Episode 10: Biofidelity - Making Genomics Simpler

A lung cancer patient can have a targeted therapy available to them and never find out — because the biomarker test failed, took too long, or was never ordered. Dr. Barney Balmforth thinks that gap is an engineering problem, not a science problem. In this episode of Precision Pulse,  Amit Jain  of  @Precision_Pulse_with_Amit sat down with  @BarneyBalmforth-Biofidelity , co-founder and CEO of  @Biofidelity   a molecular diagnostics company based in Cambridge, England  We talked about why comprehensive genomic profiling has become the default answer to questions that may not require it, what it takes to run guideline-recommended lung biomarker testing on PCR instruments labs already own, and why Biofidelity’s newer Enspyre technology goes after the inefficiency of sequencing itself rather than competing with it. We also get into reimbursement and the regulatory path scenarios, the CellCarta partnership and what changed when it expanded to global exclusivity, and where Barney thinks the life sciences industry is structurally wrong right now. — CHAPTERS —00:00 The patients who never get tested00:45 Welcome to Precision Pulse02:15 From physics to cancer diagnostics08:15 Why biomarker testing still does not reach patients13:15 Aspyre: comprehensive lung testing on a standard PCR machine20:15 Enspyre: the signal-to-noise problem inside sequencing26:15 CellCarta, biopharma, and the commercial model30:45 Near-term milestones and the five-year vision35:15 Rapid fire37:45 Closing thoughts#PrecisionMedicine #Diagnostics #LungCancer #Genomics #Oncology #MolecularDiagnostics #LiquidBiopsy #NGS #CancerResearch #HealthTech #LifeSciences #Biotech #precisiononcology  #podcastclips #podcast   #PrecisionPulse #biofidelity #precisionpulsewithamit #lungcancerawarenessmonth #lungcancerawareness #precisionmedicine  #diagnostics  #lungcancersymptoms

Precision medicine means the right treatment, for the right patient, at the right time.But what if precision goes beyond the clinic?In our latest Precision Beyond Medicine episode,  @jainamit74   of  @Precision_Pulse_with_Amit   sat down with Susanna, a boxing coach at  @titleboxingclub in Burlington, MA. Her path to recovery wasn’t a straight line. She struggled with anxiety and addiction, tried several approaches, and then walked into a boxing gym. What started as a workout turned into a source of discipline, confidence, community and, eventually, transformation.This isn’t really a boxing episode. It’s about finding what works for you.In this conversation we explore:🥊 Life before the transformation, and struggling quietly while looking fine on the outside🔍 Treatment vs. transformation: what helped, and what was still missing💡 Why boxing worked, across physical, mental, emotional and social dimensions🏃 Whether the lesson is boxing at all, or finding your thing (running, yoga, dance, hiking…)❤️ What she would tell the version of herself who was struggling years agoMedication may help. Therapy may help. Community and movement may help. The real challenge is finding the right combination for each person. That’s precision beyond medicine.If this resonates, please subscribe and share it with someone who might need to hear it.This episode shares one person’s story and isn’t medical advice. If you’re dealing with anxiety, addiction or other mental health challenges, please work with a qualified professional.#PrecisionPulse #PrecisionBeyondMedicine #Recovery #MentalHealth #Boxing #LifestyleMedicine #Resilience #Wellbeing #Podcast #physicalactivity

Episode 08: Every pregnancy should be a journey toward hope—not one overshadowed by preventable complications.In this powerful episode of @The Precision Pulse, Amit Kumar Jain (AJ)  sat down with Martina Mollers, founder of  Marti  Connecting Africa, to discuss one of the world's most important yet under-recognized healthcare challenges: pre- and postnatal complications, particularly in underserved and low-resource communities.Together, they explored:🔹 Why maternal complications continue to impact millions of women worldwide🔹 The warning signs that women and families should never ignore🔹 How awareness, education, and timely intervention can save lives🔹 Funding situation🔹 The role of healthcare systems, policymakers, and communities in improving maternal outcomes🔹 Why healthcare equity is essential for healthier mothers, babies, and familiesOne message resonated throughout our conversation:Improving maternal health isn't only about better technology—it's about earlier awareness, better access, stronger communities, and ensuring every woman receives the care she deserves before, during, and after pregnancy.A heartfelt thank you to Martina for sharing her experience, passion, and commitment to advancing maternal health awareness across Africa and beyond.🎧 listen now and join the conversation.#PrecisionPulse #MaternalHealth #WomensHealth #GlobalHealth #HealthcareEquity #PublicHealth #PatientAdvocacy #HealthcareInnovation #Pregnancy #PostpartumCare #Africa #Leadership #LifeSciences #Podcast

What happens when a research university and a global patient-advocacy organization set out to catch cancer before symptoms appear? In this episode   ⁨ @jainamit74 of  ⁨ @Precision_Pulse_with_Amit sat with Rodrigo Mora of CICICA,  University of Costa Rica and Maria Lourdes of  ⁨ @Inspire2liveChannel and discussed real-world implementation of a clinical diagnostic test (OncoSeek) for early risk assessment across 9 types of cancer, built through a partnership between the University of Costa Rica (CICICA – Cirugía y Cáncer) and Inspire2Live in Costa Rica.Few moments that stayed with us forever:* If the algorithm flags a high risk of cancer, it can also determine the tissue of origin — not just whether someone is high-risk, but the possible location* In oncology, the problem is the huge waiting lists — patients wait a year for a colonoscopy, two years for a mammography. A tool that tells you whether you might have one of nine cancers offers real relief* Many physicians came to take the test themselves — even our health minister came to have it done. People really believe in this* Technology and patient education can't be separated — you have to be just as clear about a test's limitations as its promiseGrateful to Rodrigo Mora and Maria Lourdes for a candid conversation#precisionmedicine  #diagnostics  #earlydetection  #cancerscreening  #cdx  #PatientAdvocacy #oncology  #NIAMBIO #lifestyle 

In this episode of Precision Pulse, host @amit Jain engages in a profound conversation with Peter Kapitin from Inspire2Live, a patient advocate who has lived with cancer for over a decade. They explore the concept of living well with cancer, emphasizing the importance of mental health, physical rehabilitation, and lifestyle changes. Peter shares his journey from being a successful IT account manager to becoming a passionate advocate for cancer patients through his organization, Inspire to Live. The discussion highlights the significance of awareness in cancer care, the necessity of lifestyle changes, and the power of connection and purpose in navigating life with cancer. #cancer #exercise #qualityoflife #nutrition #sociallife #society #vegetrian #longevity #precision #swimming #biking #spinbike #spinning Takeaways• Living with cancer means choosing joy and purpose.• Patient advocacy can reshape cancer care.• Awareness is crucial for prevention and early detection.• Physical rehabilitation is essential for cancer patients.• Mental health support is often overlooked in cancer care.• Lifestyle changes can significantly improve quality of life.• Nutrition plays a vital role in cancer recovery.• Exercise is beneficial, even for cancer patients.• Connection with others enhances well-being.• Contributing to society gives life meaning.

In this episode of Precision Pulse, host Amit Kumar Jain  sits down with Erin Lubien — strategist, communicator, and recovery coach — to explore how precision practices can transform recovery into a pathway for purpose and self-mastery.Erin shares her deeply personal journey from addiction to empowerment, revealing how small, intentional actions — morning structure, emotional awareness, mindful reflection — can rebuild not just sobriety, but identity and balance.Together, we discuss the science and soul of personalized recovery, the power of self-control & tracking, and how specifically optimized practices can help anyone navigate transition, resilience, and growth.“Precision isn’t about perfection — it’s about presence & self awareness.”A grounded, inspiring conversation that bridges wellness, science, and human experience — and reminds us that every intentional moment moves us closer to wholeness.#addictionrecovery #addictionawareness #addictiontreatment #addictionfree #meditation #mindfulness #wellbeing #leadership #alcoholfree

Listen to the 4th episode of "Precision Pulse Podcast" where Amit Jain    of    Precision_Pulse_Podcast   sat with Peter Riccelli and Dr. Augusto Miravalle of RUSH University to discuss 6 pillars of brain health and explore importance of precision practices for quality of life.They discussed:How 6 pillars of brain health (Diet, Exercise, Meditation, Music, Good sleep, Social life) contributes to:Good quality of lifeNavigating and managing complex neurological disorders Application/Utility of wearablesHow happiness is aligned to fast recovery and improvement in quality of lifeDon’t miss this insightful and inspiring conversation—tune in to the episode now!#multiplesclerosis #neurology #precisionmedicine #patientcare #healthcareprofessionals #healthcare #generalwareness #brainhealth #meditation #meditationmusic #diet #exercise #sleep

What if happiness wasn’t just a feeling, but a measurable, teachable, and trainable state of being?Precision Pulse: Explore Precision Practices Beyond Medicine. The podcast where we explore how precision thinking, intentional living, and evidence-based strategies can shape a more balanced, vibrant, and purpose-driven life-eventually improving the lifestyle experienceIn this episode, our host Amit Kumar Jain (AJ)  @jainamit74   is discussing how science of happiness aligns with health, performance, and precision living — and how you can begin to take small, data-driven steps toward greater emotional alignment and joy in your everyday life. So whether you're a health enthusiast, a curious mind, or someone looking to fine-tune the way you live and feel — this episode is for youEnjoy the podcast

This episode involves diving into the world of personalized health with a company that’s redefining what it means to optimize from the inside out — InsideTracker. Gil Blander, CSO at InsideTracker talks to our host Amit K. Jain (AJ) about:Importance of BiomarkersPersonalized Data and Behavior ChangePrecision in Daily LifeLongevity and Futuristic viewPersonal Insights, impact, and takeaways

Introductory episode, discusses background, why this podcast was started and inspiration behind. Also chat with first guest "Pete Riccelli" and discuss his experience of "Precision beyond medicine"