Inventing a Better Pain Pill

Shashank Samala is the CEO and co-founder of Heirloom, a carbon capture start-up. His problem is this: Can you use crushed up rocks to permanently suck carbon out of the atmosphere? And can you do it cheaply enough to have a global impact?On today’s show, Shashank explains why he believes rocks could be the backbone of carbon capture, how his childhood in India shaped his outlook on climate change, and how government policy is shaping today’s direct air capture industry.See omnystudio.com/listener for privacy information.

Today we're sharing an episode from another Pushkin podcast, Smart Talks with IBM. Scuderia Ferrari and IBM are redefining fan engagement with AI-driven insights, and cutting-edge digital tools. Learn how IBM is helping Scuderia Ferrari deepen connections with its almost 400 million fans worldwide, driving innovation and community in the digital age. This is a paid advertisement from IBM. The conversations on this podcast don't necessarily represent IBM's positions, strategies or opinions. Visit us at https://www.ibm.com/think/podcasts/smart-talksSee omnystudio.com/listener for privacy information.

Aaron Parness is a director of applied science at Amazon Robotics. His problem is this: How do you build a robot that can put stuff on shelves.Today on the show, Aaron explains why this is a surprisingly hard problem – and why the solution Aaron’s team came up with may ultimately have uses beyond the warehouse.See omnystudio.com/listener for privacy information.

In many places on Earth, there’s steam just below the surface. We don’t know where those places are — but if we could figure it out, we could unlock a lot of clean energy.Carl Hoiland is the co-founder and CEO of Zanskar, a geothermal energy company.On today’s show, Carl makes the case for geothermal in the energy transition and explains how the company is developing new ways to identify exactly where to dig a geothermal well.See omnystudio.com/listener for privacy information.

 Dr. Stephen Waxman is a professor of neurology, neuroscience and pharmacology at Yale. His research on pain helped pave the way for a newly approved, non-addictive pain drug called suzetrigine. On today’s show, he explains why he thinks suzetrigine is a promising step, but why much more work is needed to develop better pain drugs. He also gets into his work on ion channels—critical to unlocking the pain puzzle— and a rare condition known as Man on Fire syndrome.See omnystudio.com/listener for privacy information.

 Philipp Kandal is the chief product officer of Grab, an app that serves several countries across Southeast Asia. Two of Grab’s main businesses are delivery and mobility – like a combination between Instacart and Uber. And maps are at the core of its business. On today’s show, Philipp talks about improving online maps for places like Southeast Asia, where streets are often winding, narrow, and harder to access than those in the US and other developed countries.See omnystudio.com/listener for privacy information.

Dr. Allan Doctor is the co-founder and chief scientific officer at Kalocyte, a company that is developing dried red blood cells that can be rehydrated and used in medical emergencies. On today’s show, Dr. Doctor explains the complex science behind artificial blood, and how this innovation could help save millions of lives.See omnystudio.com/listener for privacy information.

Jakob Uszkoreit is the CEO and co-founder of Inceptive, a biotech start-up. He’s also a co-author of “Attention is All You Need,” the paper that created transformer models. Today, transformers power chatbots like ChatGPT and Claude. They’ve also led to breakthroughs in everything from generating images to predicting the structure of proteins. On today’s show, Jakob talks about the invention of transformer models. And he discusses how he’s using those models to try to invent new kinds of medicine, with a particular focus on RNA. See omnystudio.com/listener for privacy information.

Nan Ransohoff is the head of climate at Stripe. The company is known mainly for facilitating online payments, but it’s become a key driver of the nascent carbon-removal industry. On today’s show, Nan explains how she used a clever economic idea to get companies to spend $1 billion on carbon removal. And she talks about the different approaches startups are pursuing to pull carbon dioxide out of the atmosphere.See omnystudio.com/listener for privacy information.

Megan O’Connor is the co-founder and CEO of Nth Cycle. Megan’s problem is this: How do you create a new system that can both refine the raw metals we need for new batteries and recycle metal from old batteries?See omnystudio.com/listener for privacy information.