Scientific Seminars Diabetes Podcast Series

Metabolic alterations such as hyperglycemia, hyperlipidemia and the low-grade inflammation associated with insulin resistance, obesity and type 2 diabetes, induce metabolic and structural stress to the organism, that persists for years, even after that the noxa has been solved. This phenomenon has been called “metabolic memory”. Coherently, also the benefits of early treatment of such conditions are reflected in the long-term (legacy effect). Therefore, early treatment of diabetes, even in the prediabetes stage, might result in long term clinical benefits. This podcast is part of the continuing medical education program entitled “The 2026 Digital Learning Journey in Type 2 Diabetes Care: Global Perspectives and Practical Approaches”, targeting Diabetologists, Endocrinologists, Paediatricians, Cardiologists and General Practitioners.

Youth-onset insulin resistance is rising sharply, particularly among girls, Hispanic adolescents, and those with obesity. This early metabolic dysfunction is linked to long-term risk of type 2 diabetes and cardiovascular disease. There is poor education about the serious health complications related to excessive adipose tissue during childhood and adolescence, and their impact on the future health of our children. A call to action is needed to stop the emergency of childhood obesity. This podcast is part of the continuing medical education program entitled “The 2026 Digital Learning Journey in Type 2 Diabetes Care: Global Perspectives and Practical Approaches”, targeting endocrinologists, diabetologists, nurses and obstetricians.

Insulin resistance is a condition characterized by an impaired response of cells to insulin, which causes an initial increasein insulin levels. This hyperinsulinemia can further promote fat storage and inflammation, worsening insulin resistance andresulting in the establishment of a vicious circle which can contribute to the development of conditions like type 2 diabetesand obesity. Breaking this vicious circle is as important as it is difficult. Changes in lifestyle and pharmacotherapy, such asmetformin, have been shown effective to improve insulin resistance and prevent its deleterious condition. This podcast is part of the continuing medical education program entitled “The 2025 Learning Journey in Diabetes: A Case-Based InteractiveEducational Experience”, targeting endocrinologists, diabetologists, nurses and obstetricians.

Insulin resistance is a condition characterized by an impaired response of cells to insulin, which causes an initial increasein insulin levels. This hyperinsulinemia can further promote fat storage and inflammation, worsening insulin resistance andresulting in the establishment of a vicious circle which can contribute to the development of conditions like type 2 diabetesand obesity. Breaking this vicious circle is as important as it is difficult. Changes in lifestyle and pharmacotherapy, such asmetformin, have been shown effective to improve insulin resistance and prevent its deleterious condition. This podcast is part of the continuing medical education program entitled “The 2025 Learning Journey in Diabetes: A Case-Based InteractiveEducational Experience”, targeting endocrinologists, diabetologists, nurses and obstetricians.

In patients with diabetes, atherosclerosis is the main reason for impaired life expectancy, and diabetic nephropathy and retinopathy are the largest contributors to end-stage renal disease and blindness, respectively. Notably, a large number of people presents with vascular complications already at the time of diabetes diagnosis, suggesting that the natural history of vascular damage in diabetes starts very early in the course of the disease. Indeed, accumulating evidence shows that mechanisms leading to diabetic vascular complications starts since the prediabetes stage, which therefore may represent an ideal therapeutic window to implement precocious interventions to halt the burden of cardiometabolic disease worldwide. Prof. Pozzilli, a KOL in the field, will discuss the impact of prediabetes and related comorbidities on vascular complications of diabetes.