a red flagThe difference between purpura and “palpable” purpuraHow to connect organ clues and order the right tests🎯 Vasculitis is rare, but missing it can be deadly. This episode gives you the pattern-recognition skills to act in time.🎧 Host: Dr. Aravind Palraj🎓 Senior Resident, Clinical Immunology & Rheumatology📍 Madras Medical College, Chennai📱 Follow on X: @Rheumat_Aravind

🎙️ Episode 8 – ANA Positive, But Nothing Else: What Should I Do?“Isolated ANA positivity: red flag or red herring?”In this episode of RheumRounds, Dr. Aravind Palraj unpacks one of the most misunderstood lab results in medicine — a positive ANA in an otherwise asymptomatic patient.🧠 In just 7 minutes, you’ll learn:What ANA really means — and how common it is in healthy peopleHow to interpret titers and patternsWhen to investigate further — and when to confidently reassure🎯 Not all positive labs point to disease.Learn when to act, when to wait, and how to counsel anxious patients clearly and correctly.🎧 Host: Dr. Aravind Palraj🎓 Senior Resident, Clinical Immunology & Rheumatology📍 Madras Medical College, Chennai📱 Follow on X: @Rheumat_Aravind