Sona Nanotech achieves first patient dosing in clinical trial of Targeted Hyperthermia Therapy

Sona Nanotech CEO David Regan joined Steve Darling from Proactive to announce a significant milestone in the company’s clinical journey—the first patient dosing has been successfully completed in the early feasibility study of its Targeted Hyperthermia Therapy (THT) for advanced melanoma. This first-in-human dosing marks the culmination of years of preclinical research and development, representing a pivotal step toward validating Sona’s novel cancer treatment approach. The study is designed to assess the safety, tolerability, and early efficacy signals of THT, focusing on its ability to inhibit tumor growth and stimulate immune system engagement—particularly in patients who have not responded to standard-of-care immunotherapy treatments. The trial involves two treatments of Sona’s THT administered one week apart, targeting patients with advanced melanoma who are currently on—or have previously received—immunotherapy protocols but experienced disease progression or inadequate response. Initial readouts are expected later this summer, with final trial results anticipated in the fall. Regan also revealed the company’s plans for a second, more expansive human trial to follow shortly after, pending feedback and further engagement with regulatory authorities. Additionally, Sona intends to publish the study’s findings in a peer-reviewed scientific journal, contributing to the broader body of oncology research. Sona’s Targeted Hyperthermia Therapy uses gold nanorods designed to accumulate in tumors, which are then selectively heated using infrared light to disrupt cancerous tissue while potentially amplifying the immune system’s response—offering a non-invasive complement or alternative to existing immunotherapy options that often come with limited response rates or harsh side effects. #proactiveinvestors #sonananotechinc #cse #sona #otcqb #snanf #CancerTherapy #GoldNanorods #FDAApproval #BiotechNews #Immunotherapy #ClinicalTrials #Nanomedicine #MelanomaTreatment #CancerResearch #THTTherapy #ClinicalTrials #CancerDevice #Immunotherapy #BiotechNews #LateStageCancer #ProactiveInvestors

Condor Resources CEO Chris Buncic joined Steve Darling from Proactive to announce that the company has signed a non-binding Letter of Intent (LOI) with a Peruvian buyer for the proposed sale of its 100% interest in the Soledad project, located in Ancash, Peru, for a total consideration of $3 million USD. Under the terms of the LOI, the purchaser will be granted an exclusive 36-month option to acquire all three mineral concessions that comprise the Soledad project. As part of the agreement, Condor will also sign a Cesión Minera, allowing the buyer to begin exploration activities immediately—without waiting for the final transfer of ownership. If the option is exercised, Condor Peru will retain a 1% Net Smelter Returns (NSR) royalty, ensuring continued exposure to the project’s upside. The purchaser will also take over the existing 1% NSR royalty obligation payable to Chakana Resources S.A.C., effectively consolidating all royalty interests under the new ownership. Buncic also share with Proactive this deal will allow Condor to realize value from Soledad while avoiding shareholder dilution and refocusing our capital and efforts on its core projects, Pucamayo and Huinac Punta. The Soledad transaction aligns with Condor’s ongoing efforts to monetize non-core assets and redirect resources toward advancing its priority exploration targets in Peru. The company sees Pucamayo and Huinac Punta as offering superior discovery potential and scalability. With a strengthened balance sheet and a streamlined portfolio, Condor Resources is positioning itself to deliver meaningful exploration results from its more prospective holdings—while still maintaining future upside through retained royalty interests in Soledad. #proactiveinvestors #condorresourcesinc #tsxv #cn #MiningUpdate #PucamayoProject #CopperExploration #SoledadProject #HuiñacPunta #Pucamayo #MiningInvesting #JuniorMining #GoldExploration #MiningNews #ResourceSector

First Phosphate Corp. CEO John Passalacqua joined Steve Darling from Proactive to share a transformative milestone for the company as it successfully produced commercial-grade lithium iron phosphate (LFP) 18650 battery cells—a significant step toward establishing a fully localized, North American LFP battery supply chain. The 18650 format is a widely adopted cylindrical lithium-ion battery cell used across numerous sectors, including robotics, automation, military and defense, telecommunications, data centers, medical devices, consumer electronics, and electric mobility. First Phosphate’s breakthrough marks a pivotal achievement in de-risking and reshoring critical battery production capabilities to North America. Passalacqua detailed how the battery cells were manufactured using entirely North American-sourced raw materials, all linked to the company's Bégin-Lamarche property in Quebec. The high-purity phosphoric acid, essential for the LFP cathode material, was derived from igneous phosphate concentrate extracted in Quebec and processed through pilot installations at Prayon Technologies in Belgium. The iron powder component was sourced from magnetite concentrate also extracted from the Bégin-Lamarche property and processed by GKN Hoeganaes in Tennessee, USA. The lithium carbonate was supplied by Century Lithium, produced from its Nevada-based operations. Looking ahead, the company plans to scale up its production capacity, support further pilot programs, and deepen industry partnerships to advance the commercialization of its battery materials. With ongoing demand for sustainable and secure supply chains, First Phosphate’s fully traceable, North American production process offers a compelling solution for OEMs, battery manufacturers, and policymakers alike. #proactiveinvestors #firstphosphatecorp #cse #phos #otcqb #frspf #phosphate #CriticalMinerals #BatteryMaterials #LFPCathode #FirstPhosphate #CanadaMining #GreenEnergy #SupplyChain #QuebecMining #EVBatteries #dod

EnWave Corporation CEO Brent Charleton joined Steve Darling from Proactive to announce a significant expansion of the company’s longstanding relationship with MicroDried, EnWave’s most established and high-capacity royalty partner. The latest agreement includes a new royalty-bearing commercial license and the purchase of three additional Radiant Energy Vacuum machines—two 10kW units and one 60kW unit. Under the terms of the expanded agreement, MicroDried® secures exclusive rights to deploy the company’s dehydration technology for the production of mochi and Greek yogurt-based products in North America. Additionally, the license allows MicroDried® to expand into other dairy-based applications, including shredded cheese and cheesecake, reinforcing its move into the clean-label, high-nutrient dairy segment. In return for these broadened production rights, MicroDried® has agreed to incremental minimum annual royalty payments, which are additive to its existing royalty structure for the production of fruit and vegetable products. MicroDried, a U.S.-based leader in premium dried fruit and vegetable ingredients, is now enhancing its capabilities to meet rising consumer demand for clean-label, shelf-stable dairy and mochi snacks. With the acquisition of three more REV™ machines, MicroDried® now controls five large-scale REV™ units, making it the largest commercial operator of EnWave’s dehydration technology worldwide. #proactiveinvestors #enwavecorporation #tsxv #enw #DehydrationTech #VacuumMicrowave #RoyaltyBusinessModel #BluechipClients #FoodTech #BusinessNews #Investing #RadiantEnergyVacuum #Agritech #Procescir #DehydrationTechnology #FoodInnovation #SupplyAgreement #InvestmentNews #ProactiveInvestors #microdried

Blue Lagoon Resources CEO Rana Vig joined Steve Darling from Proactive to share a major milestone for the company as it prepares to commence gold production at its fully permitted underground mine in British Columbia. This milestone follows the receipt of a hard-won mining permit in February 2025, making Blue Lagoon one of just nine companies in the province to secure such a permit in the past decade—a significant regulatory achievement. Vig confirmed that all key infrastructure is now in place, including the completion of a state-of-the-art water treatment plant, which was the final component required before commencing operations. With 1,000 metres of underground development already completed, the company is ready to begin production shortly after its official opening ceremony scheduled for July 9th. Blue Lagoon is targeting an initial 15,000 ounces of gold production in its first year, with an expected increase to 20,000 ounces in the second year. The company is fully funded for this ramp-up, having recently raised nearly $5 million in equity, and secured an unsecured $2 million line of credit—notably, without pledging its mineral assets as collateral. Vig emphasized the long-term potential of the Dome Mountain project, noting that only 10% of the 22,000-hectare property has been explored to date. Recent drilling results have uncovered high-grade gold mineralization below the known resource area, pointing to strong upside for future resource expansion. Another key advantage of the project is its year-round accessibility by road, eliminating the need for costly camps or helicopter logistics. This infrastructure efficiency allows for continuous operations and contributes to lower operational costs. With production imminent and exploration potential still largely untapped, Blue Lagoon Resources is positioning itself as one of the few junior gold producers in British Columbia with near-term cash flow and long-term growth potential. #proactiveinvestors #bluelagoonresourcesinc #cse #bllg #otcqb #blagf #GoldMining #BlueLagoonResources #GoldProduction #MiningInvesting #BritishColumbiaMining #JuniorMiners #GoldStocks #UndergroundMining #ResourceExploration #MiningNews

Group Eleven Resources CEO Bart Jaworski joined Steve Darling from Proactive to discuss exciting new drill results from the company’s 100%-owned PG West Project in Ireland, specifically at the Ballywire zinc-lead-silver-copper discovery. The latest step-out drilling has significantly expanded the known mineralized footprint, extending the strike length of the Ballywire discovery corridor from 1,250 metres to 1,300 metres. The corridor is part of a broader 2.6 km trend of confirmed mineralization within a prospective 6 km geological horizon that remains underexplored. Jaworski emphasized the significance of the latest drill hole, which returned the thickest mineralized intercept ever recorded at Ballywire, surpassing a previously notable intercept of 29.6 metres grading 10.6% Zn+Pb, 78 g/t Ag, and 0.15% Cu. These results confirm not only increased tonnage potential but also the presence of a deeper copper-silver enriched horizon, located approximately 100 to 200 metres below the main discovery zone. This deeper zone could indicate a second, previously unrecognized layer of mineralization, potentially enhancing the project’s economic upside. Currently, three drill rigs are operating at Ballywire, and over 4,000 metres of drilling has been completed so far this year. The company is fully funded to carry out a total of 8,000 to 10,000 metres of drilling in 2025, with work focused on expanding the known resource envelope and testing deeper targets. One hole targeting the copper-silver horizon has already been completed, and a second is underway, with assays pending. Located within the heart of Ireland’s Limerick Basin, the Ballywire discovery is part of a district that has long been recognized for its world-class zinc-lead deposits. The PG West Project lies adjacent to the historic Pallas Green and Galmoy mines, providing Group Eleven with strong geological analogs and infrastructure advantages. With funding secured, multiple drill targets in play, and promising geological indicators emerging at depth, Group Eleven is advancing Ballywire as one of the most compelling zinc-lead-silver-copper exploration plays in Europe today. #proaxctiveinvestors #tsxv #zng #ptcqb #grlvf #ZincMining #GroupElevenResources #BallywireProject #IrishMining #CopperExploration #SilverDiscovery #CriticalRawMaterials #MiningInvesting #ResourceExploration #JuniorMining

As the financial year wraps up, are you making the most of your investments after tax? In this Proactive Australia podcast, host Fouad Haidar sits down with Andrew Wilson from Pitcher Partners — one of Australia's leading financial advisers — to unpack smart, tax-efficient strategies for investing in growth-stage companies across tech, biotech, and clean energy. From managing capital gains during market volatility to choosing the right investment structure — family trusts, investment companies, Self-Managed Super Funds (SMSFs) and more — this episode is a must-watch for anyone serious about long-term wealth creation. Tune in to learn how to protect and grow your wealth, even in uncertain times. #TaxEfficientInvesting #CapitalGains #InvestmentStrategy #WealthCreation #ProactiveAustralia #FinancialPlanning #SMSF #FamilyTrust #BiotechInvesting #TechStocks #CleanEnergy #PitcherPartners #AndrewWilson #EndOfFinancialYear #SmartInvesting #AustralianFinance #InvestingTips

ACG Metals Ltd Chairman and CEO Artem Volynets talked with Proactive about the company’s progress on its copper expansion and broader operational plans. Volynets confirmed that ACG Metals remains on budget and on schedule to commission the copper flotation plant at Gediktepe in the first quarter of 2026. He noted that all long-lead items have already been ordered and that the project is proceeding “like clockwork.” Discussing the company’s transition from gold to copper production, Volynets said this shift is expected to significantly increase EBITDA and free cash flow. “Even from Gediktepe our targeted EBITDA is published on base case scenario, which means consensus pricing is $110 million,” he stated, adding that at spot prices this could rise to around $225 to $230 million. He also addressed the impact of recent equity research coverage from Berenberg and Canaccord, highlighting that it has improved ACG Metals’ visibility with institutional investors and helped reinforce confidence in the company’s strategy. Finally, Volynets introduced Peter Carter as the new chief operating officer. Carter brings 40 years of experience and is expected to strengthen operations in Turkey and contribute to future M&A activity. Visit Proactive's YouTube channel for more videos. Don’t forget to like the video, subscribe to the channel and enable notifications for future content. #ACGMetals #CopperProduction #Gediktepe #MiningStocks #CopperMining #Zinc #GoldToCopper #ArtemVolynets #MiningInvesting #TurkeyMining #EBITDA #MetalsMarket #ResourceStocks #MiningExpansion

Vinanz Ltd (LSE:BTC, OTCQB:VINZF) CEO Hewie Rattray talked with Proactive's Stephen Gunnion with details of a second retail share offer as the company accumulates more bitcoin to grow its treasury holdings. The £1 million offer follows a recent oversubscribed WRAP retail offer, in which it raised £3.6 million, with the proceeds almost entirely used to purchase Bitcoin. Rattray noted that it was well received by the market, with the share price rising significantly after the transaction. Rattray also discussed the company's strategic rebrand as The London Bitcoin Company Limited. Rattray explained that the new name is intended to have global appeal and resonate with US investors as the company prepares for a Nasdaq listing. Rattray emphasised that the company's approach aims to provide London investors with comfortable tracking exposure to Bitcoin on the stock market, leveraging the region's large base of investment capital. "Our primary mission is to accumulate as much Bitcoin as possible through fundraisers and various other structured products," Rattray said. He highlighted that Vinanz aims to become a stock that outperforms Bitcoin itself by using sensible leverage and maintaining an active balance sheet. Visit Proactive’s YouTube channel for more videos, and don’t forget to give this video a like, subscribe to the channel, and enable notifications for future content. #BitcoinInvestment #VinanzLtd #LondonBitcoinCompany #BitcoinTreasury #CryptoStocks #NasdaqListing #BitcoinExposure #HewieRattray #BitcoinFundraising #ProactiveInvestors

NEXE Innovations has announced a significant commercial milestone with over 700,000 compostable coffee pods ordered in May 2025, highlighting strong demand from three customers across North America. This surge in purchase orders reflects accelerating adoption of NEXE’s BPI-certified compostable pod technology, a sustainable alternative to traditional plastic and aluminum single-serve formats. President Ash Guglani shared the update in an interview with Steve Darling of Proactive, noting that this latest batch of orders comes in addition to the more than 1.7 million pods NEXE has produced since November 2024. Among the key developments is a new partnership with Crazy Cups, a popular U.S.-based coffee brand known for its bold, dessert-inspired flavors like White Chocolate Strawberry, Cinnamon French Toast, and Amaretto Almond Kringle. The initial order from Crazy Cups includes 20 flavored SKUs, marking NEXE’s largest engagement in the flavored coffee category to date. Crazy Cups is affiliated with EKOCUPS, an existing high-volume customer of NEXE and a prominent online and Amazon retailer. This relationship not only strengthens NEXE’s foothold in the flavored single-serve market, but also enhances its direct-to-consumer reach, especially in the competitive U.S. e-commerce space. Looking ahead, Guglani confirmed that NEXE is currently developing an additional 20 new SKUs across its customer base—including 14 more for Crazy Cups—as part of a broader innovation roadmap. These new offerings are expected to support both product diversification and customer growth initiatives. Beyond expanding its product portfolio, NEXE is also making strategic operational moves to strengthen its North American supply chain and enhance profitability. The company remains on track to launch its next-generation, compostable Nespresso® OriginalLine-compatible pods later this year, a move that will allow NEXE to further tap into the premium pod market. #proactiveinvestors #nexeinnovationsinc #tsxv #nexe #otc #nexnf #Sustainability #CoffeePods #EcoFriendlyProducts #Manufacturing #PatentTechnology #StrategicPartnerships #AshGuglani #ProactiveInvestors #GreenTechnology