Many Cities Fear the ‘Doom Loop.’ St. Louis is in One.

Before Ozempic, Wegovy, Mounjaro and Zepbound, there was Lotte Bjerre Knudsen. In the 1990s, the young scientist at the Danish drug company Novo Nordisk was trying to unlock the key to a new technology for treating Type 2 diabetes. To her bosses, Lotte’s project, which focused on a hormone called GLP-1, looked like a distraction.  But as Lotte fought to save her diabetes project from the chopping block, she couldn’t have imagined how much of an impact her breakthrough would have. Her work would pave the way for a hit drug called Ozempic. And it would unleash a new class of blockbuster drugs, pitting two companies in a race to become the world’s first trillion-dollar pharmaceutical company by market cap. Listen to Part 1 of “Trillion Dollar Shot” now. Learn more about your ad choices. Visit megaphone.fm/adchoices

WSJ’s Julie Wernau wanted to test a hypothesis: are there more mentally ill homeless people now, compared to before the pandemic? That question led her to Rob Dart. Once a successful lawyer, in 2022 he went into a downward spiral, which his family has not been able to stop despite their best efforts. Further Reading: - A Lawyer Abandoned Family and Career to Follow the Voices in His Head  - A Lawyer’s Slide Into Psychosis Was Captured in a WSJ Profile. He Tells Us His Story.  Further Listening: - America's Maternal Mental Health Crisis  - Evicted on Wood Street: California's Housing Crisis  Learn more about your ad choices. Visit megaphone.fm/adchoices

Starbucks has a problem: Sales at U.S. stores have fallen sharply and now the company is looking to China, its second biggest market, to boost its revenue. But as WSJ’s Spencer Jakab explains, increased competition there is making that a tall order.  Further Reading: -Starbucks Is Running Out of Americans to Drink Its Expensive Coffee  -The Furious Race for the Future of Coffee Further Listening: -The Underdog Coffee Bean That’s Making a Comeback  Learn more about your ad choices. Visit megaphone.fm/adchoices

London and Dubai's international airports have become conduits for billions of dollars of illicit funds, potentially linked to corruption, drug trafficking and other crimes. WSJ's Margot Patrick explains how couriers in one money-laundering operation transported millions in dirty money on flights. Further Reading: - Billions in Dirty Money Flies Under the Radar at World’s Busiest Airports  Further Listening: - How The Government Tied One Couple to Billions in Stolen Bitcoin  Learn more about your ad choices. Visit megaphone.fm/adchoices

Tesla announced last week that it’s laying off the team responsible for the biggest electric-vehicle charging network in the U.S. The move comes as consumer demand for EVs is dwindling. WSJ’s Jennifer Hiller reports on how the layoffs shocked the industry and how the change will impact efforts to build out a national EV charging network. Further Reading: -Tesla Is Pulling Back From EV Charging, and People Are Freaking Out  -As Electric-Vehicle Shoppers Hesitate, Hybrid Sales Surge  Further Listening: -Money, Drugs, Elon Musk and Tesla’s Board  -How China’s BYD Overtook Tesla  Learn more about your ad choices. Visit megaphone.fm/adchoices

Walmart is offering higher pay, bonuses and more stock options this year to retain and attract managers. WSJ’s Sarah Nassauer spent a day with one manager, Nichole Hart, to understand why the job is commanding such a high salary these days, and why Hart logs about 20,000 steps a day. Further Reading: - A Day in the Life of a Walmart Manager Who Makes $240,000 a Year  - Walmart Takes On Trader Joe’s and Whole Foods With New Premium Brand  Further Listening: - What Walmart’s Aisles Say About the American Consumer  Learn more about your ad choices. Visit megaphone.fm/adchoices

The high price of baby eels has triggered an upsurge in illegal fishing and criminal activity in Canada. Earlier this year, the country announced a ban on baby-eel fishing in an attempt to contain the violence and to protect dwindling fish stocks. We speak to WSJ’s Paul Vieira and to a baby-eel fisherman about how a tiny fish has created a turf war in a remote Canadian community. Further Reading: -Guns and Death Threats Spur Canada to Reel in Baby-Eel Fishing  Further Listening: -Will Florida’s Plan to Get Cheap Drugs From Canada Work?  -Canada’s Historic Settlement with Indigenous People  Learn more about your ad choices. Visit megaphone.fm/adchoices

The National Basketball Association is in advanced stages of a new round of media-rights deals. WSJ’s Amol Sharma unpacks why several major media players are jostling for the lucrative rights. Further Reading: -NBC Prepares $2.5-Billion-a-Year Bid to Pluck NBA Rights From TNT  -Amazon, YouTube Vie for NBA Streaming Rights as League’s Media Talks Heat Up  Further Listening: -Why Three Media Giants Are Betting on Sports Streaming  Learn more about your ad choices. Visit megaphone.fm/adchoices

On Monday, Bob Bakish stepped down as CEO of Paramount, one of America’s most iconic media companies. WSJ’s Jessica Toonkel reports on how Bakish’s relationship with Shari Redstone, chair of Paramount, has deteriorated amidst one of the messiest merger dramas in recent history.  Further Reading: - A Media Heiress’s Bid to Sell Sets Off Mayhem Inside Paramount  - How Bob Bakish, the Anti-Mogul CEO, Struggled to Rescue Paramount  - Shari Redstone’s Path to Power  Further Listening: - Why Buying Paramount Global Won’t Be Easy  Learn more about your ad choices. Visit megaphone.fm/adchoices

Donald Trump's allies have drafted plans to curb the Federal Reserve’s independence, should Trump win a second term. WSJ’s Andrew Restuccia unpacks the proposals, which include giving the president a say in interest-rate decisions. Further Reading: -Trump Allies Draw Up Plans to Blunt Fed’s Independence  -Why Inflation Is Biden’s Most Stubborn Political Problem  -Even If the Fed Cuts, the Days of Ultralow Rates Are Over  Further Listening: -Why the Fed Is Steering Away From Rate Cuts  -The Man Who Waged War on Inflation  -The President, the Fed, and the Cut  Learn more about your ad choices. Visit megaphone.fm/adchoices