Ep. 118: "Triple G": What to Know About Retatrutide (vs. Semaglutide vs. Tirzepatide)

Retatrutide — nicknamed "Triple G" — has posted the largest weight-loss results ever seen from a medication, with about 28% average weight loss in its main phase 3 trial. Dr. Judith Borger breaks down how this investigational triple agonist works on GIP, GLP-1, and glucagon, what the phase 2 and phase 3 studies show, how it compares to semaglutide (Wegovy/Ozempic) and tirzepatide (Zepbound/Mounjaro), and why the "research peptide" versions sold online are a real risk. In this episode How semaglutide and tirzepatide work, and the step from single to dual to triple agonist Why glucagon is the surprising — and important — third hormone Results from TRIUMPH-1 through -4 and TRANSCEND-T2D-1 Side effects, including dysesthesia and what it means for your skin What's still unknown: head-to-head data, heart outcomes, lean mass The legal landscape   Dr. Judith Borger Links: www.theaestheticdoctor.com www.instagram.com/doctorborger

Fall has a way of sneaking up — school schedules ramp up, extracurriculars are in full swing, and the to-do list gets longer, leaving many feeling stressed and depleted. In this episode of the Aesthetic Doctor Podcast, Dr. Borger keeps it free-flowing and honest, talking through why this season feels so overwhelming for busy moms and sharing wellness tips that actually fit into a packed day. She covers: Why fall hits different — the collision of school schedules and increasing expectations Realistic ways to find pockets of wellness without adding another task to your plate (movement, breathing, sleep, and lowering the bar on what "counts") Martha Beck's Better - Barter - Bag concept, and how trading small favors and support can lighten the mental load A few other favorite tips  from Dr. Borger for staying grounded when everything feels like a lot   Dr. Judith Borger Links: www.theaestheticdoctor.com www.instagram.com/doctorborger

Dr. Judith Borger breaks down what peptides actually are at the molecular level, unpacks the fast-moving and often confusing FDA regulatory landscape around peptide compounding in 2026, and gives an evidence-based rundown of the most talked-about peptide products and stacks — including “Glow” (GHK-Cu), “Wolverine” (BPC-157/TB-500), CJC-1295/Ipamorelin, PT-141, and the GLP-1s. In This Episode: What peptides are and how they differ from proteins and amino acids Why some peptides act as hormones, antioxidants, or signaling molecules in the body The current FDA regulatory status of peptide compounding, including the 503A Bulk Drug Substances List and the 2026 Pharmacy Compounding Advisory Committee review Why “removed from the safety watch-list” is not the same as “approved for compounding” The difference between a peptide from a licensed compounding pharmacy versus an unregulated online vendor A breakdown of popular peptide products: Glow (GHK-Cu, glutathione, and vitamin C — sometimes also including BPC-157 and TB-500), Wolverine (BPC-157 + TB-500), CJC-1295/Ipamorelin, PT-141 (bremelanotide/Vyleesi), and GLP-1s (semaglutide, tirzepatide) Why “Glow” and “Wolverine” aren't always separate products — some Glow formulations fold in the same BPC-157/TB-500 combination sold as Wolverine What real human clinical evidence exists for each — and where the evidence is limited to animal studies or mechanistic theory Disclaimer: This episode is for educational purposes only and does not constitute medical advice. Regulatory status discussed reflects information available as of August 2026 and is subject to change; listeners should confirm current FDA guidance and consult a licensed physician before considering any peptide therapy. Dr. Judith Borger Links: www.theaestheticdoctor.com www.instagram.com/doctorborger

Vascular occlusion is one of the most serious — and most misunderstood — complications in filler injections. In this episode, Dr. Judith Borger breaks down exactly what vascular occlusion is, why it happens, the anatomical danger zones every injector should know cold, and the warning signs every patient should be able to recognize. This isn't a scare-tactic episode — it's an honest, clinical walkthrough from a board-certified physician, designed to help you ask better questions and feel more confident in the chair. In this episode: What vascular occlusion actually is (and how it differs from normal bruising or swelling) The two mechanisms: direct intravascular injection vs. extravascular compression High-risk anatomical zones: glabella, nose, tear trough, temple Warning signs to watch for: disproportionate pain, blanching, dusky/mottled skin What to do immediately if you notice these signs A brief overview of how it's managed and why HA filler's reversibility matters Questions to ask your injector before treatment Dr. Judith Borger Links: www.theaestheticdoctor.com www.instagram.com/doctorborger

Comparison is something we all do—but in today's world of social media and constant comparison, it can quietly rob us of our joy, gratitude, and confidence. In this episode of The Aesthetic Doctor Podcast, Dr. Judith Borger explores why our brains are wired to compare, how comparison can create a mindset of scarcity, and why measuring ourselves against others is often the fastest path to dissatisfaction. She also shares how this shows up in aesthetic medicine, where the healthiest outcomes come from enhancing your own natural beauty—not chasing someone else's. You'll learn practical strategies to shift your perspective, cultivate gratitude, and focus on your own growth instead of someone else's highlight reel.   Dr. Judith Borger Links: www.theaestheticdoctor.com www.instagram.com/doctorborger

Cristiano Ronaldo has become one of the most recognizable faces in the world—not just because of his legendary football career, but because of his commitment to health, fitness, longevity, and maintaining a polished appearance. So what can Ronaldo teach us about aesthetic medicine? Quite a bit. In this episode of The Aesthetic Doctor Podcast, Dr. Judith Borger explores the rapidly growing world of men's aesthetics, and how today's male patients are seeking subtle, natural-looking results that enhance confidence rather than change their appearance. Gone are the days when aesthetic treatments were considered "just for women." Modern men—from CEOs and physicians to athletes and everyday professionals—are investing in treatments that help them look rested, healthy, and competitive both personally and professionally. This shift reflects a broader trend toward preventative care, skin health, and minimally invasive procedures with little to no downtime. Tune in to learn what today’s top trending male aesthetic procedures are.    Dr. Judith Borger Links: www.theaestheticdoctor.com www.instagram.com/doctorborger

If you've ever sat in a consultation room wondering what the difference is between all those laser machines — this episode is for you. Dr. Judith Borger, board-certified physician and medical director of Concierge Medical Arts, breaks down energy-based devices by skin concern, so you can walk in informed and walk out glowing.  What We Cover Pigmentation & Uneven Skin Tone Sun spots, age spots, melasma, and dullness — Dr. Borger explains how IPL targets melanin, what "peppering" means and why it's actually a good sign, and how the Light & Bright treatment handles pigmentation and redness in one session. Vascular Concerns — Redness, Rosacea & Veins Not all redness is the same. Dr. Borger walks through the difference between treating diffuse rosacea versus visible facial and leg veins, and which devices reach which vessels. Skin Resurfacing — Texture, Pores, Scars & Fine Lines If your goal is smoother, clearer skin, this is your segment. Dr. Borger covers fractional laser resurfacing, thermo-mechanical treatments, and why traditional microneedling still earns its place in a comprehensive treatment plan. Skin Tightening & Lifting Loose skin, loss of firmness, jowling, crepey necks — Dr. Borger explains the difference between surface-level and deep-tissue tightening, including treatments that reach the same foundational layer targeted in surgical facelifts. Laser Hair Removal The Lutronic Clarity II's dual-wavelength system makes it safe for all skin types — and why most patients call it virtually painless.   Dr. Judith Borger Links: www.theaestheticdoctor.com www.instagram.com/doctorborger

After returning from a transformative retreat at  the Miraval Resort, Dr. Judith Borger reflects on what it truly means to feel grounded — and then breaks down the biology behind why. In this episode, she unpacks the neuroscience of stress and overwhelm, explains what's actually happening in your brain and body when you can't think your way out of anxiety, and walks through seven evidence-based grounding techniques used in clinical settings from trauma therapy to military training. Whether you're a high-achiever running on cortisol, someone navigating stress and burnout, or simply curious about how to regulate your nervous system more effectively — this episode gives you the science and the tools.   LUX RECLAMATION 2027 - https://www.theaestheticdoctor.com/lux-reclamation-2027   Dr. Judith Borger Links: www.theaestheticdoctor.com www.instagram.com/doctorborger

Yes, you read that right. Salmon sperm. And your face. In this episode, Dr. Judith Borger cuts through the viral buzz around PDRN (polydeoxyribonucleotide) — the regenerative treatment taking the aesthetic world by storm — and gives you the real science, the honest FDA truth, and the safety information that nobody else is talking about. Key Takeaways: PDRN is derived from purified salmon DNA — extensively processed, not raw salmon sperm It works by triggering cellular repair and supplying building blocks for collagen and elastin Results are gradual and cumulative — this is not a filler Topical PDRN = low risk in the US. Injectable PDRN = not FDA-approved for cosmetic use Anyone with a history of cancer should consult their oncologist before any PDRN treatment Ask about product sourcing, application method, provider training, and realistic timelines   Dr. Judith Borger Links: www.theaestheticdoctor.com www.instagram.com/doctorborger

Does Botox freeze your face? Do fillers stretch your skin? In this myth-busting episode, Dr. Judith Borger separates aesthetic fact from fiction and explains what social media often gets wrong about cosmetic treatments. With science-based insight and a compassionate physician perspective, you’ll learn how aesthetic medicine really works — and how thoughtful treatments can support natural, confident aging.   Dr. Judith Borger Links: www.theaestheticdoctor.com www.instagram.com/doctorborger