Special Episode: 2025 Articles of Import and Impact

Yang Lu, M.S., and Catharine E. Fairbairn, Ph.D. (University of Illinois, Urbana-Champaign) join AJP Audio to discuss the longitudinal effects of the use of personal alcohol breathalyzers in a natural setting on alcohol usage. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin joins the podcast to discuss the rest of the April issue, which focuses on subjects related to substance use disorders. 00:57     What did you discover about the long term effects of using a personal blood alcohol monitor? 03:12     Do health monitoring devices actually change behaviors? 04:10     What did your cohort look like? 08:49     Disparate impact of monitoring on heavy drinkers and light drinkers 11:36     Clinical implications 14:34     Limitations 15:46     Avenues for further research 18:39     Kalin interview 18:46     Lu et al. 24:00     Wittekind et al. 29:50     Nicholson et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at [email protected]

Chelsea Dyan Gober Dykan, M.A. (Tel Aviv University, Israel), joins AJP Audio to discuss a study looking at two versions of attention bias modification with an eye towards a prophylactic impact on developing PTSD in a cohort of combat-bound soldiers.  Afterwards, AJP Editor-in-Chief Dr. Ned Kalin joins the podcast to put the rest of the March issue into context. 00:57   Attention bias modifications 03:54   Response-time and gaze-contingent paradigms 05:05   Differences in efficacy between the two arms 08:06   Ethical considerations in investigating combat-bound soldiers 10:44   Controlling for combat experiences in studying PTSD 12:24   Duration of the effect 13:44   Limitations 15:03   Immediate clinical implications 16:22   Further research 17:05   Kalin interview 17:22   Dykan et al. 21:03   Kaul et al. 26:19   Kantrowitz et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at [email protected]

Dr. Ian Kelleher (University of Edinburgh, Scotland) joins AJP Audio to discuss an emulated target trial looking at the prophylactic qualities of doxycycline, an antibiotic, in an adolescent population at risk to develop schizophrenia spectrum disorder.  Afterwards, AJP Editor-in-Chief Dr. Ned Kalin joins the podcast to put the rest of the issue into context. 00:53   Doxycycline and the risk of developing schizophrenia 04:03   Emulated target trials versus randomized control trials 06:43   Methods of action 09:24   Dosage and exposure levels for doxycycline 10:15   Immediate clinical applications 10:56   Limitations of the study 11:33   Future research 12:43   Kalin interview 13:00   Lång et al. 19:43   Zhao et al. 25:20   Metrik et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at [email protected]

This special episode of AJP Audio brings together the editors of the American Journal Psychiatry and the AJP Residents' Journal to discuss important and impactful articles published in 2025. 00:39   Ned H. Kalin, M.D., discusses "Transcriptomic Analysis of the Human Habenula in Schizophrenia" by Ege A. Yalcinbas, Ph.D., et al. 06:23   Elisabeth Binder, M.D., Ph.D., discusses "Copy Number Variant Architecture of Child Psychopathology and Cognitive Development in the ABCD Study" by Zhiqiang Sha, Ph.D., et al. 11:17   Kathleen T. Brady, M.D., Ph.D., discusses "High-Potency Cannabis Use and Health: A Systematic Review of Observational and Experimental Studies" by Stephanie Lake, Ph.D., et al. 15:35   David A. Lewis, M.D., discusses "20 Years of Aberrant Salience in Psychosis: What Have We Learned?" by Philip R. Corlett, Ph.D., and Kurt M. Fraser, Ph.D. 17:27   William M. McDonald, M.D., discusses "Psychedelics for the Treatment of Psychiatric Disorders: Interpreting and Translating Available Evidence and Guidance for Future Research" by Roger S. McIntyre, M.D., F.R.C.P.C., et al. 24:04   Daniel S. Pine, M.D., discusses "Cognitive Behavioral Therapy and Lisdexamfetamine, Alone and Combined, for Binge-Eating Disorder With Obesity: A Randomized Controlled Trial" by Carlos M. Grilo, Ph.D., et al. 26:06   Carolyn Rodriguez, M.D., Ph.D., discusses "Randomized Controlled Trial of the Effects of High-Dose Ondansetron on Clinical Symptoms and Brain Connectivity in Obsessive-Compulsive and Tic Disorders" by Emily R. Stern, Ph.D., et al. 30:26   Sean T. Lynch, M.D., discusses "From Medical Practice to Mass Incarceration: A Historical Analysis of Racial and Ethnic Targeting in U.S. Drug Policy" by Rathisha Pathmathasan, D.O., et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at [email protected]  

Dr. Julia Linke (University of Mainz, Germany) joins AJP Audio to discuss the use of neural efficiency, a measure of brain activity, as a potential biomarker in the treatment of children with anxiety disorder.  Afterwards, AJP Editor-in-Chief Dr. Ned Kalin joins the podcast to put the rest of the issue into context. 00:31   Linke interview 02:15   State or a trait? 04:15   Neural efficiency and CBT 05:22   Potential as a biomarker 07:08   Patient-rated and parent-rated measures of anxiety 08:16   Immediate clinical implications 09:50   Limitations 10:43   Future directions of research 11:44   Kalin interview 11:50   Linke et al. 15:16   Mallard et al. 18:11   Naples et al. 21:44   Mac Giollabhui et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at [email protected]

Dr. Suresh Durgam (Intra-Cellular Therapies, a Johnson & Johnson Company, Bedminster, NJ) joins AJP Audio to discuss a phase 3 randomized controlled trial looking at the use of the antipsychotic medication lumateperone as adjunctive to antidepressant therapy in the treatment of patients with major depressive disorder. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the December issue of the Journal. 00:48   Durgam interview 03:09   Mechanism of action 04:44   Patient-reported outcomes 06:31   Immediate clinical implications 07:32   Limitations 08:08   Further research 09:25   Kalin interview 09:38   Durgam et al. 13:09   Lin et al. 17:22   Brodsky et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at [email protected]

Dr. Lara Coughlin (University of Michigan, Ann Arbor) joins AJP Audio to discuss a study looking the impact of contingency management on all cause mortality in patients with stimulant use disorder. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the November issue of the Journal. 01:09   Coughlin interview 02:05   Stimulant use disorder and contingency management 04:37   Mortality 05:12   Contingency management and "moral hazard" 08:30   Clinical uptake of contingency management 09:28   Broader applicability to psychiatric conditions 10:31   Limitations 11:39   Further research 12:32   Kalin interview 12:49   Coughlin et al. 16:41   Yalcinbas et al. 22:22   Na et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at [email protected]

Dr. Shau-Ming Wei (National Institute of Mental Health, Bethesda, MD) joins AJP Audio to discuss a replication study looking at impact of hormone addback to a hormone suppression regimen for the treatment of premenstrual dysphoric disorder. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the October issue of the Journal.  00:34   Wei interview 02:59   PMDD 04:22   Up and downsides of hormone suppression 05:52   Hormone addback 07:15   Limitations of the current study 08:38   Further research 10:42   Kalin interview 10:58   Wei et al. 15:25   Sanacora et al. 20:07   Whittle et al. 23:06   Cooper et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at [email protected]

Dr. Deidre Anglin (City College, CUNY, New York) joins AJP Audio to discuss the disparate impact of schizophrenia spectrum disorder diagnosis on racial and ethnic minorities in the United States based on localized neighborhood data. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the September issue of the Journal. 00:31   Anglin interview 04:40   Zip code sizes 05:18   The long legacy of redlining 07:17   Socially vulnerable neighborhoods 09:43   Structural racism, clinicians, and working with individuals 13:45   Limitations 15:56   Further research 18:08   Kalin interview 18:13   Anglin et al. 25:19   Vano et al. 29:40   Moussa-Tooks et al. 33:34   Zhang et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at [email protected]

Dr. Vinod Rao (Massachusetts General Hospital, Boston) join AJP Audio to discuss predicting the relative risk of patients with an ADHD diagnosis developing a later stimulant or substance use disorder based on the method of prescription, in person or via telehealth. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the August issue of the Journal. 00:07   Rao interview 01:53   Stimulant use disorder versus substance use disorder 02:59   Cohort size and incidence of SUDs 04:28   Length of clinician engagement in non-profit versus for profit hospital systems 05:18   Patient cohort 06:20   Potential difference in mechanism between prescribing practices 07:35   Continued use of telehealth 08:43   Limitations 10:03   Further research 11:17   Kalin interview 11:24   Rao et al. 15:41   Mahjani et al. 19:59   Zhang et al. 25:11   Sha et al. 29:33   Gao and Olfson Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at [email protected]