E219 - Sodium valproate: balancing benefits and risks especially in people of childbearing potential

Jo Cheah talks to dermatologist Belinda Welsh about her article on acne vulgaris. Belinda discusses the chronic inflammatory nature of acne and the substantial psychosocial burden if it is inadequately untreated. She discusses the different treatments available and shares practical tips for daily skincare routines and ensuring long term adherence to treatment. Read the full article in Australian Prescriber.

Dhineli Perera chats with dentist Smitha Sukumar about the use of antibiotic prophylaxis for dental procedures. They discuss the updated recommendations in Therapeutic Guidelines: Oral and Dental, including when antibiotic prophylaxis is indicated and considerations for immunocompromised patients. Read the full article in Australian Prescriber.

Dhineli Perera speaks with infectious diseases physician Josh Davis about the management of acute COVID-19 in the community. They discuss the major risk factors for severe disease, the evidence behind oral antiviral therapies, and the patients most likely to benefit from treatment. Read the full article in Australian Prescriber.

Dhineli Perera talks to neurologist Dan McLaughlin about the benefits and risks with sodium valproate, especially in people of childbearing potential. Dan outlines the evolving landscape of valproate prescribing in Australia, its adverse effects, and recent controversies surrounding potential teratogenesis linked to paternal use. Read the full article in Australian Prescriber.

Laura Beaton speaks with gastroenterologist Nicholas Talley about his paper on the diagnosis and management of irritable bowel syndrome (IBS). Nick outlines the clinical features associated with IBS and potential investigations. The conversation also covers a holistic approach to care, including diet, medications and psychological therapies. Read the full article in Australian Prescriber.

Jo Cheah talks to Jo Gross, consultant pharmacist, about her paper on emergency contraception. They discuss the types of emergency contraception available in Australia, factors that influence drug choice, and key considerations for history taking and counselling. Read the full article in Australian Prescriber.

Justin Coleman chats with nephrologist Karen Dwyer about her paper on cardiovascular-kidney-metabolic (CKM) syndrome. Karen outlines the underlying conditions, pathophysiology, and stages of progression associated with CKM syndrome. The conversation also covers the importance of managing CKM syndrome with both behavioural and lifestyle modifications as well as medications. Read the full article in Australian Prescriber.

David Liew speaks to haematologist Cecily Forsyth about her paper on vitamin B12 testing and treating deficiency. They discuss the causes, notable risk factors, and clinical signs and symptoms of B12 deficiency. Cecily also outlines testing as well as management strategies for patients diagnosed with B12 deficiency, and the importance of long-term adherence with B12 replacement. Read the full article in Australian Prescriber.

Therapeutic Guidelines expert group member Lee Fong returns to the podcast to talk to Justin Coleman about the brand-new Kidney and Urinary guidelines. Focusing on GP management, the conversation covers some of the new content, including screening and medication regimens for chronic kidney disease, lower urinary tract symptoms, wetting in children and much more.

Laura Beaton talks to hepatology research fellow Richard O'Halloran about his paper on metabolic dysfunction–associated fatty liver disease (MAFLD). Richard outlines risk factors and comorbidities to consider, and diagnostic tests for MAFLD. The conversation also covers management of MAFLD through risk stratification, addressing health risk behaviours, and surveillance. Read the full article in Australian Prescriber.