Genflow's dog gene trial: £500K raised for SIRT6 therapy

Oriole Resources PLC (AIM:ORR) CEO Martin Rosser talked with Proactive about the latest drill results from the Mbe Gold Project in Cameroon, which he described as the company’s best since his appointment. The ongoing maiden drilling program has returned 125 gold intersections from just eight holes, translating to an intersection every 21 metres drilled. Rosser emphasised the scale and quality of the results, highlighting that “Mbe eight came back with over 85 metres, I think 86.5 to be precise,” including a particularly strong section of 39.4 metres at two grams per tonne. He added that these intersections start close to surface, supporting the potential for open-pit mining. To date, over 60% of the drilling program has been completed, but only one-third of the results have been reported, suggesting more updates to come. Rosser confirmed that 16 more holes remain to be reported, with the JORC exploration target expected in Q3, followed by a maiden mineral resource estimate in Q4. In addition to ongoing analysis at Mbe South, Rosser mentioned plans to launch the first drilling program at Mbe North, indicating further upside potential. For more updates from Oriole Resources and other mining sector news, visit Proactive’s YouTube channel. Don’t forget to like this video, subscribe, and turn on notifications so you never miss a story. #OrioleResources #GoldExploration #CameroonMining #MbeGoldProject #DrillingResults #JuniorMining #MineralExploration #GoldInvesting #NaturalResources #MiningUpdates

Genflow Biosciences PLC (LSE:GENF, OTCQB:GENFF) CEO Dr Eric Leire talked with Proactive's Stephen Gunnion about the company’s latest milestone—a successful £0.5 million fundraising to support a gene therapy trial in ageing dogs using SIRT6. Dr Leire explained that the funding was secured via a share subscription from a US-based longevity fund, with shares issued at market price and without a discount—what he described as a clear “vote of confidence in the company and its therapies.” Dr Leire explained that the funding was secured via a share subscription from a US-based longevity fund, with shares issued at market price and without a discount—what he described as a clear “vote of confidence in the company and its therapies.” The trial aims to demonstrate proof of concept in dogs, replicating promising results previously seen in mice. “It worked like magic in mice. We reasonably think that it will work likewise in dogs,” Leire stated. Unlike mice, however, dogs share environmental conditions with humans, making them a more relevant model for translation into human therapies. Leire also highlighted the commercial potential of targeting animal health, as it offers a shorter regulatory pathway compared to human applications. He confirmed that the trial has reached a key milestone: the randomisation of 24 senior dogs, aged over ten years, into four arms, including one control group and three treatment groups using different SIRT6 delivery methods. He also addressed ethical considerations, stating that the therapy does not involve genetic modification, and described the use of non-integrating gene therapy approaches, including naked DNA and AAV vectors. Visit Proactive's YouTube channel for more videos, and don't forget to give the video a like, subscribe to the channel and enable notifications for future content. #GenflowBiosciences #GeneTherapy #SIRT6 #DogAgingTrial #LongevityResearch #BiotechFunding #AnimalHealth #AntiAging #Biotechnology #ClinicalTrials #LifeSciences #InvestingInBiotech #SeniorDogs

Caledonia Mining Corporation PLC chief executive Mark Learmonth talked with Proactive's Stephen Gunnion about the company’s strong first-quarter performance, driven by a rise in both gold production and gold prices. Learmonth highlighted that Caledonia sold approximately 19,000 ounces of gold in the quarter, up from 17,500 ounces in Q1 2024, and achieved a gold price of just under $2,900 per ounce. This led to gross profit nearly doubling from $14 million to $27 million, and earnings per share increasing from $0.07 to $0.45. The company is investing $41 million in capital expenditure this year, with $34 million allocated to sustaining operations at the Blanket mine. Projects include a new tailings facility, underground development to improve flexibility, and engineering upgrades for efficiency, such as converting the main winder to lower power consumption. Learmonth stated, “To some extent, we're using the higher gold price to invest for the extended life of mine and to build in more and more efficiency and robustness.” On safety, changes in senior personnel have led to visible management presence underground and proactive incident prevention strategies. Updates were also provided on Bilboes and Motapa, where Caledonia is revisiting feasibility approaches, continuing exploration, and exploring small-scale, high-return opportunities. Visit Proactive's YouTube channel for more videos, and don’t forget to give the video a like, subscribe to the channel, and enable notifications for future content. #CaledoniaMining #GoldMining #MarkLearmonth #ZimbabweMining #MiningStocks #GoldInvestment #Q1Results #MiningCapex #GoldProduction #BilboesProject #MotapaExploration #MiningUpdates #ProactiveInvestors

American Rare Earths CEO Chris Gibbs joined Steve Darling from Proactive to announce new assay results from the company’s ongoing mapping and channel sampling program at the Cowboy State Mine area of the Halleck Creek Rare Earths Project in Wyoming. The results further confirm the project's potential to become a major U.S.-based source of critical minerals. Gibbs shared that a total of 106 channel samples were collected across the Red Mountain area, a key target within the Halleck Creek project. Assay results revealed elevated levels of rare earth mineralization, with one standout sample grading 1.37% Total Rare Earth Oxide (TREO). Across the Red Mountain Pluton — the rare earth-bearing lithology — TREO grades ranged from 711 parts per million (ppm) to 13,651 ppm, with an average of 3,661 ppm. Notably, the company reported that magnet rare earth oxides, which are essential for high-performance magnets used in electric vehicles and wind turbines, account for approximately 28% of the total rare earth content. Heavy rare earth oxides, which are typically rarer and more valuable, represent about 13%. Fifteen of the collected samples exceeded 4,500 ppm TREO, further underscoring the presence of elevated-grade zones within the Red Mountain system. The company is currently incorporating the new channel sampling data into an updated geological model and mineral resource estimate for the CSM area. These updates will inform the ongoing mine planning process and play a key role in the upcoming Pre-Feasibility Study, which remains on track for completion in late 2025. #proactiveinvestors #americanrareearthslimited #asx #arr #otcqx #arrnf #adr #amrry #wyomingrareinc #AmericanRareEarths #HalleckCreek #CowboyStateMine #CriticalMinerals #Neodymium #Praseodymium #Yttrium #Dysprosium #MiningUpdate #PFS #ChannelSampling #ProactiveInvestors

Hive Digital Technologies Executive Chairman Frank Holmes joined Steve Darling from Proactive to highlight the company’s latest achievements in scaling its Bitcoin mining operations. The update comes on the heels of Hive’s successful acquisition of Bitfarms’ Yguazú assets in Paraguay and the energization of the site's initial 100 MW phase. Hive has now surpassed a significant milestone, reporting a global Bitcoin mining hashrate of 7.3 Exahash per second (EH/s). This represents a 10% increase over last month’s peak hashrate of 6.6 EH/s. The growth is primarily driven by the energization of the new hydro-powered facility in Paraguay, where Hive has deployed a blend of its proprietary BUZZ Miners and cutting-edge Bitmain S21+ air-cooled units. The company is rapidly accelerating the deployment of new ASIC miners, currently adding approximately 1 EH/s of capacity each month. With additional hardware deliveries expected, Hive anticipates increasing this pace to 1 EH/s every two weeks. Construction is also advancing at the company’s Valenzuela site, further contributing to Hive’s aggressive expansion strategy. By the end of May, Hive expects to have more than 20,000 mining machines operational at the Yguazú facility. The company remains on schedule to reach its Phase 1 target of 11.5 EH/s by June 2025, positioning itself as a major player in the global Bitcoin mining industry. #proactiveinvestors #hivedigitaltechnologieslet #tsxv #hive #nasdaq #hive #CryptoMining #GreenEnergy #BitcoinMining #ParaguayMining #DataCenter #Exahash #S21Miners #DigitalAssets #ProactiveInvestors

Synchronoss Technologies CEO Jeff Miller spoke with Steve Darling from Proactive to announce strong first-quarter 2025 results, marked by growth in cloud subscribers, improved margins, and high recurring revenue. The company reported $42.2 million in revenue, slightly down from $43 million a year earlier due to the expiration of a customer contract. However, recurring revenue rose to 93.1% of the total, up from 91.1%. Income from operations more than doubled to $8.2 million, while adjusted EBITDA grew 17% to $12.7 million, achieving a 30.2% margin. Synchronoss also completed a $200 million refinancing through a new four-year loan with TP Birch Grove, allowing it to retire $73.6 million in debt and fund the redemption of $121.4 million in senior notes. The company reaffirmed its full-year 2025 guidance, projecting revenue between $170 million and $180 million, adjusted EBITDA of $52 million to $56 million, and free cash flow of $11 million to $16 million, excluding a pending $28 million U.S. federal tax refund. #proactiveinvestors #synchronosstechnologiesinc #nasdaq #sncr #cloud #CloudRevenue #Q12025Results #JeffMiller #RecurringRevenue #TechEarnings #VerizonCloud #ATandTCloud #InvestorUpdates #TPBirchGrove #SoftwareGrowth #Refinancing

Standard Uranium Vice President of Exploration Sean Hillacre joined Steve Darling from Proactive to announce two key developments as it continues to advance its uranium exploration efforts in Canada’s Athabasca Basin. The company has signed a definitive property option agreement with Vital Battery Metals Inc., granting Vital the right to earn a 75% interest in the 12,265-hectare Corvo Project in the eastern Athabasca Basin. The project includes over 29 kilometres of exploration strike length across three northeast-southwest magnetic low trends, coincident with electromagnetic (EM) conductors and structural fault zones — key geological features for uranium targeting. Historic drill holes TL-79-3 and TL-79-5 returned uranium intercepts of 0.057% U₃O₈ over 3.5 metres and 0.065% U₃O₈ over 0.1 metres, respectively. Additionally, the Manhattan Showing on the property reported surface values of 59,800 ppm uranium. A recent high-resolution geophysical survey has enhanced target resolution, providing a solid foundation for future drilling. Standard Uranium has also completed a detailed ground gravity survey over the Wishbone, McNie, and Armbruster South targets at its 48,443-acre Sun Dog Project, located near Uranium City on the northern margin of the Athabasca Basin. The survey, combined with existing geophysical data, has outlined several high-priority drill targets. Drilling at the previously untested Wishbone target during the 2024 program returned anomalous uranium from all eight drill holes. Further gravity anomalies and favorable structures at McNie, Armbruster South, and Spring Dome offer additional kilometres of untested potential for high-grade, basement-hosted uranium mineralization. Standard Uranium’s exploration strategy continues to focus on advancing de-risked, high-impact drill targets across a growing portfolio of highly prospective projects in the world’s premier uranium district. #proactiveinvestors #standarduraniumltd #tsxv #stnd #otcqb #sttdf #mining #uranium #sundogproject #StandardUranium #BatteryMetals #AthabascaBasin #CorvoProject #SunDogProject #JuniorMining #MiningNews #CriticalMinerals #ProactiveInvestors

Tiziana Life Sciences CEO Ivor Elrifi joined Steve Darling from Proactive to share news the company has announced promising PET scan results from a patient with moderate Alzheimer’s disease treated for three months with intranasal foralumab under an expanded access program. The scan revealed a significant reduction in microglial activation, a key marker of neuroinflammation linked to Alzheimer’s progression. This outcome represents a major milestone for the company’s intranasal foralumab program. With no approved therapies for moderate Alzheimer’s disease, Tiziana sees foralumab—a fully human anti-CD3 monoclonal antibody—as a potential treatment option, both as a monotherapy and in combination with amyloid-targeting therapies. Foralumab has shown the ability to induce regulatory T cells (Tregs) that migrate to the brain and suppress neuroinflammation. These effects have been validated in preclinical models and in patients with secondary progressive multiple sclerosis, supporting further clinical development in neurodegenerative conditions. The company is set to begin a Phase 2 randomized, placebo-controlled trial in June 2025 involving mild Alzheimer’s patients. Data from this trial are expected by the end of 2025. The aim is to determine if reducing neuroinflammation translates into improved quality of life. #proactiveinvestors #tizianalifescienceslts #nasdaq #tlsa #newceo #ivorelrifi #Foralumab #AlzheimersResearch #Neuroinflammation #BiotechNews #PETscan #ClinicalTrials #AlzheimersTreatment #PharmaUpdates #HealthcareInnovation

Equinox Gold Vice President of Investor Relations Rhylin Bailie joined Steve Darling from Proactive to provide insight into the company’s recent strategic moves, including its transformative merger with Calibre Mining and continued development of key mining operations across the Americas. Founded in late 2017, Equinox Gold was built on a bold vision: to become a one million-ounce-per-year gold producer. Bailie remarked that the timing was fortuitous, as the company’s growth strategy coincided with a strong upswing in gold prices. Today, Equinox operates six active mines located in Canada, the United States, Brazil, and Mexico, steadily progressing toward its ambitious production goal. A major step toward achieving that target is the newly announced merger with Calibre Mining, a transaction Bailie described as “a significant milestone” in Equinox’s evolution. The deal brings together two world-class gold projects: Equinox’s Greenstone mine in Ontario and Calibre’s Valentine mine in Newfoundland. Both assets are characterized by long mine lives, low operating costs, and substantial production potential. Once the merger is finalized—expected by the end of Q2 2025—the combined entity will become the second-largest gold producer based in Canada. The Greenstone and Valentine mines alone are projected to contribute nearly 600,000 ounces of annual production, putting Equinox much closer to its long-term output target. Bailie noted that both mines are expected to be fully operational by early 2026. In the meantime, Equinox is focusing on scaling up operations, controlling costs, and maximizing cash flow, capitalizing on sustained strength in gold prices. With a strong asset base, robust market conditions, and a strategic merger underway, Equinox Gold is positioning itself as a leading force in the North American gold mining sector. #proactiveinvestors #equinoxgoldcorp #tsx #eqx #nyseamerican #eqx #CalibreMining #GoldStocks #GoldMining #GreenstoneMine #ValentineMine #MiningMerger #GoldInvesting #CanadaMining #ProactiveInvestors

Supernova Metals CEO Mason Granger joined Steve Darling from Proactive to discuss has appointment as Chief Executive Officer. Granger brings over two decades of capital markets experience, with a background in portfolio management of public and private oil and gas assets. He is a five-time recipient of the Brendan Wood International TopGun Investment Mind award and has earned a Canadian Lipper Fund Award. Granger is also recognized for his leadership in ESG, sustainability, and energy transition. In conjunction with his appointment, Supernova has entered into a non-binding letter of intent with Orogen Corp. to evaluate the potential acquisition of an additional 36% equity interest in WestOil Limited. WestOil, a private company based in the Republic of Seychelles, holds a 70% operating interest in Block 2712A, offshore Namibia in the highly prospective Orange Basin. Supernova, through its subsidiary NamLith Resources Corp., currently owns a 12.5% interest in WestOil. The proposed transaction would increase the company’s stake to 48.5%. This strategic move positions Supernova to significantly enhance its exposure to one of the world’s most active offshore exploration regions. #proactiveinvestors #supernovametalscorp #cse #supr #NamibiaOil #OilExploration #EnergyInvesting #OffshoreDrilling #OrangeBasin #MasonGranger #OilAndGas #3DSeismic #JuniorExplorers #ResourceStocks