The furture of IBD medicine - Dr. Yasmin Mohseni, CAR T-cell Therapy and beyond

Send us a textIn this episode, we discuss what we would tell our newly diagnosed selves about living with IBD. We emphasize the importance of seeking help early, understanding inflammation, and finding trustworthy resources. We also discuss the role of nutrition in managing IBD and the empowerment that comes from being informed and proactive in one's health journey.Takeaways-- Seek help early so that you have a supportive plan.- Understand that inflammation can exist without symptoms.- Regular monitoring of inflammation is crucial.- Low appetite and weight loss need to be assessed by your provider.- Find trustworthy resources and support systems.- Empower yourself with knowledge about your condition.- Nutrition plays a vital role in managing IBD.- You have a role in your treatment plan.You can find our Flare Guide here: 👇https://crohns-and-colitis-dietitians.thrivecart.com/flare-guide/Chapters:00:00- Navigating the Journey of IBD Diagnosis02:30- The Importance of Seeking Help Early05:27- Finding Trustworthy Resources and Support08:13- Understanding Inflammation and Monitoring Health10:47- The Role of Nutrition in Managing IBD13:53- Empowerment Through Knowledge and Resources16:26- Creating Effective Support Materials for PatientsFollow us on instagram @crohns_and_colitis_dietitiansFollow us on youtube @thecrohnscolitisdietitiansWe love helping provide quality content on IBD nutrition and making it more accessible to all through our podcast, instagram and youtube channel. Creating the resources we provide comes at a significant cost to us. We dream of a day where we can provide even more free education, guidance and support to those with IBD like us. We need your support to do this. You can help us by liking episodes, sharing them on your social media, subscribing to you tube and telling others about us (your doctors, friends, family, forums/reddit etc). Can you do this for us? In return, I promise to continually level up what we do here. 💜 Ashley

Send us a textWe are so excited to have Dr. Yasmin Mohseni back to to talk about the latest advances in the world of immunology! We discuss the recent Nobel Prize awarded for research on regulatory T cells (Tregs) and how they help keep inflammation and autoimmunity in check. We talk about the complexities of autoimmune diseases, particularly Inflammatory Bowel Disease (IBD), and why Tregs play such a big role in keeping the immune system balanced. Dr. Mohseni walks us through some of the most innovative treatments on the horizon, from cell therapies to CAR T-cell approaches, and even how AI might shape the future of medicine. We wrap things up on a hopeful note, looking ahead at where autoimmune treatments are going and why ongoing research matters more than ever.Dr.  Yasmin Mohseni, PhD is an immunologist with 6+ years of experience in the cell and gene therapy biotech space, specializing in immunotherapy for cancer and immunoregulation. Dr Mohseni earned her PhD in Immunotherapy from King’s College London, where she focused on using engineered regulatory T cells (Tregs) to promote immune tolerance in solid organ transplantation with applications to autoimmunity. She began her industry journey at Quell Therapeutics, advancing Treg-based therapies, and now works at A2 Biotherapeutics in the cancer immunotherapy space, developing therapies for solid tumors. Find Dr Yas here: https://www.instagram.com/doctor.yas_/Takeaways-- Tregs are crucial for suppressing inflammation in the immune system.- The Nobel Prize recognition highlights the importance of Tregs in immunology.- Autoimmunity involves a complex interplay of genetic and environmental factors.- Tregs can be dysfunctional in autoimmune diseases, leading to chronic inflammation.- Cell therapy, including CAR T-cells, shows promise for treating autoimmune diseases.- AI is revolutionizing target discovery in immunology and personalized medicine.- The future of autoimmune treatments is hopeful, with ongoing research and innovation.- Understanding the mechanisms of Tregs can lead to better therapeutic strategies.- The balance of immune responses is critical in managing autoimmune diseases.Chapters-00:00- Introduction and Personal Updates03:40- Nobel Prize in Immunology: Tregs and Their Significance10:34- Understanding Autoimmunity and Inflammatory Bowel Disease (IBD)16:12- The Role of Tregs in Autoimmunity21:49- Exploring Cell Therapy and CAR T-Cell Approaches27:26- Future of Autoimmunity Treatments and AI in Medicine46:36- Conclusion and Future PerspectivesFollow us on instagram @crohns_and_colitis_dietitiansFollow us on youtube @thecrohnscolitisdietitiansWe love helping provide quality content on IBD nutrition and making it more accessible to all through our podcast, instagram and youtube channel. Creating the resources we provide comes at a significant cost to us. We dream of a day where we can provide even more free education, guidance and support to those with IBD like us. We need your support to do this. You can help us by liking episodes, sharing them on your social media, subscribing to you tube and telling others about us (your doctors, friends, family, forums/reddit etc). Can you do this for us? In return, I promise to continually level up what we do here. 💜 Ashley

Send us a textWe look at the emerging research linking ultramarathoning to a possible increased risk of colorectal cancer, particularly in individuals with inflammatory bowel disease (IBD). The discussion highlights the importance of hydration, nutrition, and recovery strategies for endurance athletes. Vitamin D and gut health also play an important role in decreasing risks. Takeaways-- Some research suggests that Ultramarathoning may increase the risk of colorectal cancer.- Hydration and nutrition are critical for endurance athletes.- Vitamin D levels should be regularly assessed, especially in athletes.- The gut microbiome can change with extreme endurance activities.- Recovery is essential for preventing long-term damage in athletes.- Training the gut to tolerate nutrition is important for performance.- Repeated extreme endurance events can lead to gut ischemia (lack of blood flow).- Nutrient deficiencies can exacerbate health risks in athletes with IBD.- A tailored approach to nutrition is necessary for athletes with IBD.- Understanding the mechanisms behind gut health can inform better training practices.Chapters:00:00- Introduction to Ultrarunning and Colon Cancer Risk02:37- Exploring the Connection Between Endurance and Colorectal Cancer05:17- The Role of Hydration and Nutrition in Endurance Sports08:07- Nutritional Considerations for Athletes with IBD10:48- The Importance of Vitamin D in Athletic Performance13:38- Understanding the Mechanisms of Gut Damage in Endurance Athletes16:23- The Impact of Recovery on Gut Health19:05- Conclusions and Recommendations for Athletes with IBDFollow us on instagram @crohns_and_colitis_dietitiansFollow us on youtube @thecrohnscolitisdietitiansWe love helping provide quality content on IBD nutrition and making it more accessible to all through our podcast, instagram and youtube channel. Creating the resources we provide comes at a significant cost to us. We dream of a day where we can provide even more free education, guidance and support to those with IBD like us. We need your support to do this. You can help us by liking episodes, sharing them on your social media, subscribing to you tube and telling others about us (your doctors, friends, family, forums/reddit etc). Can you do this for us? In return, I promise to continually level up what we do here. 💜 Ashley

Send us a textIn this podcast we answer a question we got around fear of failure associated with taking medications.  We often talk about a multifaceted approach when treating IBD. It is also important to weight the risk of untreated inflammation against the possible risk of taking medication. Takeaways-- Medication is a valid part of treatment, not a failure.- Diet is often overlooked in discussions about IBD.- IBD is an autoimmune disease that requires comprehensive care.- Fear of medication side effects is common but manageable.- Cultural perceptions of wellness can impact self-acceptance.- A multifaceted approach is essential for effective IBD management.- Nutrition can support and improve outcomes of medical treatment.- Mental health plays a crucial role in managing IBD.- You're not alone; many share similar struggles.Chapters-00:00- Navigating Medication and Self-Forgiveness02:22- The Role of Diet in IBD Management04:56- Understanding the Fear of Medication07:35- Cultural Influences on Health Perception10:18- The Multifaceted Approach to IBD TreatmentFollow us on instagram @crohns_and_colitis_dietitiansFollow us on youtube @thecrohnscolitisdietitiansWe love helping provide quality content on IBD nutrition and making it more accessible to all through our podcast, instagram and youtube channel. Creating the resources we provide comes at a significant cost to us. We dream of a day where we can provide even more free education, guidance and support to those with IBD like us. We need your support to do this. You can help us by liking episodes, sharing them on your social media, subscribing to you tube and telling others about us (your doctors, friends, family, forums/reddit etc). Can you do this for us? In return, I promise to continually level up what we do here. 💜 Ashley

Send us a textIn this podcast, we discuss when it may be time to bring in a dietitian that specializes in IBD. We explore different reasons why someone might consider working with a dietitian, including stress related to food choices, nutritional deficiencies, and the need for long-term management strategies. We talk about the significance of feeling safe in one's body, the role of nutrition in managing symptoms, and the common misconception that IBD nutrition is only about tracking your food triggers.Takeaways-It's crucial to seek help when IBD symptoms are unstable.Stress about food choices can significantly impact well-being.Having a nutritional plan can alleviate stress and improve confidence.Nutritional deficiencies are often overlooked in IBD management.Long-term strategies are essential when managing IBD.Food tracking is not the only solution for managing IBD symptoms.Adding diversity to the diet can help reduce symptoms.Feeling safe in one's body can reduce IBD symptoms.Chapters-00:00- The Importance of IBD-Focused Dieticians02:53- Understanding Food Stress and Safety05:35- Addressing Nutrient Deficiencies in IBD08:04- Long-Term Strategies for Flare-Up Prevention10:57- Connecting Symptoms and Nutrition13:38- Beyond Food Tracking in IBD NutritionFollow us on instagram @crohns_and_colitis_dietitiansFollow us on youtube @thecrohnscolitisdietitiansWe love helping provide quality content on IBD nutrition and making it more accessible to all through our podcast, instagram and youtube channel. Creating the resources we provide comes at a significant cost to us. We dream of a day where we can provide even more free education, guidance and support to those with IBD like us. We need your support to do this. You can help us by liking episodes, sharing them on your social media, subscribing to you tube and telling others about us (your doctors, friends, family, forums/reddit etc). Can you do this for us? In return, I promise to continually level up what we do here. 💜 Ashley

Send us a textThis conversation dives into the often-overlooked topic of lymphocytic colitis, focusing on its unique challenges and the nutrition strategies that can help manage symptoms. We go over the importance of fiber, hydration, and being mindful of gut irritants.Takeaways-- Microscopic colitis is often overlooked in discussions about IBD.- Patients may feel forgotten and have limited treatment options.- Nutrition plays a crucial role in managing symptoms.- Increasing soluble fiber can help bulk stools.- Hydration and electrolytes are essential for those with frequent bowel movements.- Common gut irritants include caffeine, spicy foods, and sugar alcohols.- Not all fibers are the same; many can be beneficial.- Diet-related products often contain hidden sugar alcohols.- Personalized support can be vital for managing symptoms effectively.Chapters-00:00 - Understanding Lymphocytic Colitis04:44 - Nutritional Strategies for Management06:05 - Common Gut Irritants and Their ImpactFollow us on instagram @crohns_and_colitis_dietitiansFollow us on youtube @thecrohnscolitisdietitiansWe love helping provide quality content on IBD nutrition and making it more accessible to all through our podcast, instagram and youtube channel. Creating the resources we provide comes at a significant cost to us. We dream of a day where we can provide even more free education, guidance and support to those with IBD like us. We need your support to do this. You can help us by liking episodes, sharing them on your social media, subscribing to you tube and telling others about us (your doctors, friends, family, forums/reddit etc). Can you do this for us? In return, I promise to continually level up what we do here. 💜 Ashley

Send us a textIn this episode, we talk about the new trend of fiber maxing, exploring its definition, implications, and the balance needed in dietary fiber intake. We emphasize the importance of hydration and talk about the potential side effects of excessive fiber. It is always good to have a mindful and informed approach to dietary changes. Takeaways-- Fiber maxing is a recent trend focused on increasing fiber intake.- There is no clear definition of fiber maxing; it can vary from meeting to exceeding fiber needs.- Extreme dietary trends can lead to negative health effects if not approached mindfully.- Hydration is crucial when increasing fiber intake to avoid digestive issues.- Going low and slow with fiber is recommended for better tolerance.- Fiber intake is linked to reducing the risk of colon cancer.- A balanced approach to fiber intake is essential for gut health.- Listening to your body is important when making dietary changes.- Dietary trends often swing between extremes, highlighting the need for moderation.Chapters:00:00- Introduction to Fiber Maxing02:27- Understanding the Concept of Fiber Maxing05:12- The Balance of Fiber Intake07:50- Recommendations for Fiber Maxing10:17- The Role of Media in Nutrition Trends13:14- The Importance of Moderation and AwarenessFollow us on instagram @crohns_and_colitis_dietitiansFollow us on youtube @thecrohnscolitisdietitiansWe love helping provide quality content on IBD nutrition and making it more accessible to all through our podcast, instagram and youtube channel. Creating the resources we provide comes at a significant cost to us. We dream of a day where we can provide even more free education, guidance and support to those with IBD like us. We need your support to do this. You can help us by liking episodes, sharing them on your social media, subscribing to you tube and telling others about us (your doctors, friends, family, forums/reddit etc). Can you do this for us? In return, I promise to continually level up what we do here. 💜 Ashley

Send us a textIn this podcast we discuss the challenges of navigating evidence-based information in the age of AI. We explore the importance of critical thinking, the role of trust in healthcare, and the impact of misinformation. We encourage patients to advocate for themselves and to question the information they come across, especially in a time where AI can fabricate data. Takeaways-- It's challenging to differentiate between valuable information and misinformation.- AI is designed to provide information that pleases users, which can lead to inaccuracies.- Critical thinking is essential for both healthcare providers and patients.- Mistrust in the healthcare system is growing due to various factors.- Insurance companies often dictate patient care, complicating treatment options.- AI can fabricate citations, making it crucial to verify sources.- Patients should be encouraged to ask questions about their care.Chapters-00:00- Navigating Evidence in the Age of AI02:47- The Role of Trust in Healthcare05:06- The Impact of AI on Research and Writing08:17- Patient Advocacy and Self-Advocacy10:42- The Challenges of Healthcare Systems13:38- Critical Thinking in Research16:02- The Importance of Personal Stories in Healthcare18:38- Building Trust in a Distrustful Environment21:14- Final Thoughts on Navigating InformationFollow us on instagram @crohns_and_colitis_dietitiansFollow us on youtube @thecrohnscolitisdietitiansWe love helping provide quality content on IBD nutrition and making it more accessible to all through our podcast, instagram and youtube channel. Creating the resources we provide comes at a significant cost to us. We dream of a day where we can provide even more free education, guidance and support to those with IBD like us. We need your support to do this. You can help us by liking episodes, sharing them on your social media, subscribing to you tube and telling others about us (your doctors, friends, family, forums/reddit etc). Can you do this for us? In return, I promise to continually level up what we do here. 💜 Ashley

Send us a textDid you know you can be in remission and still have gut symptoms and fatigue? Medications may be addressing the inflammation - but they don't always fully address the symptoms.Sometimes you need to dig deeper with your dietitian on what nutrition related labs to run, looking into if you are fully meeting your needs and coming up with a plan and strategies to address gut symptoms.Takeaways-Remission does not always equate to feeling better.Nutritional deficiencies are common in IBD patients.Fatigue is a prevalent symptom even in remission.Hydration and electrolytes are crucial for energy levels.IBS can complicate the management of IBD symptoms.Energy management is key to improving quality of life.Long-term strategies are necessary for symptom relief for many.Dietary adjustments can help improve tolerance to foods.Follow us on instagram @crohns_and_colitis_dietitiansFollow us on youtube @thecrohnscolitisdietitiansWe love helping provide quality content on IBD nutrition and making it more accessible to all through our podcast, instagram and youtube channel. Creating the resources we provide comes at a significant cost to us. We dream of a day where we can provide even more free education, guidance and support to those with IBD like us. We need your support to do this. You can help us by liking episodes, sharing them on your social media, subscribing to you tube and telling others about us (your doctors, friends, family, forums/reddit etc). Can you do this for us? In return, I promise to continually level up what we do here. 💜 Ashley

Send us a textYou can find our new Flare Guide here: 👇https://crohns-and-colitis-dietitians.thrivecart.com/flare-guide/This podcast explores the critical role of nutrition in managing IBD flare-ups. Ashley and Danielle discuss how dietary choices can truly impact symptoms and overall health. We address common misconceptions about nutrition in IBD and practical strategies for daily life that can be very effective! Takeaways-- Nutrition plays a crucial role in managing IBD flare-ups.- Dietary patterns can increase or decrease the risk of flare-ups.- Symptoms alone are not reliable indicators of what works for IBD.- Nutritional status can affect medication response and healing.- Vitamin D and zinc are important for inflammation reduction.- Many IBD patients struggle with disordered eating or food fears.- Quality of life is a significant concern for those with IBD.- Dietitians can help simplify nutrition information and strategies.- Practical implementation of nutrition is key to success.- Support from professionals can make a significant difference in managing IBD.Chapters:00:00- The Importance of Nutrition in IBD Flare-Ups02:50- Understanding Dietary Triggers and Patterns06:46- Quality of Life and Nutrition09:09- Practical Strategies for Implementing Nutrition11:55- Conclusion: Seeking Support for Nutrition in IBDFollow us on instagram @crohns_and_colitis_dietitiansFollow us on youtube @thecrohnscolitisdietitiansWe love helping provide quality content on IBD nutrition and making it more accessible to all through our podcast, instagram and youtube channel. Creating the resources we provide comes at a significant cost to us. We dream of a day where we can provide even more free education, guidance and support to those with IBD like us. We need your support to do this. You can help us by liking episodes, sharing them on your social media, subscribing to you tube and telling others about us (your doctors, friends, family, forums/reddit etc). Can you do this for us? In return, I promise to continually level up what we do here. 💜 Ashley