748: The Truth About Inflammation and Autoimmunity That Most Women Are Missing with Mickey Trescott

“What if the life you worked so hard to build is also the thing quietly burning you out?” In this episode, Dr. Mariza sits down with Brooke Taylor to unpack the hidden emotional patterns driving burnout, overachievement, perfectionism, and chronic stress in high-performing women. Brooke shares her deeply personal story—from climbing the corporate ladder at Google while battling addiction, burnout, and health issues—to ultimately discovering what she now calls the “Success Wound.” Together, they explore how so many women unconsciously tie their worth, safety, belonging, and identity to achievement… until their body can no longer sustain the pressure. They dive into the emotional roots of over-functioning, the nervous system impact of constantly “doing,” and why midlife often becomes the moment women can no longer outrun themselves. Brooke also shares practical tools to identify your own success wound patterns, regulate your nervous system, reconnect to your true self, and move from manic ambition into aligned ambition. If you’ve ever felt exhausted despite accomplishing so much… if you’ve struggled to slow down, feel present, or believe you’re enough without constantly proving yourself… this conversation will hit deeply. BROOKE TAYLOR Brooke Taylor is a transformational career coach, speaker, and former Google marketing lead who has helped over 5,000 high-performing women redefine success on their own terms. After experiencing burnout, addiction, and deep emotional reckoning in her own life, Brooke developed the framework she now calls the “Success Wound” to help women break free from overachievement patterns and reconnect to fulfillment, purpose, and self-worth. IN THIS EPISODE What the “Success Wound” actually is—and how it develops Why high-achieving women often tie worthiness to productivity The hidden connection between burnout, perfectionism, and chronic stress How childhood conditioning shapes our relationship with achievement The 5 success wound archetypes: Grinder, Pleaser, Hider, Seeker, and Work Hard/Play Hard Why perimenopause can intensify emotional and nervous system burnout The difference between manic ambition and aligned ambition Practical tools to regulate your nervous system and reconnect to your true self Why healing your success wound is lifelong work—not a quick fix QUOTES“The more that I succeeded, the more love, belonging, and approval I would get.” “We don’t rise to the level of our confidence. We fall to the level of our self-worth.” “You are not working from the most powerful part of yourself when you’re working from fear.” “There is nothing wrong with your ambition. It’s the way your worth became tied to it that needs healing.” RESOURCES MENTIONED Grab Brooke’s new book The Success Wound https://amzn.to/3RoWBOC Order my new book The Perimenopause Revolution https://peri-revolution.com/ Brooke Taylor Website Brooke Taylor Instagram Brooke Taylor Tiktok RELATED EPISODES  717: “I Don’t Feel Like Myself Anymore”: The Mental & Emotional Reality of Perimenopause 741: Estrogen, Gut Health, Mitochondria, and Cardiovascular Health: What Changes In Perimenopause with Dr. Siobhan Mitchel 733: Why We’re Still Exhausted in the Age of “Evidence-Based” Everything with Shawn Stevenson 728: Why Brain Fog Isn’t Random: The Hormone Shift Behind It

“What if your body isn’t failing you… but asking for a different kind of support?” In this episode, Dr. Mariza sits down with Mickey Trescott to unpack the powerful connection between inflammation, autoimmune disease, gut health, and perimenopause. Together, they explore why so many women are dismissed when labs look “normal” despite debilitating symptoms like fatigue, bloating, brain fog, joint pain, skin issues, and weight resistance. Mickey shares her personal journey with Hashimoto’s, celiac disease, and autoimmune recovery—and how the Autoimmune Protocol (AIP) became a transformative tool for reducing inflammation and helping millions feel better in their bodies. They also dive into the evolution of AIP over the last 15 years, the newest research validating its effectiveness, and why perimenopause often becomes an inflammatory inflection point where hidden symptoms suddenly rise to the surface. If you’ve been struggling with chronic inflammation, unexplained symptoms, or feeling dismissed by conventional medicine, this conversation will help you connect the dots—and give you practical hope moving forward. MICKEY TRESCOTT Mickey Trescott is a nutritional therapy practitioner, cookbook author, and co-creator of the Autoimmune Protocol (AIP). After being diagnosed with Hashimoto’s thyroiditis and celiac disease in her twenties, she dedicated her work to helping people navigate autoimmune disease through nutrition, lifestyle medicine, and inflammation support. She has helped shape the modern AIP movement and trained hundreds of healthcare practitioners around the world. IN THIS EPISODE Why autoimmune disease impacts women at significantly higher rates How inflammation often worsens during perimenopause and menopause The connection between gut health, food sensitivities, and immune regulation Why “normal labs” don’t always reflect how women actually feel The science and research behind the Autoimmune Protocol (AIP) The difference between Core AIP and the newer Modified AIP approach Why food reintroductions and personalization are key for long-term healing QUOTES“Your body is not working against you. It’s asking for a different level of support.” “Three out of every four-ish people get clinical improvement from doing an elimination diet when you have autoimmune disease.” “When hormones begin to shift, the body becomes far less tolerant of underlying inflammation.” RESOURCES MENTIONED Order my new book: The Perimenopause Revolution https://peri-revolution.com/ Use code ENERGIZED and get 30% off on your first BATCH order http://hellobatch.com/ENERGIZED Grab Mickey’s new AIP book  https://theautoimmuneprotocol.com/ Visit Autoimmune Wellness Website Autoimmune Wellness Instagram Mickey Trescott Instagram Mickey Trescott Facebook Mickey Trescott Youtube RELATED EPISODES  747: The Silent Shift: Why Perimenopause Changes Everything 717: “I Don’t Feel Like Myself Anymore”: The Mental & Emotional Reality of Perimenopause 741: Estrogen, Gut Health, and Metabolism with Siobhan Mitchell 728: Why Brain Fog Isn’t Random: The Hormone Shift Behind It

“Perimenopause is more than just hot flashes and mood swings—it’s a biological inflection point.” In this solo episode, Dr. Mariza discusses the deeper, often overlooked changes happening during perimenopause and menopause. It’s more than a reproductive shift; it’s a systemic change affecting the brain, metabolism, hormones, mitochondria, gut health, and more. Dr. Mariza delves into the silent shift that many women experience—feeling exhausted, stressed, and unproductive despite their best efforts. She explains how perimenopause accelerates aging processes, and why early intervention is key to reducing long-term health risks and preserving vitality. This episode focuses on actionable steps you can take to support your body during this critical transition—from stabilizing blood sugar and building muscle to optimizing sleep and protecting your brain. If you’ve been feeling “off” but can’t explain why, this episode is a must-listen. Be sure to tune in! IN THIS EPISODE Why perimenopause is a biological and metabolic inflection point The connection between hormonal fluctuations, mitochondria, and energy How perimenopause accelerates aging and increases risk for chronic diseases Why "just pushing through" is not the solution for midlife women The importance of early intervention for better long-term health outcomes Simple strategies for building energy, optimizing brain function, and protecting your future health How stabilizing blood sugar, improving muscle mass, and prioritizing sleep can reduce inflammation and support resilience QUOTES“Perimenopause is more than just skipped periods or hot flashes. It’s a shift in every system of the body.” “You deserve so much better than being told to just survive this season.” “The moment to intervene is now—not when your health has deteriorated.” RESOURCES MENTIONED Order my newest book: The Perimenopause Revolution https://peri-revolution.com/ Use code ENERGIZED and get 10% off on your Troscription Order http://troscriptions.com/ENERGIZED Use code DRMARIZA and get 10% off on your Womeness Order https://www.womaness.com/DRMARIZA Check out the Morning Metabolic Ignition Method for better energy and resilience RELATED EPISODES  744: The Midlife Brain Reset: How to Protect Your Memory, Focus & Mental Sharpness Starting Now 717: “I Don’t Feel Like Myself Anymore”: The Mental & Emotional Reality of Perimenopause 728: Why Brain Fog Isn’t Random: The Hormone Shift Behind It 741: Estrogen, Gut Health, Mitochondria, and Cardiovascular Health: What Changes In Perimenopause with Dr. Siobhan Mitchel

“Is your nervous system stuck in overdrive?” In this episode, Dr. Mariza sits down with Jenna Free, a counselor specializing in ADHD and nervous system regulation, to discuss why so many women in midlife feel overwhelmed, scattered, and exhausted despite their best efforts to stay organized. Together, they explore how the nervous system gets stuck in a chronic fight-or-flight state, the role of dysregulation in ADHD symptoms, and why traditional productivity hacks simply don’t work when your nervous system is running on empty. Jenna breaks down her approach to resetting the nervous system and explains how small, consistent changes can lead to massive improvements in mental clarity, energy, and overall well-being. This conversation offers new insights on how to break free from the cycle of rushing, crashing, and feeling burned out—and provides tangible steps to reclaim control over your brain and nervous system. JENNA FREE Jenna Free is a counselor specializing in ADHD, nervous system regulation, and mindfulness practices. She is passionate about helping women overcome the chaos of constant overwhelm and hypervigilance by teaching them how to regulate their nervous systems and achieve sustainable productivity. Jenna is the author of The Simple Guide to ADHD Regulation and offers support to those struggling with ADHD and chronic stress IN THIS EPISODE How a dysregulated nervous system contributes to ADHD-like symptoms in midlife The link between survival mode (fight or flight) and chronic overwhelm Why traditional productivity hacks fail when your nervous system is stuck Practical tips to help interrupt dysregulation and shift into a more balanced state The importance of slowing down and creating space for mindful action How to reframe beliefs and thoughts to support nervous system regulation Why a regulated nervous system leads to more sustainable energy and better overall functioning QUOTES“Being in survival mode is a primal mechanism, but it’s not meant to be how we live in 2026.” “If you believe that being frantic and rushed is the way to be successful, you will never change.” “Regulation work isn’t about feeling nice—it’s about functioning better.” RESOURCES MENTIONED Use code ENERGIZED and get 10% off on your MitoQ Order https://www.mitoq.com/energized  Order The Simple Guide to ADHD Regulation https://www.jennafree.com/book ⁠Order my newest book: The Perimenopause Revolution⁠⁠Jenna Free https://peri-revolution.com/ Jenna Free Website https://www.jennafree.com/ Jenna Free Instagram Jenna Free Youtube RELATED EPISODES  744: The Midlife Brain Reset: How to Protect Your Memory, Focus & Mental Sharpness Starting Now 728: Why Brain Fog Isn’t Random: The Hormone Shift Behind It 717: “I Don’t Feel Like Myself Anymore”: The Mental & Emotional Reality of Perimenopause 693: Tired All the Time? It Might Be Hidden Problems With Your Mitochondria with Siobhan Mitchell

Why are so many women waking up exhausted… but unable to shut their brain off?” In this episode, Dr. Mariza sits down with Scott Sherr to unpack the hidden nervous system and biochemical shifts driving sleep struggles, anxiety, exhaustion, and feeling “wired and tired” in midlife. Together, they explore why women in perimenopause often lose stress resilience, why the brain gets stuck in overdrive at night, and how neurotransmitters like GABA, serotonin, adenosine, and cortisol shape sleep quality, recovery, and mood. They also dive into the powerful connection between mitochondrial health, nervous system regulation, energy production, and why building more “reserve” may be the missing key to feeling calm, focused, and resilient again. If you’ve been struggling with middle-of-the-night wakeups, burnout, anxiety, or feeling like your brain never truly powers down, this episode will help connect the dots—and offer practical solutions that actually move the needle. Dr. Scott Sherr Dr. Scott Sherr is a physician, health optimization expert, and Chief Operating Officer of Troscriptions. His work focuses on nervous system regulation, mitochondrial health, hyperbaric medicine, sleep optimization, and performance medicine. He is passionate about helping people improve resilience, energy, recovery, and cognitive performance through science-backed strategies and targeted support. IN THIS EPISODE Why so many women feel “wired and tired” in perimenopause The real reason behind 2–3 AM wakeups and racing thoughts How GABA, cortisol, serotonin, and adenosine impact sleep and stress Why nervous system regulation is essential for resilience and recovery The connection between mitochondrial health, energy, and brain function How chronic stress and sympathetic overload affect hormones and mood Practical tools to support sleep, focus, calm, and nervous system balance QUOTES “Sleep will make or break you the next day—especially in this season of life.” “To increase your performance is having more reserve.” “You’re not meant to live in a state of disruption, exhaustion, and feeling wired and tired all the time.” RESOURCES MENTIONED Use code ENERGIZED and get 10% off on your Troscription Order http://troscriptions.com/ENERGIZED Use code ENERGIZED and get 10% off on your MitoQ Order https://www.mitoq.com/energized%C2%A0 Troscriptions Website Dr. Scott Sherr Instagram Dr. Scott Sherr Youtube RELATED EPISODES  744: The Midlife Brain Reset: How to Protect Your Memory, Focus & Mental Sharpness Starting Now 717: “I Don’t Feel Like Myself Anymore”: The Mental & Emotional Reality of Perimenopause 728: Why Brain Fog Isn’t Random: The Hormone Shift Behind It 593: Why EVERYONE Needs Progesterone in Perimenopause & Beyond with Carol Petersen

“Is this brain fog… or something more?” In this solo episode, Dr. Mariza unpacks the hidden neurological and metabolic shifts happening during perimenopause and menopause—and why so many women suddenly feel mentally “off.” From brain fog and memory lapses to anxiety, overwhelm, and lower stress resilience, these symptoms are often dismissed as aging or stress. But Dr. Mariza explains that this is actually a neuroendocrine and metabolic transition driven by changing hormones, brain energy shifts, inflammation, and blood sugar instability. She breaks down what’s really happening inside the female brain during midlife, why women feel more sensitive to stress, and the most powerful lifestyle strategies to support long-term brain health, energy, mood, and resilience. If you’ve been wondering why you don’t quite feel like yourself anymore, this episode will help connect the dots—and give you a roadmap forward. IN THIS EPISODE Why perimenopause is a neuroendocrine and metabolic brain transition The connection between estrogen, brain energy, and brain fog How blood sugar instability worsens anxiety, fatigue, and mood swings Why inflammation and chronic stress hit harder in midlife The critical role of sleep, nervous system regulation, and muscle building The best supplements for brain health, stress resilience, and energy support Why tracking biomarkers and HRV can help protect long-term brain health QUOTES “Stabilizing your blood sugar is the fastest way to reclaim your energy, your focus, and your calm.” “What we’re dealing with is an energy problem—and once you see it that way, everything changes.” “Your brain is not broken. It is adapting and recalibrating.” RESOURCES MENTIONED Order my new book: The Perimenopause Revolution https://peri-revolution.com/ Learn more about Joi & Blokes  https://joiandblokes.com/labs-with-dr-mariza-snyder/ Explore Berkeley Life Nitric Oxide Support https://berkeleylife.pxf.io/Vxvdja Download the Midlife Lab Guide https://dmdl.s3.amazonaws.com/Dr-Mariza_Hormone-Lab-Testing-Checklist-%26-Reference-Guide.pdf RELATED EPISODES  728: Why Brain Fog Isn’t Random: The Hormone Shift Behind It 743: Why Your Heart Risk Changes in Menopause with Dr. Jayne Morgan 693: Tired All the Time? It Might Be Hidden Problems With Your Mitochondria with Siobhan Mitchell 717: “I Don’t Feel Like Myself Anymore”: The Mental & Emotional Reality of Perimenopause

“Why is heart disease still the #1 killer of women—and why aren’t we talking about it?” In this episode, Dr. Mariza sits down with Jayne Morgan to unpack the overlooked connection between perimenopause, menopause, and cardiovascular risk. Most women are told menopause is just about hormones and symptoms—but it’s actually a vascular transition that directly impacts your heart, blood vessels, and long-term health. Together, they break down why women are often misdiagnosed, why key risk markers are missed, and what you can do to advocate for yourself early—before a major event happens. If you’re in your 40s or beyond, this conversation could change how you think about your health—and your future. Be sure to tune in! DR. JAYNE MORGAN Dr. Jayne Morgan is a leading cardiologist and national voice in women’s cardiovascular health. She is passionate about redefining “preventive care” for women—shifting the focus from reproductive health alone to include heart health, vascular function, and long-term longevity. IN THIS EPISODE Why heart disease is still the #1 killer of women—and widely overlooked How perimenopause and menopause impact vascular health Why women are often misdiagnosed in cardiac and stroke events The critical labs every woman should be asking for (including Lp(a)) How inflammation, stress, and caregiving burden increase risk Why movement (not just exercise) is essential for longevity The real role of hormone therapy in protecting heart health QUOTES“Real preventive medicine for women is preventive cardiovascular medicine.” “Menopause is not just a hormonal transition—it’s a vascular one.” “If you don’t measure it, you can’t manage it.” RESOURCES MENTIONED Order my newest book: The Perimenopause Revolution https://peri-revolution.com/ Dr. Jayne Morgan Instagram Dr. Jayne Morgan Youtube RELATED EPISODES  723: Estrogen, Insulin & Heart Disease: Why Your Risk Rises in Midlife 711: Estrogen, Inflammation, and Your Heart Health: What Every Woman Needs to Know with Dr. Sanjay Bhojra 675: Feeling Off After 40? The Surprising Vitality Molecule to Reignite Your Energy, Libido & Confidence with Cathy Eason  741: Estrogen, Gut Health, and Metabolism with Siobhan Mitchell

In today’s episode, we’re talking about the very real mental energy drain that so many midlife women are experiencing—and how it can quietly lead to career burnout.  From mood swings, irritation, and resentment to brain fog and forgetfulness in high-stakes moments, these changes can leave you feeling like you’re not yourself anymore.  But here’s the truth: this is not a willpower problem or a personal failure— it’s a biological shift happening during perimenopause with very real professional consequences.  This episode is a call to stop suffering in silence and start advocating for better support, awareness, and care for women in this phase of life.  If you’re ready to reclaim your clarity and confidence— and step fully into your most powerful chapter—this conversation is for you. Tune in here! IN THIS EPISODE The neuroendocrine transition happening in perimenopause  How to adapt when your brain is functioning less in midlife  Different hormone changes and what they mean for your body  Understanding your biology and supporting your brain in midlife  Why strategic lifestyle changes matter the most right now  How to get my top recommendations for battling brain fog from my new book, The Perimenopause Revolution QUOTES “That brilliant brain of yours is suddenly running on 25% to 30% less energy because that’s what's going on in perimenopause.” “65% to 99% of women say their symptoms negatively affected their work performance, with brain fog being the biggest culprit in terms of focus, clarity, alertness, and mental bandwidth. More than half of women make career-limiting decisions during perimenopause.” “It's about you going through a profound biological transition in your life that deserves support, understanding, and solutions that actually work.” RESOURCES MENTIONED Join my Midlife on Fire Collective HERE! Order my newest book: The Perimenopause Revolution HERE! RELATED EPISODES  728: WHY BRAIN FOG ISN’T RANDOM: THE HORMONE SHIFT BEHIND IT 721: No, It’s Not All in Your Head: The Medical Truth About Perimenopause with Dr. Jila Senemar 717: “I Don’t Feel Like Myself Anymore”: The Mental & Emotional Reality of Perimenopause 690: The Perimenopause Revolution: Why midlife isn’t the end — it’s the beginning of your most energized, powerful, and vibrant self

“Why does your body stop responding… even when you’re doing everything right?” In this episode, Dr. Mariza sits down with Siobhan Mitchell to unpack the true metabolic and cellular shifts happening in perimenopause and menopause. So many women feel like their body has suddenly turned against them—weight gain, fatigue, brain fog, and rising inflammation—despite doing all the right things. But this isn’t a failure of effort. It’s a biological inflection point driven by declining estrogen and its impact on metabolism, mitochondria, and vascular health. Together, they break down how estrogen loss reshapes everything from blood sugar control to fat storage, mitochondrial function, and long-term cardiovascular risk—while also exploring the emerging role of gut health and phytoestrogens like S-equol as targeted support. If you’ve been working harder than ever with fewer results, this episode will help you understand why—and what to do instead. Be sure to tune in! SIOBHAN MITCHEL Dr. Siobhan Mitchel, PhD, is a neuroscientist and Chief Scientific Officer at MitoQ. Her work focuses on mitochondrial health, cellular energy, and the role of oxidative stress in aging—particularly in women navigating perimenopause and menopause. She is passionate about advancing research that supports women’s long-term health, metabolism, and resilience at the cellular level. IN THIS EPISODE Why your body stops responding the same way in perimenopause How estrogen loss impacts metabolism, fat storage, and blood sugar The role of mitochondria in energy, brain function, and weight changes Why visceral belly fat increases—and why it’s more dangerous The connection between gut health, estrogen metabolism, and inflammation How phytoestrogens (like S-equol) support metabolism and hormone signaling Why midlife is a metabolic and vascular inflection point—not just hormonal QUOTES “This isn’t a failure of effort—it’s a biological shift happening beneath the surface.” “When estrogen declines, you don’t just lose hormones—you lose metabolic protection.” “If you support your mitochondria, you support your energy, your metabolism, and your long-term health.” RESOURCES MENTIONED Order my new book: The Perimenopause Revolution HERE! https://peri-revolution.com/ Use code ENERGIZED and get 10% off MitoQ http://www.mitoq.com/energized MitoQ Instagram MitoQ Facebook MitoQ Youtube RELATED EPISODES  693: The Cellular Shift in Perimenopause: Mitochondria, Metabolism, and Energy 728: Why Brain Fog Isn’t Random: The Hormone Shift Behind It 717: “I Don’t Feel Like Myself Anymore”: The Mental & Emotional Reality of Perimenopause 705: The Metabolic Shift No One Warned You About in Midlife

“Is it really just hormones… or is your gut driving the symptoms?” In this episode, Dr. Mariza sits down with Cynthia Thurlow to unpack the powerful connection between gut health and hormones in midlife. Many women are told their bloating, weight gain, fatigue, and mood shifts are “just hormones.” But Cynthia explains that the gut microbiome plays a central role in how these symptoms show up—and how they can be improved. Together, they break down how gut health influences hormones, inflammation, metabolism, and brain function, while also highlighting the foundational habits that matter most in this season. If you’ve been feeling off and unsure where to focus, this episode will give you clarity and a smarter path forward. Be sure to tune in! CYNTHIA THURLOW Cynthia Thurlow is a nurse practitioner, intermittent fasting expert, and leading voice in metabolic health for women in midlife. With a background in cardiology, she now focuses on helping women navigate perimenopause and menopause through personalized nutrition, gut health, and lifestyle strategies. She is the author of The Menopause Gut and a passionate advocate for empowering women to take control of their health during this pivotal transition. IN THIS EPISODE Why so many women feel disconnected from their bodies in midlife How the gut microbiome influences hormones, inflammation, and metabolism The “Three Ps” shaping gut health: puberty, pregnancy, and perimenopause The link between leaky gut, food sensitivities, mood, and inflammation Why protein, fiber, sleep, and stress support become nonnegotiable How alcohol and sugar disrupt gut health, sleep, and resilience Why midlife is a critical window to build long-term health—not just manage symptoms QUOTES“Midlife isn’t just a hormonal shift—it’s a metabolic and microbial shift happening beneath the surface.” “When you support your gut, you’re not just improving digestion—you’re impacting your hormones, your brain, and your long-term resilience.” “This phase of life is an invitation to set boundaries, prioritize your needs, and finally major in what matters most.” RESOURCES MENTIONED 👉🏻 Order my new book: The Perimenopause Revolution HERE! ⛓️‍💥 https://peri-revolution.com/ 👉🏻 Order Cynthia’s book: The Menopause Gut ⛓️‍💥 https://amzn.to/4eoEIsX 👉🏻 Use code ENERGIZED and get 10% off on your Troscription Order ⛓️‍💥 http://troscriptions.com/ENERGIZED Cynthia Thurlow’s Website Cynthia Thurlow on Instagram RELATED EPISODES  717: “I Don’t Feel Like Myself Anymore”: The Mental & Emotional Reality of Perimenopause 728: Why Brain Fog Isn’t Random: The Hormone Shift Behind It 701: The Gut–Hormone Connection: Why Your Symptoms Aren’t Just Hormones 689: Blood Sugar, Inflammation, and the Midlife Metabolism Shift