Click chemistry marks 25 years & covalent bonding in the actinides | The chemical breakdown podcast

This week, we look back at how far click chemistry has come in the last 25 years and discuss the strange bonding behaviour of some of the largest elements on the periodic table with Mason Wakley and Frances Briggs. It started as a review paper in 2001 that has since been cited almost 20,000 times, becoming one of the most influential chemistry papers ever written. Click chemistry has revolutionised the way we build molecules. But what defines a click reaction, and what does the future hold? And, new research has revealed experimental evidence of how covalent bonding affects the 5f orbital in early actinides. We discuss the challenges of studying these elements.

This week, we discuss the latest milestone in quantum computational modelling and reveal the common laboratory item causing strange readings in microplastics research with Frankie Macpherson and Patrick Walter. A new hybrid workflow involving two IBM quantum computers and two powerful supercomputers has allowed researchers to model a protein–ligand system containing up to a record 12,635 atoms. What does this mean for the future of quantum computing? And, a recent study has found an unsuspecting source of contamination in microplastics research, distorting measurements of atmospheric pollution. We discuss the underlying cause.

This week, we are celebrating Chemistry World's Battery Week with a special battery-themed episode! We discuss the race between cathode materials for electric vehicles and a new photocatalyst capable of turning plastic waste into hydrogen and value-added chemicals, with Neil Withers and Patrick Walter. A race between competing battery cathode materials is heating up, the winner of which will shape the future of electric vehicles. But which will come out on top? And, we discuss a new photocatalyst that could change the way we recycle plastics and battery acid, demonstrating how waste streams could be transformed into resources. We explore what this could mean for building a truly circular economy. To register for more Battery Week activities, check out:  https://www.chemistryworld.com/collections/energy-storage-and-batteries

This week, we discuss vanadium's potential in the medical field and the changes you can make in our lab to reduce your carbon footprint, with Jennifer Newton and Emma Pewsey. Many are familiar with vanadium's role in metal production, but did you know that it has a history of research as a potential medicine? We explore the little-known story of vanadium's medical potential. And, how can your lab contribute to a more sustainable world? We discuss the areas where you can make a meaningful change.

This week, we discuss how to ensure experimental instruments are truly inert and chemistry's answer to the fate of the Mary Celeste, with Phillip Broadwith and Mason Wakley. A new study has demonstrated how unexpected results can arise from experiments using seemingly inert materials. How do we avoid the effects of these accidental reagents? And, scientists may have found the answer behind what happened to the crew of the infamous ship the Mary Celeste. We explain how chemistry may fill the gaps.

This week, we discuss the peculiarities of water's behaviour and how science sleuths are fighting disinformation with Philip Robinson and Emma Pewsey. A recent study from researchers at Stockholm University has found the existence of a critical point in supercooled water, which could prove the existence of two types of water. How did they do it, and what does this mean for our understanding of this fundamental substance?  And, in the growing age of disinformation, how can we equip ourselves to discern fact from false data? We discuss the latest wave of science sleuths aiming to provide us the tools.   Resources to start your sleuthing: Learn about best practice with the Cosig collection of open science integrity guides Engage in post-publication peer review at PubPeer Software for detecting image manipulation: ImageTwin and Proofig Keep up to date on the latest problem papers identified using the Problematic Paper Screener and Retraction Watch Database

This week, we discuss team discuss the boundaries of the atom and breakdown the US's plan to eliminate synthetic food dyes with Jennifer Newton and Phillip Broadwith. The atomic radius of an atom is a concept we are taught from early in our chemistry careers, but for such an important value its definition remains ambiguous. Why is there no single answer to the size of an atom? And, US Health Secretary Robert F Kennedy Jr announced last year that the US will phase out all petroleum-based synthetic dyes in foods. But what are these chemicals, and what concerns exist around their consumption?  

This week, we discuss reflections from this year's American Association for the Advancement of Science (AAAS) annual meeting and the latest advances in plasma chemistry with Rebecca Trager and Mason Wakley.  The annual meeting of the AAAS kicked off in Phoenix, on the heels of the recent minibus spending package announcement, as well as the rescinding of the 2009 Greenhouse Gas Endangerment Finding. We'll fill you in on some of the conversations that took place that weekend.  And, plasma is often described as the fourth state of matter, but what exactly is it made of? We'll explain it's make-up and dive into how chemists are learning to unlock its power.

Welcome to our latest podcast series, The chemical breakdown. Each week, we dive deeper into two stories we've covered here at Chemistry World, providing insight into the facts, why you should care, and what it means for the chemistry community. We also give you that week's headlines to keep you up to date with what's happening in the chemistry community. And finally, we'll end each episode with a brief section on what was happening this week in chemistry history.  This week, we discuss the new deep learning model AlphaGenome and visit the very beginning of life on Earth with Mason Wakley and Neil Withers. Google DeepMind has released a new deep learning model that can predict the effect of small changes to DNA sequences up to one million base pairs in length. What does this new tech mean for our understanding of the human genome? And, how did life start on Earth, before the first cell came to be? We discuss the RNA world hypothesis and breakdown the chemistry it's built on. You can find more episodes of The chemical breakdown on the Chemistry world podcast feed. We would love to hear your feedback on this new podcast, so if you have any questions or comments please get in touch.  

In this special podcast produced in partnership with Waters Corporation, find out how understanding the chemistry and materials that go into batteries marks the first step towards making them safer and increasing energy density, and unlocks new opportunities for reuse and recycling