Episode 24: Rebuilding an Airline for the 21st Century: LATAM's Data-Driven Transformation

Andrés Bucchi (Chief Data Officer, LATAM Airlines) joins High Signal to unpack how a century-old airline reinvented itself with data and AI—and how that transformation is unlocking value from fuel efficiency to fraud detection. LATAM has built a massive data operation, experimenting across everything from pricing to operations, while customers benefit from a more reliable and secure travel experience. We dig into how LATAM fostered an experimentation culture, why existing data infrastructure is a critical asset, and how the biggest bottleneck in AI adoption isn't the technology itself, but human decision-making. The conversation also looks ahead to the future of generative AI as a software engineering problem, and the organizational changes needed to unlock its full potential. LINKS Andrés Bucchi on LinkedIn (https://www.linkedin.com/in/bucchi/) Tim O'Reilly on The End of Programming As We Know It, High Signal (https://high-signal.delphina.ai/episode/tim-oreilly-on-the-end-of-programming-as-we-know-it) Watch the conversation on YouTube (https://youtu.be/U_eaOmt-Rw4) Delphina's Newsletter (https://delphinaai.substack.com/)

Anu Bharadwaj (President, Atlassian) joins High Signal to unpack how humans and AI agents will work together across the enterprise, and how that shift could change the very nature of teamwork. Atlassian employees have already built thousands of agents across product, marketing, engineering, and HR teams, while customers like HarperCollins are cutting manual work by 4x as industries from publishing to finance rethink their workflows. We dig into how Atlassian’s culture enables bottom-up experimentation, why grounding and reliability are critical for adoption, and how non-technical teams are often the ones creating the most useful agents. The conversation also looks ahead to the frontiers of multiplayer agent collaboration, proactive and ambient workflows, and the governance and compliance challenges enterprises will face as agents move from tools to teammates. LINKS Anu on LinkedIn (https://www.linkedin.com/in/anutthara/) Building effective agents by Erik Schluntz and Barry Zhang at Anthropic (https://www.anthropic.com/engineering/building-effective-agents) How we built our multi-agent research system by Anthropic (https://www.anthropic.com/engineering/multi-agent-research-system) Watch the podcast episode on YouTube (https://youtu.be/898M86sKIi8?si=YGoekFzVJ0UH6pCJ) Delphina's Newsletter (https://delphinaai.substack.com/)

Tomasz Tunguz (Theory Ventures) joins High Signal to unpack why a trillion dollars of market cap is up for grabs as AI reshapes enterprise software. He explains why workflows are now changing faster than packaged software can keep up, how “liquid software” is redefining CRM and marketing automation, and why background agents will require a new kind of “agent inbox.” We discuss the compounding errors that arise when tools are chained too finely, the hidden AI technical debt accumulating in today’s systems, and why modular stacks—mixing local and cloud models—will beat monolithic apps. The conversation also surfaces early memory architectures, what breaks when one IC manages 100 agents, and how these shifts change the real bottlenecks in scaling AI. LINKS Tomasz' Website (check out his blog!) (https://tomtunguz.com/) Tomasz on LinkedIn (https://www.linkedin.com/in/tomasztunguz/) Building effective agents by Erik Schluntz and Barry Zhang at Anthropic (https://www.anthropic.com/engineering/building-effective-agents) How we built our multi-agent research system by Anthropic (https://www.anthropic.com/engineering/multi-agent-research-system) Tim O'Reilly on The End of Programming As We Know It (https://high-signal.delphina.ai/episode/tim-oreilly-on-the-end-of-programming-as-we-know-it) Delphina's Newsletter (https://delphinaai.substack.com/)

Amy Edmondson (Harvard Business School) and Mike Luca (Johns Hopkins) join High Signal to unpack what actually drives good decisions in data‑rich organizations. Using contrasts like the Bay of Pigs vs. the Cuban Missile Crisis and product cases such as Airbnb’s work on measuring discrimination, they show how decision quality tracks conversation quality—framing options, surfacing uncertainty, and challenging assumptions. We cover common failure modes (correlation vs. causation, anchoring, hierarchy, false precision), practical meeting designs that raise the signal, and where algorithms and LLMs help or hinder human judgment. LINKS Amy on LinkedIn (https://www.linkedin.com/in/amycedmondson/) Mike on LinkedIn (https://www.linkedin.com/in/profluca/) Where Data-Driven Decision-Making Can Go Wrong: Five pitfalls to avoid by Michael Luca and Amy C. Edmondson (https://hbr.org/2024/09/where-data-driven-decision-making-can-go-wrong) Many Analysts, One Data Set: Making Transparent How Variations in Analytic Choices Affect Results (https://journals.sagepub.com/doi/10.1177/2515245917747646) Trillion Dollar Coach by Eric Schmidt, Jonathan Rosenberg, and Alan Eagle (https://www.trilliondollarcoach.com/) Delphina's Newsletter (https://delphinaai.substack.com/)

Daragh Sibley, Chief Algorithms Officer at Literati and former Director of Data Science at Stitch Fix, joins High Signal to unpack how machine-learning moves from slide-deck promise to bottom-line impact. He walks through his shift from academic research on how kids learn to read to owning inventory and personalization algorithms that decide which five books land in every child’s box. We dig into the moment a data leader stops advising and starts owning P&L-critical calls, why some problems deserve simple analytics while others need high-dimensional models, and how to design workflows where human judgment and algorithmic predictions share accountability. Along the way we talk incentive design, balancing exploration and exploitation in inventory, and measuring success in dollars—not dashboards. LINKS Daragh on LinkedIn (https://www.linkedin.com/in/daragh-sibley-2111835/) Eric Colson on Why 90% of Data Science Fails—And How to Fix It (https://high-signal.delphina.ai/episode/why-90-of-data-science-fails-and-how-to-fix-it-eric-colson) Sudarshan Seshadri on High-Stakes AI Systems and the Cost of Getting It Wrong (https://high-signal.delphina.ai/episode/high-stakes-ai-systems-and-the-cost-of-getting-it-wrong) Delphina's Newsletter (https://delphinaai.substack.com/)

Lis Costa, Chief of Innovation and Partnerships at the Behavioural Insights Team, joins High Signal to explore how behavioral science is reshaping public policy, digital platforms, and machine learning. She explains how defaults influence behavior at scale, why personalization and chatbots are unlocking new kinds of interventions, and what happens when AI systems meet real-world complexity. We also discuss the limits of nudging, the promise of boosting, and why building for human decision-making requires more than just good models. LINKS The Behavioral Insights Team (https://www.bi.team/) Lis Costa on LinkedIn (https://uk.linkedin.com/in/elisabeth-costa-6a5b35248) High Signal podcast (https://high-signal.delphina.ai/) Delphina's Newsletter (https://delphinaai.substack.com/)

Sudarshan Seshadri—VP of AI, Data Science, and Foundations Engineering at Alto Pharmacy—joins us to explore what it takes to build high-stakes AI systems that people can actually trust. He shares lessons from deploying machine learning and LLMs in healthcare, where speed, safety, and uncertainty must be carefully balanced. We talk about designing AI to support pharmacist judgment, the shift from bottlenecks to decision backbones, and why great data leaders are really architects of how irreversible decisions get made. LINKS Suddu on LinkedIn (https://www.linkedin.com/in/ss01/) Careers at Alto Pharmacy (https://www.alto.com/careers) High Signal podcast (https://high-signal.delphina.ai/) Delphina's Newsletter (https://delphinaai.substack.com/)

Roberto Medri, VP of Data Science at Instagram, explains why most experiments fail, how misaligned incentives warp product development, and what it takes to drive real impact with data science. He shares what teams get wrong about launches, why ego gets in the way of learning, and how Instagram turned Reels from a struggling product into a global success. A candid look at product, data, and decision-making inside one of the world’s most influential platforms. LINKS Roberto on LinkedIn (https://www.linkedin.com/in/robertomedri/) High Signal podcast (https://high-signal.delphina.ai/) Delphina's Newsletter (https://delphinaai.substack.com/)

Fei-Fei Li—co-director of Stanford’s Human-Centered AI Institute and one of the most respected voices in the field—reflects on AI’s evolution from the early days of ImageNet to the rise of foundation models. She explains why spatial intelligence may be the next major shift, how human-centered design applies in practice, and why AI should be understood as a civilizational technology—one that shapes individuals, communities, and society at large. LINKS Stanford HAI (https://hai.stanford.edu/) World Labs (https://www.worldlabs.ai/about) "The World I See", Fei-Fei's book (a must read!) (https://us.macmillan.com/books/9781250897930/theworldsisee/) Fei-Fei on X (https://x.com/drfeifei) Fei-Fei on LinkedIn (https://www.linkedin.com/in/fei-fei-li-4541247/) High Signal podcast (https://high-signal.delphina.ai/) Delphina's Newsletter (https://delphinaai.substack.com/)

Eoin O'Mahony—data science partner at Lightspeed, former Uber science lead, and one of the early architects of the system that kept NYC’s Citi Bikes available across the city—argues that positive metrics are meaningless if you don’t understand the mechanism behind them. At Uber, he was careful to make sure his launches both looked good on paper and made sense in practice. Now in venture, he’s applying that same rigor to unstructured data—using GenAI to scale a kind of work that’s long resisted systematization. LINKS Eoin's page at Lightspeed Ventures (https://lsvp.com/team-member/eoin-omahony/) Ramesh Johari on How to Build an Experimentation Machine and Where Most Go Wrong (https://high-signal.delphina.ai/episode/ramesh-johari-on-how-to-build-an-experimentation-machine-and-where-most-go-wrong) Chiara Farronato on Data Science Meets Management: Teamwork, Experimentation, and Decision-Making (https://high-signal.delphina.ai/episode/data-science-meets-management) Delphina's Newsletter (https://delphinaai.substack.com/)