FDA approval sees Orthocell’s Remplir enter multi-billion dollar US nerve market

Diales Group PLC (LON:DIAL) CEO Mark Wheeler talked with Proactive's Stephen Gunnion about the company’s global operations and how it supports clients across the engineering and construction sectors—particularly with dispute resolution, cost escalation claims, and complex project planning. Wheeler explained that Diales works with major contractors, joint ventures, government bodies, and clients across infrastructure, energy, and offshore projects. He said, “We support them with their contracts, planning, programming and claims and dispute resolution,” highlighting the company's niche expertise in large-scale, often novel engineering environments. In light of new US tariffs on steel and aluminum, Wheeler said Diales is seeing increased client inquiries and is well-positioned to provide strategic guidance. He noted the company’s experience with “cost escalation claims” and emphasised the value of early contractual advice to manage such risks. He also discussed supply chain challenges, especially where key components are manufactured globally. “One or two small components can really delay the delivery and completion of the construction of some quite significant pieces of equipment,” Wheeler noted. Finally, Wheeler addressed the ongoing share buyback program, which he described as popular with shareholders. He reiterated the company's belief that it is currently “the best value stock to be buying,” particularly given AIM market illiquidity. For more interviews like this one, visit Proactive's YouTube channel. Don’t forget to like this video, subscribe to our channel, and turn on notifications to stay updated on future content. #DialesGroup #EngineeringDisputes #ConstructionSector #GlobalInfrastructure #ShareBuyback #AIMMarket #CostEscalation #SupplyChainIssues #SteelTariffs #MarkWheeler #ConstructionLaw #EnergyProjects #ProactiveInvestors

Ilika PLC CEO Graeme Purdy talked with Proactive's Stephen Gunnion about the company’s latest progress in scaling up its Goliath solid-state battery technology. The discussion focused on improved results from Ilika’s collaboration with the UK Battery Industrialisation Centre (UKBIC). Purdy said: “We’re seeing an improved yield out of the industrialised process,” adding that this reduces waste and lowers costs. More notably, the batteries produced via UKBIC’s process outperform those created on Ilika’s pilot line, showing stronger power density and faster charge-discharge capabilities. Purdy confirmed the project’s shift from process to performance, marking the completion of a £2.7 million grant-supported programme funded by the Advanced Propulsion Centre. He also referenced recent government pledges of £2 billion to back automotive electrification, suggesting that future grant funding could help support Ilika’s product roadmap without shareholder dilution. Looking ahead, Ilika plans to release its P1.5 prototypes—10Ah cells—later this summer. Once enough testing data is gathered, the batteries will be shared with OEMs and Tier 1 suppliers enrolled in its evaluation programme. Purdy also teased the release of 50Ah P2 prototypes by year-end, built on insights gained from the Faraday Battery Challenge. Visit Proactive’s YouTube channel for more videos, and don’t forget to give the video a like, subscribe to the channel and enable notifications for future content. #IlikaPLC #GoliathBattery #SolidStateBatteries #EVTechnology #BatteryInnovation #UKBIC #AutomotiveElectrification #AdvancedPropulsion #BatteryManufacturing #GraemePurdy

Caledonia Mining Corporation PLC chief executive Mark Learmonth talked with Proactive's Stephen Gunnion about a record first quarter for gold production at the company's Blanket Mine. Learmonth attributed the strong operational performance to significant management changes and the restructuring of the mine's operations, which split underground and surface responsibilities. “We've got a new, younger, more energetic management team underground... and it's worked beautifully,” Learmonth noted, highlighting the benefits of recent personnel shifts and structural reforms. The conversation also covered the recent $22.35 million sale of Caledonia’s solar power plant in Zimbabwe. While the asset has been sold, Learmonth said the company retains a long-term power supply agreement and the option to participate in a second phase, if viable. He clarified the decision allows Caledonia to concentrate more on its core gold mining business. Looking ahead, Learmonth said the company remains focused on maximising gold production while intensifying efforts to reduce long-term costs. “At this gold price, with production strong, we want to get that gold out the ground... with increasing attention now to more management focus on getting those costs down,” he said. Visit Proactive's YouTube channel for more videos, and don't forget to give the video a like, subscribe to the channel and enable notifications for future content. #CaledoniaMining #GoldProduction #BlanketMine #ZimbabweMining #MarkLearmonth #MiningNews #SolarEnergy #EnergyResilience #GoldMining #ProactiveInvestors

Mosman Oil and Gas Ltd CEO Andy Carroll talked with Proactive's Stephen Gunnion about a significant milestone at the company’s Sagebrush-1 well, located in the Leadville formation. Carroll revealed that historic gas sample data from 1993 confirms the presence of helium at a concentration of 2.7%, alongside 20% methane. This discovery enables Mosman to transition from exploration to evaluating the commercialisation of the helium resource. “We were actually looking at a possible work-over at the existing well to get a gas sample, but we've got about 30 boxes of data from the previous operator and found in those boxes the original gas sample report,” Carroll said. The gas flow rate from the earlier test was in the range of 152 to 163 thousand cubic feet per day, indicating potential for commercial development. Carroll also noted the strategic benefit of methane being present alongside the helium. The methane could be used for on-site power generation to support helium processing, reducing dependence on external power sources. Additionally, existing infrastructure—including a mothballed pipeline and nearby helium plants—could significantly streamline transportation and processing. Looking ahead, Mosman is preparing feasibility studies and engaging with the Ute Mountain Ute Tribe and regulatory authorities to conduct further 3D seismic work. These efforts aim to refine drilling plans across the Sagebrush area and adjacent Coyote Wash leases. Visit Proactive's YouTube channel for more insightful updates, and don't forget to like this video, subscribe to our channel, and turn on notifications so you don’t miss future content. #MosmanOilAndGas #HeliumDiscovery #SagebrushOne #LeadvilleFormation #EnergyStocks #NaturalGas #MethanePower #HeliumCommercialisation #OilAndGasExploration #ProactiveInvestors

Solvonis Therapeutics PLC CEO Anthony Tennyson talked with Proactive's Stephen Gunnion about the company's transformation and its strategy moving into 2025. Tennyson explained that the company, formerly known as Graft Polymer, exited its industrial plastics business in 2024 to focus entirely on biotechnology, particularly mental health and addiction treatments. "These are segments which have large addressable markets, poor current standards of care and therefore significant unmet medical needs," he said. He outlined how the company raised £1.8 million in mid-2024 to support its new growth strategy, which includes partnerships, joint ventures, and acquisitions. A central part of this strategy is the pending acquisition of Awakn Life Sciences, a clinical-stage biotech company focused on alcohol use disorder (AUD) and PTSD. Solvonis is acquiring Awakn in an all-paper deal valued between £3 million and £5 million. Tennyson said this represented significant value, highlighting that similar assets could command substantially higher valuations. Awakn’s AWKN-001, targeting severe AUD, is in phase 3 trials in the UK and EU. AWKN-002, for the US market, has received FDA support for a faster 505(b)(2) development pathway, allowing the use of Johnson & Johnson’s SPRAVATO® data to accelerate progress. Tennyson said the top priority for 2025 is closing and integrating the acquisition and executing on the clinical programs. He emphasised plans to file for FDA approval of a phase 2B trial and to continue to work with Awakn's existing UK partners. Visit Proactive's YouTube channel for more updates like this. Don’t forget to like the video, subscribe to the channel, and enable notifications for future content. #Solvonis #BiotechNews #MentalHealthTreatment #AddictionRecovery #PTSDResearch #AlcoholUseDisorder #PharmaInvesting #AwaknAcquisition #ClinicalTrials #HealthcareInnovation

IXICO plc CEO Bram Goorden talked with Proactive's Stephen Gunnion about the company’s strategy for innovation, leadership, and growth in the neurodegenerative disease space. Goorden outlined how IXICO’s precision medicine platform, TTNx, uses AI to analyse imaging data for pharmaceutical and biotech companies developing new drugs, particularly in Alzheimer’s, Parkinson’s, and Huntington’s diseases. The CEO emphasised that the company's focus remains on expanding its portfolio, enhancing analytics within existing programs, and tapping into emerging opportunities like blood-based biomarkers. “You may know that IXICO is an absolute leader in especially rare diseases, Huntington's disease and so on, but we've really seen that expansion of portfolio,” Goorden said. He also discussed the company’s strategic pillars: Innovate, Lead, and Scale. This includes integrating new algorithms, raising the company’s voice in the global precision medicine market, and strengthening its US operations to support further growth. Goorden noted that IXICO is seeing increased engagement from partners seeking FDA approvals who rely on gold-standard imaging for validation. He also mentioned the company’s recent hires and commitment to driving more partnerships throughout 2025. Visit Proactive’s YouTube channel for more exclusive interviews and insights. Don’t forget to like this video, subscribe to our channel, and turn on notifications for future updates. #IXICO #BramGoorden #PrecisionMedicine #NeurodegenerativeDiseases #AlzheimersResearch #ParkinsonsDisease #DrugDevelopment #AIinHealthcare #Biomarkers #ClinicalTrials #HealthcareInnovation #FDAapproval

Jeremy Salt, CEO of The Vaccine Group (TVG), a Frontier IP Group PLC portfolio company, talked with Proactive's Stephen Gunnion about the company’s collaboration with global animal health firm Syva. Salt explained that the partnership focuses on developing a vaccine for Streptococcus suis, a major disease in pigs that also contributes significantly to the use of antibiotics in livestock farming. “One of the key aspects of this collaboration with them is that they have a significant gap in their portfolio of products for pigs,” Salt noted. He emphasised that Streptococcus suis is prevalent in around 60% of European countries and impacts pig farming worldwide, with antimicrobial resistance (AMR) being a critical concern. The zoonotic nature of the disease, particularly in Southeast Asia, adds another layer of urgency to develop effective solutions. Salt highlighted that TVG’s vaccine platform provides broader protection across multiple strains, making it potentially globally applicable. The vaccine can be administered to young piglets, which is strategically important and is also expected to be more cost-effective than conventional options. He also discussed the role of UK government support, with Innovate UK and DEFRA grants contributing around £1 million in funding. The company is also progressing with 12 vaccine candidates, including developments in poultry and biotherapeutics delivery using monoclonal antibodies. For more updates, visit Proactive's YouTube channel. Don't forget to like the video, subscribe to the channel, and turn on notifications for future content. #AnimalHealth #Vaccines #SwineIndustry #AntimicrobialResistance #BiotechNews #TVG #FrontierIP #ProactiveInvestors #PigHealth #ZoonoticDiseases #LivestockFarming #VeterinaryInnovation #MonoclonalAntibodies #PoultryVaccines #Biotherapeutics

Pinewood.AI CEO Bill Berman joined Steve Darling from Proactive at the company’s OTC studio in New York City to discuss the company’s latest developments and its expanding role in transforming automotive retail through real-time data intelligence. Pinewood.AI’s platform empowers retailers and OEMs by giving them complete visibility of their operations through real-time data updates. This unified data view ensures that every team member—across departments and locations—has access to the same up-to-date information, improving decision-making, streamlining workflows, and enabling a more seamless and consistent customer experience. The platform also simplifies reporting for management, making performance tracking faster and more accurate. Berman highlighted the company’s strong financial performance, driven by the successful rollout of the Lithia UK system and deeper vertical sales within its existing customer base. This growth was further supported by major new customer acquisitions, positioning Pinewood.AI as a key player in the UK automotive retail technology space. The company now supplies 5 of the top 20 dealership groups in the United Kingdom. Looking ahead, Pinewood.AI is focused on its North American market entry. Preparations for the rollout in the United States are well underway, with pilot programs expected to begin in Lithia Motors stores in the second half of 2025. A full-scale U.S. deployment is targeted for 2026. As part of this strategic move, the company will also establish its North American headquarters in Florida later this year. To further align with its U.S. expansion strategy, Pinewood.AI has begun trading on the OTCQX Market under the ticker symbol PINWF. This listing allows U.S. investors access to transparent and consistent financial information, mirroring the level of disclosure provided in the UK. It also ensures that Pinewood’s growing base of American stakeholders can track the company’s progress through familiar U.S.-based platforms. With a powerful data platform, strong revenue momentum, and clear global ambitions, Pinewood.AI is well-positioned to reshape the future of automotive retail on both sides of the Atlantic. #proactiveinvestors #pinewoodtechnologies #pinewood.ai #otcqx #pinwf #lse #pine #AutomotiveTechnology #AutoRetail #BillBerman #OTCListing #AutoIndustry #CRMSoftware #CloudNative #NorthAmericaExpansion #SeezAI #LithiaMotors #PinewoodTechnologies #FortLauderdaleHQ

First Phosphate Corp. CEO John Passalacqua joined Steve Darling from Proactive to outline the company’s pivotal mission: powering the resurgence of American manufacturing by supplying domestically sourced Lithium Iron Phosphate (LFP) battery materials essential to factory automation, robotics, and energy storage systems. Passalacqua emphasized that the future of U.S. manufacturing is closely tied to the widespread adoption of industrial automation and robotics—technologies that rely heavily on LFP batteries. Known for their safety, longevity, and scalability, LFP batteries are rapidly becoming the global standard for grid-scale storage and automated production systems. This shift is being accelerated by evolving national trade and security policies aimed at strengthening domestic capabilities and reducing dependence on foreign supply chains. According to First Phosphate, the demand for industrial automation is expected to soar to USD $307.7 billion by 2030. With around 60% of jobs poised to automate at least 30% of tasks, automation could boost global productivity by 1.5% annually and contribute to the creation of over 6 million new jobs. Positioning itself as a domestic solution to this global shift, First Phosphate is actively developing a vertically integrated North American LFP ecosystem—from mining to battery-grade materials. The company controls over 1,000 sq. km of high-purity igneous phosphate claims in Quebec, an area capable of supporting more than 350 GWh of LFP battery production each year. Its phosphate ore is among the cleanest in the world, naturally low in harmful elements and extractable without the use of solvents. This vertical integration strategy allows First Phosphate to manage the entire value chain, from resource extraction to the production of LFP cathode active material (CAM). The result: a fully traceable, secure, and sustainable domestic supply chain that supports the growing demands of North America’s electrified #proactiveinvestors #firstphosphatecorp #cse #phos #otcqb #frspf #phosphate #LFPBatteries #CriticalMinerals #CleanEnergy #MiningCanada #ElectricVehicles #EnergyStorage #NorthAmericaSupplyChain #FirstPhosphate #SustainableMining

Liberty Star Minerals Chairman Pete O’Heeron and Director Gerardo King joined Steve Darling from Proactive to provide an update on their recent trip to Washington, D.C. this week for a series of high-level meetings with Congressional offices to discuss the urgent need for U.S. investment in the exploration and development of critical minerals. The company’s leadership sat down with influential policymakers, including Senators Ted Cruz and John Cornyn, to emphasize the strategic importance of securing domestic sources of minerals essential to national security, clean energy, and technological innovation. “The United States is at a critical juncture in ensuring the security of its supply chain for critical minerals,” said Chairman Pete O’Heeron. “We can no longer afford to rely on foreign nations for the materials that power everything from smartphones to fighter jets. It’s imperative that the U.S. government take a leadership role in funding and incentivizing domestic mineral exploration. Liberty Star Minerals is ready to be part of that solution.” The discussions highlighted the urgent need for a coordinated national effort to support projects like Liberty Star’s Hay Mountain Project in southeast Arizona—one of the most promising undeveloped mineral properties in the U.S. The project targets a diverse range of high-demand strategic metals including copper, lithium, and rare earth elements, which are vital to the defense sector, the transition to clean energy, and the advancement of next-generation technologies. #proactiveinvestors #libertystarminerals #otc #lbsr #redrockcanyon #arizona #LibertyStarMinerals #USMining #StrategicMetals #CopperExploration #GoldOutlook #DomesticResources #MineralSupplyChain #ProactiveInvestors