#478 — The Psychedelic Mind

Sam Harris speaks with Robin Carhart-Harris about psychedelic research and its therapeutic potential. They discuss the current state of the field, the FDA denial of MDMA-assisted therapy for PTSD, the critical role of set and setting, risks for vulnerable populations, the REBUS model of how psychedelics work on the brain, the default mode network and ego dissolution, microdosing, the neuroscience of consciousness, DMT entities, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.  

Warning: This episode contains graphic descriptions of violence against civilians during the October 7 attacks (33:49 - 34:35). Listener discretion is advised. In this latest episode of the More From Sam series, Sam and Jaron talk about current events. They discuss the Trump administration's bungled Iran campaign, the information war surrounding Gaza and October 7, Nicholas Kristof's disputed New York Times report on Israeli prisoner abuse, Sam's controversial take on AI-generated music, OpenAI solving a decades-old math problem, the ethics of concealing GLP-1 use, and other topics.  

Sam Harris speaks with Susan Cain about writing, creativity, and what AI means for human culture. They discuss the future of books and reading, the tells AI inherits from good writers, why the advent of AI may spark a revival of the humanities, following your bliss, the ethics of curing sadness, the therapeutic potential of psychedelics, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.

Sam Harris speaks with Michael Pollan about consciousness, the mind, and the self. They discuss Pollan's new book, the relationship between consciousness and intelligence, whether consciousness is a product of evolution, the role of psychedelics in consciousness research, AI and the question of machine consciousness, the illusion of the self, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.

In this latest episode of the More From Sam series, Sam and Jaron talk about current events. They discuss the launch of Making Sense Community, Sam's Ben Shapiro conversation, the New York Times's embrace of Hasan Piker, Zohran Mamdani's approach to Islamism, the misuse of the word "genocide," AI-driven job displacement, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.

Sam Harris speaks with Lloyd Blankfein about finance, politics, and the state of American society. They discuss Blankfein's memoir, Goldman Sachs and its role as a market maker, the 2007-2008 financial crisis, the AI investment bubble, wealth inequality and the rise of trillionaires, the crisis of antisemitism on the left and right, Trump-era corruption and the post-truth political environment, the national debt, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.

Sam Harris speaks with Ben Shapiro about their pre-election debate and the fractures on the right. They discuss Trump's second term surprises, familial corruption, tariff policy, the ideological world of Tucker Carlson, the spread of conspiracism on the right, antisemitism as the ur-conspiracy theory, JD Vance's political calculations, the future of Israel and the Palestinian question, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.

Sam Harris speaks with Francis Fukuyama about liberal democracy, American politics, and global order. They discuss the misunderstood thesis of "The End of History," how conservatism has mutated into ethno-nationalism, the self-defeating extremes of both identity politics and neoliberalism, the damage of Trump's second term, the war in Iran, the future of Israel, antisemitism on the left and right, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.   

Sam Harris speaks with Rahm Emanuel about American politics, the state of the Democratic Party, and the 2028 presidential race. They discuss Emanuel's possible presidential run, identity politics and the left's cultural cul-de-sac, the Mississippi reading miracle, antisemitism on the left and right, the Gaza war, Netanyahu's failures, U.S. policy toward China, wealth inequality, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.

Sam Harris speaks with Tristan Harris about the dangers of AI and the race to build it. They discuss the new documentary The AI Doc: Or How I Became an Apocaloptimist, the lessons of The Social Dilemma, the arms race dynamics between AI labs, the "intelligence curse" and its implications for human political power, the psychology of tech CEOs indifferent to extinction risk, the possibilities of US-China coordination on AI safety, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.