Is it cool to have no friends?

More than 100 people were arrested at large protests against the Israeli prime minister Benjamin Netanyahu’s address to the UN general assembly. Susan Sarandon, Chelsea Manning and Caleb Hearon were among the famous faces arrested. Inside the assembly hall, Netanyahu faced a mass walkout as he took to the stage. Then, in an inflammatory address, he claimed Israel’s war in Gaza was the ‘opposite of a genocide’ and labelled the New York mayor, Zohran Mamdani, antisemitic. Lucy Hough speaks to UK global editor Devika Bhat – watch on YouTube – Listen to Thursday’s episode of Stateside with Kai and Carter on whether Netanyahu has lost America here. Help support our independent journalism at theguardian.com/infocus

Guardian columnist Marina Hyde on the release of her new book What a Time to be Alive!. Help support our independent journalism at theguardian.com/infocus

A government database has been hacked for the first time by a rogue OpenAI agent, which infiltrated part of the Australian healthcare scheme in June. OpenAI became aware of the hack in August, but only informed the government in September. Australia’s prime minister, Anthony Albanese, has expressed his ‘extreme concern’ about the hack, which raises serious AI security concerns for governments around the world. Lucy Hough speaks to the Guardian’s UK technology editor Robert Booth – watch on YouTube. Help support our independent journalism at theguardian.com/infocus

AI, Iran and Taiwan – there will be no shortage of topics when the two most powerful men in the world meet in Washington. But what do they both want? Jonathan Czin explains. Help support our independent journalism at theguardian.com/infocus

Andy Burnham has navigated his way through a first high-stakes meeting with Donald Trump at the UN general assembly in New York. The prime minister’s aides were delighted with how the meeting went, as Trump praised the US-UK relationship and described Burnham as a ‘natural businessman’. The anticipated sticking points – the Chagos Islands, West Bank settlement sanctions and Ireland – appear not to have derailed the talks nor cast a shadow over the future relationship. Lucy Hough speaks to policy editor Kiran Stacey – watch on YouTube. Help support our independent journalism at theguardian.com/infocus

Loneliness influencers are on the rise. When did social media get so unsociable? Jessica Murray explains. Help support our independent journalism at theguardian.com/infocus

In what is probably one of the biggest battles yet between the press and Donald Trump, major TV networks have united in a boycott of pooled coverage of his administration. It comes after three news organisations – CNN, MS Now and Politico – were denied access to the White House because of Trump’s concerns about their coverage. Lucy Hough speaks to the Guardian’s international news editor Paul Owen – watch on YouTube. Help support our independent journalism at theguardian.com/infocus

The Houthis now control the Bab al-Mandab strait. But where is it and why does it matter? Patrick Wintour explains. Help support our independent journalism at theguardian.com/infocus

The German chancellor, Friedrich Merz, has vowed to stay in office despite heavy losses in two state elections that he described as a ‘disaster’. The anti-immigration, Kremlin-friendly Alternative für Deutschland won with 38% of the vote in Mecklenburg-Western Pomerania, while the leftwing Die Linke was victorious in Berlin. Merz has promised political change, but speculation is growing that his party could soon oust him. Lucy Hough speaks to the Guardian’s Berlin correspondent, Deborah Cole – watch on YouTube. Help support our independent journalism at theguardian.com/infocus

From hospital wards to bathrooms, where is a transgender person supposed to go after the latest equalities guidance?. Help support our independent journalism at theguardian.com/infocus