Tig Notaro on Grief, Comedy, and Life After Loss

Gwyneth sits down with Tig Notaro—comedian, writer, actor, and producer—to talk about her Oscar-nominated documentary Come See Me in the Good Light, which follows poet Andrea Gibson through the final chapter of their life. They talk about friendship, illness, and mortality—and how everything can shift when you’re faced with what really matters. Tig reflects on witnessing Andrea’s humor, openness, and perspective in the face of stage four cancer, as well as her own experience with illness and loss—and how comedy became a way through it. They also explore art as a way of making meaning, the strange coexistence of heartbreak and laughter, and why we shouldn’t wait for something devastating to start living more fully. To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

Gwyneth sits down with Amanda Knox to reflect on life after global scrutiny—rebuilding her identity, processing the years she lost, and the extraordinary strength it takes to choose forgiveness. To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

Gwyneth sits down with Andrew Huberman—neuroscientist, Stanford professor, and host of the Huberman Lab podcast—to explore the science behind some of the most talked-about topics in health right now, from protein intake and gut health to the emerging world of peptides. Huberman breaks down what the research actually says about how much protein we need, why the gut microbiome plays such a powerful role in inflammation and overall health, and how new therapies—from peptides to the latest metabolic treatments—are reshaping the conversation around recovery and weight loss. They also discuss circadian rhythms, sleep, and the everyday habits that help regulate the nervous system and allow us to work with our biology rather than against it. To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

The Advice That Will Change How You Think About Success In this episode from 2025, Gwyneth sits down with Emma Grede — founder of Good American, co-founder of Skims, and author of Start With Yourself — to talk about what it really takes to build an empire. Emma opens up about growing up in East London with no money, dropping out of school at 16, and betting on herself when no one else would. They get into why women need to stop being polite about money, what it really takes to lead with intention, and the daily gratitude practice she swears by. To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

Emily Hickey—marketer and brand strategist—sits down with Gwyneth Paltrow to talk about personal codes, the inner principles that shape how we move through the world. They discuss reinvention, self-expression, and how aligning with your values can transform how you show up and bring clarity in moments of change. To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

Gwyneth sits down with Mike Blue—CEO of HistoSonics—to explore histotripsy, a breakthrough noninvasive ultrasound technology designed to destroy tumors without surgery, chemotherapy, or radiation. He shares the 25-year journey behind the technology, the patients already benefiting from the FDA-cleared treatment for liver tumors, and how this approach could challenge decades of invasive cancer care—signaling a profound shift toward safer, more precise treatment. To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

Gwyneth sits down with Dr. Paul Savage—integrative medicine pioneer and founder of MD Lifespan—to explore the hidden impact of environmental toxins on our health and longevity. He shares the health crisis that shifted his path from emergency medicine to advanced detoxification, and breaks down everything you need to know about therapeutic plasma exchange (TPE) and how it might reshape the way we think about detox. Free Copy of Avoiding Toxins: https://mdlifespan.com/goop To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

Gwyneth sits down with Chelsea Hirschhorn—founder and CEO of Frida—to unpack the invisible chapters of motherhood, from conception and postpartum recovery to the cultural pressure to bounce back. They discuss the myth of being ready, grieving who you were before kids, and how becoming a mother reshapes who you are and how you move through the world. To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

Gwyneth sits down with Scott Galloway—entrepreneur, NYU professor, and #1 New York Times bestselling author of Notes on Being a Man—to unpack why boys in America are struggling, what it means to redefine modern masculinity, and how to raise sons in a world of economic pressure, digital addiction, and shifting expectations. To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

Emily Hickey—growth strategist and coach—sits down with beauty founder and makeup artist Bobbi Brown for a conversation on reinvention and self-worth. Together, they reflect on what it means to keep growing through different seasons of life, from motherhood and empty nesting to aging, leadership, and learning when to let go—and the question Bobbi always returns to: why not? To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices