Episode 332 - Vanesaa Nieto-Estévez and Parul Varma, PhDs

On April 23, 2026 I met with Drs. Vanesa Nieto Estévez and Parul Varma to talk about brain organoids made from cells derived from patients with genetic childhood epilepsy. Vanesa and Parul explained how these patient-derived tissue cultures are used to isolate the defects in brain development that underly the brain disorder, and to suggest and test potential treatments.Guests:Vanesa Nieto Estévez and Parul Varma, Assistant Professors of Research, Department of Neuroscience, Developmental and Regenerative Biology, UT San AntonioHost:Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UT San Antonio Thanks to James Tepper for original music

On April 16, 2026, we met with Dr. Robert Froemke of New York University to discuss his work on parenting and co-parenting in mice. We covered a wide range of topics including his video approach to discovery in behavioral experiments and the role of oxytocin in parental behavior.Guest: Robert Froemke, Professor, Department of Otolaryngology and Department of Neuroscience at at New York University Langone Health.Participating:Alfonso Apicella, Department of Neuroscience, Developmental and Regenerative Biology, UT San AntonioAlice Bertero, Department of Neuroscience, Developmental and Regenerative Biology, UT San AntonioJon Moler, Department of Neuroscience, Developmental and Regenerative Biology, UT San AntonioHost: Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UT San Antonio

On April 9, 2026 I spoke with Dr. Marcelo Marucho, on the electrical properties of actin filaments and microtubules, ubiquitous components of the cytoskeleton of nearly all cells. He explained how the surface charge of these proteins creates a thin charged layer in the adjacent cytoplasm in which electrical signals may be generated and conducted. In the case of microtubules, the interaction between external and luminal surfaces can produce oscillations. We discussed some of the possible functions of these electrical signals in the brain.Guest:Marcelo Marucho, Professor, Department of Physics and Astronomy, UTSAHost:Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UTSA

On April 2, 2026 we met with Dr. Daniel Llano to discuss the organization of the largest subcortical auditory brain structure, the inferior colliculus. He told us about the three major subnuclei within the inferior colliculus, their synaptic connections with other auditory and somatosensory structures, and the problems encountered as we try to identify the cell types and local connectivity within the nucleus.Guest: Daniel A Llano, Department of Molecular and Integrative Physiology University of Illinois Urbana-ChampaignParticipating: Marina Silveira, Department of Neuroscience, Developmental and Regenerative Biology, UT San AntonioHost: Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UT San AntonioThanks to James Tepper for original music

On March 26, 2026, we held our annual UTSA Neuroscience Symposium entitled "From Place Cells to Cognition", featuring 5 speakers presenting original research on the cognitive functions of hippocampal place cells. They discussed the firing patterns of place cells during exploration of cognitive maps, anticipating future movements, recall of previously visited locations, and imagining the movement of objects in the environment. After the symposium, I met with the speakers to review some of the themes that emerged throughout the day.Speakers:Francesco Savelli, Assistant Professor, Department of Neuroscience, Developmental and Regenerative Biology, UTSAAnnabelle Singer, Associate Professor, Department of Biomedical Engineering, Georgia Institute of Technology and Emory UniversityAlbert Lee, Associate Professor, Department of Neurology and Howard Hughes Medical Institute, Harvard UniversityJill Leutgeb, Professor, Department of Neurobiology, University of California San DiegoKamran Diba, Associate Professor, Department of Anesthesiology, University of MichiganHost:Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UTSAThanks to James Tepper for original music

On March 19, 2026 we spoke with Dr. Se-Woong Park about the idea that many of the symptoms of Autism may arise from changes in brain mechanisms that allow us to predict events in the near future from those in the recent past. Topics included internal predictions of postural destabilization produced by our own movements, and prediction of the trajectories of moving objects. We discussed some experimental results testing this idea.Guest:Se-Woong Park, Associate Professor, Department of Kinesiology, UTSAParticipating:Hyoung-gon Lee, Department of Neuroscience, Developmental and Regenerative Biology, UTSAHost:Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UTSAThanks to James Tepper for original music

On February 26, 2026 we were joined by Dr. Peter Fox to talk about quantitative brain imaging methods and how they can reveal localized changes in brain structure in brain disorders that traditionally have not been associated with specific neuropathology. Guest:Peter Fox, Director, Brain Imaging Institute and Professor of Radiology, Neurology, and Physiology at UT Health San Antonio.Participating:George Perry, Department of Neuroscience, Developmental and Regenerative Biology, UTSA.Host:Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UTSA.

On February 19, 2026 we were visited by Dr. Dayu Lin to hear about her work on some of the cell groups that make up the hypothalamus and their function in activating innate social behaviors in mice, including parenting and protection of their young. Guest: Dayu Lin, Professor in the Departments of Psychiatry and Neuroscience, Institute for Translational Neuroscience, Langone Medical Center, New York UniversityParticipating: Antony Burgos-Robles, Department of Neuroscience, Developmental and Regenerative Biology, UTSA.Aayushma Kunwar, Department of Neuroscience, Developmental and Regenerative Biology, UTSA.Host:Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UTSA.Thanks to James Tepper for original music.

On February 5, 2026 we met with Dr.Jonathan Bohmann to learn about the structure and function of acetylcholinesterase, the extracellular enzyme that controls the strength and time course of neurotransmitter at cholinergic synapses. He explained how computational models of molecular structure is be used to understand the functional properties of the enzyme and to design drugs that can modify its action.Guest:Jonathan Bohmann, Scientist, Southwest Research Institute, San AntonioParticipating:Jenny Hsieh, Department of Neuroscience, Developmental and Regenerative Biology, UTSAHost:Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UTSA

On January 30, 2026, Fidel Santamaria returned to the podcast (after 18 years) to talk about the thermodynamics of ion channel activation and deactivation, and the changes in neuronal activity that occur with changes in temperature.Guest: Fidel Santamaria, Professor, Department of Neuroscience, Developmental and Regenerative Biology.Host: Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology.Thanks to Jim Tepper for original music