Bioengineering Psychedelics: Rethinking Sourcing and Scale - Jeffrey E. Gerst, Ph.D.

In this episode of The Psychedelic Podcast, Paul F. Austin speaks with a molecular geneticist exploring what it could look like to rethink how psychedelic medicines are sourced at a fundamental level. Find full show notes and links here: https://thethirdwave.co/podcast/episode-349/?ref=278  Jeffrey Gerst explains how his work in RNA biology and gene expression has led him to explore bioengineering as a way to produce psychedelic compounds without relying on wild harvesting or traditional chemical synthesis. The conversation looks at how cells organize and communicate, and how those same biological principles could be used to create more sustainable and scalable systems for medicine production. Paul and Jeff also reflect on the broader implications of this shift, from environmental stewardship to the long-term integrity of the psychedelic ecosystem. Professor Jeffrey Gerst is a molecular geneticist and Full Professor at the Weizmann Institute of Science, where he studies how cells regulate gene expression through RNA trafficking and localized protein synthesis. His research has advanced understanding of how mRNA moves within and between cells, revealing new forms of cellular communication and potential applications in therapeutic delivery. More recently, his work has expanded into the bioengineering of psychedelic compounds, with a focus on developing sustainable, scalable, and ethical methods of production. Highlights: Why sourcing is becoming a central challenge in psychedelics Bioengineering as a scalable alternative to wild harvesting How RNA biology informs new approaches to medicine production The limits of "natural" when demand increases Environmental risks of large-scale psychedelic use How yeast and cells can produce psychedelic compounds Balancing biotechnology with traditional practices What sustainable access could look like in the future The evolving relationship between science and psychedelics Episode Links: Prof. Jeffrey Gerst - Academic Profile (Weizmann Institute) Prof. Jeffrey Gerst - Metaformity (Project / Initiative) Episode Sponsors: Psychedelic Coacing Institute's Intensive for Psychedelic Professionals in Costa Rica - a transformative retreat for personal and professional growth. The Microdosing Practitioner Certification at Psychedelic Coaching Institute. The Practitioner Certification Program by Third Wave's Psychedelic Coaching Institute. Golden Rule - Get a lifetime discount of 10% with code THIRDWAVE at checkout Disclaimer: This content is for educational, informational, and entertainment purposes only. We do not promote or encourage the illegal use of any controlled substances. Nothing said here is medical or legal advice. Always consult a qualified medical or mental health professional before making decisions related to your health. The views expressed herein belong to the speaker alone, and do not reflect the views of any other person, company, or organization. Third Wave occasionally partners with or shares information about other people, companies, and/or providers. While we work hard to only share information about ethical and responsible third parties, we can't and don't control the behavior of, products and services offered by, or the statements made by people, companies, or providers other than Third Wave. Accordingly, we encourage you to research for yourself, and consult a medical, legal, or financial professional before making decisions in those areas. Third Wave isn't responsible for the statements, conduct, services, or products of third parties. If we share a coupon code, we may receive a commission from sales arising from customers who use our coupon code. No one is required to use our coupon codes.  

Herbal Ecstasy & The Billion Dollar Smart Drug Boom In this episode of The Psychedelic Podcast, Paul F. Austin sits down with entrepreneur Shaahin Cheyene, creator of the controversial 1990s supplement "Herbal Ecstasy," which helped launch the legal smart-drug movement. Find full show notes and links here: https://thethirdwave.co/podcast/episode-348/?ref=278 Shaahin shares how he built a multimillion-dollar business at just fifteen by creating a legal herbal alternative to MDMA during a shortage in the rave scene. The conversation explores 1990s rave culture, the ethics of prohibition, and how natural supplements intersect with psychedelics, entrepreneurship, and personal freedom. They also discuss his later ventures in Amazon commerce, podcast media, and YouTube. Shaahin Cheyene is the creator of Herbal Ecstasy, a supplement that helped spark the legal smart-drug movement in the 1990s. He built the business as a teenager into a multimillion-dollar company. Over the past three decades, Shaahin has become an award-winning entrepreneur, Amazon expert, inventor, author, and filmmaker whose ventures have generated over a billion dollars in revenue. He is the founder of PodcastCola and Viral Mirage. Through his businesses, Shaahin continues to mentor entrepreneurs and develop health and wellness products focused on optimizing human performance. Highlights: Creating Herbal Ecstasy at age fifteen The MDMA shortage that created opportunity Rave culture and the 1990s club scene Natural supplements as legal alternatives Freedom, regulation, and drug policy debates Health and wellness entrepreneurship Building product brands in emerging markets Podcasting and YouTube as influence platforms Episode Links: Shaahin's website PodcastCola Billion: How I Became King of the Thrill Pill Cult – Shaahin Cheyene Episode Sponsors: The Microdosing Practitioner Certification at Psychedelic Coaching Institute. The Practitioner Certification Program by Third Wave's Psychedelic Coaching Institute. Golden Rule - Get a lifetime discount of 10% with code THIRDWAVE at checkout Disclaimer: This content is for educational, informational, and entertainment purposes only. We do not promote or encourage the illegal use of any controlled substances. Nothing said here is medical or legal advice. Always consult a qualified medical or mental health professional before making decisions related to your health. The views expressed herein belong to the speaker alone, and do not reflect the views of any other person, company, or organization. Third Wave occasionally partners with or shares information about other people, companies, and/or providers. While we work hard to only share information about ethical and responsible third parties, we can't and don't control the behavior of, products and services offered by, or the statements made by people, companies, or providers other than Third Wave. Accordingly, we encourage you to research for yourself, and consult a medical, legal, or financial professional before making decisions in those areas. Third Wave isn't responsible for the statements, conduct, services, or products of third parties. If we share a coupon code, we may receive a commission from sales arising from customers who use our coupon code. No one is required to use our coupon codes.

In this episode of The Psychedelic Podcast, Paul F. Austin speaks with Jonathan Dickinson, CEO and Co-Founder of Ambio Life Sciences, about the evolving role of ibogaine in psychedelic medicine. Listen to the full episode: https://thethirdwave.co/podcast/episode-347/?ref=278 Jonathan shares his path from leading the Global Ibogaine Therapy Alliance to helping build one of the field's most prominent ibogaine treatment organizations. Together they explore ibogaine's expanding therapeutic potential for traumatic brain injury, addiction, and neurological conditions, along with the clinical realities of delivering this powerful medicine safely. They also discuss the challenges of scaling ibogaine treatment, the importance of preparation and integration, and how traditional Bwiti knowledge from Gabon continues to shape ethical and culturally grounded approaches to this work. Jonathan Dickinson is the CEO and Co-Founder of Ambio Life Sciences and a leading expert on ibogaine therapy. With more than 15 years of experience in psychedelic research, clinical care, and traditional practice, he has helped shape global safety standards for ibogaine treatment. A Mexico-licensed psychologist and former Executive Director of the Global Ibogaine Therapy Alliance, Jonathan has published research on ibogaine's therapeutic potential for trauma, traumatic brain injury, and neurological conditions. He has also been initiated into the Bwiti traditions of Gabon and holds a Nagoya-compliant export license for Tabernanthe iboga root. Highlights: Jonathan Dickinson's path from the Global Ibogaine Therapy Alliance to Ambio Life Sciences How ibogaine treatment expanded beyond opioid detox The growing use of ibogaine for traumatic brain injury and veterans' recovery Why ibogaine treatment requires extensive medical screening and preparation The importance of integration and community support after treatment What Bwiti traditions in Gabon teach about working with iboga The challenges of scaling ibogaine treatment safely Why ibogaine may create a longer window for lasting change

In this episode of The Psychedelic Podcast, Paul F. Austin speaks with Christopher Solomon, founder of Salvia Healings, about how Salvia divinorum can be approached as a therapeutic and introspective tool when used with preparation and somatic awareness. Find full show notes and links here: https://thethirdwave.co/podcast/episode-346/?ref=278  They discuss dosage, harm reduction, and the importance of building a supportive container for working with intense altered states. The conversation explores how somatic awareness, breath, and pacing can help transform the Salvia experience into an opportunity for meditation, trauma processing, and self guided healing. Christopher Solomon is a somatic Salvia guide and educator focused on helping people approach Salvia with safety, structure, and intention. Drawing from his training in somatic psychotherapy, he teaches how to work with this powerful plant in ways that support introspection and personal growth. Highlights: Reframing Salvia's cultural reputation Set and setting with Salvia Somatic awareness during altered states Microdosing vs threshold experiences Harm reduction and preparation Episode Links: Christopher's website Somatic Salvia Network Episode Sponsors: The Microdosing Practitioner Certification at Psychedelic Coaching Institute. The Practitioner Certification Program by Third Wave's Psychedelic Coaching Institute. Golden Rule - Get a lifetime discount of 10% with code THIRDWAVE at checkout Third Wave occasionally partners with or shares information about other people, companies, and/or providers. While we work hard to only share information about ethical and responsible third parties, we can't and don't control the behavior of, products and services offered by, or the statements made by people, companies, or providers other than Third Wave. Accordingly, we encourage you to research for yourself, and consult a medical, legal, or financial professional before making decisions in those areas. Third Wave isn't responsible for the statements, conduct, services, or products of third parties. If we share a coupon code, we may receive a commission from sales arising from customers who use our coupon code. No one is required to use our coupon codes."

In this episode of The Psychedelic Podcast, Paul F. Austin speaks with Jodi Lomask, an artist, choreographer, and creative guide whose work bridges art, science, embodiment, and psychedelic experience. Find full show notes and links here: https://thethirdwave.co/podcast/episode-345/?ref=278  They explore how psychedelic experiences can be approached as acts of creative design shaped by context and environment. Jodi shares insights from decades of immersive performance work and discusses flow, embodied intelligence, psychological safety in groups, and the differences between microdosing and vision quests. Jodi Lomask is an artist and founder of Capacitor, a performance company exploring the intersection of dance, science, and consciousness. Through Creative Journey, she supports individuals and teams in cultivating creative flow and embodied insight. Highlights: Designing psychedelic experiences intentionally Embodiment and integration Flow states and healing Psychological safety in group work Microdosing versus vision quests Episode Links: Creative Journey Jodi's website   Episode Sponsors: The Practitioner Certification Program by Third Wave's Psychedelic Coaching Institute. The Microdosing Practitioner Certification at Psychedelic Coaching Institute. Golden Rule - Get a lifetime discount of 10% with code THIRDWAVE at checkout Disclaimer: This content is for educational, informational, and entertainment purposes only. We do not promote or encourage the illegal use of any controlled substances. Nothing said here is medical or legal advice. Always consult a qualified medical or mental health professional before making decisions related to your health. The views expressed herein belong to the speaker alone, and do not reflect the views of any other person, company, or organization. Third Wave occasionally partners with or shares information about other people, companies, and/or providers. While we work hard to only share information about ethical and responsible third parties, we can't and don't control the behavior of, products and services offered by, or the statements made by people, companies, or providers other than Third Wave. Accordingly, we encourage you to research for yourself, and consult a medical, legal, or financial professional before making decisions in those areas. Third Wave isn't responsible for the statements, conduct, services, or products of third parties. If we share a coupon code, we may receive a commission from sales arising from customers who use our coupon code. No one is required to use our coupon codes.

In this episode of The Psychedelic Podcast, Paul F. Austin speaks with Hunt Priest, founder of Ligare, about Christianity, mysticism, and the ethical integration of psychedelic experience within spiritual life. Find full show notes and links here: https://thethirdwave.co/podcast/episode-344/?ref=278  They discuss Hunt's participation in a 2016 Johns Hopkins psilocybin study for clergy, Christianity's long history of mystical experience, and how non-ordinary states can be held within ethical and communal containers. The conversation also explores legality versus ethics, justice and institutional risk, and how psychedelics relate to prayer, meditation, and service within a broader spiritual life. Hunt Priest is a Christian minister and founder of Ligare, a nonprofit exploring the relationship between Christianity and psychedelics. Formerly an Episcopal priest, he works at the intersection of spiritual formation, ethics, and community-based integration of mystical experience. Highlights: Johns Hopkins clergy study Christian mysticism and non-ordinary states Psychedelics as catalysts for spiritual practice Legal versus ethical tensions Institutional risk and grace Episode Links: Ligare Hunt on Substack Episode Sponsors: The Practitioner Certification Program by Third Wave's Psychedelic Coaching Institute. The Microdosing Practitioner Certification at Psychedelic Coaching Institute. Golden Rule - Get a lifetime discount of 10% with code THIRDWAVE at checkout Disclaimer: This content is for educational, informational, and entertainment purposes only. We do not promote or encourage the illegal use of any controlled substances. Nothing said here is medical or legal advice. Always consult a qualified medical or mental health professional before making decisions related to your health. The views expressed herein belong to the speaker alone, and do not reflect the views of any other person, company, or organization. Third Wave occasionally partners with or shares information about other people, companies, and/or providers. While we work hard to only share information about ethical and responsible third parties, we can't and don't control the behavior of, products and services offered by, or the statements made by people, companies, or providers other than Third Wave. Accordingly, we encourage you to research for yourself, and consult a medical, legal, or financial professional before making decisions in those areas. Third Wave isn't responsible for the statements, conduct, services, or products of third parties. If we share a coupon code, we may receive a commission from sales arising from customers who use our coupon code. No one is required to use our coupon codes.

In this episode of The Psychedelic Podcast, Paul F. Austin speaks with Justin Wolf, co-founder and CEO of New Brew, about plant-based alternatives to alcohol and how social drinking culture may be shifting. Find full show notes and links here: https://thethirdwave.co/podcast/episode-343/?ref=278  Justin shares how exploring kava and kratom traditions in Mexico shaped New Brew's approach to formulation, emphasizing reliable dosing, transparency, and harm reduction. Together, they discuss why alcohol became the default social drug, the limits of most "functional beverages," and the nuance behind terms like "Cali sober." The conversation also explores dependency risk, intention, moderation, and why plant-based alternatives are not positioned for those pursuing full abstinence. At its core, this episode is about expanding optionality and building new social rituals responsibly. Justin Wolf is the co-founder and CEO of New Brew, a plant-powered social tonic designed as an alternative to alcohol. Prior to launching New Brew, Justin spent five years leading Global Partnerships at Google and helped launch DripDrop, an electrolyte hydration brand now sold nationwide. Inspired by kava and kratom traditions he encountered in Mexico, he founded New Brew with a focus on transparency, education, and harm reduction. He is also an early investor and advisor in the psychedelic medicine Highlights: Why alcohol became the default social drug The limits of "functional" beverages Discovering kava and kratom in Mexico Harm reduction through formulation and dosing Intention over abstinence or excess The nuance behind "Cali sober" Building new social rituals responsibly Episode Link: New Brew (use code: THIRDWAVE) Episode Sponsors: The Practitioner Certification Program by Third Wave's Psychedelic Coaching Institute. The Microdosing Practitioner Certification at Psychedelic Coaching Institute. Golden Rule - Get a lifetime discount of 10% with code THIRDWAVE at checkout Disclaimer: This content is for educational, informational, and entertainment purposes only. We do not promote or encourage the illegal use of any controlled substances. Nothing said here is medical or legal advice. Always consult a qualified medical or mental health professional before making decisions related to your health. The views expressed herein belong to the speaker alone, and do not reflect the views of any other person, company, or organization. Third Wave occasionally partners with or shares information about other people, companies, and/or providers. While we work hard to only share information about ethical and responsible third parties, we can't and don't control the behavior of, products and services offered by, or the statements made by people, companies, or providers other than Third Wave. Accordingly, we encourage you to research for yourself, and consult a medical, legal, or financial professional before making decisions in those areas. Third Wave isn't responsible for the statements, conduct, services, or products of third parties. If we share a coupon code, we may receive a commission from sales arising from customers who use our coupon code. No one is required to use our coupon codes.

In this episode of The Psychedelic Podcast, Paul F. Austin speaks with Dr. Paul Ryder, founding minister of the Congregation for Sacred Practices, about an alternative framework for psychedelic work rooted in spirituality, ritual, and community rather than medicine alone. Paul Ryder shares how his own experiences led him to treat psychedelics as sacraments, and why he believes the medical model, while valuable, represents only an early phase of the psychedelic renaissance. Together, they explore how CSP operates as both a church and a seminary, training licensed ministers to hold ceremonies ethically, safely, and within a religious legal framework. The conversation also examines the role of community in long-term transformation, the distinction between therapists and ministers, and why practices like breathwork, meditation, and integration circles are central to spiritual development. Throughout, Ryder offers a grounded perspective on how psychedelics can support not just healing, but maturation, responsibility, and a deeper sense of purpose. You can find the full episode summary and related resources here: https://thethirdwave.co/podcast/episode-342/?ref=278 Episode Links The Congregation for Sacred Practices Episode Sponsors: The Practitioner Certification Program by Third Wave's Psychedelic Coaching Institute. The Microdosing Practitioner Certification at Psychedelic Coaching Institute. Golden Rule - Get a lifetime discount of 10% with code THIRDWAVE at checkout Disclaimer: This content is for educational, informational, and entertainment purposes only. We do not promote or encourage the illegal use of any controlled substances. Nothing said here is medical or legal advice. Always consult a qualified medical or mental health professional before making decisions related to your health. The views expressed herein belong to the speaker alone, and do not reflect the views of any other person, company, or organization. Third Wave occasionally partners with or shares information about other people, companies, and/or providers. While we work hard to only share information about ethical and responsible third parties, we can't and don't control the behavior of, products and services offered by, or the statements made by people, companies, or providers other than Third Wave. Accordingly, we encourage you to research for yourself, and consult a medical, legal, or financial professional before making decisions in those areas. Third Wave isn't responsible for the statements, conduct, services, or products of third parties. If we share a coupon code, we may receive a commission from sales arising from customers who use our coupon code. No one is required to use our coupon codes.

In this episode of The Psychedelic Podcast, Paul F. Austin speaks with Jhaimy Alvarez-Acosta, a traditional Andean curandero from Cusco, Peru, about lineage, ceremony, and responsibility within Indigenous wisdom traditions. Find full show notes and links here: https://thethirdwave.co/podcast/episode-341/?ref=278  They explore Andean cosmology as a living worldview and reframe master plant work as a form of deep education rather than clinical healing. The conversation emphasizes mentorship, initiation through lived experience, and healing as a relational process rooted in land, ancestors, and community. Maestro Jhaimy Alvarez Acosta has walked the path of Andean wisdom for over thirty years, guiding ceremonies and pilgrimages throughout the Andes and internationally. His work emphasizes humility, relationship, and long-term commitment to lineage-based traditions. Highlights: Fear as a guide rather than an obstacle Initiation through lived experience Huachuma in Andean tradition Roles within Indigenous healing lineages Master plants as teachers, not tools Healing as acceptance and relationship Andean cosmology in the modern world Mentorship and community-based learning Episode Links: Children of the Seven Rays Heart of the Condor Podcast Jhaimy's Instagram Microdosing San Pedro for Nervous System Regulation | Traditional vs Modern Protocols Episode Sponsors: The Practitioner Certification Program by Third Wave's Psychedelic Coaching Institute. The Microdosing Practitioner Certification at Psychedelic Coaching Institute. Golden Rule - Get a lifetime discount of 10% with code THIRDWAVE at checkout Third Wave occasionally partners with or shares information about other people, companies, and/or providers. While we work hard to only share information about ethical and responsible third parties, we can't and don't control the behavior of, products and services offered by, or the statements made by people, companies, or providers other than Third Wave. Accordingly, we encourage you to research for yourself, and consult a medical, legal, or financial professional before making decisions in those areas. Third Wave isn't responsible for the statements, conduct, services, or products of third parties. If we share a coupon code, we may receive a commission from sales arising from customers who use our coupon code. No one is required to use our coupon codes."

Can Europe Legalize Psychedelic Therapy? In this episode of The Psychedelic Podcast, Paul F. Austin speaks with Théo Giubilei, founder of PsychedeliCare, about how psychedelic therapy could become a public health issue at the European Union level. Find full show notes and links here: https://thethirdwave.co/podcast/episode-340/?ref=278  They discuss how EU policymaking works, why stigma and political risk continue to shape reform, and the challenges of coordinating psychedelic care across multiple healthcare systems. The conversation also explores why patient testimony and citizen-led advocacy may be essential to shifting public health policy in Europe. Théo Giubilei is a Brussels-based mental health advocate and founder of the PsychedeliCare European Citizens' Initiative. A graduate in European Politics and Public Affairs from Sciences Po Strasbourg, he previously worked in European public affairs before dedicating himself full-time to psychedelic policy reform. Since 2022, Théo has led a grassroots coalition across all 27 EU member states working to advance safe, legal, and equitable access to psychedelic therapies as a public health issue. Highlights: European Citizens' Initiative explained Political and cultural barriers to reform Patient testimony in policy debates U.S. vs EU access models Public funding and coordination Episode Links: PsychedeliCare Initiative PsychedeliCare on Instagram Episode Sponsors: The Practitioner Certification Program by Third Wave's Psychedelic Coaching Institute. The Microdosing Practitioner Certification at Psychedelic Coaching Institute. Golden Rule - Get a lifetime discount of 10% with code THIRDWAVE at checkout Third Wave occasionally partners with or shares information about other people, companies, and/or providers. While we work hard to only share information about ethical and responsible third parties, we can't and don't control the behavior of, products and services offered by, or the statements made by people, companies, or providers other than Third Wave. Accordingly, we encourage you to research for yourself, and consult a medical, legal, or financial professional before making decisions in those areas. Third Wave isn't responsible for the statements, conduct, services, or products of third parties. If we share a coupon code, we may receive a commission from sales arising from customers who use our coupon code. No one is required to use our coupon codes."