The Problem of “Research Waste” in the Form of Unpublished Clinical Trials

In this episode, Mo and Marc chat with Dr. Evalina Burger-Van Der Walt about her inspiring personal and professional journey, from growing up in South Africa to becoming the first female chair of orthopaedics at the University of Colorado, with a focus on her approach to leadership, mentorship, resident support, facing challenges, and achieving a fulfilling work-life balance.     Subspecialties:  Orthopaedic Essentials  Spine  Trauma  Education and Training 

In this episode, Mo and Marc share their insights on the importance of outside reading and its impact on broadening knowledge, enriching life, increasing enjoyment, and fostering creativity.    Links:   Paulo Coelho. The Alchemist.  https://rb.gy/ks2tao Ernest Hemingway. The Old Man and the Sea. https://rb.gy/669rno Ernest Hemingway. For Whom the Bell Tolls. https://rb.gy/90va2b Siddhartha Mukherjee. The Emperor of All Maladies: A Biography of Cancer. https://rb.gy/3yb67u  Solomon. The Book of Proverbs. https://rb.gy/350laz  Rick Rubin. The Creative Act: A Way of Being. https://bit.ly/441CBV2 David Maraniss. When Pride Still Mattered: A Life of Vince Lombardi. https://bit.ly/3Tkn65r David Maraniss. Path Lit By Lightning: The Life of Jim Thorpe. https://bit.ly/3Zv2mvw  Ron Chernow. Alexander Hamilton. https://bit.ly/45QDVfO Erik Larson. The Devil in the White City: Murder, Magic, and Madness at the Fair That Changed America. https://bit.ly/44aqPZA Fyodor Dostoevski. Crime and Punishment. https://bit.ly/3HAWZEV Kahlil Gibran. The Prophet. https://bit.ly/4jKPxo4 Thomas Mann. The Magic Mountain. https://bit.ly/4jPiFui Erik Larson. The Demon of Unrest: A Saga of Hubris, Heartbreak, and Heroism at the Dawn of the Civil War. https://bit.ly/3HFoZal   James Herriot https://bit.ly/3FzRAgP    Subspecialties:  Orthopaedic Essentials 

In this bonus episode, from the JBJS OrthoCorps audio archive, Ross K. Leighton, MD, FRCSC, FACS, discusses his history with orthopaedic trauma in North America with Anna Miller, MD.     Links:  Swiontkowski M. Introducing JBJS OrthoCorps: An Online Audio Archive of Stories from the Orthopaedic Community. J Bone Joint Surg Am. 2023 Mar 8. doi: 10.2106/JBJS.23.00222. Epub ahead of print. PMID: 36888940. https://bit.ly/42PUnZZ  JBJS OrthoCorps: https://bit.ly/3lTBaG5  OrthoCorps submission guidelines: https://bit.ly/4dD2sqr     Subspecialties:  Orthopaedic Essentials  Trauma 

In this episode, Mo and Marc are joined by special guests Karim Ramji (bariatric surgeon, entrepreneur, and researcher at McMaster University) and Jamie Le (internal medicine and obesity specialist at HOW Clinics) in a discussion on GLP-1 agonists and their role in orthopaedics, particularly for weight loss and surgical outcomes.    Links:   Kim BI, LaValva SM, Parks ML, Sculco PK, Della Valle AG, Lee GC. Glucagon-Like Peptide-1 Receptor Agonists Decrease Medical and Surgical Complications in Morbidly Obese Patients Undergoing Primary TKA. J Bone Joint Surg Am. 2025 Feb 19;107(4):348-355. doi: 10.2106/JBJS.24.00468. Epub 2024 Dec 24. PMID: 39719003. https://bit.ly/4jvCvdX    Subspecialties:  Orthopaedic Essentials 

In this episode, Mo and Marc are joined by special guest Professor Rudolf Poolman (Leiden University, OLVG) in a discussion about evidence-based management, leadership, curiosity, Stoicism, and the importance of questioning everything.    Links:   Ioannidis JP. Why most published research findings are false. PLoS Med. 2005 Aug;2(8):e124. doi: 10.1371/journal.pmed.0020124. Epub 2005 Aug 30. Erratum in: PLoS Med. 2022 Aug 25;19(8):e1004085. doi: 10.1371/journal.pmed.1004085. PMID: 16060722; PMCID: PMC1182327. https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.0020124  Seneca, Ad Lucilium Epistulae Morales (Moral Letters to Lucilius) https://en.wikisource.org/wiki/Moral_letters_to_Lucilius    Subspecialties:  Orthopaedic Essentials 

In this bonus episode, from the JBJS OrthoCorps audio archive, Jeffrey Abrams, MD, discusses his relationship with Richard Hawkins, MD, FRCS(C), and the community and friendships fostered by the TCOA, in conversation with Ronald Navarro, MD.  Links:  Swiontkowski M. Introducing JBJS OrthoCorps: An Online Audio Archive of Stories from the Orthopaedic Community. J Bone Joint Surg Am. 2023 Mar 8. doi: 10.2106/JBJS.23.00222. Epub ahead of print. PMID: 36888940. https://bit.ly/42PUnZZ  JBJS OrthoCorps: https://bit.ly/3lTBaG5  OrthoCorps submission guidelines: https://bit.ly/4dD2sqr     Subspecialties:  Orthopaedic Essentials 

In this episode, Mo and Marc discuss are joined by special guest Brad Petrisor, MD, FRCRC (Professor Orthopaedic Surgery, McMaster University) to discuss femoral neck fractures in younger patients, with a focus on the question of which outcomes really matter?    Links:   Wagner BC, Oliver WM, Bell KR, Scott CEH, Keating JF, White TO, Clement ND, Duckworth AD. Outcomes for Younger Patients with Femoral Neck Fractures. J Bone Joint Surg Am. 2025 Apr 2;107(7):678-686. doi: 10.2106/JBJS.23.00582. Epub 2024 Dec 23. PMID: 39715295; PMCID: PMC11949204. https://bit.ly/4ikAfWs  Slobogean G. Can We Improve the Results of Internal Fixation?: Commentary on an article by Boris C. Wagner, BMedSci(Hons), MBChB, et al.: "Outcomes for Younger Patients with Femoral Neck Fractures". J Bone Joint Surg Am. 2025 Apr 2;107(7):e29. doi: 10.2106/JBJS.25.00033. Epub 2025 Apr 2. PMID: 40172566. https://bit.ly/4jfeFE2    Subspecialties:  Hip  Orthopaedic Essentials  Trauma 

In this episode, Mo and Marc are joined by special guest Jason Busse (Professor, Department of Anesthesia, McMaster University; Canada Research Chair) to discuss his recent BMJ systematic review and network meta-analysis on chronic non-cancer spine pain, with an emphasis on the relative benefits of interventional vs. sham procedures.    Links:   Wang X, Martin G, Sadeghirad B, Chang Y, Florez ID, Couban RJ, Mehrabi F, Crandon HN, Esfahani MA, Sivananthan L, Sengupta N, Kum E, Rathod P, Yao L, Morsi RZ, Genevay S, Buckley N, Guyatt GH, Rampersaud YR, Standaert CJ, Agoritsas T, Busse JW. Common interventional procedures for chronic non-cancer spine pain: a systematic review and network meta-analysis of randomised trials. BMJ. 2025 Feb 19;388:e079971. doi: 10.1136/bmj-2024-079971. PMID: 39971346. https://bit.ly/3FR2Jth     Subspecialties:  Orthopaedic Essentials  Pain Management  Spine 

In this bonus episode, from the JBJS OrthoCorps audio archive, Paul D. Sponseller, MD, interviews Bruce E. Fredrickson, MD, about the backstory of Dr. Fredrickson's landmark paper, "The Natural History of Spondylolysis and Spondylolisthesis," and its 45-year follow-up study.    Links:  Swiontkowski M. Introducing JBJS OrthoCorps: An Online Audio Archive of Stories from the Orthopaedic Community. J Bone Joint Surg Am. 2023 Mar 8. doi: 10.2106/JBJS.23.00222. Epub ahead of print. PMID: 36888940. https://bit.ly/42PUnZZ  JBJS OrthoCorps: https://bit.ly/3lTBaG5  OrthoCorps submission guidelines: https://bit.ly/4dD2sqr     Subspecialties:  Spine  Pediatrics 

In this episode, Mo and Marc discuss the “research waste” associated with unpublished clinical trial results and emphasize the importance—to both patients and the research community—of reporting the findings of all such trials, even those with negative results. The episode concludes by urging listeners to “send us your negative trials!”    Links:   OrthoEvidence. Research Waste: The Problem of Unpublished Research. OE Insights. 2024;():. Available from: https://bit.ly/41DJGLs    Subspecialties:  Ethics  Foot & Ankle  Hand & Wrist  Hip  Infection  Knee  Oncology  Orthopaedic Essentials  Pain Management  Rehabilitation  Pediatrics  Spine  Shoulder  Elbow  Sports Medicine  Trauma