CXOTalk

What does it take to keep global financial markets stable during extreme volatility and AI-driven trading? Chris Isaacson, Chief Operating Officer of Cboe Global Markets, the world's largest options market exchange, reveals the high-stakes playbook for building resilient systems, people, and processes that handle over a trillion messages a day without failure.In CXOTalk episode 885, we go behind the scenes of one of the world's largest exchange operators to learn how they prepare for and manage market crises. Chris shares concrete strategies and the leadership mindset required to operate in an environment where nanoseconds and trillions of dollars are on the line.Topics Discussed:Building Holistic Resilience: The framework of "resilient people, processes, and platforms."Preparing for Volatility: The "2X rule" for engineering systems to handle extreme scenarios.Managing AI Risk: How to control AI-driven trading by focusing on effects, not intent.Leadership Under Fire: The critical importance of composure and a codified cultural framework.The Future of Trading: The operational realities of moving toward a 24/7 market.Chris Isaacson is the Executive Vice President and Chief Operating Officer of Cboe Global Markets, one of the world's leading derivatives and securities exchange networks. He oversees all of Cboe's technology, operations, and risk management.🔷 Newsletter: www.cxotalk.com/subscribe🔷 LinkedIn: www.linkedin.com/company/cxotalk🔷 Twitter: twitter.com/cxotalk🔷 Episode notes: https://www.cxotalk.com/episode/inside-the-worlds-largest-options-exchange-where-milliseconds-mean-millionsVideo Chapters:[00:00] Introduction to Cboe Global Markets and the Importance of Resilience[01:04] Building Resilient Systems, Teams, and Processes[10:01] Handling Market Volatility and Preparing for Extreme Scenarios[13:15] Role of a COO in Maintaining Market Stability[14:14] Lessons from Market Crises and Risk Management[16:41] Generative AI and Risk Controls in Financial Markets[19:33] Managing Risks in AI-Driven Trading[23:53] The Evolution and Limits of Trading Speeds[27:52] Leadership During Market Turbulence[29:53] Exploring 24/5 and 24/7 Trading in Financial Markets[35:35] Leadership and Building a Global Team Culture[37:42] Navigating Market Volatility and Personal Reflections[40:25] Efficiency and the Role of Data in Financial Markets[43:02] Managing Risk and Educating Investors in Derivatives Trading[49:00] Future of Markets: Cross-Asset Trading, Digital Assets, and AI

The generative AI revolution has created an insatiable demand for efficient, powerful computing. How is a key industry leader like AMD navigating this critical inflection point?In CXOTalk episode 884, Michael Krigsman sits down with Mark Papermaster, CTO and Executive Vice President of AMD, to explore the future of AI infrastructure. Discover AMD's strategy for winning in the AI era, which hinges on a tight integration of hardware and software, a commitment to open ecosystems, and a relentless focus on energy efficiency.Mark shares invaluable insights for technology leaders on the rise of hybrid AI, the future of tailored language models, and the leadership practices required to foster innovation and agility in this fast-paced environment. ===+🔷 Newsletter: www.cxotalk.com/subscribe🔷 LinkedIn: www.linkedin.com/company/cxotalk🔷 Twitter: twitter.com/cxotalk🔷 Episode: https://www.cxotalk.com/episode/inside-amds-ai-strategy-with-evp-and-cto-mark-papermaster====00:00 🚀 AMD's Journey and AI Evolution03:34 🧠 AMD's Strategy in the AI Era09:38 🤝 Building Expertise and Collaborating with AI Leaders11:40 🏃‍♂️ Agility and Cultural Transformation at AMD15:25 🤖 Navigating AI Infrastructure Challenges19:13 🔮 The Future of AI: Tailored and Efficient Models19:36 🤖 AMD's AI and Product Innovations20:50 🏗️ AMD's Internal AI Adoption and Development Process23:51 🌍 AMD's Technology Strategy and Sustainability Goals30:01 🌱 Energy Efficiency and Technological Milestones31:07 🤖 Holistic Design and Competition in AI Technology34:39 🗣️ Leadership, Communication, and AI Integration40:03 🧠 Exploring Reasoning Models and Computational Challenges43:12 🌍 AMD's Global Expansion and AI Strategy47:01 🔮 Future Trends in AI and Agentic AI Applications50:12 🤖 The Role of Agentic AI in Enhancing Efficiency52:07 💡 Advice for CIOs and CTOs in the AI Era54:06 🎤 Closing Remarks and Future Outlook

AI expert Nate B. Jones joins Michael Krigsman on CXOTalk episode 883 to discuss prompting strategies and how they impact the performance of large language models (LLMs). Learn how to use ChatGPT to generate better results and understand the importance of AI prompt engineering. Discover effective methods to improve AI productivity using proper prompting techniques.🔷 Newsletter: www.cxotalk.com/subscribe🔷 LinkedIn: www.linkedin.com/company/cxotalk🔷 Twitter: twitter.com/cxotalk🔷 Episode: https://www.cxotalk.com/episode/ai-prompting-for-business-leaders-what-works-and-why#AI #PromptEngineering #CXOTalk #Leadership #ArtificialIntelligence

In episode 882 of CXOTalk, Michael Krigsman sits down with Kevin De Liban, founder of TechTonic Justice and former legal aid attorney, who reveals the shocking truth about AI's impact on vulnerable communities. De Liban shares how 92 million low-income Americans now have critical life decisions, such as healthcare, housing, employment, and government benefits, that are determined by algorithms that often fail catastrophically.Drawing from his groundbreaking 2016 legal victory in Arkansas, where he successfully challenged an algorithm that devastated the lives of disabled Medicaid recipients, De Liban exposes the myth of AI neutrality and demonstrates how these systems reflect the biases and incentives of their creators. He explains why self-regulation and "ethical AI" initiatives often fail when they conflict with business interests, and why effective regulation is crucial.What you'll learn: The real scale of AI harm affecting 92 million Americans Why AI systems aren't neutral decision-making toolsHow algorithms denied healthcare to disabled people in ArkansasWhy ethical AI initiatives fail without enforceable accountabilityPractical steps technology leaders can take to prevent harmThe expansion of AI monitoring into middle-class professionsWhy regulation benefits ethical companiesHow to determine if AI is appropriate for high-stakes decisionsThis conversation challenges conventional wisdom about AI adoption and offers essential guidance for executives, developers, and policymakers navigating the intersection of technological innovation and social responsibility.Whether you're a C-suite executive, technology professional, policymaker, or concerned citizen, this discussion provides crucial insights into one of the most pressing issues of our time: ensuring AI serves humanity rather than harming those who need protection most.=====Subscribe to CXOTalk: www.cxotalk.com/newsletterRead the episode summary and transcript: www.cxotalk.com/episode/ai-failure-injustice-inequality-and-algorithmsLearn more about TechTonic Justice: www.techtonicjustice.org

How do you transform a tech giant into an AI-first (or AI-native) organization? In CXOTalk episode 881, Cisco's President and Chief Product Officer, Jeetu Patel, reveals the blueprint for building AI-native companies in 2025.Discover why AI won't replace your job – but someone using AI better than you will. Learn how Cisco is revolutionizing its entire operation, from engineering to customer support, with artificial intelligence at the core.Key topics covered:Building an AI-first culture and overcoming employee resistanceManaging non-deterministic AI systems and security challengesThe global AI race and why speed matters more than perfectionAutonomous agents and the future of workEthical AI implementation across international bordersReal-world AI applications transforming enterprise operationsPatel shares candid insights about jailbreaking AI models, the importance of "market-in" thinking, and why he spends 2-3 hours nightly learning with AI. Plus, hear his perspective on global AI partnerships and why regulatory restraint is crucial for maintaining competitive advantage.Whether you're a C-suite executive, technology leader, or business strategist, this conversation delivers actionable strategies for thriving in the AI era.🔔 Subscribe for more enterprise AI insights📧 Get the CXOTalk newsletter: www.cxotalk.com/subscribe💬 Share your AI transformation questions belowRead the episode summary: https://www.cxotalk.com/episode/how-to-build-an-ai-first-enterprise-from-culture-to-code#AI #ArtificialIntelligence #DigitalTransformation #CXOTalk #Cisco #EnterpriseAI #Leadership

AI strategist and TikTok commentator Nate B. Jones joins CXOTalk host Michael Krigsman to explain the high-stakes race among OpenAI, Google, Meta, and others to advance large language models. The discussion explores token economics, model specialization, and hands-on prompting skills every executive needs to translate AI progress into business results. Watch Episode 880 now and subscribe for weekly conversations with top tech leaders.🔔 Don’t forget to like, subscribe, and share for more thought-provoking conversations with top industry leaders.🔷 Newsletter: www.cxotalk.com/subscribe🔷 Read the summary and key points: https://www.cxotalk.com/episode/inside-the-ai-arms-race-llms-economics-and-strategy🔷 LinkedIn: www.linkedin.com/company/cxotalk🔷 Twitter: twitter.com/cxotalk00:00 The Evolution of the AI Arms Race02:11 Diverging Strategies in AI Development07:14 Economic and Business Impacts of AI13:20 The Role of Specialization and Prompting in AI Usage16:17 Building Relationships with AI and Shifting Mindsets23:01 Maximizing Value from AI Interactions24:09 Operationalizing AI for Business ROI26:14 The Next Generation and AI's Evolution31:18 Human Psychology and AI's Persuasive Power35:24 Exploring Cognitive Parasitism and Model Personalities37:53 Comparing AI Models and Their Applications39:47 Specialized AI Models for Coding and Learning40:31 Exploring LLM Ecosystems and Tools44:30 Economics and Efficiency of LLMs48:55 Challenges and Norms in AI Usage52:47 Wrapping Up with Gratitude and Reflections53:08 Announcements and Farewell

Join GoTo and CXOTalk for a deep dive into the world of AI and the virtual workforce. Learn about AI receptionists, agentic AI, and how AI agents dramatically improve customer service for small and mid-sized companies.Our guest is Damon Covey, General Manager of UCC at GoTo.Learn more at: www.goto.com🔔 Don’t forget to like, subscribe, and share for more thought-provoking conversations with top industry leaders.🔷 Newsletter: www.cxotalk.com/subscribe🔷 Read the summary and key points: https://www.cxotalk.com/episode/ai-receptionists-transforming-customer-service🔷 LinkedIn: www.linkedin.com/company/cxotalk🔷 Twitter: twitter.com/cxotalk00:00 AI's Role in Customer Communication01:19 Examples and Benefits of AI in Small Business05:49 AI Receptionist and the Future of Virtual Workforce08:33 Benefits of AI Receptionists and Virtual Workforce11:27 Deployment and Integration of AI Systems17:11 Collaboration Between AI and Human Workforce20:00 Ensuring Privacy and Security in AI Systems21:16 The Future of AI: Personalization and Actionability22:28 Closing Thoughts and Mission Statement

Join Andrew Wesbecher (Powered_By) and Michael Krigsman on CXOTalk episode 878 to discuss how AI agents can help small businesses succeed in 2025. Learn from industry experts and discover the benefits of using AI technology for your SMB to stay ahead of the competition!Learn more from www.poweredby.agency===================🔔 Don’t forget to like, subscribe, and share for more thought-provoking conversations with top industry leaders.🔷 Newsletter: www.cxotalk.com/subscribe🔷 Read the summary and key points: https://www.cxotalk.com/episode/ai-agents-for-small-business-winning-in-2025🔷 LinkedIn: www.linkedin.com/company/cxotalk🔷 Twitter: twitter.com/cxotalk00:00 Democratizing AI for Small to Medium-Sized Businesses02:38 Technical Architecture and AI Agent Implementation07:59 Use Cases and Ethical Considerations11:14 The Evolution and Capabilities of AI Agents13:27 Practical Use Cases and Optimization of AI Agents18:43 ROI and Democratization of AI Agents for SMBs#aiagents #smb #smallbusiness #cxotalk

Learn about the impact of AI in healthcare in CXOTalk episode 877 on AI in clinical trials. Discover how artificial intelligence is revolutionizing clinical trials and the potential benefits for the healthcare industry.AI promises faster, safer clinical trials and better patient experiences. Clario's EVP & Chief Information Technology & Product Officer, Jay Ferro, joins CXOTalk host Michael Krigsman to explain how his team unifies IT, product, data, security, and marketing under one roof, giving sponsors, sites, and patients a single, seamless platform. He outlines responsible AI governance with legal, medical, privacy, and security leaders. He shows how predictive tools speed recruitment, sharpen protocol design, cut dropout risk, and support image interpretation while physicians keep the final judgment.Watch to learn• How a unified tech-product structure cuts cost and removes friction• Steps for enterprise-wide AI oversight in a regulated environment• Real use cases for AI in recruitment, imaging, and trial optimization🔔 Don’t forget to like, subscribe, and share for more thought-provoking conversations with top industry leaders.🔷 Newsletter: www.cxotalk.com/subscribe🔷 Read the summary and key points: https://www.cxotalk.com/episode/ai-in-clinical-trials-what-you-need-to-know🔷 LinkedIn: www.linkedin.com/company/cxotalk🔷 Twitter: twitter.com/cxotalk00:00 🧬 The Role of AI in Clinical Trials01:18 🔗 Unified Roles and Seamless Experiences10:45 📉 Customer Concerns and Future Challenges11:54 🔬 Navigating Uncertainty in Clinical Research13:13 ⚖️ Balancing Priorities and Saying 'No' Strategically18:02 🤖 AI's Role in Healthcare and Clinical Trials24:07 🤖 Ensuring Responsible AI Development27:19 🧪 AI's Role in Clinical Trials32:23 📜 Navigating Regulatory Challenges and Organizational Readiness36:24 🤝 Proactive Collaboration and Regulatory Compliance in AI Development38:57 🌐 Transparency and Cross-Industry Collaboration in AI42:12 🔗 Industry Similarities and the Role of Technology44:40 💡 Purpose-Driven Technology and AI in Healthcare50:15 🚀 Scaling AI Projects and Overcoming Adoption Challenges#AI #ClinicalTrials #DigitalHealth #CIO #cxotalk

Join this deep dive into Agentic AI with Phil Fersht of HFS Research on CXOTalk episode #876. Learn about the future of AI and how it impacts business strategies.🔔 Don’t forget to like, subscribe, and share for more thought-provoking conversations with top industry leaders.🔷 Newsletter: www.cxotalk.com/subscribe🔷 Read the summary and key points: https://www.cxotalk.com/episode/agentic-ai-in-the-enterprise-what-it-means-for-you🔷 LinkedIn: www.linkedin.com/company/cxotalk🔷 Twitter: twitter.com/cxotalk#agenticai #aiagents #industryanalysis #cxotalk cxotalk