Episode 495: New Research On Aged Garlic Extract, NAD+, And Heart Health

This week, Joel Kahn, MD, dives into fascinating new research on aged garlic extract and its potential role in healthy aging, muscle function, and cardiovascular wellness. He reviews a recent study showing how aged garlic extract improved muscle and aging markers in mice while also activating the NAMPT pathway in humans, which may help boost NAD+ production. Dr. Kahn also breaks down several newer studies highlighting the cardiovascular benefits of aged garlic extract, a supplement he's used at the Kahn Center for more than a decade. He discusses the specific Kyolic formula available here: Kyolic Aged Garlic Extract Additional topics include dietary nitrates from greens and nitric oxide production, the Mediterranean diet and longevity, high-intensity interval training and heart health, visual acuity and lifespan, plant-based diets and breast cancer outcomes, and the connection between poor sleep and survival rates.  This episode is brought to you by VINIA and their line of heart-supporting products.

This week, Dr. Kahn discusses his long-standing interest in the amino acid glycine and its potential health benefits. Sleep is a key focus, highlighted by a new report on the widespread difficulty adults face in getting a full night's rest. Glycine may also offer favorable cardiovascular support. Additional topics include coffee and aging, methamphetamines and heart attacks, Lipoprotein(a) and cardiovascular risk, yoga and overall health, a tribute to Eugene Braunwald, MD, TMAO and atherosclerosis, and a new study on the benefits of adopting heart-healthy habits early in life.  Thanks to the Fresh Pressed Olive Oil Club and the special discount offer at getfreshdrkahn.com

This week, Dr. Kahn reviews new data from the Global Burden of Disease study analyzing the relationship between diet and death from heart disease. In 2023, an estimated 5.9 million deaths worldwide were linked to poor dietary choices, led by excessive sodium intake and insufficient consumption of fruit and whole grains. It's a fascinating and important study with clear takeaways. Other topics include stents for angina, causes of sudden cardiac death, daytime napping and health outcomes, plastic-free diets, PCSK9 inhibitors vs. statins, calcium supplements, and the purity of fish oil samples. Thanks to the Fresh Pressed Olive Oil Club. Visit getfreshdrkahn.com for an incredible introductory offer.

This week, Dr. Kahn addresses a topic gaining attention in the media: whether taking the shingles vaccine (Shingrix in the USA) may reduce the risk of heart events and dementia. Multiple studies suggest this could be true, although no randomized trials have been performed to confirm it. Furthermore, most of these studies focus on a version of the vaccine that was discontinued in the U.S. in 2020 (Zostavax), making the assumption that Shingrix provides the same benefits somewhat speculative. This is a topic worth discussing with your primary care team. Other topics include controversies in nutrition, B vitamins and stroke risk, and the impact of medications for mild dementia.  This episode is sponsored by the Fresh Pressed Olive Oil Club at getfreshdrkahn.com, featuring a limited $1 offer on high-quality olive oils.

This week, Dr. Kahn dives into heart disease in "masters athletes," highly active individuals over 35 who train and compete at a serious level. Despite their fitness, research shows they may face equal—or even higher—rates of cardiovascular issues like arrhythmias, coronary artery disease, and aortic dilation. A new consensus statement breaks down what to watch for and recommends advanced screening like EKGs, coronary calcium scans, and detailed blood work. Beyond that, Dr. Kahn shares insights from his own recent mitral valve surgery recovery and explores why common heart risk calculators often miss people who go on to have heart attacks. He highlights better testing options, including coronary calcium scoring, and discusses a study showing most heart attack patients would have been labeled "low risk" using standard tools.  The episode also covers research on plant-based diets lowering dementia risk and reducing environmental impact, plus findings that avocados and mangos may improve vascular health. Sleep gets a spotlight too, with evidence that irregular sleep patterns can double heart attack risk, and that both too little and too much sleep may increase dementia risk. This episode is sponsored by the Fresh Pressed Olive Oil Club at getfreshdrkahn.com , featuring a limited $1 offer on high-quality olive oils.

This week, Dr. Kahn shares an update on his recovery following robotic mitral valve repair surgery at the Cleveland Clinic. Just 10–12 days post-op, he walks through his experience—from diagnosis and testing to surgery with Marc Gillinov, MD.  He covers the procedure, time in the ICU, and early recovery milestones, along with what's next in his healing journey. Thanks to Igennus for sponsoring this episode—visit igennus.com and use code DrKahn.

This week, Dr. Kahn shares exciting updates from the American College of Cardiology meeting, highlighting several new trials focused on reducing heart events in patients with diabetes and those with established heart disease. The results are promising and could help prevent strokes, heart attacks, and even save lives. Additional topics include vegan diets and cancer risk, heart disease in police officers, the link between Alzheimer's disease and statins, concerns around erythritol sweeteners, Lp(a) levels in stent patients, niacin for fatty liver disease, and the role of beta blockers after heart attacks.  This episode is brought to you by Igennus Healthcare Nutrition—formulators of high-quality, science-backed supplements designed for optimal absorption and effectiveness. Their products are rigorously tested and trusted by health professionals worldwide. Visit igennus.com and use code DrKahn to save on your order.

What if a quick, painless ultrasound could reveal your true vascular age? In this bonus episode of Heart Doc VIP, host Dr. Joel Kahn sits down with Joseph Ence to discuss CIMT (carotid intima-media thickness)—a simple, non-invasive test used in over 5,000 research studies over the past 20+ years to measure plaque and thickness in the carotid arteries. Safe and radiation-free, this ultrasound provides valuable insight into your cardiovascular health by estimating your "vascular age."  They also explore how targeted interventions—like lifestyle changes, supplements, and medications—may help improve—and even reverse—vascular age.

This week, Dr. Kahn breaks down new research on dementia risk, including the roles of high blood pressure and early menopause. He looks at conflicting studies on red meat and ApoE4, which pretty much sums up nutrition science: one study says yes, another says absolutely not. For now, limiting red meat—especially processed—is still the safest move. He also covers the risks of skipping breakfast, calcium CT scoring for elevated lipoprotein(a), tooth loss and heart disease, long-term clopidogrel use after stents, ultraprocessed foods, Repatha and statins, Cleerly AI scans, micro-exercise breaks, and why elevated TMAO may increase blood clot risk.  This episode is sponsored by Igennus. Visit igennus.com and use code DRKAHN for a discount.

The replay of the 4th Reversing Heart Disease Summit is going on now. Register here: drtalks.com/summits/reversing-heart-disease This week, Dr. Kahn addresses the newly published 2026 guidelines for the management of hyperlipidemia (high cholesterol), which will be studied and used by medical professionals all over the world. The top 10 takeaways are presented and are similar to the approach used at the Kahn Center for over a decade. Other topics include the challenge of staying vegan, the influence of cold temperatures on aortic dissection, the development of clogged arteries after a normal heart artery CT scan, the role of olive oil on the brain, red light therapy and music and the autonomic nervous system, plant-based diets and TMAO, bacteria and the brain, the role of a low uric acid level, the advantages of Eliquis over Xarelto in a new trial, and the FDA inquiry into the maker of Wegovy and Ozempic.  Thanks to Igennus.com for their support. Use the discount code DrKahn to save.