
Episode 260: Do GLP-1s Really Cause Muscle Loss? ft. Dr. Angie Sadeghi
In this episode of Muscles by Brussels Radio, Ben sits down with Dr. Angie Sadeghi for an in-depth conversation on GLP-1 medications, gut health, digestion, fiber, and the growing confusion surrounding modern nutrition advice.
Dr. Sadeghi explains how medications like Ozempic and Mounjaro actually work, why they’ve been so effective for appetite regulation and metabolic health, and what the research really says about concerns like muscle loss and long-term safety. The discussion also dives into insulin resistance, intramuscular fat, and why she believes many people have been misled about carbohydrates and fiber for years.
Ben and Dr. Sadeghi explore why most Americans are severely lacking in fiber intake, the differences between soluble and insoluble fiber, and how gut health is often oversimplified online. They also discuss probiotics, fermented foods, microbiome testing, digestive discomfort during transitions to plant-based eating, and why Dr. Sadeghi no longer recommends the FODMAP diet for most patients.
Throughout the conversation, Dr. Sadeghi shares practical insights from years of clinical experience helping patients improve their digestion, body composition, metabolic health, and long-term quality of life.
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