Cows Producing Human Antibodies for a New Type 1 Diabetes Treatment with Samuel Reich SAB Bio TRANSCRIPT

Samuel Reich, Chief Executive Officer at SAB Bio, is developing a fully human antibody therapy designed to transform type 1 diabetes treatment by preserving patients' beta cells and their ability to produce insulin, rather than just managing symptoms with insulin and glucose monitoring. The drug is produced using the company's bovine platform which uses genetically modified cows to generate human immunoglobulins offering a safer more scalable alternative to rabbit-derived therapies. If successful, this approach could represent a functional cure, potentially transforming type 1 diabetes from a disease requiring daily insulin management to one requiring only periodic infusions. Samuel explains, "Our mission at SAB Bio is to transform what it means to get a type 1 diabetes diagnosis by changing the course of the disease, and not just treating the symptoms, with our new medicine, which is called SAB-142. Why type 1 diabetes? It's a major global unmet medical need that has largely been underserved in research until recently."  "Insulin and glucose monitoring are the standard of care, but they don't treat the disease. They don't treat the patient's illness. They just manage the symptoms and allow the patient to survive. So, they're essential, but they're not helping the patient be healthier or manage the disease process. Our mission is to treat the disease causing type 1 diabetes by saving the patient's beta cells and saving the patient's ability to make their own insulin. And exogenous insulin is no substitute for the patient's own ability to make insulin." "So we have a platform at SAB called the TcBovine, which is a transchromosomal bovine. And these are cows that are healthy and happy cows that look like normal dairy cows, but the cows make human IgG, or human antibodies, instead of cow IgG. And we vaccinate our cows with human thymocytes and purify the IgG from the cow plasma. And our drug is a fully human immunoglobulin, which targets human thymocytes. So, it does what the rabbit drug does, thymoglobulin, but it's human and can be given more safely without making the patient sick, and can be given for the life of the patient to continue to preserve their beta cells for the long term." #SABBio #Type1Diabetes #TD1 #JDRF#Immunology #ClinicalResearch #Endocrinology #AutoimmuneDisease #MedicalInnovation #BetaCells #T1D #HealthcareInnovation #ClinicalTrials sab.bio  Listen to the podcast here

Samuel Reich, Chief Executive Officer at SAB Bio, is developing a fully human antibody therapy designed to transform type 1 diabetes treatment by preserving patients' beta cells and their ability to produce insulin, rather than just managing symptoms with insulin and glucose monitoring. The drug is produced using the company's bovine platform which uses genetically modified cows to generate human immunoglobulins offering a safer more scalable alternative to rabbit-derived therapies. If successful, this approach could represent a functional cure, potentially transforming type 1 diabetes from a disease requiring daily insulin management to one requiring only periodic infusions. Samuel explains, "Our mission at SAB Bio is to transform what it means to get a type 1 diabetes diagnosis by changing the course of the disease, and not just treating the symptoms, with our new medicine, which is called SAB-142. Why type 1 diabetes? It's a major global unmet medical need that has largely been underserved in research until recently."  "Insulin and glucose monitoring are the standard of care, but they don't treat the disease. They don't treat the patient's illness. They just manage the symptoms and allow the patient to survive. So, they're essential, but they're not helping the patient be healthier or manage the disease process. Our mission is to treat the disease causing type 1 diabetes by saving the patient's beta cells and saving the patient's ability to make their own insulin. And exogenous insulin is no substitute for the patient's own ability to make insulin." "So we have a platform at SAB called the TcBovine, which is a transchromosomal bovine. And these are cows that are healthy and happy cows that look like normal dairy cows, but the cows make human IgG, or human antibodies, instead of cow IgG. And we vaccinate our cows with human thymocytes and purify the IgG from the cow plasma. And our drug is a fully human immunoglobulin, which targets human thymocytes. So, it does what the rabbit drug does, thymoglobulin, but it's human and can be given more safely without making the patient sick, and can be given for the life of the patient to continue to preserve their beta cells for the long term." #SABBio #Type1Diabetes #TD1 #JDRF#Immunology #ClinicalResearch #Endocrinology #AutoimmuneDisease #MedicalInnovation #BetaCells #T1D #HealthcareInnovation #ClinicalTrials sab.bio Download the transcript here

Marcus Ionker, Product Line Manager and Messaging Evangelist at Retarus, which is a cloud-based transactional electronic messaging service provider offering fax, SMS, email, and logistics services to regulated industries like healthcare. By moving fax to the cloud, Retarus helps providers and payers reduce administrative costs, improve patient services, and comply with privacy regulations. The company is addressing the critical challenge of providing reliable, secure, and fast messaging to replace outdated physical fax machines and to eliminate paper-based processes in favor of digital workflows.  Marcus explains, "So Retarus is a cloud service provider of what I like to call transactional electronic messaging. So we are talking about fax services, SMS services, email services, as well as even further logistics services. And we do this in many countries, especially in the United States. And a number of those messaging services really play an important role in regulated industries, especially in the healthcare industry, for example." "Email is just not accepted in many of these industries, and that's why fax is still there. And if I may take this opportunity, I think if you do faxing right and if you do it digitally, it makes no difference. It can be an enabler of automated processes, rather than a hindrance." "The paper that we use in the office is when people print emails, not faxes. So no, definitely not. I mean, also, let's keep in mind, a lot of these customers that we offer our service for, they're sending millions and millions of pages every month, and there's no way that you could do that in paper form. So it's coming from an application in a digital form, and quite often on the recipient side is consumed as a digital document, as a PDF or a TIF image, and maybe fed into an AI IDP process immediately. So no, paper often doesn't play a part in this at all." #Retarus #Digitaltransformation #HealthcareCommunications #HealthcareIT #DigitalHealth #CloudFax #HealthcareLeadership #HealthcareInnovation #AdminEfficiency #HealthcareOperations retarus.com  Listen to the podcast here

Marcus Ionker, Product Line Manager and Messaging Evangelist at Retarus, which is a cloud-based transactional electronic messaging service provider offering fax, SMS, email, and logistics services to regulated industries like healthcare. By moving fax to the cloud, Retarus helps providers and payers reduce administrative costs, improve patient services, and comply with privacy regulations. The company is addressing the critical challenge of providing reliable, secure, and fast messaging to replace outdated physical fax machines and to eliminate paper-based processes in favor of digital workflows.  Marcus explains, "So Retarus is a cloud service provider of what I like to call transactional electronic messaging. So we are talking about fax services, SMS services, email services, as well as even further logistics services. And we do this in many countries, especially in the United States. And a number of those messaging services really play an important role in regulated industries, especially in the healthcare industry, for example." "Email is just not accepted in many of these industries, and that's why fax is still there. And if I may take this opportunity, I think if you do faxing right and if you do it digitally, it makes no difference. It can be an enabler of automated processes, rather than a hindrance." "The paper that we use in the office is when people print emails, not faxes. So no, definitely not. I mean, also, let's keep in mind, a lot of these customers that we offer our service for, they're sending millions and millions of pages every month, and there's no way that you could do that in paper form. So it's coming from an application in a digital form, and quite often on the recipient side is consumed as a digital document, as a PDF or a TIF image, and maybe fed into an AI IDP process immediately. So no, paper often doesn't play a part in this at all." #Retarus #Digitaltransformation #HealthcareCommunications #HealthcareIT #DigitalHealth #CloudFax #HealthcareLeadership #HealthcareInnovation #AdminEfficiency #HealthcareOperations retarus.com Download the transcript here

Andrew Hall, CEO of Consano Bio, is developing an allogeneic approach to treat chronic sciatica by activating healing in damaged spinal nerves, emulating the natural healing properties of human platelets.  This condition currently has no approved treatments and is managed through symptomatic approaches like opioids, muscle relaxers, or surgery. Consano Bio's lead candidate represents the first potential disease-modifying therapy for pain management and can be manufactured at scale to treat the estimated 10 million Americans affected by this condition. Andrew explains, "We are developing a potentially disease-modifying treatment that would be given locally for orthopedic painful conditions. The concept is that human platelets are wonderful at eliciting healing in a normal physiological setting. Why can't we create a biologic product that, when given locally, emulates that same functionality where the imbalance has gone bad?"   "I'd call this version one of the first generation of platelet- and plasma-derived biologic therapy. So it runs in the same path. It goes to the same regulators, but it's not so much an evolution as it is a parallel path."   "So chronic sciatica, or when you get fancy with medical terminology, chronic lumbosacral radiculopathy, is basically, and we'll try to keep this PG. I'm a bit Australian and tend to get a little fruity with my language. When you do something silly- wake up, twist, lift the weight badly, bend over- you can pretty easily piss off your spinal nerves, which are the small nerves that come out of your spine and then innervate your extremities."  #ConsanoBIo #Sciatica #BackPain #ChronicPaint #PainTreatment #NonOpioids #LumbosacralRadiculopathy #LSR  #ChronicPain #Biotech #ClinicalTrials #PainManagement #Orthobiologics #DrugDevelopment #HealthcareInnovation #Neurology #MedicalResearch consanobio.com Listen to the podcast here

Andrew Hall, CEO of Consano Bio, is developing an allogeneic approach to treat chronic sciatica by activating healing in damaged spinal nerves, emulating the natural healing properties of human platelets.  This condition currently has no approved treatments and is managed through symptomatic approaches like opioids, muscle relaxers, or surgery. Consano Bio's lead candidate represents the first potential disease-modifying therapy for pain management and can be manufactured at scale to treat the estimated 10 million Americans affected by this condition. Andrew explains, "We are developing a potentially disease-modifying treatment that would be given locally for orthopedic painful conditions. The concept is that human platelets are wonderful at eliciting healing in a normal physiological setting. Why can't we create a biologic product that, when given locally, emulates that same functionality where the imbalance has gone bad?"   "I'd call this version one of the first generation of platelet- and plasma-derived biologic therapy. So it runs in the same path. It goes to the same regulators, but it's not so much an evolution as it is a parallel path."   "So chronic sciatica, or when you get fancy with medical terminology, chronic lumbosacral radiculopathy, is basically, and we'll try to keep this PG. I'm a bit Australian and tend to get a little fruity with my language. When you do something silly- wake up, twist, lift the weight badly, bend over- you can pretty easily piss off your spinal nerves, which are the small nerves that come out of your spine and then innervate your extremities."  #ConsanoBIo #Sciatica #BackPain #ChronicPaint #PainTreatment #NonOpioids #LumbosacralRadiculopathy #LSR  #ChronicPain #Biotech #ClinicalTrials #PainManagement #Orthobiologics #DrugDevelopment #HealthcareInnovation #Neurology #MedicalResearch consanobio.com Download the transcript here

Isobel Handler, Senior Director of Product Management at Kontakt.io addresses critical inefficiencies in clinical exam room utilization.  By capturing data about staff-patient interactions and facility usage, the Kontakt.io platform incorporates real-time location data to optimize patient access, reduce waiting time, and improve staff safety. The solution helps healthcare organizations understand their current capacity utilization before investing in new facilities and supports integration of digital tools to include virtual visits and asychronous communication to better serve patients and reduce clinician burnout.    Isobel explains, "Kontakt.io uses real-time location data, often referred to as RTLS, to improve hospital and clinic operations. We'll talk a lot today about our ambulatory use cases focused on patient access. Still, we also have solutions for inpatient flow, length-of-stay reduction, staff safety, asset tracking, and much more that I won't list. But I think what's really exciting about Kontakt.io is you'll see a lot of RTLS companies in the industry who have built solutions that provide really beautiful blue dots on a map. But at Kontakt.io, we see the opportunity to leverage RTLS beyond that blue dot to produce a set of data that's really well trained and tuned to feed AI models. RTLS data is plentiful, it's machine-generated, it's unbiased, and it doesn't require a human being with a clinical license to enter it. So it produces a lot of really useful information for AI models that are solving some of the top health system problems out there today."   "I think it's an environment that's really ripe for some more data to help us understand what's going on in the exam room, as you pointed out. But a shocking statistic is that most exam rooms are only utilized 33% of the time during standard business hours, which feels incredibly low the first time you hear it. But if you think through the logic of how we get to that utilization rate, the performance actually seems quite intuitive." #KontaktIO #IntelligentOrchestration #HospitalOperations #HealthcareAI #PatientAccess #DigitalHealth #HealthcareInnovation #RTLS #AmbulatoryCare #HealthIT #ClinicianBurnout #HealthcareLeadership  Kontakt.io Listen to the podcast here

Isobel Handler, Senior Director of Product Management at Kontakt.io addresses critical inefficiencies in clinical exam room utilization.  By capturing data about staff-patient interactions and facility usage, the Kontakt.io platform incorporates real-time location data to optimize patient access, reduce waiting time, and improve staff safety. The solution helps healthcare organizations understand their current capacity utilization before investing in new facilities and supports integration of digital tools to include virtual visits and asychronous communication to better serve patients and reduce clinician burnout.    Isobel explains, "Kontakt.io uses real-time location data, often referred to as RTLS, to improve hospital and clinic operations. We'll talk a lot today about our ambulatory use cases focused on patient access. Still, we also have solutions for inpatient flow, length-of-stay reduction, staff safety, asset tracking, and much more that I won't list. But I think what's really exciting about Kontakt.io is you'll see a lot of RTLS companies in the industry who have built solutions that provide really beautiful blue dots on a map. But at Kontakt.io, we see the opportunity to leverage RTLS beyond that blue dot to produce a set of data that's really well trained and tuned to feed AI models. RTLS data is plentiful, it's machine-generated, it's unbiased, and it doesn't require a human being with a clinical license to enter it. So it produces a lot of really useful information for AI models that are solving some of the top health system problems out there today."   "I think it's an environment that's really ripe for some more data to help us understand what's going on in the exam room, as you pointed out. But a shocking statistic is that most exam rooms are only utilized 33% of the time during standard business hours, which feels incredibly low the first time you hear it. But if you think through the logic of how we get to that utilization rate, the performance actually seems quite intuitive." #KontaktIO #IntelligentOrchestration #HospitalOperations #HealthcareAI #PatientAccess #DigitalHealth #HealthcareInnovation #RTLS #AmbulatoryCare #HealthIT #ClinicianBurnout #HealthcareLeadership  Kontakt.io Download the transcript here  

Dr. Steffen-Sebastian Bolz, Founder of QanatPharma, emphasizes the critical role of resistance arteries, microscopic blood vessels that regulate blood flow and pressure throughout the body, in maintaining organ function. Due to their size, these resistance arteries have been overlooked but with new lab techniques, QP is discovering how their dysfunction contributes to heart failure, cognitive impairment and strokes. The company's lead candidate is a repurposed drug already approved for cystic fibrosis that shows promise in restoring brain blood flow and cognitive function in heart failure patients. Steffen-Sebastian explains, "So what we would consider resistance arteries is anything between the capillary level, which would be 10 micrometers, up to, let's say, a few hundred micrometers. And 300 micrometers is the thickness of a blonde hair. That's kind of what we're talking about here. And everything else, and what I talk about in function is what I said before: they can change their diameter. They can open up or close, which large arteries can not do. They are stiff as a garden hose. They are conduits with arteries. They are made to conduct blood at the lowest resistance possible, whereas the small resistance arteries are made to change resistance and regulate flow and pressure."   "As I said, these small resistance arteries and capillaries are everywhere. Every organ has them. And if you compromise the function of those resistance arteries, you compromise blood flow to the capillaries, which actually means that the capillaries don't get enough oxygen. They cannot transport CO2 away from the tissues. They don't get enough nutrients and so on, which then leads to functional damage, which is number one." "And if it persists, if the problem persists, it can also lead to structural damage, which we can actually see. You mentioned the heart. The heart can deal with it, and also the brain can deal with reductions in that flow to a certain extent. But if the reduction in blood flow exceeds a certain limit, you get structural damage. And we see that structural damage. And we call them infarctions in the heart, but also in the brain, which is a stroke." #QanatPharma #VascularBiology #MicrovascularHealth #DrugDiscovery #HeartFailure #CognitiveImpairment #BiotechInnovation #PrecisionMedicine #AIinDrugDiscovery#Microvascular #Neurology #DrugRepurposing #Cardiology #MedicalResearch #ClinicalTrials #Hypertension qanatpharma.com Listen to the podcast here

Dr. Steffen-Sebastian Bolz, Founder of QanatPharma, emphasizes the critical role of resistance arteries, microscopic blood vessels that regulate blood flow and pressure throughout the body, in maintaining organ function. Due to their size, these resistance arteries have been overlooked but with new lab techniques, QP is discovering how their dysfunction contributes to heart failure, cognitive impairment and strokes. The company's lead candidate is a repurposed drug already approved for cystic fibrosis that shows promise in restoring brain blood flow and cognitive function in heart failure patients. Steffen-Sebastian explains, "So what we would consider resistance arteries is anything between the capillary level, which would be 10 micrometers, up to, let's say, a few hundred micrometers. And 300 micrometers is the thickness of a blonde hair. That's kind of what we're talking about here. And everything else, and what I talk about in function is what I said before: they can change their diameter. They can open up or close, which large arteries can not do. They are stiff as a garden hose. They are conduits with arteries. They are made to conduct blood at the lowest resistance possible, whereas the small resistance arteries are made to change resistance and regulate flow and pressure."   "As I said, these small resistance arteries and capillaries are everywhere. Every organ has them. And if you compromise the function of those resistance arteries, you compromise blood flow to the capillaries, which actually means that the capillaries don't get enough oxygen. They cannot transport CO2 away from the tissues. They don't get enough nutrients and so on, which then leads to functional damage, which is number one." "And if it persists, if the problem persists, it can also lead to structural damage, which we can actually see. You mentioned the heart. The heart can deal with it, and also the brain can deal with reductions in that flow to a certain extent. But if the reduction in blood flow exceeds a certain limit, you get structural damage. And we see that structural damage. And we call them infarctions in the heart, but also in the brain, which is a stroke." #QanatPharma #VascularBiology #MicrovascularHealth #DrugDiscovery #HeartFailure #CognitiveImpairment #BiotechInnovation #PrecisionMedicine #AIinDrugDiscovery#Microvascular #Neurology #DrugRepurposing #Cardiology #MedicalResearch #ClinicalTrials #Hypertension qanatpharma.com Download the transcript here