Predictive Biomarkers for Immune Checkpoint Inhibitor Efficacy: Challenges, Innovations, and a Pathway to Precision Medicine in the Era of Cancer Immunotherapy

Melissa Ix, Richard Dodel, J Alexander Ross. Alpha-Synuclein-Specific RT-QuIC As a Tool for the Differential Diagnosis of Neurodegenerative Diseases Using Peripheral Tissues.  Clinical Chemistry, Volume 72, Issue 8, August 2026, Pages 830–844.  https://doi.org/10.1093/clinchem/hvag037

Matthew Lee, Jeffrey A SoRelle, Arun Everest-Dass, David E Gerber, Mitchell S von Itzstein. Predictive Biomarkers for Immune Checkpoint Inhibitor Efficacy: Challenges, Innovations, and a Pathway to Precision Medicine in the Era of Cancer Immunotherapy. Clin Chem 2026; 72(9): 926–47. https://doi.org/10.1093/clinchem/hvag062

Shengjie Li, Jiazhen Cao, Jun Ren, Kun Chen, Jianing Wu, Yingzhu Li, Yunxiao Song, Chengxun Li, Wenjun Cao, Ming Guan. Tumor-Derived HAVCR1 As a Reliable Fluid Biomarker for the Diagnosis of CNS Lymphoma. Clin Chem 2026; 72(8): 880–92.  https://doi.org/10.1093/clinchem/hvag036

Luuk F P Giesen, Jeroen A Roest, Frederique M A Koopman, Martine M L Deckers, Helena Chon, Christian M Hackeng, Jurgen A Riedl, Michiel de Bruin, Brooke M Katzman, Warry van Gelder, Janne Cadamuro, Mads Nybo, Michael A Fouraux, Thijs C van Holten, Robert de Jonge. Performance, Safety, and Patient Experience of an Autonomous Robotic Phlebotomy Device: A Multicenter Trial. Clinical Chemistry, Volume 72, Issue 8, August 2026, Pages 845–856. https://doi.org/10.1093/clinchem/hvag029

Ingar Ziad Restan, Yong Yong Tew, Ole-Thomas Steiro, Ziwen Li, Hilde L Tjora, Jørund Langørgen, Torbjørn Omland, Paul Collinson, Rune Bjørneklett, Kjell Vikenes, Trude Steinsvik, Øyvind Skadberg, Øistein R Mjelva, Alf Inge Larsen, Vernon V S Bonarjee, Nicholas L Mills, Kristin M Aakre. Exploring Sex-Specific High-Sensitivity Cardiac Troponin Thresholds for Rule-Out of Non-ST-Elevation Myocardial Infarction. Clinical Chemistry, Volume 72, Issue 8, August 2026, Pages 868–879. https://doi.org/10.1093/clinchem/hvag030

Juexiao Sherry Wang, C J Battey, Kyle Trettin, Ravi Patel, Anu Srinivasan, Janani Saikumar, Divya Kushnoor, Ben F Habermeyer, Sangita Ganesh, Nafei Xu, Nathaniel Friedrich, Summer Pierson, Helen Wan, Heather LaBreche, Genevieve M Gould, Dale Muzzey. Simultaneous Prenatal cfDNA Screening of Aneuploidy, Recessive Single-Gene Conditions, and Fetomaternal Blood Compatibility. Clinical Chemistry, Volume 72, Issue 6, June 2026, Pages 679–691. https://doi.org/10.1093/clinchem/hvag005

Ryan Pearce, Leslie J Donato, Vlad C Vasile, Allan S Jaffe, Jeffrey W Meeusen. From Pooled Cohorts to PREVENT: A Perspective for Clinical Laboratorians. Clinical Chemistry, Volume 72, Issue 7, July 2026, Pages 814–816. https://doi.org/10.1093/clinchem/hvag044

Anna C H Hoge, Thomas E Grys, Erin H Graf. Disseminated Coccidioidomycosis in Immunocompetent Hosts: Opportunities for Increased Recognition and Timely Diagnosis. Clinical Chemistry, Volume 72, Issue 5, May 2026, Pages 575–582. https://doi.org/10.1093/clinchem/hvaf187