Peripheral Blood Gene Expression and Scleroderma Lung Disease

In this episode, Dr. Shervin Assassi discusses a secondary analysis of the SENSCIS trial, exploring how peripheral blood gene expression may predict response to mycophenolate in systemic sclerosis–associated lung disease. He highlights key findings linking immune and metabolic gene signatures, as well as C-reactive protein, to changes in lung function, and considers their potential role in guiding treatment and clinical trial design. The episode also touches on his career journey and insights into leadership, mentorship, and sustaining research productivity.  Peripheral Blood Gene Expression Profiling and Prognostic Significance for the Course of Interstitial Lung Disease in Patients With Systemic Sclerosis 

In this episode, we speak with Dr. Sasha Bernatsky about her research on the relationship between exposure to fine particulate air pollution and the development of systemic autoimmune rheumatic diseases. She explains what fine particulate matter is, how her team used large population datasets to study environmental exposures, and what their findings suggest about the potential health impacts of air pollution. The conversation also explores the challenges and limitations of studying environmental risk factors, what comes next for this line of research, and Dr. Bernatsky's reflections on building a career in rheumatology and epidemiology, mentoring the next generation of scientists, and staying resilient through the inevitable setbacks of scientific work.  Systemic Autoimmune Rheumatic Disease Risk: Association With Long-Term Exposure to Fine Particulate Matter 

In this episode, Dr. Elizabeth Volkmann discusses emerging research on the gut microbiome in systemic sclerosis, building on findings from early-diagnosis and prior microbiome studies. She explains her team's analysis of microbiome-derived metabolites, including short-chain fatty acids, and their potential role in symptom development, highlighting key findings, clinical implications, and study limitations. The conversation also touches on holistic patient care, international collaboration, and her perspective on the future of systemic sclerosis research and treatment.  Characterization of the Fecal Metabolome in Patients With Early Systemic Sclerosis 

In this episode, Dr. Madeline O'Sullivan discusses her retrospective study of U.S. veterans in the Veterans Health Administration, examining outcomes among patients with rheumatoid arthritis treated with immune checkpoint inhibitors for cancer. She explains how the cohorts were defined, how use and timing of immunosuppressive therapies were analyzed, and how mortality and cause of death were determined. Dr. O'Sullivan summarizes the patient population, cancer types represented, and key findings on survival differences between RA and non-RA groups, as well as insights from secondary analyses and important study limitations. She also reflects on balancing research with clinical training, the mentorship that supported her work, lessons learned, and practical advice for trainees aiming to complete and publish research projects. 

In this episode, we speak with Dr. Jayne MacMahon about an international collaborative study in juvenile dermatomyositis (JDM) involving pediatric rheumatology centers in Genoa, Italy, and Toronto, Canada. She discusses the study's motivation, key disease activity measures, treatment targets, and definitions of remission, along with major findings on time to remission, steroid exposure, and treatment outcomes across cohorts. Dr. MacMahon also reflects on the study's limitations, future research directions, her career path in pediatric rheumatology, and how international collaboration can shape the future of care for children with autoimmune diseases.  Toward a Treat-to-Target Strategy in Juvenile Dermatomyositis: What Are the Suitable Targets and Optimal Timing of Their Achievement?   

In this episode, we sit down with Dr. Evelyne Vinet about a new study examining whether TNF inhibitors increase the risk of serious infections during pregnancy among women with chronic inflammatory diseases. Using large real-world data from the MarketScan database, the discussion explores how pregnancy, inflammatory disease, TNF inhibitor exposure, and serious infections were defined, how confounders were addressed, and what the data reveal across pregnancy and the postpartum period. Dr. Vinet also reflects on study limitations, the impact of COVID-19, and her broader work on pregnancy outcomes and long-term child health in rheumatic diseases, offering insights for clinicians and researchers alike.  Tumor Necrosis Factor Inhibitors and Risk of Serious Infections in Pregnant Women With Chronic Inflammatory Diseases 

In this episode, we explore why rheumatoid arthritis matters to the broader public, with a focus on difficult-to-treat RA (D2T-RA)—what it is, how often it occurs, and why early identification is critical. Our guest demystifies common RA research terms and outcome measures, introduces the real-world data sets behind the study, and explains—in plain language—how a predictive model was developed using modern statistical tools. We discuss the key risk factors for D2T-RA, including which findings were surprising, as well as the study's major strengths and limitations. The conversation wraps up with thoughts on how this work may shape future research, the potential role of AI in risk modeling, and practical advice for early-career researchers on balancing productivity and sleep. 

In this episode, we speak with a leading investigator in large-vessel vasculitis, Dr. Anne Bull Haaversen, to clarify the full spectrum of giant cell arteritis (GCA), including its aortic involvement. We reviewed the prevalence of GCA-related aneurysms, why the team compared ultrasonography with other imaging modalities, and how the ascending aorta can be assessed with ultrasound. Our Dr. Haaversen summarizes the study design, key findings, and limitations, and reflects on how these results may inform future guidelines. We close by discussing the evolution of their research focus on large-vessel imaging and how rheumatologists can balance advanced diagnostics with empathetic patient care. 

In this episode, we sit down with Dr. Aaron Smith to explore why the rheumatology community urgently needs stronger grounding in aging principles and more adaptable care strategies for older adults living with rheumatic conditions. Dr. Smith walks us through his innovative research examining the attitudes and perspectives of healthcare professionals, explains how tools like the ERA-12 help illuminate key patterns, and shares what his team learned about how clinicians approach the care of aging patients. He discusses which findings surprised him, what limitations shaped the study, and how this work opens new directions for future investigation. Near the end, Dr. Smith offers practical takeaways clinicians can apply right away and reflect on his own early-career journey—including what he hopes to accomplish between fellowship and the far future stages of his career. 

In this episode, we sit down with Dr. Sandra Pinho, Assistant Professor in the Department of Pharmacology and Regenerative Medicine at the University of Chicago, to explore the fascinating intersection of stem cell biology, aging, and the bone marrow niche. From her early days studying biology in Portugal to groundbreaking research in London and New York, Dr. Pinho shares her scientific journey and the mentors who shaped her career. In a conversation that begins with Halloween monsters and ends with cutting-edge aging research, we uncover how megakaryocytes—cells best known for making platelets—play surprising roles in immune regulation and the aging process. Dr. Pinho discusses how changes in these cells can influence immune balance, contribute to age-related dysfunction, and even hint at new therapeutic strategies for healthy aging. Blending curiosity, science, and a touch of the spooky, this episode offers both personal insight and a deep dive into the hidden dynamics of our "spooky skeletons."