Sell, close, or continue? The transfer of US businesses is at a crossroads

Tariff tumult. Shifting geopolitical alliances. AI acceleration. Structural shifts are reshaping global trade. On this episode of The McKinsey Podcast, McKinsey Senior Partner Shubham Singhal and McKinsey Partner Jeongmin Seong speak with Global Editorial Director Lucia Rahilly about how to adapt to the current phase of global trade reconfiguration—from where to manufacture to supply chain decisions—and how best to invest. In the second half of this episode, McKinsey Senior Partner Kate Smaje joins Lucia to answer some audience questions from our last McKinsey Live webinar, based on the second edition of the book Rewired, about how to rewire your organization in the age of digital and AI. This episode has been adapted from our McKinsey Live webinar series.See www.mckinsey.com/privacy-policy for privacy information

McKinsey’s latest research on global banking demonstrates that artificial intelligence isn’t just another efficiency play for financial institutions; it represents a fundamental shift in how these companies manage costs, attract and retain customers, and stay ahead of the competition. In this episode, Ido Segev, McKinsey senior partner and Roberta Fusaro, editorial director talk about the speed with which AI is advancing, what’s holding banks back from scaling it, and the potential advantages for early movers. Theme music composed, performed, and produced by Joy Ngiaw.See www.mckinsey.com/privacy-policy for privacy information

For more than a century, medicine has largely followed a one-size-fits-all model—but that paradigm is beginning to break. On this episode of The McKinsey Podcast, Stéphane Bancel, CEO of Moderna, joins Eric Kutcher, McKinsey’s North America chair, to explore how mRNA technology is transforming healthcare. From the rapid development of COVID-19 vaccines to new approaches to rare genetic diseases and individualized cancer treatments, Bancel explains how treating biology as information could reshape how drugs are discovered, manufactured, and delivered. In this recurring series, Eric speaks with top CEOs about the practice of leadership. The McKinsey Podcast is cohosted by Lucia Rahilly and Roberta Fusaro. To watch the full-length version of this interview, visit The McKinsey Podcast playlist on McKinsey’s YouTube channel.See www.mckinsey.com/privacy-policy for privacy information

A historic wave of ownership transitions is set to reshape the backbone of the US economy. The fate of jobs, local spending, and wealth creation all hinge on whether enough qualified—and diverse—buyers can step in to continue to pave the way for small business ownership. In this episode, Shelley Stewart III, McKinsey senior partner and Roberta Fusaro, editorial director, talk about the scale and stakes of the "Great Ownership transfer". After, Ken Yearwood, McKinsey partner, joins to talk about the risks of inaction and the practical pathways to making these transitions work.  The McKinsey Podcast: https://www.mckinsey.com/featured-insights/mckinsey-podcast Shelley Stewart III: https://www.mckinsey.com/our-people/shelley-stewart The Great Ownership Transfer report: https://www.mckinsey.com/institute-for-economic-mobility/our-insights/the-great-ownership-transfer-a-new-era-of-business-stewardship McKinsey Institute for Economic Mobility: https://www.mckinsey.com/institute-for-economic-mobility/overview Theme music composed, performed, and produced by Joy Ngiaw.See www.mckinsey.com/privacy-policy for privacy information

As generative and agentic AI reshape how work gets done, the real divide isn’t who has the best ideas—it’s who can turn them into real results at speed and scale. In this webinar, McKinsey Global Editorial Director Lucia Rahilly speaks with Senior Partners Kate Smaje and Robert Levin about the updated Rewired playbook—and why winning with AI now depends less on ambition and more on building the organizational capabilities to deliver. The McKinsey Podcast is cohosted by Lucia Rahilly and Roberta Fusaro. This conversation has been adapted from our McKinsey Live series. Theme music composed, performed, and produced by Joy Ngiaw.See www.mckinsey.com/privacy-policy for privacy information

Most leaders herald the promise of AI, but many employees see it as a looming threat—a modern echo of Annie Oakley’s classic lines: “Anything you can do, I can do better. I can do anything better than you.” What does it take, then, to lead constructive partnerships between humans and AI agents at work? In this episode of The McKinsey Podcast, McKinsey Senior Partner Alexis Krivkovich and McKinsey Global Institute Partner Anu Madgavkar speak with Global Editorial Director Lucia Rahilly about new research on what AI can and can’t do, where humans will continue to add value, and what needs to happen to help all of us work side-by-side with agents and robots successfully. Theme music composed, performed, and produced by Joy Ngiaw.See www.mckinsey.com/privacy-policy for privacy information

People often expect their leaders to have all the answers; David Novak built his career by challenging that assumption. On this episode of The McKinsey Podcast, the former CEO and cofounder of Yum! Brands and current chair of Versant speaks with Eric Kutcher, McKinsey’s chair of North America, about the experiences that shaped his leadership—from engaging with front-line franchisees to managing a very public product flop—and how other leaders can learn from them. Theme music composed, performed, and produced by Joy Ngiaw.See www.mckinsey.com/privacy-policy for privacy information

Foreign direct investment (FDI) used to sit in the background—important, but distant from day-to-day strategy. That’s no longer true. Today, massive capital commitments into areas like AI, semiconductors, and clean energy are signaling which industries will scale, where supply chains will land, and which regions will dominate. In this episode of The McKinsey Podcast, McKinsey Senior Partners Nick Leung and Olivia White explain to Editorial Director Roberta Fusaro why FDI has become a critical early indicator of competitive advantage—and what leaders should be watching now. Theme music composed, performed, and produced by Joy Ngiaw.See www.mckinsey.com/privacy-policy for privacy information

The US has had a phenomenal run of success: at 250 years old, it’s home to the world’s most competitive economy, accounting for more than a quarter of global GDP and more than half of the world’s top 100 companies. But America also confronts a raft of new challenges—mounting national debt, eroding infrastructure, slipping test scores, persistent income disparity, and more—that could threaten its historical momentum. “I don’t bet against the US,” says McKinsey’s North America Chair Eric Kutcher. “If you believe in entrepreneurial spirit as core to who we are, then you have to believe this success will continue. But it’s not a foregone conclusion. There’s a lot that must happen to enable it.” In this episode of The McKinsey Podcast, Kutcher and Senior Partner Olivia White speak with Global Editorial Director Lucia Rahilly about new McKinsey Global Institute research on what drives the US’s competitive edge—and what leaders need to do to maintain that edge in the AI era. Theme music composed, performed, and produced by Joy Ngiaw.See www.mckinsey.com/privacy-policy for privacy information

Yes, AI is astonishing: fast, powerful, and learning every day. But even as leaders strike up new pilots across their organizations, most still struggle to translate experimentation into enterprise value—and now, agentic AI is raising the stakes. In this episode of The McKinsey Podcast, McKinsey Senior Partner Alexis Krivkovich speaks with Global Editorial Director Lucia Rahilly about what it will take to build an “agentic organization”—from reimagining workflows to reshaping leadership roles, skills, and culture for a future where humans increasingly operate above the loop. Theme music composed, performed, and produced by Joy Ngiaw.See www.mckinsey.com/privacy-policy for privacy information