Immunic CEO on key 2025 highlights and 2026 milestones

Genflow Biosciences Ltd (LSE:GENF, OTCQB:GENFF) CEO Dr Eric Leire talked with Proactive's Stephen Gunnion about the company’s key programs and upcoming catalysts as it enters what management expects to be a pivotal year. Leire discussed why 2026 is shaping up as “a year of catalysts” for the company, with particular focus on the dog ageing trial, progress in MASH, and the group’s approach to partnerships and licensing. Leire explained that the dog longevity study is the nearest catalyst, with the trial expected to be unblinded shortly and early efficacy readouts anticipated in the near term. While safety has already been confirmed, the study remains blinded, meaning efficacy results are still unknown. The first data will focus on biological age, measured using a methylation clock, with a more detailed analysis of muscle biopsies and mitochondrial function to follow. According to Leire, “this trial could be very important for our shareholders, because it will trigger a deal with an animal health company bringing non-dilutive money in the company.” The interview also explored Genflow’s repositioning in MASH toward advanced fibrosis and the prevention of hepatocellular carcinoma. Leire highlighted the significant unmet need in late-stage disease, noting that recent therapies target earlier stages and leave patients with advanced fibrosis facing limited options. He said the company’s preclinical data have been encouraging and form a key part of the IND package, helping differentiate Genflow from existing and emerging treatments. In addition, Leire discussed the company’s licensing strategy, including plans to out-license the dog program to an animal health specialist and pursue early-stage partnerships for glaucoma, while retaining focus on age-related conditions such as sarcopenia. With meetings planned during JPMorgan week, Leire said the company is seeking non-dilutive capital and strategic validation as it moves forward. For more interviews like this, visit Proactive’s YouTube channel, give the video a like, subscribe to the channel, and enable notifications so you don’t miss future updates. #GenflowBiosciences #GENF #GENFF #Biotechnology #LongevityResearch #DogAging #AnimalHealth #MASH #LiverDisease #Fibrosis #BiotechStocks #LifeSciences #LicensingDeals #JPmorganHealthcare

Santhera Pharmaceuticals (SIX:SANN) executive vice president for corporate planning and business development Andreas Missy talked with Proactive's Stephen Gunnion about a major licensing agreement signed with Nxera for the development, manufacturing, and commercialisation of AGAMREE in Japan, South Korea, Australia, and New Zealand. Missy explained that AGAMREE, Santhera’s treatment for Duchenne Muscular Dystrophy (DMD), is already available in the US, EU, UK, Canada, and China. The deal with Nxera is valued at up to $205 million, including a $40 million upfront payment - $30 million in cash and $10 million as an equity investment priced at a 20% premium. Santhera is also eligible for up to $165 million in regulatory and sales milestones, plus double-digit tiered royalties on net sales. “Nxera is a technology-powered biopharma company with the ability to execute, as shown by its commercialisation of PIVLAZ,” said Missy, citing the company’s regional infrastructure and experience from its acquisition of Idorsia’s APAC operations. Missy noted a bridging clinical study may be required in Japan, and Nxera will be responsible for regulatory filings and regional manufacturing setup. He added that Japan alone represents a DMD patient population of over 2,000, with a high percentage already treated with steroids. Missy also outlined Santhera’s broader global expansion strategy, which includes recent deals in Turkey, the GCC region, India, and Russia, and plans for further licensing in markets like Latin America. For more interviews and company updates, visit Proactive's YouTube channel. Don’t forget to like this video, subscribe, and enable notifications so you never miss out. #Santhera #AGAMREE #DuchenneMuscularDystrophy #BiotechNews #PharmaDeals #Nxera #JapanHealthcare #OrphanDrugs #PharmaceuticalLicensing #RareDiseaseTreatment #InvestorNews #HealthcareInnovation #ProactiveInvestors

Solvonis Therapeutics PLC (LSE:SVNS) CEO Anthony Tennyson talked with Proactive's Stephen Gunnion about the company’s latest US patent allowance, progress within its PTSD drug development program, and what investors should expect during a potentially catalyst-rich 2026. Tennyson explained that the newly allowed US patent for the SVN-SDN-14 program represents a significant step in building long-term value. He said the patent provides “composition of matter protection over a new chemical series within our PTSD program,” strengthening the intellectual property foundation as the company approaches lead candidate selection. According to Tennyson, this protection improves the commercial quality of the asset while extending its future value window, without altering near-term development timelines. The CEO outlined the company’s focus on treating post-traumatic stress disorder, noting it affects around 13 million people across the major pharmaceutical markets and currently lacks a specifically licensed medicine. Solvonis Therapeutics PLC is pursuing a differentiated approach, concentrating on mechanisms that support therapeutic engagement through pro-social neurochemistry rather than symptom suppression alone. Looking ahead to Q1 2026, Tennyson highlighted the milestones investors should monitor, including completion of in-vivo work, confirmation of brain activity, narrowing the candidate set, and final lead selection. He described this as “a key inflection point as the program transitions from discovery to IND enabling work.” Beyond PTSD, Tennyson discussed broader pipeline progress across addiction and psychiatric indications. He said 2026 could be a catalyst-rich year, with advancement of clinical programs, potential partnering discussions, and continued progress within the company’s discovery engine. For more interviews like this, visit Proactive’s YouTube channel, give the video a like, subscribe, and enable notifications so you never miss future updates. #SolvonisTherapeutics #SVNS #BiotechStocks #DrugDevelopment #PTSDResearch #MentalHealthBiotech #AddictionTreatment #ClinicalTrials #Biopharma #HealthcareInvesting #LSEStocks #PatentNews

Immunic Inc (NASDAQ:IMUX) CEO Dr Daniel Vitt talked with Proactive's Stephen Gunnion about the company’s major milestones in 2025 and key expectations for 2026. He highlighted the significance of the phase 2 CALLIPER study, which demonstrated a 31% reduction in confirmed disability worsening in patients with primary progressive multiple sclerosis (MS), and a 34% reduction in those without baseline gadolinium lesions. According to Vitt, this points to a “neuroprotective effect” of vidofludimus calcium. He also noted consistent long-term results from the phase 2 EMPhASIS study, where 92.3% of relapsing-remitting MS patients remained free of 12-week confirmed disability worsening after 144 weeks. Only 13.8% of in total 29 disability events were progression independent of relapse activity (PIRA), supporting the drug’s potential effect on progression regardless of relapse activity. Beyond MS, Vitt said Immunic has strengthened its patent position for vidofludimus calcium, with potential exclusivity to 2041 in key markets. He also discussed early findings on IMU-856, which showed increases in natural GLP-1 levels—suggesting gut health benefits and potential links to weight management. Looking ahead, the company expects top-line data from the phase 3 ENSURE trials by the end of 2026. Vitt said, “That’s a big step for the company forward to getting vidofludimus calcium ready to be launched and ready to be submitted for approval to the FDA.” Visit Proactive’s YouTube channel for more interviews and updates. Don’t forget to like the video, subscribe, and turn on notifications for future content. #ImmunicInc #MultipleSclerosis #VidofludimusCalcium #MSResearch #BiotechStocks #FDAApproval #ClinicalTrials #CeliacDisease #GLP1 #Neuroprotection #Biopharma #HealthcareInnovation #DrugDevelopment #MSAwareness #InvestorUpdate

Hive Digital Technologies Executive Chairman Frank Holmes joined Steve Darling from Proactive to highlight the company’s strong Bitcoin production performance in December 2025, underscoring significant year-over-year growth, continued quarter-over-quarter momentum, and consistent month-over-month operational strength, despite seasonal weather challenges affecting parts of the Northern Hemisphere. During December, HIVE produced a total of 306 Bitcoin, representing a 197% increase compared to the same period last year. This achievement came even as global Bitcoin mining difficulty rose approximately 40% year-over-year, emphasizing the company’s operational efficiency and expanding mining capacity. HIVE also delivered solid sequential growth, with production increasing 6% month-over-month and 23% quarter-over-quarter, reflecting rising hashrate levels and continued improvements in fleet efficiency. The company averaged approximately 9.9 Bitcoin per day during the month, supported by an average hashrate of 23.3 exahash per second, with peak performance reaching 24 EH/s. While extreme cold weather in certain Northern Hemisphere regions temporarily constrained peak hashrate availability, HIVE’s geographically diversified operating model helped mitigate these impacts. With operations spread across three continents, nine time zones, and five languages, the company was able to maintain high uptime, operational resilience, and consistent production levels. Looking ahead, Holmes also outlined HIVE’s plans for further expansion of its renewable-powered infrastructure. The company intends to develop an additional 100 megawatts of hydroelectric-powered data center capacity at its Yguazú campus in Paraguay, with full commissioning targeted for the third quarter of calendar year 2026. Long-lead-time substation components have already been ordered, positioning the project to stay on schedule. HIVE plans to deploy the new capacity under a disciplined return-on-invested-capital framework, with a focus on optimizing free cash flow from its green-energy-powered data center assets. Upon completion of the Yguazú expansion, HIVE’s total renewable energy footprint is expected to reach approximately 540 megawatts across its operations in Paraguay, Canada, and Sweden, reinforcing the company’s commitment to sustainable, large-scale digital infrastructure growth. #proactiveinvestors #hivedigitaltechnologieslet #tsxv #hive #nasdaq #hive #CryptoMining #GreenEnergy #BuzzHPC #AIInfrastructure #NvidiaH200 #QuebecDataCenter #SustainableTech #GPUCluster #TorontoTech #AITraining #HiveDigital #LiquidCooling #Supercomputing #GreenEnergyAI #Exahash #HighPerformanceComputing

Seeing Machines Ltd (AIM:SEE, OTC:SEEMF) CEO Paul McGlone talked with Proactive's Stephen Gunnion about the company’s latest announcement regarding an accelerated lump sum royalty payment of about US$14.1 million from a major automotive customer, its improving financial position, and key technology demonstrations at CES. McGlone explained that the payment follows a material change to an automotive production program, enabling Seeing Machines to trigger contractual guarantees tied to minimum volumes or absolute payments. As a result, the company has negotiated the full value of expected royalties, discounted over five years, to be received as a lump sum and recognised this month. He described the outcome as “a very good deal for us,” noting that the revenue will flow directly through to profit and cash. Importantly, McGlone emphasised that the payment is incremental to Seeing Machines’ existing trajectory. He confirmed that the company achieved a cash-flow breakeven run rate by the end of December, stating that “the December month was a cash flow positive and profitable month, the first for us.” He added that Seeing Machines is highly confident of profitability in the third and fourth quarters, meaning the entire second half is expected to be profitable, even without factoring in the accelerated royalty payment. The discussion also covered Seeing Machines’ presence at CES, where the company is demonstrating advanced 3D interior perception mapping technology with partners including Valeo. McGlone highlighted growing opportunities across software-defined vehicles, robotics and autonomous vehicle applications, as well as progress in intoxication detection technology and future mobility initiatives. To stay up to date with more interviews like this, visit Proactive’s YouTube channel, give the video a like, subscribe to the channel, and enable notifications so you never miss future content. #SeeingMachines #PaulMcGlone #AutomotiveTechnology #DriverMonitoring #AutomotiveRoyalties #CashFlowPositive #Profitability #CES2026 #AutonomousVehicles #FutureMobility #ADAS #VehicleSafety #ProactiveInvestors

Arizona Gold and Silver CEO Mike Stark joined Steve Darling from Proactive to announce the receipt of new assay results from the company’s latest diamond drill hole, PC25-158, at the Philadelphia Project in Arizona. The results further confirm and extend the scale of high-grade gold mineralization at the Perry Discovery, marking another important step in defining the potential of the project. Hole PC25-158 successfully extended the wide zone of high-grade gold mineralization by approximately 110 metres to the north of previously reported hole PC25-156. The company reported a standout intercept of 4.33 metres grading 19.37 grams per tonne gold and 19.36 grams per tonne silver, starting at a downhole depth of 290.09 metres. These results continue to demonstrate the strength and continuity of mineralization within the Perry system. Stark told Proactive that the Perry Discovery remains consistently well mineralized and has now been extended a further 60 metres north beyond the last reported drilling. He added that observed vein textures suggest the drilling has only reached the upper portion of the boiling zone of the mineralizing system, indicating strong potential for improved grades and wider mineralization at depth. Drilling is ongoing, with hole PC25-159 currently in progress and stepping out an additional 60 metres to the north. The company is eager to receive results from this hole, which will provide further insight into the continuity and scale of the mineralized structure. Arizona Gold and Silver plans to continue expanding the strike length of the Perry Discovery both to the north and south, with the objective of demonstrating the full scale of the mineralized structure. The company notes that the structure extends for more than three kilometres and lies entirely within its property boundaries. Management is focused on determining how much of this extensive structure hosts significant gold mineralization. Stark emphasized that the potential scale of the Perry Discovery—both along strike and at depth—is highly significant. With drilling ongoing and strong results continuing to emerge, the company believes the Philadelphia Project is shaping up to be a compelling gold discovery with substantial exploration upside. #proactiveinvestors #arizonagoldandsilverinc #tsxv #azs #otcqb #azasf #GoldExploration #PhiladelphiaProject #MiningNews #JuniorMining #HeapLeach #Metallurgy #ResourceInvesting #GoldStocks #PreciousMetals #MiningNews #GoldExploration #SilverMining #JuniorMining #ArizonaMining #GoldInvesting #DrillResults #MiningInfrastructure #ProactiveInvestors #perryzone #risingfawnzone #Antimony #CriticalMinerals #ArizonaGoldAndSilver #MiningNews #SilvertonProject

Aftermath Silver CEO Ralph Rushton joined Steve Darling from Proactive to announce that the company has successfully completed the acquisition of the Berenguela silver-copper-manganese project. With the final payment obligation now fulfilled under the acquisition agreement between Aftermath Silver and SSR Mining, the transfer of ownership has been completed and Aftermath now holds a 100% interest in the Berenguela project. Rushton told Proactive that Berenguela represents Aftermath Silver’s flagship asset and a cornerstone of the company’s growth strategy. He explained that recent drilling programs have been primarily focused on infilling the historic mineral resource estimate (MRE), with the goal of upgrading inferred resources into the measured and indicated categories. This work supports a stronger technical foundation for future economic and development studies. A new mineral resource estimate was published in December, incorporating results from recent drilling and providing an updated view of the project’s scale and grade potential. Building on this progress, Aftermath has now launched its Phase 3 drilling program at Berenguela, which is designed to advance the project on multiple fronts. The current drilling campaign is focused on three key objectives. First, the company is targeting untested areas in the eastern and southeastern zones of the known mineralization, where both historic drilling and the 2024–2025 drill program encountered notably high copper grades. These areas are considered highly prospective for resource expansion. Second, drilling is being carried out in areas identified as potential initial mining zones, with the intent of supporting future mine planning and complementary technical studies. Finally, subject to the completion of permitting, which Rushton noted is well advanced, the company plans to test the Southwest Intrusive target, a priority exploration area with potential to further enhance the overall resource base. #proactiveinvestors #aftermathsilverltd #tsxv #aag #otcqx #aagff #mining #SilverMining, #BerenguelaProject, #Mining #Silver #Copper #Manganese #Peru #DrillingResults #BatteryMetals #ResourceModel #Investing

Ocean Power Technologies CEO Philipp Stratmann joined Steve Darling from Proactive to announce that the company has reached another major milestone with the award of a multi-buoy contract valued at more than $5 million. The contract calls for the deployment and operation of MERROWS®-equipped PowerBuoy® systems in support of a U.S. Coast Guard mission under the U.S. Department of Homeland Security, aimed at enhancing efforts to protect the homeland. The demonstration project will enable persistent, resident maritime domain awareness off the coast of San Diego, California, showcasing Ocean Power Technologies’ ability to deliver long-duration, autonomous offshore surveillance capabilities. The initiative highlights the growing role of renewable, ocean-based platforms in supporting national security and defense-related missions. Stratmann told Proactive that the demonstration will involve the deployment of four PowerBuoy® platforms, each integrated into the Department of Homeland Security’s selected command, control, communications, computers, cyber, and intelligence (C5I) environment. These offshore platforms will be deployed alongside several Anduril surveillance towers, together forming a highly integrated and resilient sensing architecture. All data streams collected from the buoy-based sensors and the tower-based systems will feed into Anduril’s Lattice Command-and-Control platform. This unified system will provide mission operators with enhanced situational awareness, improved detection and monitoring capabilities, and real-time decision support across the maritime domain. According to Stratmann, the contract underscores Ocean Power Technologies’ ability to deliver reliable, scalable, and mission-ready solutions that integrate seamlessly with advanced defense and security networks. The project is expected to further validate the company’s PowerBuoy® technology as a critical asset for persistent offshore surveillance and intelligence gathering in support of U.S. national security objectives. #proactiveinvestors #oceanpowertechnologiesinc #nyseamerican #optt #PhillipStratmann, #USGovernmentContract, #OffshoreAutonomy, #MaritimeSecurity, #CommercialPlatforms, #GrowthStrategy, #BuoyBusiness, #VehicleBusiness, #InternationalExpansion, #ReadyToDeploy #AutonomousVehicles #MaritimeTech #CleanEnergySolutions #AUVSI #SustainableTechnology #MarineInnovation #EnergyEfficiency #UncrewedSystems #GlobalExpansion

Nextech3D.ai CEO Evan Gappelberg and KraftyLab CEO Boris Sotnikov joined Steve Darling from Proactive to announce that Nextech3D.ai has officially closed its acquisition of KraftyLab following the successful completion of due diligence. The transaction represents a significant strategic milestone for Nextech3D.ai as it strengthens its position in the enterprise segment of the rapidly growing AI-powered event and engagement market. Sotnikov explained that KraftyLab brings a strong and diversified roster of blue-chip enterprise customers, including global technology leaders such as Google, Microsoft, Netflix, Oracle, Yelp, ZoomInfo, Spotify, and Meta, among others. He emphasized that this customer base reflects the credibility and effectiveness of KraftyLab’s engagement solutions within the enterprise ecosystem. In addition, KraftyLab has generated approximately $1.2 million in year-to-date 2025 revenue, supported by robust gross margins of roughly 72%, underscoring the scalability, efficiency, and profitability of its platform. Gappelberg told Proactive that a key near-term initiative following the acquisition will be the integration of Nextech3D.ai’s proprietary ARitize3D technology into KraftyLab’s product offering. As part of this effort, Nextech3D.ai plans to convert KraftyLab’s top five best-selling kits into high-fidelity 3D models that will be embedded directly into the KraftyLab sales and purchasing experience. With this enhancement, corporate HR managers and team-building buyers will be able to interact with products in a more immersive way. By clicking a “View in 3D” option, customers can see kits virtually placed on their own desks using augmented reality, delivering an intuitive, interactive, and Amazon-style shopping experience that aligns with modern enterprise buyer expectations. According to Gappelberg, the combined Nextech3D.ai and KraftyLab platform is well positioned to drive higher average contract values, improve customer retention, and foster deeper, longer-term relationships with enterprise clients. The integration is also expected to unlock new monetization opportunities across a broad range of event formats, including in-person, virtual, and hybrid experiences. By strengthening its foothold in the enterprise market through the KraftyLab acquisition, Nextech3D.ai aims to accelerate revenue growth, broaden its customer reach, and reinforce its position as a leading provider of AI-powered event, engagement, and experiential technology solutions. #nextech3d.al #otcqx #nexcf #cse #ntar #EvanGappelberg #ARway #AugmentedReality #SpatialMapping #IndoorNavigation #MapDynamics #EventTech #TradeShowSolutions #TechStocks #ARRevenueGrowth #3DTechnology #ProactiveInvestors #aws #amazonwebservice #tickets #kraftylab