#485 — The New Science of Cancer

From the archive: In this 2019 episode, Sam Harris speaks with Daniel Kahneman at the Beacon Theatre in NYC. They discuss the replication crisis in science, System 1 and System 2, where intuitions reliably fail, expert intuitions, the power of framing, moral illusions, anticipated regret, the asymmetry between threats and opportunities, the utility of worrying, removing obstacles to wanted behaviors, the remembering self vs the experiencing self, improving the quality of gossip, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.

Sam Harris speaks with Neal Brennan about the experiences that shaped his life and work. They discuss Sam's mother's television career, growing up with an absent father, his struggles with perfectionism, his first experience with MDMA, dropping out of Stanford, meditation retreats, spiritual charisma and claims of psychic powers, the illusion of self, the limits of pacifism, deleting Twitter, Trump and the politics of shamelessness, hypocrisy and vice signaling, the future of American democracy, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.

Sam Harris speaks with Cameron Berg about whether AI systems are or could become conscious. They discuss self-reports in LLMs, what models say when deception is switched off, the "bliss attractor" state, consciousness and sentience, the hard problem of consciousness, parallels between neural networks and biological brains, the moral risk of building minds that can suffer, possible parallels to factory farming, moral patienthood, the alignment problem, and other topics. Annaka Harris's upcoming book: Unlocking Consciousness If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.  

Sam Harris speaks with Kathryn Paige Harden about behavioral genetics, moral luck, and the problem of blame. They discuss Harden's book Original Sin, the controversy over Charles Murray and Ezra Klein, why behavioral genetics remains taboo, the meaning of heritability, nature and nurture as feedback loops, why biological explanations can increase blame, psychopathy as a continuum, a hypothetical cure for evil, embryo selection and IVF, and other topics. Related Episode: #212 - A Conversation with Kathryn Paige Harden If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.

Sam Harris speaks with Siddhartha Mukherjee about the science of cancer. They discuss the updated edition of The Emperor of All Maladies, whether cancer is one disease or many, why prevention is so hard, inflammation and air pollution as carcinogens, the myth that cell phones cause cancer, liquid biopsies and Bayesian reasoning, immunotherapy and CAR T cells, drug pricing, the promise of AI in drug discovery, the state of American medical science, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.

Sam Harris speaks with Paul Bloom about our relationships with AI and the future of human connection. They discuss the surprising pace of AI progress, AI companions as a remedy for loneliness, the importance of mattering to other people, digitally resurrecting the dead, whether AI can be conscious, the moral failings of artists, what science actually knows about parenting, the ethics of apology, why late converts from Trump provoke outrage, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.  

Sam Harris speaks with Alain de Botton about the psychology of unhappiness, the secular world's discomfort with ecstasy and ritual, psychedelics as a tool for self-discovery, Freud's legacy, AI as the ultimate mirror, the case against meritocracy, the cancel culture purity trap, the psychological meaning of death, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.

In this latest episode of the More From Sam series, Sam and Jaron talk about current events. They discuss topics from Making Sense Community, including one-world government, the value of a degree as AI reshapes careers, and factory farming ethics, along with Mamdani's DSA-aligned candidates, Trump's humiliating capitulation in the Iran deal, the Tulsi Gabbard guru story, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.  

Richard Dawkins presents Sam Harris with the 2026 Richard Dawkins Award at a live Center for Inquiry event. After the tribute, the two friends discuss consciousness and epiphenomenalism, AI and the Turing test, the scientific basis of morality, the failures of democracy and Trump's corruption, the role of philosophy, changing deeply held beliefs, Sam's path to meditation, the legacy of Christopher Hitchens, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.

Sam Harris speaks with economist and Substack writer Noah Smith about the U.S. national debt, wealth inequality, and the economic consequences of AI. They discuss the mechanics of debt and inflation, the case for fiscal austerity, why the U.S. squandered low interest rates, modern monetary theory, how AI may restructure labor and ownership, the anti-billionaire politics of the American left, the degrowth movement and its failures, demographic decline and fertility trends, the role of smartphones in eroding democratic culture, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.