Hepcidin Pathway and Pancreatic Ductal Adenocarcinoma

In this episode, Kevin C. Klatt, PhD, RD (he/him) speaks with Section Editor Nancy Krebs MD MS, and Stephanie Waldrop MD MPH, both from the Section of Nutrition at the University of Colorado Anschutz Medical Center. Drs Kreb and Waldrop discuss their recent publication, the inaugural case in the new “Nutrition for the Clinician” series, detailing a case of a pediatric patient presenting with SARS-CoV-2 (COVID-19) and additional unexplained symptoms that resulted in consulting the nutrition team. Drs Kreb and Waldrop discuss the events leading up to their consultation, their approach to assessment and diagnosis of the patient, and ultimate intervention and monitoring. The case contains numerous teaching points, including nutritional adequacy on a ketogenic diet and the challenges of nutrition assessment. Relevant Links:A perform storm in a pandemic - Case StudyInformation on claiming CME creditBe sure to connect with us! AJCN: @AJCNutrition; Dr. Klatt: @kcklatt. Find all of the publications from the American Society for Nutrition (@nutritionorg; @jnutritionorg) at our website: https://nutrition.org/publications/.

In this episode, Kevin C. Klatt, PhD, RD (he/him) speaks with Editor In Chief Christopher Duggan MD MPH, Section Editor Nancy Krebs MD MS, and Early Career Editor Cora Best PhD MHS RD about the newly launched section of the American Journal of Clinical Nutrition titled “Nutrition for the Clinician”. Drs Duggan, Krebs and Best discuss the impetus for launching this new case study series and tips for prospective authors. Relevant Links:Introductory Editorial for the seriesInformation on claiming CME creditInformation for prospective authorsBe sure to connect with us! Dr Best, @CoraMBest; AJCN: @AJCNutrition; Dr. Klatt: @kcklatt. Find all of the publications from the American Society for Nutrition (@nutritionorg; @jnutritionorg) at our website: https://nutrition.org/publications/.

In this episode, Early Career Editor Kevin C. Klatt, PhD, RD speaks with Briana Stephenson, PhD (she/her/hers), an Assistant Professor in the Departments of Biostatistics at the Harvard TH Chan School of Public Health, about her recent publication, “Racial and ethnic heterogeneity in diets of low-income adult females in the United States: results from National Health and Nutrition Examination Surveys from 2011 to 2018” in the American Journal of Clinical Nutrition. Dr Stephenson discusses her research on robust profile clustering as an extension of latent class models to define dietary patterns in population subgroups, focusing in this analysis on low-income female adults to identify racial and ethnic differences in dietary patterns. As Dr Stephenson noted (as of March 2022), she is currently recruiting a postdoc in Statistical Methods in Population Health Disparities research.Be sure to connect with us! Dr Stephenson, @BJKstephenson; AJCN: @AJCNutrition; Dr. Klatt: @kcklatt. Find all of the publications from the American Society for Nutrition (@nutritionorg; @jnutritionorg) at our website: https://nutrition.org/publications/.

Happy 2023 from everyone at the American Journal of Clinical Nutrition! In this episode, our Early Career Editor Kevin C. Klatt, PhD, RD chats with AJCN Editor in Chief, Christopher Duggan MD, MPH,  and Academic Editor, Deirdre (DeeDee) Tobias, ScD, as they all reflect on the past year at AJCN and dive into some our top papers for the year.Find more about Drs. Duggan and Tobias, and all of our editors: https://ajcn.nutrition.org/editorialboardPapers discussed in this episode:A link to the top cited and top Altmetric papers at AJCN in 2022 can be found at the following link: https://tinyurl.com/4n4tpstb.Be sure to connect with us on twitter ( Dr. Tobias:@deirdre_tobias; AJCN: @AJCNutrition; Dr. Klatt: @kcklatt. Find all of the publications from the American Society for Nutrition (@nutritionorg; @jnutritionorg) at our website: https://nutrition.org/publications/.

In this episode, Early Career Editor Kevin C. Klatt, PhD, RD speaks with Harry Jarrett, PhD, Helene McNulty, PhD, RD, MRIA and Mary Ward, PhD, RD about their recent publication, “Vitamin B6 and riboflavin, their metabolic interaction and relationship with MTHFR genotype, in adults aged 18-102 years” in the American Journal of Clinical Nutrition. The authors discuss the rationale for looking at Vitamin B2 and B6 status marker interactions, including MTHFR genotype, and provide epidemiological evidence in support of riboflavin functional status (the erythrocyte glutathione reductase activation coefficient or EGRAC) being a determinant of Vitamin B6 (PLP) status.  Paper Discussed in this Episode:Vitamin B6 and Riboflavin, Their Metabolic Interaction and Relationship With MTHFR Genotype, in Adults Aged 18-102 YearsRiboflavin offers a targeted strategy for managing hypertension in patients with the MTHFR 677TT genotype: a 4-y follow-up  Be sure to connect with us! AJCN: @AJCNutrition; Dr. Klatt: @kcklatt. Find all of the publications from the American Society for Nutrition (@nutritionorg; @jnutritionorg) at our website: https://nutrition.org/publications/. 

In this episode, Dennis M. Bier MD Young Career Editor Kevin C. Klatt, PhD, RD speaks with a Christopher Gardner, PhD, and Matthew Landry, PhD, RD about their new study published in the American Journal of Clinical Nutrition titled “Effect of a ketogenic diet versus Mediterranean diet on glycated hemoglobin in individuals with prediabetes and type 2 diabetes mellitus: The interventional Keto-Med randomized crossover trial”. In this Episode, Drs Gardner and Landry detail the rationale for undertaking this trial and its design, the challenges in both improving and assessing adherence in free-living diet assignment trials, and the nuances in accounting for medication changes in dietary intervention studies.  Be sure to connect with us! AJCN: @AJCNutrition; Dr. Klatt: @kcklatt; Dr Gardner, @GardnerPhD; Dr Landry, @TheGuyititian.. Find all of the publications from the American Society for Nutrition (@nutritionorg; @jnutritionorg) at our website: https://nutrition.org/publications/. 

In this episode, Dennis M. Bier MD Young Career Editor Kevin C. Klatt, PhD, RD speaks with a distinguished team of authors about their recent work published in the American Journal of Clinical Nutrition titled “Metagenomic profile of the fecal microbiome of preterm infants consuming mother's own milk with bovine milk-based fortifier or infant formula: a cross-sectional study”. In this episode, we dive into the rationale for this newest work examining the relationship between the mode of feeding for preterm infants and the metagenomic potential of their microbiome, as well as discussing emerging methods for characterizing the microbiome composition and function and the challenges of identifying how environmental factors influence this. Be sure to connect with us! AJCN: @AJCNutrition; Dr. Klatt: @kcklatt. Find all of the publications from the American Society for Nutrition (@nutritionorg; @jnutritionorg) at our website: https://nutrition.org/publications/.

In this episode, Dennis M. Bier MD Young Career Editor Kevin C. Klatt, PhD, RD speaks with Mark A. Levine, MD, Section Chief of the Molecular and Clinical Nutrition Section of the Digestive Disease Branch at the National Institutes of Health. Dr. Levine’s laboratory conducts basic, translational and clinical research to better understand Vitamin C kinetics in health and disease and its potential role in disease prevention and treatment. In this episode, Dr. Levine details his groups’ recently accepted publication titled “Abnormal urinary loss of vitamin C in diabetes: prevalence and clinical characteristics of a vitamin C renal leak”, detailing the pharmacokinetics of vitamin C during depletion-repletion studies in individuals with diabetes and non-diabetic controls, defining evidence for a vitamin C renal leak in diabetes and clinical predictors of such a phenomenon.Be sure to connect with us on twitter! NIH: @NIHClinicalCntr @NIDDKgov; AJCN: @AJCNutrition; Dr. Klatt: @kcklatt. Find all of the publications from the American Society for Nutrition (@nutritionorg; @jnutritionorg) at our website: https://nutrition.org/publications/.

In this episode, Dennis M. Bier MD and Young Career Editor Kevin C. Klatt, PhD, RD speaks with Dylan McKay, PhD, Assistant Professor of Food and Human Nutritional Sciences at the University of Mannitoba and senior author of the recently published AJCN manuscript, “Genosets for APOE and CYP7A1-rs3808607 variants do not predict LDL cholesterol lowering upon intervention with plant sterols in a randomized, double-blind, placebo-controlled trial”. In this episode, we dive into the potential to predict LDL-lowering through a nutraceutical intervention (i.e. plant phytosterols) using genetic variants and more broadly, discuss the emerging field of nutrigenetics and the need for rigor and application of gold-standard clinical trial designs in the field. Be sure to connect with us on twitter Dr. MacKay: @DylanMacKayPhD; AJCN: @AJCNutrition; Dr. Klatt: @kcklatt. Find all of the publications from the American Society for Nutrition (@nutritionorg; @jnutritionorg) at our website: https://nutrition.org/publications/.

In this episode, Dennis M. Bier MD Young Career Editor Kevin C. Klatt, PhD, RD speaks with first author, Sachelly Julián-Serrano and leader author, Rachael Z Stolzenberg-Solomon, of the recently published AJCN manuscript “Hepcidin-regulating iron metabolism genes and pancreatic ductal adenocarcinoma: a pathway analysis of genome-wide association studies”. In this episode, we dive into genetic epidemiology approaches, iron metabolism, and the risk of PDAC with our 2 guest authors from the Division of Cancer Epidemiology and Genetics at the National Cancer Institute.Be sure to connect with us on twitter ( Sachelly Julián-Serrano: @sachellyjs; AJCN: @AJCNutrition; Dr. Klatt: @kcklatt. Find all of the publications from the American Society for Nutrition (@nutritionorg; @jnutritionorg) at our website: https://nutrition.org/publications/.