HCM Pills Episode 14 | Dr. Martin Maron "The Difference Between Obstructive and Non-obstructive HCM”

HCM Pills is a series of webcasts organized by the HCM Patient Foundation. The purpose of each webcast is to pose the most burning questions from patients to world-renowned HCM experts, who reply in a clear and understandable way. Our fourteenth guest is Dr. Martin Maron, the medical director of the Lahey HCM Center and an assistant professor at Tufts University.The primary host of HCM Pills is Dr Niccolò Maurizi, Chief Resident in Cardiology at CHUV (The Lausanne University Hospital). Previously, he worked as a researcher at the Università degli Studi di Firenze. In 2015, he co-founded D-Heart, a startup developing innovative wearable cardiology devices. He has authored and co-authored nearly 100 scientific articles focusing on HCM-related topics, including sudden cardiac arrest management, pregnancy in HCM, and the use of smart devices in clinical practice. While Niccolò normally asks the experts questions on behalf of patients, in this episode, Emil Tsenov, the General Manager of the HCM Patient Foundation, is standing in for him while he is away on family leave.

HCM Pills is a series of webcasts organized by the HCM Patient Foundation. The purpose of each webcast is to pose the most burning questions from patients to world-renowned HCM experts, who reply in a clear and understandable way. Our thirteenth guest is Dr Milind Desai, MD, MBA, a prominent US-based cardiologist, Professor of Medicine, and Director of the Center for Hypertrophic Cardiomyopathy at the Cleveland Clinic.The primary host of HCM Pills is Dr Niccolò Maurizi, Chief Resident in Cardiology at CHUV (The Lausanne University Hospital). Previously, he worked as a researcher at the Università degli Studi di Firenze. In 2015, he co-founded D-Heart, a startup developing innovative wearable cardiology devices. He has authored and co-authored nearly 100 scientific articles focusing on HCM-related topics, including sudden cardiac arrest management, pregnancy in HCM, and the use of smart devices in clinical practice. While Niccolò normally asks the experts questions on behalf of patients, in this episode, Emil Tsenov, the General Manager of the HCM Patient Foundation, is standing in for him while he is away on family leave.

In this episode, we revisit a truly special moment from the first HCM Patient Foundation meeting:Tu "Little Etudes for Piano based on aberrations of cardiac electrophysiology" by Elaine Chew, beautifully performed byDora Deliyska.Plus, insights from a pilot study by the Music Theranostics Lab, exploring cardiac responses to live music.Where science, music, and the heart come together...

HCM Pills is a series of webcasts organized by the HCM Patient Foundation. The purpose of the webcast is to ask the most burning questions of patients to world-renowned HCM experts who reply to them in a clear and understandable way. Our ninth guest, Dr. Ahmad Masri, is the Cardiomyopathy Section Head at the Oregon Health & Science University (OHSU). He is also director of the OHSU's HCM Center and Cardiac Amyloidosis Program. His work focuses on risk stratification, imaging-based assessment, and management of patients with hypertrophic cardiomyopathy and other structural heart diseases. He has published extensively in peer-reviewed cardiology journals on these and other topics. The anchor of HCM Pills is Dr. Niccolo' Maurizi, Chief Resident in Cardiology at CHUV | Lausanne university. Prior to that, he worked as a Researcher at Università degli Studi di Firenze. He co-founded D-Heart, a startup for innovative cardiologic wearable concepts in 2015. He has authored and co-authored almost 100 scientific articles with concentration on HCM-related issues (sudden cardiac arrest management, pregnancy in HCM, smart devices in clinical practice, etc.). Niccolo' will be asking all questions of HCM patients to our patients.In this episode the General Manager of the HCM Patient Foundation Emil Tsenov stands in for Niccolo' who is away on family matters.

HCM Pills is a series of webcasts organized by the HCM Patient Foundation. The purpose of the webcast is to ask the most burning questions of patients to world-renowned HCM experts who reply to them in a clear and understandable way. Our seventh guest, Juan Pablo Kaski, is Professor of Paediatric Inherited Cardiovascular Medicine at the UCL Institute of Cardiovascular Science, where he leads the UCL Centre for Paediatric Inherited and Rare Cardiovascular Diseases, and Consultant Paediatric Cardiologist at Great Ormond Street Hospital (GOSH), London, UK. His clinical and research interests are focused on the clinical and genetic characterisation of inherited cardiovascular disease and sudden cardiac death in childhood. He has established an internationally-recognised research programme in the field of paediatric cardiomyopathy, having established a unique clinical cohort and the only UK bioresource for paediatric inherited cardiovascular disease, with the aim of stratifying disease phenotypes and identifying novel therapeutic targets.He is immediate past-Chair of the Association for European Paediatric Cardiology (AEPC) Working Group on Genetics, Basic Science and Myocardial Disease and sits on the Executive Board of the European Society of Cardiology (ESC) Cardiomyopathy and Myocarditis Registry Programme and the ESC Council on Cardiovascular Genomics, as Liaison Officer. He leads an international paediatric HCM consortium of over 45 centres, which was responsible for the development of the first sudden death risk prediction model for childhood HCM. He chaired the Task Force for the 2023 European Society of Cardiology Guidelines for the Management of Cardiomyopathies.The anchor of HCM Pills is Dr. Niccolo' Maurizi, Chief Resident in Cardiology at CHUV | Lausanne university. Prior to that, he worked as a Researcher at Università degli Studi di Firenze. He co-founded D-Heart, a startup for innovative cardiologic wearable concepts in 2015. He has authored and co-authored almost 100 scientific articles with concentration on HCM-related issues (sudden cardiac arrest management, pregnancy in HCM, smart devices in clinical practice, etc.). Niccolo' will be asking all questions of HCM patients to our patients.

HCM Pills is a series of webcasts organized by the HCM Patient Foundation. The purpose of the webcast is to ask the most burning questions of patients to world-renowned HCM experts who reply to them in a clear and understandable way. Our sixth guest, Dr. Harald Jorstad, is a consultant cardiologist at the Amsterdam UMC, the Netherlands. He specializes in preventive cardiology and sports cardiology, and is the current chair of the Dutch Sports Cardiology Section. He is also the author of numerous studies and articles on the topic of physical activity in HCM patients.The anchor of HCM Pills is Dr. Niccolo' Maurizi, Chief Resident in Cardiology at CHUV | Lausanne university. Prior to that, he worked as a Researcher at Università degli Studi di Firenze. He co-founded D-Heart, a startup for innovative cardiologic wearable concepts in 2015. He has authored and co-authored almost 100 scientific articles with concentration on HCM-related issues (sudden cardiac arrest management, pregnancy in HCM, smart devices in clinical practice, etc.). Niccolo' will be asking all questions of HCM patients to our patients.

HCM Pills is a series of webcasts organized by the HCM Patient Foundation. The purpose of the webcast is to ask the most burning questions of patients to world-renowned HCM experts who reply to them in a clear and understandable way. Our fifth guest, Prof. Connie Bezzina, is a Full Professor of Heart Failure and Arrhythmias at Amsterdam University Medical Centre. She conducts research on genetic factors underlying inherited cardiac disorders, focusing mainly on primary electrical disorders associated with sudden cardiac death in the young. Her work considers the broad spectrum of genetic complexities of these disorders, ranging from monogenic to polygenic, and has pioneered the concept of polygenic inheritance in the rare rhythm disorders such as Brugada syndrome. To enable such studies, she established international consortia of researchers from all over the world, bringing together hundreds of patients. In an integrative approach, her group also studies the identified genetic factors in induced pluripotent stem cell-derived cardiomyocytes and gene-targeted mice in order to understand the causative mechanisms and identify preventive and therapeutic strategies. She has authored numerous important articles and is an editorial member of the European Heart Journal.The anchor of HCM Pills is Dr. Niccolo' Maurizi, Chief Resident in Cardiology at CHUV | Lausanne university. Prior to that, he worked as a Researcher at Università degli Studi di Firenze. He co-founded D-Heart, a startup for innovative cardiologic wearable concepts in 2015. He has authored and co-authored almost 100 scientific articles with concentration on HCM-related issues (sudden cardiac arrest management, pregnancy in HCM, smart devices in clinical practice, etc.). Niccolo' will be asking all questions of HCM patients to our patients.

HCM Pills is a series of webcasts organized by the HCM Patient Foundation. The purpose of the webcast is to ask the most burning questions of patients to world-renowned HCM experts who reply to them in a clear and understandable way. Our fourth guest, Prof. Jolanda van der Velden, is the Chair of the Department of Physiology at the Amsterdam University Medical Center, and director of the Amsterdam Cardiovascular Sciences Institute. Her main research interest is the role of sarcomeric proteins in cardiac performance. As mutations in sarcomeric proteins are a frequent cause of heart disease, research on inherited cardiomyopathies is a central research line in Amsterdam UMC. Prof. van der Velden’s team at the Physiology department collaborates with clinical geneticists, cardiologists, cardiac surgeons and experts in in vivo cardiac imaging, enabling translational studies from bench to the patient. Their expertise includes functional studies at single cardiac muscle cell and multicellular level, and mitochondrial studies in patient samples obtained during cardiac surgery, and stem cell-derived heart models.The anchor of HCM Pills is Dr. Niccolo' Maurizi, Chief Resident in Cardiology at CHUV | Lausanne university. Prior to that, he worked as a Researcher at Università degli Studi di Firenze. He co-founded D-Heart, a startup for innovative cardiologic wearable concepts in 2015. He has authored and co-authored almost 100 scientific articles with concentration on HCM-related issues (sudden cardiac arrest management, pregnancy in HCM, smart devices in clinical practice, etc.). Niccolo' will be asking all questions of HCM patients to our patients.

HCM Pills is a series of webcasts organized by the HCM Patient Foundation. The purpose of the webcast is to ask the most burning questions of patients to world-renowned HCM experts who reply to them in a clear and understandable way. Our third guest, Prof. Perry Elliott, is Professor of Cardiovascular Medicine at University College London and a Senior Investigator of the UK National Institute for Health Research. He is director of the UCL Institute of Cardiovascular Science UCL and a consultant cardiologist at St. Bartholomew's Hospital London. He is Chairman of the European Society of Cardiology (ESC) Heart Academy and past chair of the ESC Council on Cardiovascular Genomics, the ESC Working Group on Myocardial and Pericardial Diseases and the Executive Committee for the European Outcomes Research Programme registry on cardiomyopathies. He is an executive Editor for the European Heart Journal.Perry Elliott is a recognized world authority in heart muscle disease. His most important research contributions include: gene identification; development and application of risk tools; biomarker discovery, and clinical trials in rare diseases. The direct benefits to patients include accurate risk prediction, effective family screening, and prevention of sudden cardiac death. His work is intrinsically collaborative and he has coordinated numerous global consortia that have informed disease classifications, US and European Practice guidelines, and genetic testing, including detailed rare cardiovascular disease data models for the 100K-genome project.The anchor of HCM Pills is Dr. Niccolo' Maurizi, Chief Resident in Cardiology at CHUV | Lausanne university. Prior to that, he worked as a Researcher at Università degli Studi di Firenze. He co-founded D-Heart, a startup for innovative cardiologic wearable concepts in 2015. He has authored and co-authored almost 100 scientific articles with concentration on HCM-related issues (sudden cardiac arrest management, pregnancy in HCM, smart devices in clinical practice, etc.). Niccolo' will be asking all questions of HCM patients to our patients.

HCM Pills is a series of webcasts organized by the HCM Patient Foundation. The purpose of the webcast is to ask the most burning questions of patients to world-renowned HCM experts who reply to them in a clear and understandable way. Our second guest, Prof. Iacopo Olivotto, is a Professor of Cardiovascular Medicine at the University of Florence and Head of Cardiology, Meyer Children’s Hospital, Florence, Italy. Over the last two decades, his main clinical and research interests have included various aspects of cardiomyopathies, with special focus on hypertrophic cardiomyopathy (HCM), ranging from clinical predictors of disease progression and outcome, arrhythmias, medical and surgical management, advanced imaging and genetic studies, developmental, translational studies addressing cardiac myofilament contractility and cellular electrophysiology. Prof. Olivotto has been involved in drug development, design and execution of randomized studies in genetic cardiomyopathies. He has co-authored over 300 papers in international, peer-reviewed journals. Prof. Olivotto is a co-founder and board member of The Sarcomeric Human Cardiomyopathy Registry (Share) and ICON (International CardiomyOpathy Network).The anchor of HCM Pills is Dr. Niccolo' Maurizi, Chief Resident in Cardiology at CHUV | Lausanne university. Prior to that, he worked as a Researcher at Università degli Studi di Firenze. He co-founded D-Heart, a startup for innovative cardiologic wearable concepts in 2015. He has authored and co-authored almost 100 scientific articles with concentration on HCM-related issues (sudden cardiac arrest management, pregnancy in HCM, smart devices in clinical practice, etc.). Niccolo' will be asking all questions of HCM patients to our patients.