861: Melatonin 101: Anxiety, Sun Exposure, and Sleep Disorders

Wrinkles, Aging, and Youthfulness - In the quest for youthful, radiant skin, a range of cutting-edge treatments and therapies has emerged to combat the signs of aging. From lymphatic massage, which aids in detoxification and reducing inflammation, to LED therapy that stimulates collagen production and reduces fine lines, and finally, PRP treatments with microneedling to enhance skin texture and elasticity — these innovative approaches offer promising solutions for those seeking to turn back the clock on aging skin. Join us as we delve into the science behind these treatments and discover how they can help you achieve a more youthful and vibrant appearance.

Are you fascinated by the molecular science of aging and senescence? In this episode of Beauty Bytes, I am joined by Dr. Frederick Beddingfield III, the CEO of Rubedo Life Sciences, a physician-scientist, and a former senior leader at Allergan. We focus on the cutting edge of longevity and how Rubedo is developing adaptive senotherapeutics to reverse cellular aging and extend healthspan.  Dr. Beddingfield explains the science behind their lead drug, RLS 1496, which targets the enzyme glutathione peroxidase 4 (GPX4) to regulate ferroptosis, an iron-dependent cell death pathway. We discuss how this drug not only eliminates toxic senescent cells but also acts as a "redox reset" for aged cells, reducing their biological age by improving mitochondrial function and autophagy. We also explore their groundbreaking human clinical trials, which demonstrated a 50% reduction in precancerous actinic keratoses in just four weeks without causing skin irritation. Plus, Dr. Beddingfield shares his personal biohacking stack, including low-dose rapamycin, fisetin, and quercetin.  Guest Information:Dr. Frederick Beddingfield III is the CEO of Rubedo Life Sciences. You can learn more about their clinical trials at rubedolifesciences.com or follow him on Instagram and LinkedIn at @FrederickBeddingfield.  

Earplugs, blindfolds, or milk before bed time-if these can’t help you get a good night’s rest, you might turn to for help. But is this really the best way to solve your sleeping issues? That said, you might want to understand the mechanism behind melatonin before jumping into any impulsive decisions. Tune into this week’s Five Minutes Friday to discover the secrets behind melatonin on the market!

In this episode of Beauty Bytes with Dr. Kay: Secrets of a Plastic Surgeon, I am joined by Dr. Koji Tanabe, a leading stem cell scientist, founder and CEO of iPeace, and one of the researchers behind the landmark development of human induced pluripotent stem cells, or iPSCs. Dr. Tanabe breaks down the science of Yamanaka factors and explains how mature cells can be reprogrammed into a younger, pluripotent state with the ability to develop into many different cell types. We explore how iPSC technology differs from traditional stem cells, PRP, exosomes, and other regenerative treatments, as well as why creating and quality-checking these cells outside the body may offer important advantages over attempting cellular reprogramming directly inside the body. Dr. Tanabe also shares how iPSC-derived cells are being explored in regenerative applications involving heart failure, Parkinson’s disease, spinal cord injury, and other areas of medicine. We dive into the future of personalized cell banking, why he believes it may be beneficial to preserve cells while you are healthy, and how iPSC-derived factors, or iPSF, are being explored for skin rejuvenation, hair restoration, and systemic longevity treatments. The iPSF treatments discussed in this episode are currently available only in Japan and are not available in the United States at this time due to differences in regulatory standards. From cellular aging and DNA mutations to epigenetic clocks, regenerative medicine, and the difference between lifespan and healthspan, this conversation offers a fascinating look at how cellular reprogramming could change the way we approach aging, disease, and the future of personalized medicine.Clarification: During the discussion of iPSC-derived therapies for heart failure, the conversation referenced the possibility of creating patient-specific, autologous iPSC-derived cells. The currently approved application discussed in this episode is allogeneic, not autologous. Dr. Tanabe was referring to the potential for iPSC technology to be developed for personalized autologous applications.Guest Information: Dr. Koji Tanabe is a stem cell scientist and the founder and CEO of iPeace. He spent eight years conducting research at Kyoto University in Nobel laureate Dr. Shinya Yamanaka’s laboratory and was the second author on the landmark 2007 paper describing the generation of human induced pluripotent stem cells. His work focuses on cellular reprogramming, regenerative medicine, personalized iPSC manufacturing, and the potential use of iPSC technology in longevity and future cell-based therapies. Check them out at: https://ipeace.com/en/ or @mypeace_ips.

In this Five-Minute Friday episode, Dr. Kay discusses Khloé Kardashian's recent admission about her cosmetic procedures, including a nose job and past facial fillers. This candid revelation offers a much-needed breath of fresh air in an industry often fueled by denial and curated perfection.Explore how the Kardashian aesthetic has influenced beauty standards for over a decade, and the consequences of denying cosmetic enhancements. Dr. Kay emphasizes that this transparency is crucial for fostering healthier conversations around beauty, allowing individuals to differentiate between naturally achievable looks and medically enhanced ones. Learn why honesty from public figures can empower young people, reduce societal pressure, and pave the way for a more authentic and liberating approach to beauty.

Are you wondering why ADHD can feel so different for women, especially during perimenopause and other major hormonal transitions? In this episode of Beauty Bytes with Dr. Kay: Secrets of a Plastic Surgeon, I am joined by Dr. Jolene Brighten, a women’s health expert, author, and hormone specialist, to break down the complex relationship between ADHD, estrogen, dopamine, brain energy, and inflammation. Dr. Brighten explains why ADHD is not simply an inability to focus, but a disorder of attention regulation and executive function, and why symptoms can become more noticeable as hormones begin to fluctuate. We dive into the role of estrogen in dopamine, serotonin, acetylcholine, and norepinephrine signaling, as well as the emerging connection between ADHD and mitochondrial dysfunction. Dr. Brighten also discusses why perimenopause can intensify brain fog, forgetfulness, emotional reactivity, sleep disruption, and difficulty concentrating, and how neuroinflammation and declining brain energy may contribute. We also explore practical strategies for supporting the ADHD brain, including exercise, protein intake, blood sugar regulation, sleep optimization, magnesium, creatine, saffron, and other nutrients that may support cognitive function. From GLP-1 medications and thyroid health to stress, sleep, and lifestyle habits, this conversation looks at ADHD through a whole-body lens and gives women a clearer understanding of why their brain may feel different at different stages of life.Guest Information: Dr. Jolene Brighten is a women’s health expert, author, and host of The Dr. Brighten Show. Her upcoming book, ADHD in Women, explores how female hormones influence ADHD symptoms across the lifespan. You can find her online at @DrJoleneBrighten and learn more about her work at drbrighten.com.

Are you noticing more hair in your shower drain or hairbrush this summer and wondering if it is time to panic? In honor of National Hair Loss Awareness Month, this Five Minute Friday episode of Beauty Bytes breaks down everything you need to know about your hair's natural shedding cycle.  I explain exactly how to tell the difference between normal seasonal shedding, damage-induced hair breakage from chlorine and tight ponytails, and true progressive hair loss. We discuss why getting a comprehensive blood panel is the absolute first step you must take, including the specific hormone and ferritin levels your body requires to actually grow hair. Finally, I share my top regenerative and medical treatments for rescuing your follicles—from PRP microneedling and KeraFactor serums to oral minoxidil and dual-wavelength red light therapy.  

Are you looking to optimize your skin health from the inside out? In this episode of Beauty Bytes, I am joined by Dr. Mark Tager, a physician, integrative aesthetics educator, and co-founder of the Vagal Nerve Society. Dr. Tager has authored 12 books, including Feed Your Skin Right and Integrative Aesthetics, and brings decades of expertise in personalized nutrition and regenerative medicine. We explore the true meaning of integrative aesthetics, noting that 5 to 10% of your blood flow goes to your skin, making internal nutrition the ultimate foundation for beauty.  We dive deep into the gut-skin connection, exploring how the standard American diet glycates your collagen and why maintaining a healthy microbiome with dietary fiber is essential for producing neurotransmitters. Dr. Tager also breaks down the incredible science of the vagus nerve, explaining its role in the body's inflammatory reflex and how tools like 4-7-8 breathing and the Truvaga transcervical device can calm a "wired and tired" nervous system. Finally, we discuss the "wild west" of peptides, the importance of genetic testing for personalized supplementation, and the psychological hardiness required for a long, passionate life.  Guest Information:Dr. Mark Tager is the CEO of ChangeWell and an expert in integrative aesthetics. You can find his books on Amazon or connect with him on LinkedIn and Instagram at @DRMTager. 

Lipid Barrier Repair, Dryness, Inflammation - Join us in this week's podcast episode as we discuss the impact of summer heat on the skin, particularly focusing on issues such as dryness, irritation, and barrier disruption. We explain the importance of maintaining the skin's hydro lipid barrier, which acts as a protective layer against environmental aggressors. With summer coming to a close, we offer practical advice on how to care for the skin after these hot months, including the benefits of moisturizing soaks, the use of ceramide-rich products, and the importance of avoiding over-exfoliation. From the role of diet to end-of-summer chemical peels, we provide a comprehensive guide to maintaining a healthy skin barrier to rejuvenate and repair sun-damaged skin as we step into fall!

Are you ready to discover the next massive breakthrough in skincare and immunology? In this episode of Beauty Bytes, I am joined by Dr. Jocelyn Strand, a naturopathic physician and the Vice President of Clinical Education and Research at BWH Labs. Dr. Strand breaks down the incredible, largely untapped science behind beta glucan, a complex polysaccharide molecule that acts as a powerful biological signal for your innate immune system.  We dive deep into why the skin should be viewed as an immune organ and how specific 1,3/1,6 beta glucan molecules—isolated from yeast cell walls—perfectly bind to pattern recognition receptors on our immune cells. Dr. Strand explains the fascinating concept of "trained immunity," where beta glucan creates functional epigenetic changes that awaken and coordinate our first responder cells, creating a broader, more efficient readiness against environmental stressors. We also discuss how applying beta glucan topically can accelerate wound healing after cosmetic procedures, instantly soothe severe sunburns, improve overall barrier hydration, and clear out damaged tissue caused by inflammaging.  Guest Information:Dr. Jocelyn Strand is a naturopathic physician and the VP of Clinical Education and Research at BWH Labs. You can explore her research and clinical education at bwhlabs.com or find consumer beta glucan products at BetterWayHealth.com.