Stroke Alert December 2025

On Episode 59 of the Stroke Alert Podcast, host Dr. Negar Asdaghi is joined by Dr. Eva Mistry, Stroke Associate Editor and Vice Chair of Research and Divisional Director of Vascular Neurology at the Department of Neurology and Rehabilitation Medicine at the University of Cincinnati, for the 2025 Ralph Sacco Review of Top Cerebrovascular Research. In honor of the late Dr. Ralph L. Sacco, former Editor-in-Chief of Stroke, who died in January 2023, Drs. Asdaghi and Mistry review some of the top cerebrovascular science published in any journal or presented at any scientific forum throughout the past year. For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20251216.704704

On Episode 58 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the November 2025 issue of Stroke: "Fingolimod as a Potential Cerebroprotectant Results From the Stroke Preclinical Assessment Network" and "Apixaban and Recurrent Stroke Risk With Left Ventricular Dysfunction: A Secondary Analysis of the ARCADIA Trial." She also interviews Drs. Aaron Rodriguez-Calienes and Santiago Ortega-Gutierrez about their article "Endovascular Thrombectomy Versus Best Medical Therapy for Large Vessel Occlusion Stroke Beyond 24 Hours: A Systematic Review and Meta-Analysis." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20251114.13070

On Episode 57 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the October 2025 issue of Stroke: "Oxygen Extraction Fraction on Baseline MRI Predicts Infarction Growth in Successfully Reperfused Patients" and "Tadalafil Treatment in Patients With Cerebral Small Vessel Disease: The ETLAS-2 Randomized Clinical Trial." She also interviews Dr. Thomas Meinel on the article "Intravenous Thrombolysis in Patients With Recent Intake of Direct Oral Anticoagulants: A Target Trial Analysis and Comparison With Reversal Agent Use." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20251008.578434

On Episode 56 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the September 2025 issue of Stroke: "Glucagon-Like Peptide-1 Receptor Agonists and Risk of Nontraumatic Intracerebral Hemorrhage in Patients With Type 2 Diabetes" and "White Matter Hyperintensity Multispot Pattern Lesions and Cerebrovascular Amyloid Burden in Cerebral Amyloid Angiopathy." She also interviews Dr. Cora Nijboer and Prof. Manon Benders on their article "Perinatal Arterial Stroke Treated With Stromal Cells Intranasally: 2-Year Safety and Neurodevelopment." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250910.502300

On Episode 55 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the August 2025 issue of Stroke: "Anticoagulation Timing in Acute Stroke With Atrial Fibrillation According to Chronic Kidney Disease: The OPTIMAS Trial" and "Risk of Intracranial Hemorrhage With Apixaban Versus Aspirin Therapy: A Meta-Analysis of Randomized Controlled Trials." She also interviews Dr. Stephen Ryan and Prof. Anne Aamodt about the Tenecteplase in Central Retinal Artery Occlusion Study (TenCRAOS), presented in May at the European Stroke Organisation Conference. For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250815.784085

On Episode 54 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the July 2025 issue of Stroke: "Association of the Timing and Type of Acute Symptomatic Seizures With Poststroke Epilepsy and Mortality" and "Effect of Argatroban Plus Dual Antiplatelet in Branch Atherosclerosis Disease: A Randomized Clinical Trial." She also interviews Dr. Amrou Sarraj about the article "Mechanical Thrombectomy for Large Ischemic Stroke: A Critical Appraisal of Evidence From 6 Randomized Controlled Trials." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250710.454589

On Episode 53 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the June 2025 issue of Stroke: "Effects of Intensive Blood Pressure Lowering on Brain Swelling in Thrombolyzed Acute Ischemic Stroke: The ENCHANTED Results" and "Association of Ischemic Core Hypodensity With Thrombectomy Treatment Effect in Large Core Stroke: A Secondary Analysis of the SELECT2 Randomized Controlled Trial." She also interviews Drs. Samantha Rivet and Felix Ng about their article "Persistent Tissue-Level Hypoperfusion (No-Reflow) Negates the Clinical Benefit of Successful Thrombectomy." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250611.774006

On Episode 52 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the May 2025 issue of Stroke: "Assessing the Impact of the COVID-19 Pandemic on Childhood Arterial Ischemic Stroke: An Unanticipated Natural Experiment" and "Low Hemoglobin Causes Hematoma Expansion and Poor Intracerebral Hemorrhage Outcomes." She also interviews Dr. David Fiorella about the MIND trial, presented in February at the International Stroke Conference. For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250508.399500

On Episode 51 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the April 2025 issue of Stroke: "Clinical Severity and Outcomes in Large Infarcts With Endovascular Therapy: A Post Hoc Analysis of the ANGEL-ASPECT Trial" and "Association Between Thrombus Composition and Etiology in Patients With Acute Ischemic Stroke Treated by Thrombectomy." She also interviews Dr. Roland Veltkamp about the PRESTIGE-AF trial, presented in February at the International Stroke Conference. For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250414.579089

On Episode 50 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the March 2025 issue of Stroke: "Impact of Subarachnoid Hemorrhage on Human Glymphatic Function: A Time-Evolution Magnetic Resonance Imaging Study" and "Thrombolysis for Ischemic Stroke Beyond the 4.5-Hour Window: A Meta-Analysis of Randomized Clinical Trials." She also interviews Drs. Mayank Goyal and Michael Hill about the ESCAPE-MeVO trial, presented in February at the International Stroke Conference. For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250314.838310