The Wholesome Fertility Podcast podcast

EP 308 Can This Natural Compound be the Key to Reversing Your Reproductive Age? Leslie Kenny

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On today’s episode of The Wholesome Fertility Podcast, I speak to longevity expert Leslie Kenny. @lesliesnewprime   Leslie shares her personal journey of overcoming autoimmune diseases and infertility through patient empowerment and alternative therapies. She emphasizes the importance of partnering with doctors and exploring alternative treatments that resonate with individuals. Leslie's story highlights the power of lifestyle changes, such as an anti-inflammatory diet and the use of anti-aging molecules like spermidine in improving health and reversing the aging process.    Our conversation covers the topic of spermidine and its role in healthy aging. Spermidine is a compound found in our diet and produced by our gut biome. It is correlated with healthy lifespan and can be obtained from plants and fermented foods. Our conversation also touches on gluten-free options for spermidine, the importance of fiber in the diet, and the potential benefits of systemic enzymes.    Leslie also shared her personal experience with hypothyroidism and the importance of finding a doctor who will help you uncover solutions for your reproductive health.    Podcast Takeaways:
  • Partnering with doctors and exploring alternative treatments can empower patients to take control of their health.
  • Lifestyle changes, such as an anti-inflammatory diet, can have a significant impact on autoimmune diseases and overall health.
  • Anti-aging molecules like spermidine and rapamycin have the potential to slow down the aging process and improve fertility.
  • Maintaining a balanced hormonal system is crucial for reproductive health and overall well-being.
  • Spermidine can promote cell renewal and recycling. Spermidine is correlated with healthy lifespan and can be obtained from plants and fermented foods.
  • Fiber is important for the gut biome to produce spermidine.
  • Finding a doctor who believes in you and is willing to explore your symptoms is crucial.
  Guest Bio:   Leslie is a longevity expert, and co-founder of the prestigious Oxford Longevity Project, a non-profit that brings scientists together to discuss breakthroughs around the science of ageing and autophagy, which is our body's natural cell recycling system.   www.oxfordhealthspan.com - Use coupon code WHOLESOMELOTUS for 15% off all items!   https://www.instagram.com/lesliesnewprime/ https://oxfordlongevityproject.org       Learn more about my new book “The Way of Fertility” here: https://www.michelleoravitz.com/thewayoffertility   For more information about Michelle, visit: www.michelleoravitz.com   The Wholesome FertilityFacebook group is where you can find free resources and support:   https://www.facebook.com/groups/2149554308396504/   Instagram: @thewholesomelotusfertility   Facebook: https://www.facebook.com/thewholesomelotus/     Transcript:   Michelle (00:00) Welcome to the podcast Leslie.   Leslie Kenny Oxford Healthspan (00:02) Thanks so much for having me, Michelle. It's a pleasure.   Michelle (00:05) So I would love for you to share your story of how you got into the work that you do today. And I know that you're very passionate. We just had a little pre -talk and I'm very excited to get started.   Leslie Kenny Oxford Healthspan (00:14) You   Well, my story is one of patient empowerment, just like you. And it started, as it can with many women, with a fertility quest. So in my mid to late 30s, I really wanted to have a baby and found that I was having problems. So started with IUI, did three of those, didn't work, and then moved on to IVF.   And it was as I was doing my fifth IVF round with donor eggs, I might add, and being mixed race, I'll tell you, it's not easy to find a donor, you know? And it was a high stakes game, as it were. And right before embryo transfer, I began to notice pain in my hands. I was having trouble.   Michelle (00:54) Mm   Leslie Kenny Oxford Healthspan (01:08) using scissors, turning doorknobs, turning faucets. And I just thought, strange, I think this is probably what arthritis feels like. I better just have it checked out since obviously I want this IVF with donor eggs to go perfectly. And I went to the doctor, she ran some tests. I thought, you know, they'd say, you know, it's something, have steroids do something that I'd heard of before. And instead she called me and asked me to have a meeting with her in her office.   Michelle (01:17) Mm   Leslie Kenny Oxford Healthspan (01:38) and always a bad sign, right? If they can't explain it to you over the phone, and if it's not the nurse telling you, there's nothing to worry about. So I went and talked to her and she said, you do have arthritis, it's rheumatoid arthritis. This is where your body is attacking your joints. And here are some pre -filled syringes that you can inject into your belly, they're immune suppressants to basically   Michelle (01:40) Yeah.   Leslie Kenny Oxford Healthspan (02:08) halt your immune system from attacking your body. And, and I immediately said, Hmm, don't I want my immune system to be strong? Like, don't I need that? And she said, well, normally you would, but in this case, it looks like your body is fighting cancer, except you're trying to destroy your own tissues. So I thought, okay, well, fine. Got the drugs. these are tiny diabetic needles. It'll be okay.   And then she said, but you also have something else. You have lupus. And that I'd never heard of. It was almost as if she'd said, you you have funny tree disease or something. It just made no sense to me. I didn't know what it was, had never heard of it. And I said, what's that? And she said, another autoimmune disease. And I said, okay, so what's the prescription for that?   And she said, unfortunately, there isn't a prescription for that. There's really nothing that we have right now to treat it. And you will slowly and progressively get worse. And I said, this is really not a good time for me to have this happen because I'm doing my fifth IVF with donor eggs. I'm waiting for embryo transfer. This is a terrible time. Can't we do something?   something else, anything else? Is there anything I can do? No, there's nothing you can do. Like, could I do my diet, my sleep? No, there's nothing you can do. Well, but what about this round? You know, I've done a lot to tee this up and a lot of money has gone into this. As you probably know, I've put in over a hundred thousand US dollars at this point in time into all of these treatments. And she said, I wouldn't do it. Don't do it.   you have a good five years left. And I thought, okay, well, that's a big statement to make. And I was so gobsmacked by it.   Michelle (04:08) That's crazy.   Wait, wait, She was saying you have five years left to live? Is that what she was saying?   Leslie Kenny Oxford Healthspan (04:16) That's how I interpreted it. That's how I interpreted that if I, if this was successful, if this round was successful, I would only be able to parent this child for five years or four years, I guess, as it were. And I, it was a lot to process. you know, if you're a patient and you're told you have one thing that's a lot to take on, you know, and then you're thinking about.   the treatment protocol and the things you have to do. And I think already, if it's not a tablet to swallow, but you're injecting yourself, that's another big thing to take on board. Then an illness that you've never heard of before where they say there's no treatment, there's no cure, and then she says five years left. I'm thinking in the back of my mind, thinking, have this, I want to become a mother. I have this.   cycle I have to go through, we're going to embryo transfer. My uterus has to be in good shape. What are you doing? What are you saying? How does this impact that? Because I've got acupunctures lined up for embryo transfer, right, before and after. And so I did have at least the presence of mind to say to her, can I, well, could this be a false positive? She said, no, we've done multiple types of tests.   Michelle (05:11) Yeah.   Leslie Kenny Oxford Healthspan (05:35) and they all come back consistently indicating that you have these diseases. So then I said, can I test again? And she said, she shrugged her shoulders and said, sure, it's your insurance. So I vowed then and there that I would test again. And in the meantime, I would do everything possible. didn't matter what it was, whether it was my in uterine massage, which I did, or visualization, which I did.   Michelle (06:00) Mm -hmm.   Leslie Kenny Oxford Healthspan (06:05) or trauma work, which I did, or, you know, new therapy, intravenous immunoglobulin transfusions, which I did, an anti-inflammatory diet. I was gonna do it all. I was gonna throw the kitchen sink at it. And any woman who is trying to get pregnant knows exactly where I was and that feeling of, I've gotta make this happen. And I will just pull out all the stops. We're doing a full court press, right? And...   And so I did all those things and I came back within six months for a regular sort of review with your doctor. She opened the folder and she clearly not looked at the results ahead of time. And she said, well, look at that. You, don't have lupus and you don't have RA. And I said, would you like to know what I did? And she said, no, that's okay.   Michelle (06:54) What?   Leslie Kenny Oxford Healthspan (07:04) And I said, well, that is, you know, that's pretty, that's pretty groundbreaking, right?   Michelle (07:11) Yeah,   Leslie Kenny Oxford Healthspan (07:12) so in any event, I was so, I was so shocked by all of this and, really for me, the penny dropped that doctors don't know everything that we treat them as if they must, that they are the Oracle and that they are the, the guide to whom we can outsource our health problems.   Michelle (07:23) Mm   Leslie Kenny Oxford Healthspan (07:35) But in fact, we have to work in partnership with them. And sometimes they're not willing for insurance or liability reasons to talk about or consider alternative therapies that might work. But we patients have the opportunity to explore those things that resonate with us that might have a meaningful impact. so my journey has really begun   Michelle (07:38) Yes.   Mm   Leslie Kenny Oxford Healthspan (08:04) as a patient advocate, really telling other women, you have more power than you think to move the needle on your health. And as a matter of fact, the things that you do might even be more important than what happens when you go to your acute care doctor, right? When you go into the doctor's office or into a hospital. And it has then...   taken me on a journey all the way to Oxford, England, where I ended up meeting a wonderful group of scientists here, a number of whom I helped fundraise for their companies for, all in the regenerative medicine space, and some of whom I've worked on longevity, healthy longevity advocacy.   other scientists whom I've worked on to bring an interesting anti -aging molecule called spermidine to market. So those are the...   Michelle (09:04) Yes. Is that, that's, that comes from   Leslie Kenny Oxford Healthspan (09:10) We can get it from wheat germ. We can get it from mushrooms. can get it from a huge variety of foods that are all plants. Essentially, if you want spermidine, it's almost exclusively in plants. only animal source is chicken liver, which is ironic because, of course, I remember my mother saying, you have to eat chicken liver. So moms do know, right? They've got a wisdom.   Michelle (09:19) Mm   Mm -hmm.   Yes.   Leslie Kenny Oxford Healthspan (09:36) But it comes from plant sources. We also make it in our tissues. We moms make it in our breast milk. When we give it to our babies, it's there to help them grow. Men, of course, make it in their seminal fluid. is in there because DNA wraps itself around spermidine. And it's very tightly wound.   Michelle (10:00) Mm   Leslie Kenny Oxford Healthspan (10:04) Normally DNA is wrapped around something called histone bond. It's too big to really fit into semen. And it's also there in semen as an anti -inflammatory because it turns out that when men make sperm, it's a high reactive oxygen species event. Women and men can both make it in our gut biome as well. so those would be the main, the three sources would be from our tissue production.   Michelle (10:27) Mm   Leslie Kenny Oxford Healthspan (10:33) And that falls, that declines dramatically similar to the decline in production of estradiol, progesterone, testosterone, melatonin as we get older. And then the second area is the microbiome and then third is from our food.   Michelle (10:51) So interesting. So let's go back and talk about what, what do you think it was specifically that changed? Like, what do you think happened with your body? Because you came into the doctor and you had all the signs that showed that you had two different autoimmune diseases that she could pick up. And then you changed your diet, you changed your lifestyle. You really went through so much. and of course it's hard sometimes to figure out exactly what specifically, but now that you know what you know, and this is   Leslie Kenny Oxford Healthspan (11:03) Yeah.   Yum, yum.   Michelle (11:21) the work that you're doing. What are some of the things that come to mind?   Leslie Kenny Oxford Healthspan (11:22) Hmm.   I went on an anti -inflammatory diet. So one of the first things I did was I researched a lot about both of these illnesses and I could see that inflammation was part of the root cause. And I'd heard about a diet called the Zone Anti -inflammatory Diet. This was popular in the early 2000s. And so I did that and that had a high emphasis on omega -3fatty acids.   on extra virgin olive oil. These are anti -inflammatories. It had a high emphasis on plants. And so my diet changed dramatically from more meat and charcuterie, sort of salami, these types of things over to plants. I also eliminated things which were known to be inflammatory triggers for me. So I had an allergy test done.   I could see that dairy was a problem, gluten was a problem, eggs happened to be a problem, which was a shame because I loved eggs. But we can't eat them every day and think the body won't notice. We have to kind of mix it up and have a diverse diet. So I essentially removed the inflammatory triggers to the immune system. I added in things that were naturally anti -inflammatory, like the omega -3s. And at the same time, when I did the intravenous immunoglobulin,   Michelle (12:44) you   Leslie Kenny Oxford Healthspan (12:50) I reset my immune system and there were studies in, there were small groups of patients with both rheumatoid arthritis and lupus who had done IVIG already in 2004 when I was diagnosed and I could see it work for them and I sort of felt like I have nothing to lose. It's kind of this or I wait for the inevitable.   And I did have people tell me, don't do the IVIG, because this was the time of mad cow disease. And people were quite concerned about prions, these proteins in blood plasma. And they were worried that you might be able to get that or hepatitis C. These were things that had been transmitted through transfusion products previously. But I still felt that, what, five years?   Michelle (13:25) Mm   Leslie Kenny Oxford Healthspan (13:49) I have nothing to lose. So I'm so glad that I did do that. know that everyone has to weigh up the risk -benefit analysis of any new treatment and their own situation. But for me, that was a decision that I made, and I'm so glad I did, because I spent 20, my insurance company spent $24 ,000 US on two transfusions, eight hours in total. And I have   Michelle (13:52) Mm   Leslie Kenny Oxford Healthspan (14:19) Going into remission meant that I have foregone over a million US dollars worth of immune suppressing drugs or chemo drugs because often we autoimmune patients get moved on to methotrexate, which is a chemo drug. I've not had to do any of those over these 20 years. And of course, I also don't live in pain and I don't.   Michelle (14:29) Mm Right.   Leslie Kenny Oxford Healthspan (14:45) live in fear of because I'm suppressing my immune system, I have to avoid social situations where people might have a cold and give it to me and compromise my immune system. So it was a fantastic outcome for me. It's not one I think a lot of people hear about, but I think they should.   Michelle (15:06) for sure. I mean, it's good to hear everything. And I agree with you that everybody has to really assess their own personal situation. I think, I believe in the innate intuition that's kind of like our body's intelligence speaking to us, just like it does when we have an allergy or we feel some things off when we eat something. So I think that that is a really important component to that. And it's the thing that spoke to you when you were at your doctor's office, because it,   Leslie Kenny Oxford Healthspan (15:20) Yeah, agreed.   Yeah.   Michelle (15:36) You could have just said, okay, I'm going to completely bypass any questions that I have and fully just accept everything that I'm given. But something inside of you said, wait, hold up. Let me just do this again. Let me look at this. me think about this. So I really believe in that. think that is so important and important for people to hear because so often we do that. We bypass our own internal judgment and knowing.   You said something important is partnering up with your provider so that it's not an all or nothing. Of course you're going to utilize and you did, you got benefit from getting those tests because that woke you up to doing so many new and amazing things in your own life and implementing a better diet and so on. As far as Omega -3 goes, this is just something that I've been hearing of late.   that some of the supplements go rancid and that it makes it worse. it, have you heard about that?   Leslie Kenny Oxford Healthspan (16:36) Yeah, I've heard that. Yeah, and apparently what you need to do is take this supplement and put it into the freezer. And if it gets cloudy, that is what I've heard is that then that's not good. It's supposed to remain clear throughout. I'm not an omega -3 fatty acid expert. I have lived for a number of years, very nearby one here in Oxford, Professor John Stein.   Michelle (16:45) Mm   Leslie Kenny Oxford Healthspan (17:05) who's done a lot of the research on mental health issues and omega -3s and how important they are for brain health. But yeah, I think, you know, get it from your diet first and foremost. Fatty fish is a great source, right? Yeah. Salmon, if we, you haven't already eaten all of it. Yeah.   Michelle (17:18) Right. Good fish. Yeah.   Wild caught, yeah. Yeah, I know. It's so crazy. Well, also just the mercury in some of the salmon, you know, the chemicals, but wild caught, I always say just.   Leslie Kenny Oxford Healthspan (17:33) Yeah, wild caught. Yeah. And also anchovies, mackerel, sardines, right? The small fish are a really good source of omega -3 fatty acids. And those tend not to have the mercury. Obviously, if we're trying to get pregnant, mercury, definitely not your friend. So yeah.   Michelle (17:38) Sardines, yeah.   Yeah.   Yeah, for sure. I always say, you know, if you're not going to have it when you're pregnant and if you don't have it when you're trying to get pregnant because tuna, for example, they always caution not to have that because of the high mercury, but you don't want that in your system if you're trying to conceive. So for I was very intrigued by your story and I was also intrigued by what you do because when you think about egg quality, sperm quality and really reproduction,   Leslie Kenny Oxford Healthspan (18:02) Yum. Yum.   Hmm.   Michelle (18:18) you think anti -aging, that's like ultimately anti -aging in a nutshell. Like that's really what I do for people that I work with. And it benefits me because I'm like, okay, you know, I'm just going to apply a lot of these things as I learn. it definitely, but that's what it is. It's anti -aging. Like I'm big on meditation, which has also been shown take our clocks back, but food and diet and certain supplements,   Leslie Kenny Oxford Healthspan (18:20) Mm -hmm. 100%. Yeah.   Yeah. Yeah.   Michelle (18:46) can actually shift and slow down your aging or sometimes even like reverse your biological clock. And I know you're the expert in this specific topic. So I'd love for you to talk about that and what has been discovered and seen in this subject.   Leslie Kenny Oxford Healthspan (18:57) Sure.   So when we are at our peak health is when we are reproductively capable. And we visually know this when we go out and we see a woman with glossy long hair, with long eyelashes, with healthy radiant skin, of healthy body weight, we know that that is someone who is   who is really attractive and why are they attractive? Because they are at their reproductive height. And interestingly, all of the things I have described are also linked with your spermidine levels. And so that's quite interesting. But also, your hormones are in perfect balance when you can reproduce and that includes not just the usual female sex hormones,   Michelle (19:36) Mm   Mmm.   Leslie Kenny Oxford Healthspan (20:01) but also your thyroid hormones. So I'm also a Hashimoto's survivor as well. And so I'm a hypothyroid patient and that is also really important. So it's got to be in perfect balance then. And one of the things that happens with some of these anti -aging molecules is that they extend fertility.   Michelle (20:07) Mm   Mm   Leslie Kenny Oxford Healthspan (20:28) partly by reversing your age, but they will start the reproductive cycle back up for some people. And it kind of depends how far away from menopause you are. But we've certainly had clients who've said, what happened? I've been in menopause for two years and I've gotten my cycle back. And...  

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