PMOS: how the new draft NICE guideline could transform diagnosis and care

Prescriptions for two NICE-recommended tablets for endometriosis and fibroids have risen sharply in England. In this episode of NICE Talks, we hear from Lucy Ford, Ruth Ajayi and Clare Gallagher, three women living with these conditions, about their experiences of diagnosis and treatment. We also hear from Dr Nilofer Husain, consultant gynaecologist, and Dr Marie Anne Ledingham, NICE consultant clinical adviser, about the growing use of these treatments, who they may be suitable for and where they fit among the options available.

In this episode, we explore the research taking place behind the scenes at NICE and how it helps us prepare for the future of healthcare. From new medicines and digital health technologies to artificial intelligence and innovative ways of using health data, the Research team works with partners across the UK and around the world to tackle some of the biggest challenges facing health and care today. Associate Director of Research Sarah Fothergill and senior scientific adviser Jamie Elvidge explain how NICE identifies emerging trends, develops new methods for evaluating health technologies, and ensures that future guidance is based on the best available evidence. You'll find more about the work of the research team, including how to get involved, on our website: https://www.nice.org.uk/what-nice-does/our-research-work/how-to-partner-with-us-in-our-research-work

In this episode, we explore how new machine perfusion technology is changing the landscape of organ transplantation in the UK. NICE has published guidance recommending routine NHS access to specialist devices that keep donated livers and lungs functioning outside the body, potentially unlocking hundreds of organs for transplant each year. We hear from cardiothoracic surgeon Marius Berman, Clinical Director of the Transplant Programme at Royal Papworth Hospital. And by Monica Walsh, who received a liver transplant almost 10 years ago and now mentors others waiting for transplants. - Read NICE's guidance on liver preservation machines - Read NICE's guidance on lung preservation technology

In this episode we explore the draft NICE guideline for PMOS (formerly known as PCOS), out for public consultation until 11 August 2026. We're joined by guideline committee members Aled Rees, professor of endocrinology at Cardiff University, and Sharon Manship, a lay member with lived experience of PMOS. Together they discuss how the recent name change, a new annual review, and a stronger focus on earlier diagnosis could transform care for the estimated 1 in 8 women living with the condition. Learn more: https://www.nice.org.uk/news/articles/nice-recommends-annual-review-for-pmos-in-new-draft-guideline-aimed-at-improving-diagnosis-and-care Read the draft guideline: https://www.nice.org.uk/guidance/indevelopment/gid-ng10436/consultation/html-content-9

NICE has recommended teplizumab for NHS use — the first treatment to delay the onset of symptomatic type 1 diabetes by an average of nearly three years. In this episode, we speak to Lucy Chambers, Head of Research Impact and Communications at Diabetes UK, and Amy Norman, whose daughter Imogen accessed teplizumab through a managed access programme after being identified through the ELSA screening study. Find out more: NICE recommendation for teplizumab: https://www.nice.org.uk/guidance/gid-ta10981/documents/html-content-10 | ELSA screening study (children aged 2–17): https://www.elsadiabetes.nhs.uk/taking-part/ | T1DRA trial (adults): https://t1dra.bristol.ac.uk/

In this episode we discuss the recent changes to the NICE guideline for neonatal infections, that mean newborn babies receiving antibiotics in hospital could potentially switch to oral antibiotics and be cared for at home, if they are doing well and responding to treatment. Guests: • Dr Tim Watts, guideline committee member and Consultant Neonatologist at the Evelina • Dr Harriet Aughey, Neonatal paediatrician at the Royal Devon and Exeter Hospital and co-lead on the NOAH (Neonatal Oral Antibiotics at Home) project • Emily Rose Jeffrey, mother to Luna took part in the NOAH trial Link to neonatal infections guideline: https://www.nice.org.uk/guidance/ng195 Link to news story: https://www.nice.org.uk/news/articles/nice-updates-neonatal-infection-guidance-to-allow-home-antibiotic-treatment-for-some-babies

In this episode of NICE Talks, we're covering some of the most significant guidance updates of the year so far for women's health and cancer care. For the first time, NICE's updated fertility guideline includes a dedicated pathway specifically for people with endometriosis who are trying to conceive — a direct result of patient and clinician voices being heard during public consultation. We then turn to important updates to NICE's suspected cancer recognition and referral guideline, including changes to how ovarian cancer is investigated across different age groups and new guidance on endometrial cancer for people on HRT. Useful links: Fertility problems: assessment and treatment (NG257): https://www.nice.org.uk/guidance/ng257 Suspected cancer: recognition and referral (NG12): https://www.nice.org.uk/guidance/ng12

When the right technology reaches the right patient, lives change. In this episode of NICE Talks, we hear directly from people whose lives have been transformed by NICE-recommended healthtech, including a hybrid closed loop system for type 1 diabetes, an implantable cardiac monitor to detect atrial fibrillation following a stroke, and a rapid genetic test that protects newborns from hearing loss caused by a common antibiotic. NICE's chief executive, Jonathan Benger, also shares our plans to support faster, fairer healthtech adoption across the NHS. Guests Jonathan Benger, NICE chief executive Ammaarah Ahmed and Aleix Rowlandson, who both benefit from a hybrid closed loop system to help manage their type 1 diabetes Peter Hooper, who was fitted with an implantable cardiac monitor to detect atrial fibrillation following his stroke Becky Ridley and baby Ginny, who benefitted from a rapid genetic test to help prevent hearing loss Caroline Knight who uses one-piece colostomy bags following bowel surgery Links Explore support for adopting or developing healthtech: https://www.nice.org.uk/what-nice-does/our-guidance/about-healthtech-guidance/nice-backing-the-healthtech-that-changes-lives NICE Advice service (for healthtech developers): www.nice.org.uk/niceadvice Subscribe to NICE News for Health and Social Care: www.nice.org.uk/nice-newsletters-and-alerts Subscribe to NICE News for Life Sciences: www.nice.org.uk/nice-newsletters-and-alerts Follow NICE on social media: search @NICEComms.

In this episode, we discuss two innovative migraine treatments recommended by NICE. We explore the rapid uptake across the NHS with our three guests. We're joined by Joanne McShane, an NHS health visitor who suffered from migraine for a decade; Dr Kay Kennis, GP with an extended role in Headache at Bradford Community Neurology Service; and Rob Music, chief executive at The Migraine Trust.

In this episode of NICE Talks, we learn the impact of the joint asthma guideline published in November 2024. Developed collaboratively by the British Thoracic Society, NICE and the Scottish Intercollegiate Guidelines Network, the guideline has transformed how asthma is diagnosed and treated across the UK. We hear from frontline clinicians putting the guidance into practice and from those who helped develop it – including a patient who has lived with asthma for 65 years. Guests Maria Eurton – Respiratory Nurse Specialist, working across a primary care network of eight GP surgeries in Southampton Nazir Hussain – Specialist Respiratory Pharmacist, Dudley Group NHS Foundation Trust Phil Taverner – Lay Member, Guideline Development Committee (living with asthma for 65 years) Dr Sunil Gupta – GP and Clinical Advisor for NICE The Guideline Joint BTS/NICE/SIGN Asthma Guideline: http://www.nice.org.uk/guidance/ng245